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      • KCI등재후보

        무질서계의 노화현상에 대한 계층적 에너지 장벽 모델

        조영걸 한국물리학회 2002 새물리 Vol.45 No.2

        A hierarchical barrier model has been developed with insight gathered from a spinglass experiment. The model is based on a hierarchical tree structure in which metastable states are separated by energy barriers. The barrier heights depend monotonically upon the distance along the tree. The arrangements of the finite barriers are found to be self-similar. We showed numerically that a complicated diffusion process among the ultrametric barriers could quantitatively account for the dynamics of disordered systems. The model, developed from the spin-glass system, can easily be extended to non-magnetic disordered systems. 스핀글래스의 잔류자화 실험에 기초한 에너지 장벽 모델을 제시한다. 이 모델은 무질서계의 기억효과를 자기모사적인 계층적 에너지 장벽 사이에서의 준정적 상태들이 열적 평형을 찾는 과정으로 설명한다. 준정적상태들이 만족하는 확산 방정식을 제시하고, 수치적인 해를 구함으로써 기억효과를 정량적으로 계산하였으며 실험치와 상당히 일치하는 결과를 얻었다. 다양한 시스템에서 비슷한 노화현상이 발견되고 있어, 이 모델은 비자성체의 경우에도 쉽게 적용할 수 있다.

      • KCI등재

        Effect of Korean Red Ginseng intake on the survival duration of human immunodeficiency virus type 1 patients

        조영걸,김정은 고려인삼학회 2017 Journal of Ginseng Research Vol.41 No.2

        Background: Long-term ginseng intake can increase longevity in healthy individuals. Here, we examined if long-term treatment with Panax ginseng Meyer (Korean Red Ginseng, KRG) can also enhance survival duration (SD) in patients with human immunodeficiency virus type 1 (HIV-1) infection. Methods: We retrospectively analyzed 252 HIV-1 patients diagnosed from 1986 to 2013 prior to the initiation of antiretroviral therapy. Overall, 162 patients were treated with KRG (3,947 『 4,943 g) for 86 『 63 mo. The effects of KRG on SD were analyzed according to the KRG intake level and the length of the follow-up period. Results: There were significant correlations between the total amount of KRG and SD in the KRG intake group (r ¼ 0.64, p < 0.0001) as well as between total amount of KRG and mean annual decrease in CD4þ T-cell count in all 252 patients (r¼』0.17, p < 0.01). The annual decrease in CD4þ T-cell count (change in cells/mL) was significantly slower in KRG-treated patients than in patients receiving no KRG (48 『 40 vs. 106 『 162; p < 0.001). The SD (in months) was also significantly longer in the KRG group than in the no- KRG group (101 『 64 vs. 59 『 40, p < 0.01). Conclusion: KRG prolongs survival in HIV-1 patients, possibly by slowing the decrease in CD4þ T-cell count.

      • KCI등재

        GEANT4를 이용한 선형가속기 기초 코드 작성과 전자선 에너지 분포 계산

        조영걸,김형동,김병용,김성진,오세안,강정구,김성규,Joh, Young-Gull,Kim, Hyung-Dong,Kim, Byung-Young,Kim, Sung-Jin,Oh, Se-An,Kang, Jeong-Ku,Kim, Sung-Kyu 한국의학물리학회 2011 의학물리 Vol.22 No.2

        GEANT4 Medical Linac 2 예제 코드를 이용하여 선형가속기 전자선의 에너지 분포를 계산하였다. 입사 전자의 평균 에너지는 6, 9, 12, 16, 20 MeV이었으며, 전자선 특성에 영향을 주는 전자선 산란박 물질, 두께, 위치에 따른 에너지 분포를 계산하였다. 산란박 물질은 납, 구리, 알루미늄, 금을 사용하였다. 산란박 위치를 변경하여 선형 가속기 헤드 속 산란박 위치가 전자 및 광자 에너지 분포에 미치는 영향을 분석하였다. 의료용 선형가속기 시뮬레이션의 기초자료인 에너지 분포에 대해 여러 가지 산란박 조건을 적용하여 경향을 나타내었다. 이 결과는 선형가속기 헤드 설계에 이용될 수 있을 것으로 본다. The energy spectra for electron beam of medical linear accelerator were calculated using a GEANT4 Medical Linac 2 example code. The incident electron mean energy were 6, 9, 12, 16, 20 MeV. This code was designed to calculate electron beam energy spectra according to material, thickness and location of electron scattering foil affecting electron beam characteristic. Lead, Copper, Aluminum and Gold were used for scattering foil. The energy distribution for electron and photon were analyzed by changing position of scattering foil in the head of linear accelerator. The effect of electron scattering foil on energy spectra which is basic data of simulation for medical linear accelerator were presented. The calculated results would be used in design of medical accelerator head.

      • SCOPUSKCI등재

        장기간 진행하지 않는 인면역결핍바이러스(Human Immunodeficiency Virus, HIV)-1 감염자로부터 분리한 HIV-1의 전체 염기서열 결정

        조영걸,이희정,Cho, Young-Keol,Lee, Hee-Jung,Desrosiers, Ronald C. 대한미생물학회 1999 Journal of Bacteriology and Virology Vol.28 No.1

        To characterize the molecular nature of human immunodeficiency virus (HIV)-1, we determined the full-length HIV-1 sequences from cultured peripheral blood mononuclear cells (PBMC) of a Korean long-term nonprogressor (LTNP). Without antiretroviral therapy, the individual has maintained CD4+ T counts over $500/{\mu}l$ from 1989 to 1999. Plasma viral RNA copy was 992 U/ml in 1998. Culture supernatant showed positive from culture days 9. A series of 9 overlapping PCR products were amplified from cultured PBMC and cloned About 9.2 kb from R of 5' LTR to R of 3' LTR was determined by automated sequencing. The G-to-A hypermutations were shown throughout the entire region. As a result of G to A hypermutations, premature stop codon was found in integrase coding region. Though there was no recombination between subtypes over all genomes, TATA box in both LTRs was TAAAA which is detected in subtype E instead of TATAA in subtype B. And, there were nucleotide GC insertion between $NF-{\kappa}B$ I and Sp1 III, and duplication of $TCF-1{\alpha}$ in LTR. We could not find any deletion of amino acid in Nef, Gag, Pol and Env gene. This study is the first report on molecular nature of full genomes of HIV-1 isolated in Korea.

      • KCI등재

        성인에서 나타난 일과성 소장 장중첩증 1예

        조영걸,이태희,권순효,천강일,김현건,김완중,김진오,이준성 대한소화기내시경학회 2011 Clinical Endoscopy Vol.42 No.5

        Intussusception occurs when a segment of the bowel invaginates into the lumen of an adjacent distal segment. Intussusception in adults is a rare disease, accounting for only 5% of all cases. Asymptomatic small bowel intussusception in adults without a lead point is usually transient. When the length of the intussusception is less than 3.5 cm, it can be managed conservatively. This case was an asymptomatic small bowel intussusception without a lead point, which was discovered incidentally during an abdominal computed tomography scan. Spontaneous reduction in the intussusception was observed without any complications while maintaining conservative treatment only. 장중첩증은 장 일부가 원위부 장관 내로 유입되는 상태로 성인의 경우 전체 장중첩증의 5%에서 발생하는 드문 질환이다. 최근 영상 검사가 증가하면서 성인 소장 장중첩증의 진단이 증가하고 있고, 그 중 수술적인 치료가 불필요한 일과성 장중첩증인 경우 정확한 치료방향 정립이 무엇보다 중요하다. 성인 일과성 소장 장중첩증은 대개 증상이 없고 영상 검사에서 선행 병변이나 중첩 근위부의 소장 확장 소견이 보이지 않으며 특히 중첩 길이가 3.5 cm 이하일 경우 수술적인 치료 없이 보존 치료로 회복될 수 있다. 이번 증례는 성인에서 소장 장중첩증이 일시적으로 발생하였다가 대증 치료로 소실된 증례로서 문헌고찰을 통해 재조명하고자 한다.

      • KCI등재

        Effect of CoTiO3 formation on the magnetic properties of Co-doped TiO2 rutile

        조영걸,김동호,B. Y. Kim,조채용,김응찬,H. D. Kim,조종호,S. H. Moon,S. I. Woo 한국물리학회 2004 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.44 No.2

        We studied the structural and the magnetic properties of TiO2 rutile powder with various Co concentrations synthesized by using a solid-state reaction. For Co concentrations higher that 2 %, a second phase of CoTiO3 was observed on the X-ray diraction (XRD) experiment. The magnetization measurement showed room-temperature ferromagnetism in this material, but the magnetic moment per Co atom decreased signicantly as the Co concentration was increased. We attribute this reduction of magnetization to the formation of non-magnetic CoTiO3 complexes as probed by XRD. For samples with Co concentrations less than 2 %, the observed ferromagnetism seemed to be due to an exchange interaction between substitutional or interstitial Co atoms rather than to Co clusters.

      • SCOPUSKCI등재

        국내 HIV감염 동성연애자들의 역학적 특징 (1992년)

        조영걸,신영오,김영봉,Cho, Young-Keol,Shin, Yung-Oh,Kim, Young-Bong 대한예방의학회 1993 예방의학회지 Vol.26 No.4

        In order to investigate psychological and behavioral characteristics of homosexuals and to present evidence that homosexuals are in danger of HIV infection in Korea, this study was done by self-administered questionnaire and then direct interview with the 28 (35%) HIV infected homosexual/bisexuals of 79 HIV infected persons reported in 1992. Homosexuals without heterosexual activity were 9 and the others were bisexuals. Sixty-five percent of respondents had a guilty conscience for their homosexual activty. Twenty (71%) were in twenties and 5 (18%) in thirties. Twelve(43%) were detected via health card checking by health office, 21% by blood donation, 18% by hospital visit, and 7% by partner notification. Motivations for homosexual activity were curiosity (36%), temptation or recommendation (14%) and compulsion (11%). Eighteen (72%) never used condom on anal sex. Nine of 26 respondents had experience for anal sex with foreigners. Fourteen (54%) of 26 respondents had history for sexually transmitted diseases. Fighty percent did not have sexual contact after HIV infection and the others usually used condom. It was confirmed that over 57% of the respondents were infected within 1 year before HIV diagnosis and over 82% within 2 years. These data suggest that HTV infection among homosexual group is rapidly spreading.

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