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토끼에서 EPO(erythropoietin)의 4주간 정맥 반복투여 독성시험에 관한 연구
제정환,남정석,양재만,이석만,강병철,이학모,박재학,송동호,유선희 한국독성학회 1997 Toxicological Research Vol.13 No.1
Four-week toxicity of EPO(erythropoietin) was investigated using New Zealand White rabbits according to the established regulations of Korean National Institute of Safety Research. Rabbits were administered intravenously seven days per week for 28 days with dosage of 0, 80, 400 and 2000IU/kg B. W./day. Animals administered with EPO showed no significant changes of body weight, water consumption and feed consumption, and no clinical signs and death. They were not significantly different from the control group in hematological and serum biochemical analysis, urinalysis, prothrombin time, and partial thromboplastin time. In this study, we concluded that EPO had no toxic effect in the New Zealand White rabbits when they were administered intravenously below 2000IU/ kg B.W./ day for 28 days.
Erythropoietin(EPO)에 대한 변이원성시험
제정환(Jeong-Hwan Che),이광훈(Guang-Xun Lu),박진성(Jin-Sung Park),윤준원(Jun-Won Yun),김태원(Tae-Won Kim),김형섭(Hyung-Sub Kim),박지은(Jie-eun Park),윤신근(Sin-Keun Youn),이영순(Yong-Soon Lee) 한국독성학회 1999 Toxicological Research Vol.15 No.3
In order to evaluate the mutagenic potential of erythropoietin (EPO), Salmonella typhimurium reversion assay, chromosomal aberration test on chinese hamster lung cells and in vivo micronucleus assay using mouse bone marrow cells were performed. In the reverse mutation test using Salmonella typhimurium TA98, TA100, TA1535, TA1537, TA102 did not increase the number of revertant at any of the concentration tested in this study. EPO did not increase the number of cells having structural or numerical chromosome aberration in cytogenetic test. In mouse micronucleus test, no significant increase in the occurrence of micro nucleated polychromatic erythrocytes was observed in ICR male mice intraperitoneally administered with EPO. These results indicate that EPO has no mutagenic effects under these experimental conditions.
랫드에서 EPO(erythropoietin)의 4주간 정맥 반복투여 독성시험
남정석,제정환,이석만,양재만,강병철,이학모,박재학,송동호,유선희 한국독성학회 1997 Toxicological Research Vol.13 No.1
Group of 40 male and 40 female Sprague-Dawley rats were given daily intravenous injections of different dosage of Erythropoietin (EPO), 80 IU/ kg/day (low dosage group), 400 IU/ kg/day (middle dosage group), or 2000 IU /kg/day (high dosage group)for 4 weeks by tail vein according to Established Regulation of Korean National Institute of Safety Research (1994. 4. 14). Appearance, behavior, mortality, and food consumption of rats of treated groups were not affected during the experimental periods. No significant EPO (erythropoietin)-related changes were found in urinalysts, eye examination, hematology, serum chemistry, and organ weight. No histopathological lesions were observed in both control and treatment groups. Our results strongly suggest that no toxic changes were found in rat treated intravenously with EPO (erythropoietin)for 4 weeks.
기니픽, 마우스 그리고 랫드에서 Intralipidos의 항원성
이병희,제정환,이광훈,강병철,이원우,임종희,정지윤,이영순,Yi, Beoung-Hi,Che, Jeong-Hwan,Li, Guang-Xun,Kang, Byeong-Cheol,Lee, Won-Woo,Ihm, Jong-Hee,Jung, Ji-Youn,Lee, Yong-Soon 한국독성학회 1998 Toxicological Research Vol.14 No.3
The antigenicity of intralipidos was investigated in guinea pig, mice and rats. Antigenicity tests-active systemic anaphylaxis (ASA), passive systemic anaphylaxis (PSA), passive cutaneous anaphylaxix (PCA) of this materials were performed. The results were followed: 1. After sensitizaion with YPL, YPL+intralipidos, and intralipidos, emulsified with complete Freund's adjuvant (CFA), guinea pigs didn's show any anaphylatic shock symptom in the ASA test, 2. These materials didn't show any anaphylatic shock symptom in the PSA test, 3. After sensitization with antisera of YPL, YPL+intralipidos, and intralipidos sensitized mice, blue spots were not observed on the hypodermis of back of rats in the PCA test. From the results of this investigation, the antigenicity of YPL, intralipidos was negative under the present experimental condition.
강경선,제정환,김형섭,김경배,이지혜,조성대,조종호,김배환,이병렬,이영순 한국독성학회 2001 Toxicological Research Vol.17 No.1
This study was carried out to evaluate the irritant potential of A mouthwash in hamster cheek pouch. The test substances were applied twice daily to right pouches of hamsters for 14 consecutive days. Animals were administered with A mouthwash, Listerine, salline and control solution, respectively. In order to evaluate the irritant potential in mucosa of hamster cheek pouch, we observed clinical signs, mortality, body weight changes and gross and histopathological findings for 14 days. In all groups, there were neither dead animals nor significant changes of body weights. In addition, there were no differences between saline and A mouthwash treated group in gross and histopathological findings. Therefore, these results suggest that there was no irritant potential of A mouthwash in hamster cheek pouch.