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Lupus anticoagulant-hypoprothrombinemia in healthy adult
정춘해,박치영 대한내과학회 2008 The Korean Journal of Internal Medicine Vol.23 No.3
The presence of lupus anticoagulant is associated with an elevated risk of venous and arterial thrombosis, and recurrent miscarriages as well. For some cases, this disease can present with bleeding as a consequence of lupus anticoagulant‐hypoprothrombinemia (LAHPS). LAHPS is a rare disease and it is reported to be most frequent in young females with/without systemic lupus erythematosus or in healthy children who are suffering with a viral infection. In such cases, steroid therapy is usually effective in normalizing the biological abnormalities and controlling the bleeding problems. A 34-year-old previously healthy man was admitted to our department because of his prolonged coagulation times; these abnormalities were discovered before performing orthopedic surgery. The prothrombin time (PT) was 15.2 sec, and the activated partial thromboplastin time (APTT) was 37.7 sec. A 1:1 dilution of patient plasma with normal plasma nearly corrected the PT, but this failed to correct the APTT. Evaluation of the clotting factors revealed decreased levels of factors II, V, VIII, IX and XI. The presence of LA was demonstrated by the dRVVT test, and the patient was diagnosed with LAHPS. He was successfully treated with corticosteroid before performing the orthopedic surgery. The presence of lupus anticoagulant is associated with an elevated risk of venous and arterial thrombosis, and recurrent miscarriages as well. For some cases, this disease can present with bleeding as a consequence of lupus anticoagulant‐hypoprothrombinemia (LAHPS). LAHPS is a rare disease and it is reported to be most frequent in young females with/without systemic lupus erythematosus or in healthy children who are suffering with a viral infection. In such cases, steroid therapy is usually effective in normalizing the biological abnormalities and controlling the bleeding problems. A 34-year-old previously healthy man was admitted to our department because of his prolonged coagulation times; these abnormalities were discovered before performing orthopedic surgery. The prothrombin time (PT) was 15.2 sec, and the activated partial thromboplastin time (APTT) was 37.7 sec. A 1:1 dilution of patient plasma with normal plasma nearly corrected the PT, but this failed to correct the APTT. Evaluation of the clotting factors revealed decreased levels of factors II, V, VIII, IX and XI. The presence of LA was demonstrated by the dRVVT test, and the patient was diagnosed with LAHPS. He was successfully treated with corticosteroid before performing the orthopedic surgery.
정춘일,Jeong, Chun-Il 대전대학교 군사연구원 2006 군사학연구 Vol.4 No.-
In present, advanced countries in the world are seen concentring on Military Transformation to create new military capability as there is a shift in Warfare Paradigm. Rapid development of technology enables military system, operational concept and organization innovated. As a result, Revolution in Military Affairs(RMA) that dramatically increased warfighting capability is pursued. Especially, advanced information technology constructs system of systems with abilities of battle visualization, information sharing in battlefield, long-range strike capability that are interoperable and combined. Corresponding to this, engagement methods and organizations are being progressively developed. The purpose of this thesis is overview of newly developing Warfare Paradigm and analysis of tendency of Military Transformation that advanced countries are pursuing preparation to this. Above all, specific aspects and contents of the Warfare Paradigm which emerged by information age were summarized. Subsequently, Military Transformation which provides the basic concepts and principles to the advanced countries in the world for the creation of new military capability was discussed. In conclusion, the tendency of Military Transformation by U.S.A, Japan, China, and Russia surround the Korean peninsular as the major power in military was carefully observed.