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멸균법에 따른 황금의 미생물학적 품질보증과 바이칼린 함량에 미치는 영향
정춘식 한국생약학회 2005 생약학회지 Vol.36 No.3
− The purposes of this study was to develop the best one among the methods using dry heat, gamma irradiation and alcohol gas, to sterilize Scutellariae Radix selected based on high frequency of circulation between merchants and high susceptibility to microbial contamination, through comparing these methods in terms of the followings; i) the efficacy of sterilization in comparison with cost, and ii) the alteration of chemical components of these herbal medicines. The results of this study will be taken advantage of establishment of the maximum limit of microorganism contaminated in herbal medicines. From the results of this study we conclude the followings: i) The sterilizing method using dry heat may be inappropriate, because it seriously changed their color and morphology which is an essential criterion to estimate a measure of quality between merchants and consumers, although it effectively got rid of contaminated microorganism and did not alter major components, baicalin; ii) The sterilizing method using gamma irradiation may be appropriate, because it showed a strong sterilizing effect, and no alteration of chemical components, color and morphology; iii) The sterilizing method using alcohol gas may also be appropriate, because it had a similar effects as in the case of gamma irradiation. Collectively, we suggest that appropriate sterilizing methods to guarantee the microbial quality of this herbal medicine may be those using gamma irradiation and alcohol gas.
Steptozotocin 유발 당뇨 흰쥐에서 Tabebuia avellandae의 항당뇨 효과
정춘식,정기화 德成女子大學校 藥學硏究所 1997 藥學論文誌 Vol.8 No.1
Hypoglycemic effect of Tabebuia avellandae was investigated in the streptozotocin(STZ)-induced diabetic rats. Diabetes was induced in male Sprague-Dawley rats by injections of STZ(45 mg/kg, i.v.). Rats weighing 200-250g were divided into 6 groups:normal, STZ-control, hexane fr., CHCI_3 fr., BuOH fr. and H_2O fr. gourp. Normal and STZ-control rats received 3% tween 80 only. Four groups of diabetic rats were administered orally at doses of 100, 400, 300 and 400 mg/kg/day of hexane, CHCI_3, BuOH and H_2O fr. respectively. Fractions were administered orally to the rats for 7 days after STZ injection. All rats were anesthetized with ether, blood samples were taken by cardiac puncture for clinical chemistry and the rats were killed by exsanguination. Liver, kidney, heart and spleen were removed, weighed and analyzed. We measured glucose, protein, cholesterol and triglyceride levels in the plasma and glycogen, cholesterol and triglyceride levels in liver. The extent of blood glucose decrement in rats administered H_2O fraction was greater than that in the STZ-control rats. The serum cholesterol and triglyceride levels were significantly lowered by administration of H_2O fraction compared with those of STZ-control group. Treatment of rats with Tabebuia avellandae fractions caused decreases in STZ-induced elevation of cholesterol and triglyceride. Liver triglyceride level was significantly lowered hexane and BuOH fraction group compared with STZ-control group. These results suggest that H_2O fraction of Tabebuia avellandae has the hypoglycemic action against STZ-induced diabetic rats.
정춘식,Sang Hwa Yu,Jeong Eun Lee,Dong Keun Lee 대한대장항문학회 2012 Annals of Coloproctolgy Vol.28 No.3
Purpose: This study was aimed to compare the results of a transanal repair with those of a transvaginal levatorplasty and to determine the long-term clinical outcomes according to the change in the depth of the rectocele after the procedure. Methods: Of 50 women who underwent a rectocele repair from March 2005 to February 2007, 26 women (group A) received a transanal repair, and 24 (group B) received a transvaginal repair with or without levatorplasty. At 12 months after the procedures, 45 (group A/B, 22/23 women) among the 50 women completed physiologic studies, including anal manometry and defecography, and clinical-outcome measurements. The variations of the clinical outcomes with changes in the depth of the rectocele were also evaluated in 42 women (group A/B, 20/22) at the median follow-up of 50 months. Results: On the defecographic findings, the postoperative depth of the rectocele decreased significantly in both groups (group A vs. B, 1.91 ± 0.20 vs. 2.25 ± 0.46, P = 0.040). At 12 months after surgery, 17 women in each group (group A/B,77/75%) reported improvement of their symptoms. However, only 11 and 13 women (group A/B, 55/59%) of groups A and B, respectively, maintained their improvement at the median follow-up of 50 months. Better results were reported in patients with a greater change in the depth of their rectocele (≥4 cm) after the procedure (P = 0.001)Conclusion: In both procedures, clinical outcomes might become progressively worse as the length of the follow-up is increased. Purpose: This study was aimed to compare the results of a transanal repair with those of a transvaginal levatorplasty and to determine the long-term clinical outcomes according to the change in the depth of the rectocele after the procedure. Methods: Of 50 women who underwent a rectocele repair from March 2005 to February 2007, 26 women (group A) received a transanal repair, and 24 (group B) received a transvaginal repair with or without levatorplasty. At 12 months after the procedures, 45 (group A/B, 22/23 women) among the 50 women completed physiologic studies, including anal manometry and defecography, and clinical-outcome measurements. The variations of the clinical outcomes with changes in the depth of the rectocele were also evaluated in 42 women (group A/B, 20/22) at the median follow-up of 50 months. Results: On the defecographic findings, the postoperative depth of the rectocele decreased significantly in both groups (group A vs. B, 1.91 ± 0.20 vs. 2.25 ± 0.46, P = 0.040). At 12 months after surgery, 17 women in each group (group A/B,77/75%) reported improvement of their symptoms. However, only 11 and 13 women (group A/B, 55/59%) of groups A and B, respectively, maintained their improvement at the median follow-up of 50 months. Better results were reported in patients with a greater change in the depth of their rectocele (≥4 cm) after the procedure (P = 0.001)Conclusion: In both procedures, clinical outcomes might become progressively worse as the length of the follow-up is increased.
Probenecid Sulfonamides의 藥物動力學的 效果에 미치는 影響
정춘식 德成女子大學校 藥學硏究所 1990 藥學論文誌 Vol.1 No.1
Although Sulfonamides have broad Antibacterial ability, they have frequently administrated for maintance therapeutic level because protein binding ability is large, and crystalluria, their acetylmetabolite, has been reported frequently. In order to diminished those problem, Probenecid was administrated to rabbit concomitant, before 1 hour, after 1 hour of Sulfonamides. The results was follows: 1. Before 1 hour Sulfonamides, plasma level was increase and after 1 hour Sulfonamides, half-life was increase. 2. Plasma level of Acetylsulfadiazine, their acetylmetabolite, was diminished in concomitant, before 1 hour, after 1 hour of Sulfonamides.