Predictors of Distant Metastasis after Radical Surgery Followed by Postoperative Radiotherapy with or without Chemotherapy for Oropharyngeal Cancer

정미주,김연실,김지윤,이윤희,장지현,강진형,유이령,이연수 대한암학회 2016 Cancer Research and Treatment Vol.48 No.4

Purpose We investigated the prognostic factors for distant metastasis (DM) in patients with locally advanced oropharyngeal cancer (OPC) treated with surgery and adjuvant radiotherapy with or without concurrent chemotherapy. Materials and Methods Eighty-five patients treated between January 1995 and August 2014 were evaluated retrospectively. Data regarding the pathological tumour and nodal status, human papillomavirus (HPV) status, treatment characteristics, and pretreatment maximum standardized uptake value (SUVmax) of 18-fluoro-2-deoxyglucose positron emission tomography–computed tomography scan (18F-FDG PET-CT) were evaluated, and their influence on DM and survival outcomes were analyzed. Results Median follow-up period was 48.0 months. Recurrence was observed in 20 patients, including locoregional recurrence and DM. DM was observed in 13 patients. A multivariate analysis confirmed that the presence of lymphovascular invasion (p=0.031), lower neck lymph node (LN) involvement (p=0.006), SUVmax  9.7 (p=0.014), and tumour size  3 cm (p=0.037) significantly affected DM. HPV status was not associated with DM. Perineural invasion (p=0.048), lower neck LN involvement (p=0.008), SUVmax  9.7 (p=0.019), and tumour size  3 cm (p=0.033) were also significant factors for the DM-free survival rate. Conclusion Lower neck LN involvement, high SUVmax in pretreatment 18F-FDG PET-CT, and large tumour size were predictive factors for DM in patients of OPC.

A Dosimetric Comparative Analysis of TomoDirect and Three-Dimensional Conformal Radiotherapy in Early Breast Cancer

정미주,김성환,이종훈,서영진 한국유방암학회 2015 Journal of breast cancer Vol.18 No.1

Purpose: The purpose of this study is to compare dosimetric parametersof intensity-modulated mode of TomoDirect and threedimensionalconformal radiotherapy (3D-CRT) in patients withearly breast cancer. Methods: TomoDirect and 3D-CRT planningwere carried out for 26 patients with early breast cancer whohad received breast-conserving surgery. A total of 50.4 Gy in 28fractions were prescribed to the planning target volume. The organsat risk (OAR) such as lung and heart were contoured. Planningtarget volume (PTV) dose coverage, radiation conform-ityindex (RCI), radical dose homogeneity index (rDHI), and irradiationdose of organs at risk were compared between TomoDirectand 3D-CRT planning. Results: The mean PTV dose (51.65±0.37Gy) and V47.8 (100%) in TomoDirect were significantly higher thanthe mean PTV dose (50.88±0.65 Gy) and V47.8 (89.23%±0.06%)in 3D-CRT (all, p<0.001). The RCI value in TomoDirect was significantlybetter than that in 3D-CRT (1.00 vs. 1.13, p<0.001). However, the rDHI value in TomoDirect was not significantly betterthan that in 3D-CRT (0.72 vs. 0.67, p=0.056). The mean lungdose and V10, V20, V30, and V40 values of ipsilateral lung in Tomo-Direct were significantly lower than those in 3D-CRT (all,p<0.05). There is no significant difference in the V10, V20, V30, andV40 values of heart between TomoDirect and 3D-CRT. And themean dose for heart in TomoDirect was .marginally lower thanthat in 3D-CRT (1.05 Gy vs. 1.62 Gy, p=0.085). The mean dosefor left anterior descending coronary artery in left breast cancerwas significantly lower in TomoDirect than in 3D-CRT (7.2 Gy vs. 12.1 Gy, p<0.001). Conclusion: Compared to 3D-CRT, TomoDirectcould result in favorable target coverage while reducing theirradiation dose of the ipsilateral lung for patients with earlybreast cancer.

Optimizing Interfacial Bonding Strength in Carbon Fiber-Elium Resin-Graphene Oxide Composites via all Covalent Bonded Structure

정미주,성동기 한국고분자학회 2024 한국고분자학회 학술대회 연구논문 초록집 Vol.49 No.1

Tumor bed volumetric changes during breast irradiation for the patients with breast cancer

정미주,이종훈,서영진,이효천,강대규,김은중,김성환 대한방사선종양학회 2013 Radiation Oncology Journal Vol.31 No.4

Purpose: The aim of this study was to evaluate changes in breast tumor bed volume during whole breast irradiation (WBI). Materials and Methods: From September 2011 to November 2012, thirty patients who underwent breast-conserving surgery (BCS) followed by WBI using computed tomography (CT) simulation were enrolled. Simulation CT scans were performed before WBI (CT1) and five weeks after the breast irradiation (CT2). The tumor bed was contoured based on surgical clips, seroma, and postoperative change. We retrospectively analyzed the factors associated with tumor bed volumetric change. Results: The median tumor bed volume on CT1 and CT2 was 29.72 and 28.6 mL, respectively. The tumor bed volume increased in 9 of 30 patients (30%) and decreased in 21 of 30 patients (70%). The median percent change in tumor bed volume between initial and boost CT was -5%. Seroma status (p = 0.010) was a significant factor in tumor bed volume reduction of 5% or greater. However, patient age, body mass index, palpability, T stage, axillary lymph node dissection, and tumor location were not significant factors for tumor bed volumetric change. Conclusion: In this study, volumetric change of tumor bed cavity was frequent. Patients with seroma after BCS had a significant volume reduction of 5% or greater in tumor bed during breast irradiation. Thus, resimulation using CT is indicated for exquisite boost treatment in breast cancer patients with seroma after surgery.

The characterization of poly(trimethylene 2.6-naphthalate) surface structure in nano-space using RA-FTIR and GIXRD methods

정미주,이한섭,최기운 한국고분자학회 2007 한국고분자학회 학술대회 연구논문 초록집 Vol.2007 No.4

Prognostic Significance of Serum Carcinoembryonic Antigen Normalization on Survival in Rectal Cancer Treated with Preoperative Chemoradiation

정미주,정수미,김지윤,유미령 대한암학회 2013 Cancer Research and Treatment Vol.45 No.3

Purpose The purpose of this retrospective study was to identify factors predictive of survival in rectal cancer patients who received surgery with curative intent after preoperative chemoradiotherapy (CRT). Materials and Methods Between July 1996 and June 2010, 104 patients underwent surgery for rectal cancer after preoperative CRT. The median dose of radiotherapy was 50.4 Gy (range, 43.2to 54.4 Gy) for 6 weeks. Chemotherapy was a bolus injection of 5-fluorouracil and leucovorin for the first and last week of radiotherapy (n=84, 77.1%) or capecitabine administered daily during radiotherapy (n=17, 16.3%). Low anterior resection (n=86,82.7%) or abdominoperineal resection (n=18, 17.3%) was performed at a median 47days from the end of radiotherapy, and four cycles of adjuvant chemotherapy was administered. The serum carcinoembryonic antigen (CEA) level was checked at initial diagnosis and just before surgery. Results After a median follow-up of 48 months (range, 9 to 174 months), 5-year disease free survival (DFS) was 74.5% and 5-year overall survival (OS) was 86.4%. Down staging of T diagnoses occurred in 32 patients (30.8%) and of N diagnoses in 40 patients (38.5%). The CEA change from initial diagnosis to pre-surgery (high-high vs. highnormal vs. normal-normal) was a statistically significant prognostic factor for DFS (p=0.012), OS (p=0.002), and distant metastasis free survival (p=0.018) in a multivariate analysis. Conclusion Patients who achieve normal CEA level by the time of surgery have a more favorable outcome than those who retain a high CEA level after preoperative CRT. The normalization of CEA levels can provide important information about the prognosis in rectal cancer treatment.

P의 세계 외 2편

정미주 고요아침 2023 열린시학 Vol.28 No.4

Highly Stretchable Conductive Composites Based on Elastomer/Silver nanomaterials

정미주,허완수,김희숙 한국고분자학회 2017 한국고분자학회 학술대회 연구논문 초록집 Vol.42 No.2

Setup Error and Effectiveness of Weekly Image-Guided Radiation Therapy of TomoDirect for Early Breast Cancer

정미주,이국진,서영진,이효천,이시원,정송미,이정원,김성환,강대규,이종훈 대한암학회 2015 Cancer Research and Treatment Vol.47 No.4

Purpose This study investigated setup error and effectiveness of weekly image-guided radiotherapy(IGRT) of TomoDirect for early breast cancer. Materials and MethodsOne hundred and fifty-one breasts of 147 consecutive patients who underwent breastconserving surgery followed by whole breast irradiation using TomoDirect in 2012 and 2013were evaluated. All patients received weekly IGRT. The weekly setup errors from simulationto each treatment in reference to chest wall and surgical clips were measured. Random,systemic, and 3-dimensional setup errors were assessed. Extensive setup error wasdefined as 5 mm above the margin in any directions. ResultsAll mean errors were within 3 mm of all directions. The mean angle of gantry shifts was0.6°. The mean value of absolute 3-dimensional setup error was 4.67 mm. In multivariateanalysis, breast size (odds ratio, 2.82; 95% confidence interval, 1.00 to 7.90) was a significantfactor for extensive error. The largest significant deviation of setup error was observedin the first week of radiotherapy (p < 0.001) and the deviations gradually decreased withtime. The deviation of setup error was 5.68 mm in the first week and within 5 mm after thesecond week. ConclusionIn this study, there was a significant association between breast size and significant setuperror in breast cancer patients who received TomoDirect. The largest deviation occurred inthe first week of treatment. Therefore, patients with large breasts should be closely observedon every fraction and fastidious attention is required in the first fraction of IGRT.

여성 근로자의 일·가정양립지원제도 인식과 활용에 관한 연구

정미주 ( Mi Joo Jung ),임상호 ( Sang Ho Lim ) 산업진흥원 2016 산업진흥연구 Vol.1 No.2

본 연구는 여성 근로자의 일·가정양립지원제도에 대한 인식과 활용 간의 관계성 및 이용실태를 분석하였다. 연구결과 현 직장에서 시행 비중이 높으며 가장 많이 이용한 일·가정양립지원제도는 육아휴직제-시차출퇴근제-육아기 근로시간단축제 순이었다. 일·가정양립지원제도 인지도(p<.001)와 이용 만족도(p<.05)는 일·가정양립지원제도 효과성 인식에 긍정적인 영향을 미쳤다. 향후 일·가정양립지원제도 이용의도에 대한 일·가정양립지원제도 인지도 및 이용 만족도의 영향은 유의하지 않았으나 가족적 지지(배우자, 부모, 시부모)가 한계적으로 유의한 영향을 미치는 것으로 나타났다. 본 연구는 여성 근로자의 일·가정양립지원제도에 대한 인식과 활용 간의 영향관계를 분석함으로써 정책의 효과성을 파악하고, 가족적 차원까지 고려대상을 넓힌 데에 연구의 의의가 있다. This study analyzed the relationship between recognition and utilization of work-family balance support policy. ``Childcare leave`` was the most Implemental and utilized policy, and ``working hours reductuion``, ``flexible commute time`` in order. Awareness(p<.001) and satisfaction(p<.05) of using work-family balance support policy positively affected the effectiveness recognition. For intention to use work-family balance support policy, awareness and satisfaction of work-family balance support policy was not significant but family support marginally affected. This study provided implications for expanding policy consideration on female workers’ family and understanding the effectiveness of work-family balance support policy.