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Phenylethanolamine N-methyltransferase: 부신, 뇌간, 시상하부 효소의 조절
전양숙,서유헌,Chun, Yang-Sook,Suh, Yoo-Hun 대한약리학회 1996 대한약리학잡지 Vol.32 No.2
To determine the regulatory mechanism of phenylethanolamine N-methyltransferase (PNMT) in the adrenal gland and in central nervous system, we observed the change of enzyme activity and mRNA level of PNMT in the adrenal gland, the brain stem, and hypothalamus of rats, which were injected with two neuroleptic agents(reserpine and haloperidol ). Reserpine depleting catecholamines in presynaptic vesicle increased PNMT activities in the adrenal gland and the brain stem to 150% of the control in time-dependent manner, but not in the hypothalamus. Haloperidol blocking dopamine receptor decreased PNMT activities in the adrenal gland and the hypothalamus, but not in the brain stem. Thus, the results indicate that catecholamines inhibit synthesis of epinephrine in the brain stem and the adrenal gland, and that dopamine stimulates synthesis of epinephrine in the hypothalamus and the adrenal gland. In addition, since the change of mRNA levels were nearly in accordance with the change of activities, the transcriptional regulation of PNMT is considered the mechanism of the regulation of epinephrine neuron.
선천성 고혈압 성장 백서에서의 카테콜아민 합성효소에 관한 연구
서유헌,전양숙,최웅,김헌식,임정규,김성수,박찬웅,조현섭 대한내분비학회 1989 Endocrinology and metabolism Vol.4 No.3
Central catecholaminergic nerves have an integral place in the central connections of the autonomic nervous system. It has long been thought that sympathetic nervous system plays an importantpart in the regulation of blood pressure, but there is no firm evidence of excessive activity of the sympathetic nervous system in development and maintenance of essential hypertension. It seems clear that central catecholaminergic systems participate in the regulation of normal blood pressure. However, it is not yet clear which system is altered in hypertension and which changes are of primary causal importance and which are secondary in nature. In the present study, we investigated activities of catecholamine synthesizing enzymes tyrosine hydroxylase (TH), dopamine β-hydroxylase (DBH), phenylethanolamine N-methyl transferase (PNMT) in various regions of the brain and the adrenals in spontaneous hypertensive (SH) and normotensive wistar rats at 16 weeks of age when the hypertension is fixed. TH, DBH and PNMT activities n the adrenal glands of SH rats were significantly higher than that those of normotensive wistar rats. TH activity was higher in the hypothalamus of SH rats than that of wistar control rats. In the medulla, DBH activity of SH rats was lower than that of wistar rats. But PNMT activity was higher in the medulla of SH rats than that of wistar rats. These results suggest the possibility of over-activity of the adrenal medulla of SH rats and a participation of both norepinephrine and epinephrine neurons in the maintenance of hypertension. (J. Kor Soc Endocrinol 4:231~239, 1989)