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광주지역 어린이놀이터 내 놀이시설과 환경요인이 모래바닥재 중금속 농도에 미치는 영향에 관한 연구
장정원,김연희,이윤국,조민철,정희윤,조영관,김은선,김동수 한국폐기물자원순환학회 2017 한국폐기물자원순환학회지 Vol.34 No.4
The concerns about potential risks and hazards in children’s playgrounds are increasing and the restrictions for environmental harmful substances in playgrounds have been reinforced in many countries. In this study, the concentrations of heavy metals were analyzed in 142 samples including 105 of sand flooring and 37 playing equipment such as swing, slide, sporting equipment, bench and fence in 18 children’s playgrounds. Heavy metals in sand flooring were investigated and categorized by natural environmental factors such as season, rainfall, post-rainy day, and artificial factors as road, type, and material of nearby play equipment. The concentration of heavy metals such as Pb, Hg, Cu, and Zn were significantly higher in sand flooring near the play equipment than at places away from the playing equipment (p < 0.05). Spearman’s rank correlation analysis showed that play equipment had a positive correlation with the sand flooring with regard to the concentration of Pb (r = 0.42, p < 0.01) and Cu (r = 0.39, p < 0.01). The concentration of heavy metals in the sand flooring showed a statistically significant difference depending on the season, post-rainy day, the distance from a roadway, type of equipment, and the material. The play equipment’s heavy metal concentration and other environmental factors contributed to the heavy metal concentration in the sand flooring’s surface in playgrounds.
장정원,배시현,윤승규,Seong Tae Park,Jung Hyun Kwon,Chan Ran You,최종영,정찬권 생화학분자생물학회 2011 Experimental and molecular medicine Vol.43 No.5
Although continuous low-dose (metronomic [MET])therapy exerts anti-cancer efficacy in various cancer models, the effect of long-term MET therapy for hepatocellular carcinoma (HCC) remains unknown. This study assessed the long-term efficacy of MET on suppression of tumor growth and spontaneous metastasis in a rat model of HCC induced by administration of diethylnitrosamine for 16 wk. The rats were divided into 3 groups: MTD group received intraperitoneal (i.p.)injections of 40 mg/kg cyclophosphamide on days 1,3, and 5 of a 21-day cycle; Control and MET groups received i.p. injections of saline and 20 mg/kg cyclophosphamide twice a week, respectively. Anti-tumor and anti-angiogenic effects and anti-metastatic mechanisms including matrix metalloproteinases (MMPs)and tissue inhibitors of MMPs (TIMPs) were evaluated. Twelve wk of MET therapy resulted in a significant reduction in intrahepatic tumors than control or MTD therapy. The MET group had fewer proliferating cell nuclear antigen-positive cells and decreased hypoxia-inducible factor-1α levels and microvessel density. Lung metastases were detected in 100%, 80%, and 42.9% in the control, MTD, and MET groups, respectively. MET therapy significantly decreased expression of TIMP-1,MMP-2 and -9. For mediators of pro-MMP-2 activation,MET therapy induced significant suppression in the TIMP-2 and MMP-14 level. The survival in the MET group was significantly prolonged compared to the control and MTD groups. Long-term MET scheduling suppresses tumor growth and metastasis via its potent anti-angiogenic properties and a decrease in MMPs and TIMPs activities. These results provide a rationale for long-term MET dosing in future clinical trials of HCC treatment.
커플치료에서의 신경과학적 관점의 도입과 치료적 함의 -취약성 싸이클 모형을 중심으로-
장정원,최연실 한국가족치료학회 2022 가족과 가족치료 Vol.30 No.4
본 연구의 목적은 신경과학적 관점의 도입을 통해 국내 커플치료에 적용할 수 있는 방안을 모색하고 시사점을 도출하는 것이다. 본 연구의 목적을 위해 신경과학, 심리치료와 커플치료 관련 선행연구를 문헌 고찰을 통해 분석하였다. 본 연구의 결과는 다음과 같다. 첫째, 심리치료 분야에서는 최근 신경과학적 관점의 도입이 부각되고 있으며, 이는 커플치료 분야에서의 신경과학적 관점 도입에 교량 역할을 수행한다. 둘째, 커플치료에서의 신경과학적 관점은 커플의 갈등 문제를 다루는 데 효과적인 관점을 제공한다. 셋째, ‘취약성 싸이클 모형’은 커플의 취약성과 생존전략이 순환되는 교착상태를 다룸으로써 커플치료 과정에 구체적인 접근 전략을 제공할 수 있다. 넷째, ‘취약성 싸이클 모형’은 기존 가족치료의 이론적 모델들과 다양하게 접목시켜 현장에서 활용될 가능성을 지니고 있다. 본 연구는 커플치료에서의 신경과학적 관점의 도입이 커플치료의 외연 확장과 더불어 내담자의 치료 개입에 효율성 증진에 기여할 수 있음을 살펴볼 수 있었다는 데 의의가 있다.
장정원 대한의사협회 2013 대한의사협회지 Vol.56 No.11
Globally, viral hepatitis due to hepatitis B virus (HBV) and/or hepatitis C virus (HCV) infection is the major cause of advanced liver diseases such as liver cirrhosis and hepatocellular carcinoma (HCC). Chronic inflammation resulting from persistent viral hepatitis is also associated with an increased risk of HCC recurrence. Replication of HBV and/or HCV can reactivate during anti-cancer treatments of HCC and lead to hepatic dysfunction, adversely affecting patient outcomes. The most effective way to prevent chronic viral hepatitis, cirrhosis, or HCC would be the implementation of a vaccine. Unfortunately, a vaccine for HCV is currently not available. For chronically infected patients, antiviral therapy may be the only option that can prevent or retard disease progression. Emerging evidence continues to support direct or indirect benefits from antiviral therapy for preventing liver disease progression to cirrhosis, HCC development,and recurrence after curative treatments in patients with chronic HBV or HCV infection. This paper reviews the literature on the management of viral hepatitis in patients with HCC,focusing on primary and tertiary prevention of HCC.