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장소용 대한영상의학회 1997 대한영상의학회지 Vol.37 No.1
Purpose : To determine the clinical and mammographic characteristics of primary lymphoma of the breast.Materials and Methods : The clinical and mammographic records of five patients (six breasts; bilateral involvementin one patient) with histologically-proven lymphoma of the breast were retrospectively reviewed. Results : Allpatients had complained of a palpable tender mass with relatively rapid growth over a period of about 3 months. Infive cases, the mass was located in the right breast and in one case in the left. Mammography revealed diffuseincreased opacity of the entire breast in three cases, a homogeneous well-defined mass in one, multiplewell-defined masses in one, and ill-defined lobulated opacity in one. Skin thickening and architectural distortionwas seen in one case, and asillary lymphadenopathy in two. In no case was microcalcification and nipple retractionseen. Conclusion : In primary breast lymphoma, mammographic finding are non-specific. When a breast grows rapidlyand is tender, however, and mammography shows a relatively large well defined mass and associated axillarylymphadenoapathy, the possibility of primary lymphoma should be considered.
Attenuation of Morphine Tolerance and Withdrawal Syndrome by Coadministration of Nalbuphine
장소용,Heejeong Kim,Donghyun Kim,Myeon Woo Jeong,Tangen Ma,Seongyoul Kim,Ing K. Ho,오세관 대한약학회 2006 Archives of Pharmacal Research Vol.29 No.8
Morphine has been used widely on the treatment of many types of chronic pain. However the development of tolerance to and dependence on morphine by repeat application is a major problem in pain therapy. The purpose of the present study was to investigate whether combined administration of nalbuphine with morphine affects the development of tolerance to and dependence on morphine. We hypothesize that the use of nalbuphine, κ-agonist may prove to be useful adjunct therapy to prevent morphine-induced undesirable effects in the management of some forms of chronic pain. Morphine (10 mg/kg) was injected to rats intraperitoneally for 5 day. The variable dose of nalbuphine (0.1, 1.0 and 5.0 mg/kg) was administered (i.p.) in combination with morphine injection. The development of morphine tolerance was assessed by measuring the antinociceptive effect with the Randall-Selitto apparatus. The development of dependence on morphine was determined by the scoring the precipitated withdrawal signs for 30 min after injection of naloxone (10 mg/kg, i.p.). Nalbuphine did not attenuate antinociceptive effect of morphine in rats. Interestingly, combined administration of morphine with nalbuphine (10:1) significantly attenuated the development of dependence on morphine. The elevation of [3H]MK-801 binding in frontal cortex, dentate gyrus, and cerebellum after chronic morphine infusion was suppressed by the coadministration of nalbuphine. In addition, the elevation of NR1 expression by morphine was decreased by the coadministration of nalbuphine in rat cortex. These results suggest that the coadministration of nalbuphine with morphine in chronic pain treatment can be one of therapies to reduce the development of tolerance to and dependence on morphine.
장소용 대한영상의학회 1996 대한영상의학회지 Vol.35 No.5
Purpose : To evaluate characteristic CT features of twisted ovarian tumors and to assess the diagnostic valueof the existence of twisted vascular pedicle in torsion of ovarian tumors. Materials and Methods : Weretrospectively reviewed the clinical and CT findings in eleven patients with ovarian tumor torsion confirmed bysurgery. Pre- and post-contrast CT were available in nine patients and post-contrast CT in two. All twistedovaries, tubes, and tumors showed hemorrhagic infarction and necrosis. Results : All patients had twisted vascularpedicle of the ovarian tumor evaluated by CT. Eight patients with left ovarian tumor had twisted vascular pedicleon the left side of the tumor, and three patients with right ovarian tumor on the right side of the tumor. Themorphologic characteristics of twisted vascular pedicle were coiled target appearance (4 cases), beak appearance(3 cases), doughnut appearance (3 cases), and mass with irregular margin (1 case). High density on precontrast CTscan was present in the pedicle in four cases and linear contrast enhancement was seen in the peripheral portionof the pedicle in four cases. The shape, density and location of ovarian tumors were inconsistent, however,contrast enhancement was not seen in all patients. Other findings were uterine deviation, loss of fat plane andpelvic fluid. Conclusion : Detection of twisted vascular pedicle by CT may be useful for the diagnosis of ovariantumor torsion.
진공보조유방생검에서양성유두상병변으로진단된 병소에 대해 추가로 절제생검술이 필요한가?
박해린,장소용,허정인,김지영 한국유방암학회 2010 Journal of breast cancer Vol.13 No.2
Purpose: There is ongoing controversy regarding the management of papillary lesions that are diagnosed by core needle biopsy (CNB). The development of vacuum assisted biopsy now permits non-operative removal of papillary breast lesions. Our aim was to evaluate whether the papillary lesions diagnosed by vacuum assisted breast biopsy (VABB) can be followed up without further diagnostic excision. Methods: From January 2003 to July 2009, a total of 4,655 US-guided mammotome excision were performed in 3,714 patients at Kangnam CHA Hospital. Out of 4,655 lesions, 156 lesions were proved to be papillary lesions. Among these, 82 lesions that had histologic findings that were consistent with benign papillary lesions and that were followed up for more than 2 years without further diagnostic surgical excision were collected and retrospectively analyzed. Ultrasonographic followup was done at 3-6 month intervals to assess for recurrence. The mean follow up period was 49.6 months. Results: The pathologic diagnoses for the 82 lesions obtained via VABB were benign intraductal papilloma and papillomatosis. Half of the lesions were palpable and 50.0% (41 cases) were nonpalpable. Twenty eight lesions (34.1%) were classified as BIRADS category 3, 50 lesions (61.0%) were category 4A, 3 lesions (3.7%) were category 4B and only 1 lesion (1.2%) was category 5 according to the ultrasound exams. No local recurrence developed during the follow up period that needed surgical re-excision or rebiopsy. None of those diagnosed as benign lesions at VABB were upgraded to a more advanced lesions. Conclusion: The benign papillary lesions that are diagnosed and excised by mammotome may not need further diagnostic surgical re-excision if surgeons are sure that the targeted lesions were excised completely.
초음파로 진단된 유방영상보고데이터체계 범주 4a 질환의 조직병리학적 분석
조백현,김의정,장소용,김희정,문희정,박양순,이일균,김도일,이원흥,류정규,최문혜,이영란,윤회수,윤세옥 한국유방암학회 2008 Journal of breast cancer Vol.11 No.3
PURPOSE: We analyzed the histopathologic findings of the patients with ultrasongraphic BI-RADS Category 4a breast lesions to determine which patient can be excluded from any invasive, diagnostic procedure in the future. METHODS: Of the 180 cases of BI-RADS Category 4a breast lesions that were diagnosed with ultrasonography during a 6 month-period, 132 cases were pathologically confirmed and these were analyzed retrospectively. Four benign cases that did not undergo any further procedure after fine needle biopsy and 6 malignant cases (4.5%) were excluded from this study. RESULTS: Of the 122 cases, 77 cases (63.1%) showed homogeneous benign finding, and 45 cases (36.9%) showed heterogeneous finding that was made up of two or more different pathologic lesions. Fibroadenoma(55.8%) was the most frequent pathologic finding in the cases with homogeneous finding, followed by fibrocystic change(14.3%), and fibrosis(7.8%). The cases with heterogeneous finding presented fibrocystic change (55.5%), microcalcification(48.8%), ductal hyperplasia(42.2%), and fibroadenoma(31.1%) in the order of frequency. CONCLUSIONS: Lesion with heterogeneous histopathologic nature was the most frequent finding defined as category 4a in breast ultrasonography, followed by fibrodenoma, fibrocysic change, microcalcification, and ductal hyperplasia. Refining more specific ultrasonographic findings of these lesions would guarantee that radiologists exclude more benign lesions from category 4a.