이묘산(二妙散)의 항(抗)류마티즘 효능(效能)에 대한 연구(硏究)

임창경,윤용갑,Lim, Chang-Kyung,Yun, Young-Gab 대한한의학방제학회 2009 大韓韓醫學方劑學會誌 Vol.17 No.1

Rheumatoid arthritis is characterized by focal loss of cartilage due to an up-regulation of inflammatory pathways, which produce pro-inflammatory mediators, such as interleukin-1(IL-1), tumour necrosis factor alpha($TNF-\alpha$), prostaglantin, and nitric oxide(NO). We investigated the anti-arthritic effects of water extracts from Pellodendri cortex and Atractylodis rhizoma in vitro and in vivo. Each extract suppressed the production of inflammatory mediators(NO, $IL-1\beta$, $TNF-\alpha$, and prostaglandin $E_2$) and the expression of inducible NO synthase and cyclooxygenase-2 in lipopolysaccharide-stimulated macrophages in a dose-dependent manner. These suppressive effects were synergistically increased by their combination. The same results were also observed in the rat osteoblast sarcoma cell line ROS17/2.8 stimulated with $IL-1\beta$, $IFN-\gamma,$ and $TNF-\alpha$. Moreover, the combination of these water extracts significantly suppressed collagen-induced mouse arthritis. These results suggest that the combination of water-extractable components of Pellodendri cortex and Atractylodis rhizoma may be useful for therapeutic drugs against rheumatoid arthritis, probably by suppressing the production of inflammatory mediators.

특성화고등학교 여학생의 정서적 요인과 신체화 증상의 관계에서 인지적 요인의 매개효과

이미정(Lee mi Jung),임창경(Lim Chang Kyung),유정이(Ryu Jeong Yii) 학습자중심교과교육학회 2014 학습자중심교과교육연구 Vol.14 No.12

본 연구에서는 여자고등학생의 정서적 요인(우울, 불안, 감정표현 불능증, 스트레스)이 신체화 증상에 미치는 영향에서 인지적 요인(신체감각 증폭지각, 신체적 귀인)의 매개효과를 검증하고자 하였다. 자료는 경기도 소재 특성화고등학교 4개교에 재학 중인 2학년 여학생을 대상으로 설문하여 수집했다. 총 1,178부의 설문지를 수거하여 분석하였다. 연구대상의 일반적인 특성을 알아보기 위해 빈도와 백분율을 산출하였고, 각 변인이 신체화 증상에 미치는 영향을 알아보기 위하여 단순회귀분석을 실시하였으며, 정서적 요인(우울, 불안, 감정표현 불능증, 스트레스)이 신체화 증상에 미치는 영향에서 인지적 요인(신체감각증폭지각, 신체적 귀인)의 매개효과를 알아보기 위하여 Baron과 Kenny(1986)가 제안한 매개효과 검증 절차를 사용하였다. 연구결과, 특성화고 여고생의 우울이 신체화 증상에 미치는 영향력은 유의한 것으로 나타났으나, 신체감각 증폭지각과 신체적 귀인 모두 매개효과가 유의하지 않았다. 둘째, 불안이 신체화 증상에 미치는 영향력이 유의하며, 신체감각 증폭지각과 신 체적 귀인 모두 부분 매개효과를 가지는 것으로 나타났다. 셋째, 감정표현 불능증이 신체화 증상에 미치는 영향력이 유의하며, 신체감각 증폭지각과 신체적 귀인 모두부분 매개효과를 가지는 것으로 나타났다. 넷째, 스트레스가 신체화 증상에 미치는 영향력이 유의하며, 신체적 귀인 모두 부분 매개효과를 가지는 것으로 나타났다. The purpose of this study was to investigate the mediating effects of cognitive factors(somato-sensory amplification, somatic attribution) on the relationships between specialized vocational high school student s affective factors(depression, anxiety, alexithymia and stress) and somatization symptom. The subjects of this study were 1,178 students in the 2nd grade in high schools located in Kyunggi-Do. They were assessed by K-CSI(Korean Children s somatization Inventory), CDI( Children s Depression Inventory), BAI(Beck Anxiety Inventory), TAS-20(Toronto 20 item Alexithymia Scale), Stress Inventory, KSAS(Korean Versions of Somatosensory Amplification Scale) and SIQ(Symptom Interpretation Questionnaire). The data were analyzed using frequency analysis and regression analysis by SPSS 18.0 statistics program. In addition, Baron and Kenny s(1986) model was used to verify mediational effects. The results were as follows: First, student s affective factors had a significant on total score of somatization sympom. Second, cognitive facts, which were somato-sensory amplification, somatic attribution, had significant effects on somatization symptom. Third, somato-sensory amplification partially mediated the relationships between student s affective factor(anxiety, Alexithymia, stress) and somatization symptom. Fourth, somatic attribution parlially mediated the associiations between student s affective factor(anxiety, Alexithymia, stress) and somatIzatIon symptom. The results from the findings suggested that it was encouraged to consider cognitive facts in order to understand the relationship between student s affective factor and somatization symptom more comprehensively. Particularly, this study confirmed that somato-sensory amplification and somatic attribution were proved to have the mediating effects between student s affective factor(anxiety, Alexithymia, stress) and somatization symptom.

호두仁 에탄올 抽出物의 四鹽化炭素 유도 肝纖維化 억제 효과

장선일(Seon Il Jang),임창경(Chang Kyung Lim),유진덕(Jin Duk Ryu),김희수(Hui Soo Kim),윤용갑(Yong Gab Yun) 한의병리학회 2003 동의생리병리학회지 Vol.17 No.5

東洋醫學的 胎敎에 對한 考察

任昌慶,朴炅 圓光大學校 韓醫學硏究所 1992 원광한의학 Vol.2 No.1

Now we can abstract as following after considering the Fetal Education. To conceire a healthy baby, man and wife shall have sexual intercourse when mind and body are sound, weather os fine and shall take position at ease. Pregnant woman should not be overworked on, idle and should take proper exercise and rest. The emotion if pregnant woman shall not be onesided. When the weather changes heavily, pregnant woman had better not go out. Pregnant woman shall avoid sexual intercourse. The mind of fetus will be sound when the pregnant woman keep quiet always by seeing, hearing and speaking good things. Pregnant women had better have simple food and avoid the greasy or hot diet. Pregnant women shall be free from hot on poisonous drugs and blood activating and coagulation removing. Human education is consisted of native and acquired education. Acquired education can be better by the help of native education, therefore Fetal Education had better be done positively as a project of nation.

항 백혈병작용에 관련된 천연물의 자료조사

배현옥,임창경,장선일,한동민,안원근,윤유식,전병훈,김원신,윤용갑 대한동의병리학회 2003 동의생리병리학회지 Vol.17 No.3

人蔘, 虎杖根, 常山 등에서 분리한 성분들이 HL60, HL-60, Jurkat, Molt-4에 대한 억제작용이 있는 것으로 조사되었고, 益母草의 Leonunrine, 大靑葉의 Indirubin, 天門冬의 Aspargus polysaccharide A.B.C.D, 百合의 Colchicnamile, 益母草의 Leonunrine, 山豆根, 紫草根 추출물이 여러유형의 백혈병 환자에 대한 백혈병 억제효과가 있는 것으로 조사되었으며, mouse의 P388, L1210, L615, L120, S-180 등에 항 백혈병 효과가 있는 것으로는 莞花, 노회, 遠志, 吳茱萸, 巴豆, 雷公藤, 石蒜, 白朮, 丹蔘, 山藥, 牧丹皮, 靑黛, 甘草, 當歸에서 분리한 성분들이 있으며 白屈菜, 馬錢子, 가시오가피, ??草 축출물들이 동물실험에서 항암작용이 있는 것으로 조사되었다. 또 천연물에서 분리한 성분이 항백혈병 작용이 있는것으로는 ginsenoside Ro, ginsenoside Rh2, Emodin, Yuanhuacine, Aleemodin, phorbocdiester, Triptolide, Homolycorine, Atractylol, Colchicnamile, Paeonol, 당귀다당체, Aspargus, polysaccharideABCD, Indirubin, Leonunrine, Acinosohic acid, Trichosanthin, Ge 132, Schizandrin, allicin, Indirubin, cmdiumlactone chuanxiongol, 18A glycyrrhetic acid, Kansuiphorin A, 13 oxyingenol Kansuiphorin B 등이 조사되었고 추출물이 항 백혈병 작용이 있는 것으로는 遠志, 吳茱萸, 白屈菜, 大黃, 山豆根, 馬錢子, 가시오가피, 천초 등이 조사되었다. According to the Leukemia and Lymphoma Society, leukemia is a malignant disease (cancer) that originates in a cell in the marrow. It is characterized by the uncontrolled growth of developing marrow cells. These are two major classifications of leukemia: myelogenous or lymphocytic, which can each be acute or chronic. The terms myelogenous or lymphocytic denote the cell type involved. Thus, four major types of leukemia are: acute or chronic myelogenous leukemia and acute or chronic lymphocytic leukemia. Leukemia, lymphoma and myeloma are considered to be related cancers because they involve the uncontrolled growth of cells with similar function and origins. The diseases result from an acquired (not inherited) genetic injury to the DNA of a single cell, which becomes abnormal (malignant) and multiplies continuously. In the United States, about 2,000 children and 27,000 adults are diagnosed each year with leukemia. Treatment for cancer may include one or more of the following: chemotherapy, radiation therapy, biological therapy, surgery and bone marrow transplantation. The most effective treatment for leukemia is chemotherapy, which may involve one or a combination of anticancer drugs that destroy cancer cells. Specific types of leukemia are sometimes treated with radiation therapy or biological therapy. Common side effects of most chemotherapy drugs include hair loss, nausea and vomiting, decreased blood counts and infections. Each type of leukemia is sensitive to different combinations of chemotherapy. Medications and length of treatment vary from person to person. Treatment time is usually from one to two years. During this time, your care is managed on an outpatient basis at M. D. Anderson Cancer Center or through your local doctor. Once your protocol is determined, you will receive more specific information about the drug(s) that will be used to treat your leukemia. There are many factors that will determine the course of treatment, including age, general health, the specific type of leukemia, and also whether there has been previous treatment, there is considerable interest among basic and clinical researchers in novel drugs with activity against leukemia, the vast history of experience of traditional oriental medicine with medicinal plants may facilitate the identification of novel anti leukemic compounds. In the present investigation, we studied 31 kinds of anti leukemic medicinal plants, which its pharmacological action was already reported through many experimental articles and oriental medical book: 「pharmacological action and application of anticancer traditional chinese medicine」 In summary : Used leukemia cellline are HL60, HL-60, Jurkat, Molt-4 of human, and P388, L-1210, L615, L-210, EL-4 of mouse. 31 kinds of anti leukemic medicinal plants are Panax ginseng C.A Mey; Polygonum cuspidatum Sieb, et Zucc; Daphne genkwa Sieb, et Zucc; Aloe ferox Mill; Phorboc diester; Tripterygium wilfordii Hook .f.; Lycoris radiata(L Her)Herb; Atractylodes macrocephala Koidz; Lilium brownii F.E. Brown Var; Paeonia suffruticosa Andr; Angelica sinensis (Oliv.) Diels; Asparagus cochinensis (Lour.)Merr; Isatia tinctoria L; Leonurus heterophyllus Sweet; Phytolacca Roxb; Trichosanthes kirilowii Maxim; Dioscorea opposita Thumb; Schisandra chinensis (Rurcz.)Baill; Auium Sativum L; Isatis tinctoria, L; Ligustisum Chvanxiong Hort;Glycyrrhiza uralensis Fisch; Euphorbia Kansui Liou; Polygala tenuifolia Wild; Evodia rutaecarpa (Juss.) Benth; Chelidonium majus L; Rumax madaeo Mak; Sophora Subprostmousea Chunet T.ehen; Strychnos mux-vomical; Acanthopanax senticosus (Rupr.et Maxim.)Harms; Rubia cordifolia L. Anti leukemic compounds, which were isolated from medicinal plants are ginsenoside Ro, ginsenoside Rh2, Emodin, Yuanhuacine, Aleemodin, phorbocdiester, Triptolide, Homolycorine, Atractylol, Colchicnamile, Paeonol, Aspargus polysaccharide A.B.C.D, Indirubin Leonunrine, Acinosohic acid, Trichosanthin, Ge 132, Schizandrin, allicin, Indirubin, cmdiumlactone chuanxiongol, 18A glycyrrhetic acid, Kansuiphorin A 13 oxyingenol Kansuiphorin B. These investigation suggest that it may be very useful for developing more effective anti leukemic new dregs from medicinal plants.