영향인자의 복합적 평가를 통한 낙동강 물금의 조류발생 특성 해석

임지성 ( Ji Sung Lim ),이재호 ( Jae Ho Lee ),김영우 ( Young Woo Kim ),이병헌 ( Byung Hun Lee ),변임규 ( Im Gyu Byun ) 한국수처리학회 2014 한국수처리학회지 Vol.22 No.6

Nakdong River is one of the major river in South Korea. Downstream of this river is the intake station of big cities such as Busan. Algae occurrence in the river was one of problem for a long time. Thus, in this study, long term variation of chl-a and water quality, hydraulic and climate parameters were evaluated in winter and summer season at Mulgeum site in downstream the Nakdong River. Water quality, hydraulic and climate parameters are also used for determination of the parameters significantly affecting chl-a concentration by correlation analysis. As a result high concentration of chl-a has been appeared in winter season by bloom of diatom. Thus, control of algae occurrence at Mulgeum site in winter season is needed more than summer season. Inorganic nutrients and BOD5, pH, DO showed similar variation patterns to chl-a. The value of Hydraulic parameters were increased in summer by Monsoon season in South Korea. In this period, low concentration of chl-a was also caused by Monsoon season. With the result of correlation analysis between chl-a and the other parameters, ten parameters (BOD5, COD, DO, NO3-N, NH4-N, PO4-P, pH, discharge, water velocity and precipitation) showed significant correlation(p<0.05) in winter season. On the other hand, seven parameters (BOD5, DO, water temperature, pH, PO4-P, water velocity and water depth) showed significant correlation with chl-a in summer season. Therefore, we need to make a plan for control of algae occurrence through different significant parameters by seasonal change.

다중회귀분석을 이용한 낙동강 하류의 Chlorophyll-a 농도와 복합 영향인자들의 상관관계 분석

임지성(Ji Sung Lim),김영우(Young Woo Kim),이재호(Jae Ho Lee),박태주(Tae Joo Park),변임규(Im Gyu Byun) 大韓環境工學會 2015 대한환경공학회지 Vol.37 No.5

1998년부터 2008년까지 낙동강 물금지점의 수질, 수리 및 기상 인자를 통해 조류발생의 주요 영향인자를 평가하고 chlorophyll-a (chl-a) 예측 모델을 도출하였다. 분석 전 데이터의 신뢰도 향상을 위해 이상치를 제거하는 전처리 과정을 수행하였다. 국내 태풍영향기간을 산정하여 태풍영향기간에 포함된 데이터는 제외를 하였고 관리도 기법을 적용하여 이상치를 제거하였다. 이후 분석과정은 Method 1과 2 두 가지 방법으로 나뉘었다. Method 1은 전처리 과정을 거친 17개 항목의 데이터를 직접 이용하여 chl-a 예측모형을 도출 하였고, Method 2는 전처리 후 주요 영향인자를 도출하여 이를 통해 모형을 개발하였다. Method 2의 상관관계 분석결과 물금지역의 chl-a에 대한 주요영향인자는 수온, pH, DO, BOD, COD, T-N, NO₃-N, PO₄-P, 유량, 유속 및 수심으로 나타났다. Method 1, 2에 의한 chl-a 회귀모형은 각각 R2 값이 0.799 및 0.790의 높은 유의성을 나타내었고 2009~2010년의 데이터로 검증하였다. Method 1에 의한 chl-a 예측모형의 training period와 validation period의 RMSE 값은 각각 20.912와 24.423으로 나타났으며 Method 2를 통한 모델은 각각 21.422 및 26.277을 나타냈다. 예측 모형 도출 결과 Method 1 및 2 모두 BOD, DO 및 PO₄-P 세 가지 인자가 주요한 역할을 한 것을 볼 때 향후 물금 지점의 조류 발생은 BOD, DO 및 PO₄-P를 중점적으로 관리할 필요가 있다고 판단된다. In this study, Chlorophyll-a (chl-a) prediction model and multiple parameters affecting algae occurrence in Mulgeum site were evaluated by statistical analysis using water quality, hydraulic and climate data at Mulgeum site (1998~2008). Before the analysis, control chart method and effect period of typhoon were adopted for improving reliability of the data. After data preprocessing step two methods were used in this study. In method 1, chl-a prediction model was developed using preprocessed data. Another model was developed by Method 2 using significant parameters affecting chl-a after data preprocessing step. As a result of correlation analysis, water temperature, pH, DO, BOD, COD, T-N, NO₃-N, PO₄-P, flow rate, flow velocity and water depth were revealed as significant multiple parameters affecting chl-a concentration. Chl-a prediction model from Method 1 and 2 showed high R2 value with 0.799 and 0.790 respectively. Validation for each prediction model was conducted with the data from 2009 to 2010. Training period and validation period of Method 1 showed 20.912 and 24.423 respectively. And Method 2 showed 21.422 and 26.277 in each period. Especially BOD, DO and PO₄-P played important role in both model. So it is considered that analysis of algae occurrence at Mulgeum site need to focus on BOD, DO and PO₄-P.

소경활혈탕가미방(疎經活血湯加味方)의 관절염에 미치는 효과

조주현 ( Joo-hyun Jo ),임지성 ( Ji-sung Im ),김종규 ( Jong-gyu Kim ),박중현 ( Jung-hyun Park ),최학순 ( Hag-soon Choi ),황규원 ( Geu-won Hwang ),송용선 ( Yung-sun Song ) 한방재활의학과학회 2021 한방재활의학과학회지 Vol.31 No.1

Objectives The aim of this study is to evaluate anti-inflammatory and anti-arthritic effects of Sogyunghwalhyel-tang-gamibang (SGHHTGB) in cell and animal models and also to suggest one of putative mechanisms underlying its anti-arthritic effects. Methods Enzyme-linked immunosorbent assay was applied to measure the concentrations of tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6 and prostaglandin E2 (PGE2) in culture medium and blood serum and nitric oxide (NO) was assayed by Griess reagent. The expressions of inducible NO synthase (iNOS) and cyclooxygenase- 2 (COX-2) were analyzed by Western blot method. Results In a cell model using RAW264.7 macrophages stimulated with the endotoxin lipopolysaccharide (LPS), the drug, at its non-cytotoxic concentrations, inhibited the production of the pro-inflammatory cytokine TNF-α, IL-1β and IL-6. In addition, it suppressed the expression of the inflammatory enzyme iNOS and COX-2, and reduced the synthesis of the enzyme product NO (as stable nitrite) and PGE2 in activated macrophages. Meanwhile, in an animal model using rheumatic arthritis (RA) mice induced with injection of type II collagen antibody (CAb) and LPS, the drug improved clinical symptom of arthritis and reduced paw thickness and inflammatory cell infiltration. In blood of RA mice, the drug reduced serum levels of TNF-α, IL-1β, IL-6, nitrite, and PGE2, all inflammatory mediators produced by activated macrophages. Conclusions SGHHTGB may ameliorate CAb and LPS-induced RA in mice, presumably by inactivating macrophages that are capable of initiating joint inflammation by producing pro-inflammatory cytokines and expressing inflammatory enzymes. (J Korean Med Rehabil 2021;31(1):33-46)

지질다당류로 유발한 염증성 뇌손상 동물모델에 대한 황금작약탕의 억제효과 연구

김종규 ( Jong-gyu Kim ),임지성 ( Ji-sung Im ),안성후 ( Sung-hu An ),송용선 ( Yung-sun Song ) 한방재활의학과학회 2021 한방재활의학과학회지 Vol.31 No.4

Objectives Hwanggeumjakyak-tang (HJT) has traditionally been used to treat gastrointestinal inflammatory diseases; however, its protective effects against neuronal inflammation are still undiscovered. Methods We investigated the anti-neuroinflammatory effects of HJT water extract on lipopolysaccharide (LPS)-stimulated BV2 mouse microglia cells. BV2 cells were treated with LPS (1 μg/mL) 1 hour prior to the addition of HJT. We measured cell viability using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay and nitrite production using the Griess assay. We performed a reverse transcriptionpolymerase chain reaction assay to measure messenger RNA expression of inflammatory cytokines including interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α. Western blot analysis was performed to determine protein expression of mitogen-activated protein kinases (MAPKs) and inhibitor of nuclear factor kappa B (NF-κB)α. Results HJT inhibited excessive nitrite release in LPS-stimulated BV2 cells and also significantly inhibited inflammatory cytokines such as IL-1β, IL-6, and TNF-α in LPS-stimulated BV2 cells. Moreover, HJT significantly suppressed LPS-induced MAPK and NF-κB activation and inhibited the elevation of IL-1β, IL-6, and TNF-α in the brain of LPS-injected mice. Conclusions Our study highlights the anti-neuroinflammatory effects of HJT via MAPK and NF-κB deactivation. (J Korean Med Rehabil 2021;31(4):1-11)

늑골골절의 한의학적 치료에 대한 최신 연구동향: China National Knowledge Infrastructure (CNKI), PubMed를 중심으로

박은상,황현호,박기현,김호걸,임지성,강준혁,Park, Eun Sang,Hwang, Hyeon Ho,Park, Ki Hyun,Kim, Ho Geol,Im, Ji Sung,Kang, Jun Hyuk 한방재활의학과학회 2022 한방재활의학과학회지 Vol.32 No.4

Objectives The purpose of this study is to identify the latest research trends regarding the nonsurgical treatment of rib fractures and suggest the direction for future research. Methods We searched for papers published from January 1, 2015 to July 1, 2022 in PubMed and the China National Knowledge Infrastructure (CNKI) based on keywords 'rib fracture'. 'Korean medicine', 'oriental medicine', 'TCM', 'moxibustion', 'acupunture', 'cupping', 'electroacupuncture', 'pharmacopuncture', 'fire needling'. Results A total of 79 studies were searched at first research. Then the studies were screening according to criteria and Finally 20 studies were selected. The oriental medical interventions analyzed in this study were fumigation method, herbal medicine, external application, acupuncture, ointment, herb fomentation, Tending Diancibo Pu far-infrared therapy. Conclusions Various oriental medical interventions such as herbal medicine, acupuncture, fumigation, herb fomentation, ointment, and physical therapy are being studied abroad for the treatment of rib fractures. It is considered that additional research related to the nonsurgical treatment for rib fractures is needed in the future in korea.

마이크로파의 유전가열을 이용한 하수슬러지의 가용화 반응에서 강산과 이온성 물질의 첨가 효과

이정민 ( Jeong Min Lee ),이재호 ( Jae Ho Lee ),김영우 ( Young Woo Kim ),임지성 ( Ji Sung Lim ),박태주 ( Tae Joo Park ),변임규 ( Im Gyu Byun ) 한국물환경학회(구 한국수질보전학회) 2014 한국물환경학회·대한상하수도학회 공동 춘계학술발표회 Vol.2014 No.-