http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : 이회삼 (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
-
류강선,이회삼,김기영,김미자,강필돈 한국잠사학회 2013 International Journal of Industrial Entomology Vol.27 No.2
Silkworm powder, which contains 1-deoxynojirimycin (DNJ), is a promising complementaryand alternative medicine (CAM) in Korea. Silkworm powder was produced from Yeonnokjampupae at d 3 of the 5th instar at the National Academy of Agricultural Science. The powderwas derivatized with 9-fluorenylmethyl chloroformate (FMOC-Cl), and the DNJ-FMOC contentwas measured by HPLC. We investigated the content of 1-DNJ in the silkworm powder andits glucose-lowering effect when it was treated at different temperatures. The content of 1-DNJwas the lowest at 150°C, while it was constant at other temperatures. The silkworm extractpowder was orally administered to diabetic mice (20 mg/kg/d) for 4 wk. Water intake did notsignificantly change when compared with the control group (T0). The blood glucose levelssignificantly decreased when mice where administered silkworm powder treated at 60°C (T60)compared to the control group, but no difference was observed between the groups T100and T150. Moreover, the blood levels of TG significantly decreased compared with the controlgroup. Based on these results, we surmise that the properties of the silkworm extract powderwere stable upon heating at 100°C but not at 150°C.
-
류강선,이회삼,김기영,김미자,성규병,지상덕,강필돈 한국잠사학회 2013 International Journal of Industrial Entomology Vol.27 No.2
We investigated the 1-deoxynojirimycin (1-DNJ) content of extracts from silkworm larvae ateach developmental stage within three silkworm varieties. We also compared the contentof the following polyhydroxylated alkaloids in the silkworm extracts: 1-DNJ, fagomine, and1,4-dideoxy-1,4-imino-d-arabinitol (DAB). In addition, we evaluated the glucose-loweringeffects of silkworm extract powder in db/db mice. The 1-DNJ content was the highest inYeonnokjam 5th instar 3rd d larvae and Hansaengjam 5th instar 3rd d larvae, which contained18.4 mg/100 g dry weight and 18.3 mg/100 g dry weight, respectively. The 5th instar 3rdd larvae exhibited a higher content of 1-DNJ than that of 5th instar 5th d larvae among allvarieties. The glucose-lowering effects of silkworm extracts and Yeonnokjam powder weretested on db/db mice, and the blood glucose levels were found to decrease significantly inthe YR70 group. Silkworm extracts (180 mg/kg, 90 mg/kg, 45 mg/kg, and 22.5 mg/kg) andacarbose (50 mg/kg) were administered orally for 4 wk. Changes in water intake were notstatistically significant between control and silkworm extract-treated groups. Compared to thecontrol group, blood glucose levels in the silkworm extract powder-treated group decreasedin the 22.5 mg/kg/d group after being administered for 4 wk. This decrease was statisticallysignificant. Furthermore, biochemical changes in the AST(Aspartate aminotransferase),ALT(Alanine aminotransferase), TCHO(Total Cholesterol), TG(Triglyceride), LDL(Low densitylipoprotein), and HDL(High density lipoprotein) levels in blood were not observed. However,statistically significant decreases in blood GLU in the 22.5 mg/kg/d group compared to thatof the control group occurred. In addition, the epididymal fat weight of the silkworm extractpowder-treated group decreased significantly in both the 22.5 mg/kg/d group and 180 mg/kg/dgroup compared to that of the control group, but there were no statistically significant changesin perirenal fat weight. These results demonstrate that silkworm extracts inhibit changes inblood glucose levels in model diabetic mice.
-
Effect of Silk Fibroin Hydrolysate on the Apoptosis of MCF-7 human Breast Cancer Cells
전정우,조유영,이광길,이회삼,여주홍,권해용 한국잠사학회 2013 International Journal of Industrial Entomology Vol.27 No.2
Breast cancer is one of the most common cancers among women worldwide. Recentlyanticancer agents have been developed using natural substances. To evaluate the anticancereffect of hydrolysates of silk fibroin (HSF), we investigated the effect of HSF on cell viability andapoptosis of a breast cancer cell line, MCF-7, induced through the mitochondrial pathway. Theresult showed that HSF decreased cell viability in MCF-7 cells in a dose- and time-dependentmanner, resulting in an increase in the sub-G1 phase cell population. HSF increased the levelof the pro-apoptotic Bax protein and decreased the levels of the anti-apoptotic Bcl-2 protein. Inaddition, HSF induced apoptosis in MCF-7 cells through a mitochondria-dependent pathwayby increasing levels of cytochtome c, and cleavage of PARP. Taken together, these findingssuggest that HSF inhibits the proliferation of MCF-7 breast cancer cells through a mitochondriaand caspase dependent apoptotic pathway.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
