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쥐의 망막 미세구조에 미치는 급성 메탄올 중독에 대한 에탄올의 효과 관찰
이호경,유진형,구본술 인제대학교 1983 仁濟醫學 Vol.4 No.3
복강내 메탄올 주입으로 급성 메탄올 중독을 일으킨 쥐와 메탄올 주입 직후, 8시간 후 및 24시간 후에 에탄올을 투여한 쥐의 망막 미세구조를 관찰하여, 메탄올 주입 직후와 8시간 후에 에탄올을 투여한 쥐에서 메탄올에 의한 망막 조직 파괴가 경감되었음을 관찰하였다. Methanol is a widely-used chemical which can cause serious visual loss by accidental ingestion, and ethanol therapy has been considered effective in maintaining life as well as preserving vision, if performed appropriately. To provide histopathologic basis of ethanol therapy in acute methanol poisoning, which is still obscure, methanol was injected intraperitoneally to the rat and ethanol therapy was carried out immediately after, 8 hours after, and 24 hours after methanol injection. One month later, specimens of retina were obtained and examined using electron microscope, comparing with only methanol-injected case. The results were as follows. 1.Ultrastructural examination of retina of the only methanol·injected rat revealed such histologic changes as retinal ganglion cell degeneration, vacuole formation in nerve fiber layer, photoreceptor outer segment destruction, and separation of inter-pigment epithelial junction, which are compatible with clinically observed visual deterioration. 2.Retinal changes were much reduced in the rat which had received ethanol therapy immediately after methanol injection, but the reduction was not conspicuous in the 8 hour-interval ethanol treated rat. No differences were found between only methanol-injected rat and 24 hour-interval ethanol-treated case.
초자제절제술 관류액에 혼합된 Cefazolin 항생제의 안전농도에 관한 실험적 관찰
李虎經,李柱華,柳珍馨 인제대학교 1988 仁濟醫學 Vol.9 No.1
안구내염의 치료에 쓰이는 초자체절제술관류액내의 Cefazolin 항생제의 안전농도 설정의 기초 자료를 마련코자, 유색가토를 사용한 동물실험을 시행하여 전자현미경으로 병리조직학적관찰을 함으로써, 1㎍/ml의 농도에서 안전농도일 가능성을 시사하는 결과를 얻었다. Management of infectious endophthalmitis presents one of the most challenging problems in ophthalmology. Retention of vision even in culture-proven cases has remained consistently poor Recently vitrectomy is introduced into the management of endophthalmitis, often with antibiotics in the infusion fluid, to promote intraocular drug diffusion. In this animal experiment, the author studied ultrastructural changes of the rabbit retina caused by various concentrations of cefazolin mixed in the infusion fluid to help determine the non - toxic concentration. Pars plana core vitrectomy was performed with infusion fluid containing 40, 10. 5, and 1 ㎍/ml cefazolin on the 4 eyes of 4 rabbits respectively. Eyeballs were enucleated 2 weeks after and specimens were immediately processed for transmission electron microscopic examination. Same procedures were repeated using gentamicin to compare with the already known toxicity. Osmolar concentration of each infusion fluid was checked to evaluate the possible high osmolar toxicity. The results were as follows ; 1.In the 40 ㎍/ml group, pyknosis and cytoplasmic degeneration were observed in the inner and outer nuclear layer, and photoreceptor inner segment showed swelling and destruction of organelles, resulting in prominent fiber baskets of Muller cell processes. Retinal pigment epithelium also showed loss of apical microvilli, breaks in the cytopalsm, and widening of basal infoldings. 2.Findings in the 10 and 5 ㎍/ml groups were similar to the 40 ㎍/ml group. 3.In the 1 ㎍/ml group, the changes were reduced but not as normal as in the comparison group. 4.It was confirmed that the changes noticed in the 40. 10, 5, and 1 ㎍/ml groups were not related with high osmolar concentration of the infusion fluid. In comparison with the gentamicin experiment, we may conclude. in spite of the ultrastructural changes noticed in the 1 ㎍/ml group, that these changes are reversble and functionally unharmful, provided that those additional tests such as electroretinography and fluorescein angiography be supplemented. Taking into consideration the mechanism by which cephalosporin makes retinal toxicity, we could suppose that this antibiotics might reach the enzyme-rich retinal cells and inhibit the enzyme-rinked metabolism to make the morphological and functional changes is them.
Zero Wait 조업 방식에서의 다품종 생산용 회분식/반연속식 공정의 최적 설계
이호경,정재학,이인범,장근수 한국화학공학회 1994 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.32 No.4
스케줄링을 고려한 회분식 공장의 최적 설계는 초기 자본비를 절감시킨다. 중간저장탱크 조업 방식의 하나인 ZW(Zero Wait)에 대하여 세척시간(cleanup times)과 이동시간(transfer times)을 고려한 스케줄링 방법을 회분식 공장의 설계수식에 첨가함으로써 비선형 프로그램을 이용하여 장치의 최적크기와 생산 순서를 결정하는 방법을 제안한다. 두 개의 예제들을 통하여 본 방법의 효율성을 입증한다. The optimal design of batch plants considering scheduling effects gives us savings of capital cost. Using a nonlinear programming formulation, which includes zero wait scheduling policy with cleanup and transfer times, we propose a method to obtain the optimum size and production sequence. The effectiveness of this method is verified by solving two problems.
李鎬京 弘益大學校 科學技術硏究所 1998 科學技術硏究論文集 Vol.9 No.2
In this paper, we explains the upstream channel of interactive CATV system and simulate the system performance. In this simulation, we consider the R-S block code and burst mode QPSK modem synchronization. In CATV upstream channel, subscribers share the same frequency band by the time sharing method. To realize this TDMA scheme, we consider the data packet which consist of (53, 59) R-S Coded ATM cell and 4-byte preamble. We present simulation results on cell error rates.
이호경,고석원 한국섬유공학회 1993 한국섬유공학회지 Vol.30 No.11
Three sones of polyether polyurethaneurea(PEUU) elastomers based on polytetramethylene glycol (PTMG, MW: 1000 or 2000). 4,4'- diphenylmethane diisocyanate(MDI) and three kinds of diamine chain extenders, i.e., 4.4'-diaminodiphenyl methane(DAM). m-phenylene diamine(MPD) and P-phenylene diamine (PPD) were synthesized. The effect of hard segment structure, hard segment content and block length on the hard domain morphology was studied by using SAXS, stress hysteresis and IR measurements. The samples with lower hard segment content or those with shorter block length at the same hard segment content exhibited more isolated hard domain morphology with diffuse interfacial boundaries. Anisotropic superstructure could be observed by polarized microscopy and TEM, but the size were dependent on the kinds of chain extenders or hard segment contents.