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당뇨병성 신병증에서 Prostaglandin E2이 단백뇨에 미치는 영향
이혜란,이태원,김명제,임천규 대한신장학회 1989 Kidney Research and Clinical Practice Vol.8 No.2
We evaluated the effects of prostaglandin E, on proteinuria and renal function in three patients with diabetic nephropathy. Two-hour intravenous infusion of 40 pg of PGE, dissolved in 200 ml of normal saline was performed twice daily for three weeks with the evaluation of weekly creatinine clearance and protein excretion rate. Three weeks of infusion of PGE tended to decrease the urinary protein excretion rate with the decrease of creatinine clearance. Therefore, careful observation of renal functional status may be required during the periods of PGE administration.
쥐 뇌와 간에서 연령에 따른 Protein Carboxy Methylation
이혜란,전길자 ( Hye Ryan Lee,Gil Ja Jhon ) 생화학분자생물학회 1991 BMB Reports Vol.24 No.1
Protein methylation by protein carboxyl methyltransferase (EC 2.1.1.77) which has the specificity for the protein containing atypical aspartyl residues is investigated in rat brain and liver from fetus to adult. The level of protein carboxyl methyltransferase increased in rat brain and fetal liver during aging but decreased in liver after birth. Methylatabilities of endogenous substrates in creased in brain cytosol during maturation. The method of PAGE utilizing the disc pH-stacking gel format, the cationic detergent cetylpyridinium chloride and an acidic buffer has been applied to detect the level of specific substrates according to maturation. By CPC-PAGE, 20K protein in brain showed the highest methylatability and its methylatability increased during maturation. These results in brain were consistent with the hypothesis that this enzyme participates in repair of degradation of age-dependent deamidated proteins. But it is assumed that this enzyme in liver has an uncertain regulatory function.
영국 전후세대 작가의 저택 신화 허물기—가즈오 이시구로의 『남아 있는 나날』과 이언 매큐언의 『속죄』
이혜란 21세기영어영문학회 2018 영어영문학21 Vol.31 No.4
This paper demonstrates that Kazuo Ishiguro and Ian McEwan, two representative English novelists who belong to the postwar generation, engage in the literary tradition of the country-house novel critically through both using it and distancing themselves from it. Ishiguro’s The Remains of the Day and McEwan’s Atonement examine the entity of the English country house, which has been one of the most important subjects of English literature, and disclose their historical context. In The Remains of the Day, Mr. Stevens’ recollections reveal the hierarchical order of Darlington Hall and its involvement in Nazism, which results in the demythification of the ‘Englishness’ the country house represents. In Atonement, Briony’s repeated writings on Robbie and Cecilia can be interpreted as atonement for the historical and literary fallacy which has eliminated the history of common people from center stage. This paper affirms that Ishiguro and McEwan, being conscious of the English country house as a key symbol of Englishness and the most popular icon of the 1980s’ nostalgia industry of English society, participate actively in the ground of cultural politics of English society by appropriating the literary tradition of country-house novel subversively in their works.
이혜란 대한소아청소년과학회 2000 Clinical and Experimental Pediatrics (CEP) Vol.43 No.9
아토피 피부염의 진단이 현재까지도 임상적 특징을 중심으로 이루어지고 있기는 하지만, 최근에 들어 면역기전을 포함한 이 질병의 병태 생리 기전의 이해에 많은 발전이 있어 왔다. 즉, IgE의 역할과 TH2 세포의 피부로의 귀소능력(homing capability), 비만세포, 랑게르한스 세포, 각질세포(keratinocyte), 호산구가 피부 염증반응을 초래하는데 복합적으로 작용한다는 것이다. 이런 기전들을 기초로 항염제와 면역억제제들이 치료에 사용되고 있으며, 향후 유전적 연구의 발전이 좀 더 이 질환에 근본적으로 접근하는 길을 마련할 것으로 기대된다.