지모(Anemarrhena asphodeloides Bunge)의 근경으로부터 Anemarsaponin B의 분리 및 함량분석

이주미,이승호,박정일,강신정,장승엽,이경순,손건호,Lee, Joo-Mi,Lee, Seung-Ho,Park, Jeong-Hill,Kang, Shin-Jung,Chang, Seung-Yeup,Lee, Kyong-Soon,Son, Kun-Ho 한국생약학회 1999 생약학회지 Vol.30 No.2

A method for isolation and qantitative determination of anemarsaponin B from the rhizomes of Anemarrhena asphodeloides has been developed. Isolation of anemarsaponin B was achieved by silica gel and RP-18 column chromatography. The HPLC method for quantitative determination of anemarsaponin B provided a method for standardization of the crude drug. It suggested that the content of anemarsaponin B in Anemarrhena asphodeloides is about 0.12-1.48%.

일차 마르코프 잡음 환경에서의 국소 최적 검파: 1. 검정 통계량

이주미,박주호,송익호,권형문,김홍직,윤석호,Lee, Ju-Mi,Park, Ju-Ho,Song, Iic-Ho,Kwon, Hyoung-Moon,Kim, Jong-Jik,Yoon, Seok-Ho 한국통신학회 2006 韓國通信學會論文誌 Vol.31 No.10C

이제까지 국소 최적 검파를 다룬 연구들에서는 대부분 관측을 독립이라 두었다. 독립 관측 모형에서 얻은 검파기는 의존성 잡음 성분이 있는 현대 고속 통신 시스템에서 성능이 쾌 떨어질 수 있다. 이 논문의 1부에서는 곱셈 꼴 잡음과 일차 마르코프 덧셈꼴 잡음이 일어나는 환경에서 알려진 약한 신호를 검파할 때 알맞은 검정 통계량을 자세히 살펴본다. 이어, 2부에서는 여러 검파기의 점근 성능과 유한 표본 크기 성능을 얻고 서로 견주어 보며, 성능을 가장 좋게 하려면 간섭끼리의 의존성을 생각하여 검파기를 꾸며야 함을 보인다. In most of the studies on locally optimum detection assumes independent observations. The use of an independent observation model may cause a considerable performance degradation in detection applications of modern high data rate communication systems exhibiting dependence among interference components. In this paper, we address the detection of weak known signals in multiplicative and first order Markov additive noises. In Part 1, the test statistics of the locally optimum detectors are investigated in detail. In Part 2, the asymptotic and finite sample-size performance of several detectors are obtained and compared, confirming that the dependence among interference components need to be taken into account to maintain performance appropriately.

일차 마르코프 잡음 환경에서의 국소 최적 검파 : 2. 성능 분석

이주미,박주호,송익호,오종호,강현구,김선용,Lee, Ju-Mi,Park, Ju-Ho,Song, Iick-Ho,Oh, Jong-Ho,Kang, Hyun-Gu,Kim, Sun-Yong 한국통신학회 2007 韓國通信學會論文誌 Vol.32 No.2C

이 논문의 1부에서는, 곱셈꼴 잡음과 일차 마르코프 덧셈꼴 잡음으로 손상된 약한 신호를 검파할 수 있는 검정 통계량을 얻었다. 이제, 이 2부에서는 이를 바탕으로 여러 검파기의 점근 상대 효율 및 유한 표본 크기 성능을 얻고 견준다. 검파 성능을 처음 뜻한 만큼 내려면 간섭끼리의 의존성을 생각해야 함을 보인다. In Part 1 of this paper, the test statistics are obtained for detecting weak known signals in observations corrupted by multiplicative and first-order Markov additive noise. In this second part, the asymptotic and finite sample-size performance of several detectors are obtained and compared based on the test statistics. From the performance comparisons, it is confirmed that the dependence among interference components need to be taken into account to maintain the detection performance.

삼각분할표 자료에서 베이지안 모형을 이용한 예측

이주미,임요한,한규섭,이경은,Lee, Ju-Mi,Lim, Jo-Han,Hahn, Kyu-S.,Lee, Kyeong-Eun 한국데이터정보과학회 2009 한국데이터정보과학회지 Vol.20 No.2

In the current paper, by extending Verall (1990)'s work, we propose a new Bayesian model for analyzing run-off triangle data. While Verall's (1990) work only account for the calendar year and evolvement time effects, our model further accounts for the "absolute time" effects. We also suggest a Markov Chain Monte Carlo method that can be used for estimating the proposed model. We apply our proposed method to analyzing three empirical examples. The results demonstrate that our method significantly reduces prediction error when compared with the existing methods. 본 논문은 삼각 분할표 자료의 예측문제에 있어 Verrall (1990)의 발생연도효과와 경과년도효과만 있는 베이지안 선형모형을 절대연도효과가 있는 모형으로 확장한 모형을 제시하고 이에 대한 추정 방법으로 마르코프 연쇄 몬테칼로 방법을 제안한다. 제안된 모형과 추정 방법은 세 가지 실제 예를 통하여 기존의 방법들에 비해서 일반적으로 작은 상대 예측오차를 제공함을 보였다.

두충(杜沖, Eucommiae Cortex)으로부터 Geniposide의 분리 및 함량분석

이주미,장승엽,이경순,손건호,Lee, Joo-Mi,Chang, Seung-Yeup,Lee, Kyong-Soon,Son, Kun-Ho 한국생약학회 2001 생약학회지 Vol.32 No.2

Geniposide, an iridoid glucoside, was isolated from the cortex of Eucommia ulmoides by repealed silica gel chromography and identified by its spectral data. The quantitative determination of geniposide with HPLC has been developed and this method provided a tool for standardization of the commercial Eucommiae Cortex.

Novel Hybrid Molecules of Epinastine and Mefenamic Acid for Bioactive Assessment as Potential Anti-inflammatory Agents

이주미,콩가라다무다,Yeontaek Lee,Hyeong Ryeol Woo,서홍원,전성호,이정태 대한화학회 2020 Bulletin of the Korean Chemical Society Vol.41 No.4

A set of novel epinastine (1) and mefenamic acid (2) hybrids (3?7) tethered via amide bond were designed and synthesized with the artistry of molecular hybridization. Then their inhibitory effect on nitric oxide (NO) production in LPS-induced RAW-264.7 macrophages and the expression levels of prostaglandin (PG) synthesis regulatory genes were evaluated in vitro. All the hybrids were found to have remarkable NO production inhibitory potential with IC50 values ranging in between 27.69?±?3.06 and 40.19?±?5.52??M without notable cytotoxicity (CC50?≥?100??M) except 6. Comparing the inhibitory effects, cytotoxicity and in vitro efficacy index (iEI), 4 (IC50 = 32.09?±?4.04??M; iEI = 6.23) and 7 (IC50 = 27.69?±?3.06??M; iEI = 6.40) were better suited than other hybrids as well as their parent compounds EH and MA. This outcome was further harmonized with the reduced microsomal prostaglandin E synthase-1 expression and unaltered housekeeping COX-1 expression by hybrids 4 and 7 treatment. Altogether, our findings signify that hybrids 4 and 7 may serve as platforms for continued investigations for the development of more efficient anti-inflammatory agents.

이청준 동화의 특징과 아동문학적 가치 -전래동화 채록의 의미 해석을 중심으로-

이주미 ( Joo Mi Lee ) 한민족문화학회 2011 한민족문화연구 Vol.38 No.-

이청준은 90년대 중반부터 판소리동화와 전래동화를 발표하기 시작하였다. 거대서사에 대한 불신이 증폭된 시기이자 포스트모더니즘 사조와 다양한 소비문화가 대중의 일상과 의식을 지배하기 시작한 시기인 90년대 중반에 작가가 동화에 관심을 기울이게 된 것은 근대적 합리주의 이전의 세계를 복원하려는 의지를 구체화한 것으로 보인다. 동화라는 장르 자체는 근대성의 산물이지만 이청준의 전래동화는 어린이의 정체성이나 동화문법을 충분히 고려하기보다는 구전의 의미와 가치를 환기시키는 데에 주력하였으며 동화의 내용 전개에 있어서도 지혜나 미담을 강조하여 전통사회의 윤리적 덕목을 재생시키고자 하였다. 특히 이청준의 전래동화는 개작보다는 채록에 역점을 두었다. 말의 타락이 심각한 수준에 달한 90년대에 이청준은 순결한 말을 모색하는 과정에서 자신이 유년 시절에 들은 옛이야기를 복원하기 시작한 것이다. 또한 이청준은 전래동화의 보급을 통해 삶의 유전적 정서를 되살리고자 하였다. 우화소설 『인문주의자 무소작 씨의 종생기』에 등장하는 꽃씨 할머니 이야기는 기교를 절제한 원초적 상태를 상징하는 것으로, 꽃씨 할머니가 꽃씨를 뿌리고 다니는 행위는 삶의 유전적 정서가 담긴 옛이야기의 유포방식으로 해석된다. 이청준의 전래동화 작업은 궁극적으로 게마인샤프트를 지향하는데, 게마인샤프트는 접촉성과 친밀성을 전제로 하고 구성원 상호간의 양해와 용서를 질서의 동력으로 삼는다는 점에서 작가가 기왕의 작품에서 꾸준히 구상해 온 대안적 공간들과 동질적이다. Lee Chung-jun began introducing pansori children`s books and children`s folk tales in the mid 1990s. Lee Chung-jun paid attention to create children`s books in the 1990s in which a consumption culture began to rule the ordinary lives and consciousnesses of the public, and it seems that he concretized his will to restore the world which existed prior to modern rationalism. The genre of children`s books is the product of modernity, but the children`s folk tales by Lee Chung-jun focused on arousing the meaning and value of oral tradition rather than satisfactorily considering the identity of children or grammar in children`s books, and also tried to revive the ethical virtue of traditional society by emphasizing wisdom or moving stories. In particular, children`s folk tales by Lee Chung-jun emphasized recording in existing stories rather than rewriting them. In the 1990s when there appeared to be a severe deterioration in the language, Lee Chung-jun began to restore old stories he heard in his childhood in the process of searching for ``pure words``. Also, he attempted to revive the hereditary emotion of life through the distribution of children`s folk tales. In <Humanist, Musojak`s life story>, the act of scattering flower seeds by the flower seed granny is interpreted to be an act of disseminating old stories that contain the hereditary emotion of life. His work on children`s folk tales ultimately inspires Gemeinschaf, and Gemeinschaft is homogeneous to alternative spaces that he had consistently devised in existing works in that Gemeischaft considers the understanding and forgiveness among its members as the driving force of public order.

이청준 판소리동화에 나타난 판소리의 변형과 보존 양상

이주미(Lee, Joo-mi) 한국언어문학회 2011 한국언어문학 Vol.78 No.-

Lee Cheong-jun had oneself independent literary world. He adopted the organization of narrative called ‘Stratified structure’. But He recreated Pansori into a fairy tale in the mid-1990s. Fairy tale consists of simple plot, simple character and concise sentences. Therefore he gave up his literary personality to write the Pansori fairy tales. He were trying to pass on literary tradition through the Pansori fairy tales. But Lee Cheong-jun’s Pansori fairy tales did not preserve the tradition intact because he made reference a block book of Sinjaehyo. He adapted a block book of Sinjaehyo to match Child’s identity. He has enhanced tragic aesthetic to emphasize the subject in 〈Singcheong-ga〉 and 〈Chunhyang-ga〉. Also, he was removed a critical consciousness about social in 〈Sugung-ga〉. Nevertheless, Lee Cheong-jun’s Pansori fairy tales are an important value because realistic hope was realized by using fantasy. In 〈Heungbu-ga〉 〈Onggojip-taryeong〉, a punishment is a prerequisite of enlightenment. In other words, a fantasy is a prerequisite of initiation.

『비화밀교』의 주제의식과 작가의 태도

이주미(Lee, Joo-mi) 한국언어문학회 2015 한국언어문학 Vol.94 No.-

The Watch Night event in ｢Bihwamilgyo｣ is to sublimate pathological psychology resulted from suppressive reality in the form of a ritual. This ‘cult’ has been maintained as the order different from the worldly order was formed spontaneously, and its concrete symbol is the ‘embers’. It is noteworthy that in this work, ‘flashlight’ is used as a subject matter that implies that consideration. It is because in the previous works, ‘flashlight’ symbolizes authoritative sight contrastively. The writer prospects the destiny of this cult pessimistically. He admits that all that is hidden takes the need to actualize itself and impulse and sees that it gets to take destructive aspects when the shade order goes into the realistic order. As it is implied in Your Heaven, too, the ‘heaven’ can exist only when it is grounded on autonomous destiny, and this is because revealing a secret assumes collision with another community. The writer reveals the consciousness of his defeatism by showing that sir Jo’s mentalism anticipates defeat from the first place. What the writer pays attention to in this work is a novelist’s roles. Lee Cheong Jun already defined in his ｢Let’s write an autobiography｣ that ‘an autobiography is a story from the future though it is written in past tense’ and emphasized that the future should be the future for all. In ｢Bihwamilgyo｣, Lee Cheong Jun emphasizes sir Jo’s defeat is the mission of a novelist showing the tragedy of our time just as it is.

『신화를 삼킨 섬』에 나타난 아기장수 신화의 소설적 전유 방식

이주미 ( Lee Joo-mi ) 한민족문화학회 2017 한민족문화연구 Vol.59 No.-

『신화를 삼킨 섬』에는 아기장수 신화가 액자 형식으로 배치되어 있다. 이청준 소설에 신화나 굿이 등장하게 된 시점은 80년대 이후 작가가 공동체의 운명을 탐색하던 시기와 맞물린다. 아기장수의 운명은 노력에 의해서가 아니라 우연에 의해 결정되며, 아기장수 신화는 결과적으로 실패가 예정된 결정적 세계를 압축적으로 보여준다. 『신화를 삼킨 섬』의 현실은 아기장수 신화의 분위기와 크게 다르지 않은데, 진정성이 결여된 사업에 동원될 처지가 된 제주 심방들은 `역사 씻기기 사업`으로 양분된 두 집단 중 어느 쪽에도 속하지 않으려 한다. 신화의 꿈을 종결짓지 않고 자기치유에 나서는 제주 심방들의 행보는 자유의지의 표현이라 할 수 있다. 『신화를 삼킨 섬』에서 운명공동체로서의 속성을 잘 드러내는 인물들은 섬 심방들이다. 이청준이 굿에 관심을 갖게 된 것은 판소리에 대한 관심에서 자연스럽게 연결된다. 주지하는 바와 같이 「서편제」에서 이청준은 판소리로 용서와 화해를 모색한 바 있다. 판소리가 개인적 차원에서 한을 풀어내는 양식이었다면 굿은 집단의 원한을 풀어내는 양식이라 할 수 있다. 『Island that Swallowed a Myth』 has the myth of baby Samson as a frame story. Taking a look at the time when a myth or a gut in Lee Cheong-chun`s novels, his early novels dealt with personal existential issues while those in the 1980s and thereafter explored the fate of communities. The characters that have well revealed the attributes of a community sharing a common fate are none other than island shamans. The fate of baby Samson is to be determined by accident not by effort. The Jeju shamans are destined to be mobilized into carrying out a project lacking sincerity in inner narration and, at this time, the actions of Jeju villagers seeking to belong to neither of those two groups split due to the `history washing project` can be considered an expression of free will. The process of developing interest in gut by Lee Cheong-chun is naturally linked to his interest in pansori, a traditional Korean genre of musical storytelling. In 「Sopyonje」, Lee Cheong-chun sought forgiveness and reconciliation by means of pansori. While pansori is used as a vehicle to release `han`, spite or resentment, on a personal level, gut is performed in a bid to release grudge or resentment of a group or community.