인공수정시술주기에서 내인성 LH, GnRH Agonist 및 hCG를 이용한 배란유발후 임신율의 비교연구

이종인,허영문,전은숙,윤정임,정구성,홍기언,유승환,이현숙,홍정의,이지삼,Lee, Jong-In,Hur, Young-Mun,Jeon, Eun-Suk,Yoon, Jeong-Im,Jung, Goo-Sung,Hong, Ki-Eon,You, Seung-Hwan,Lee, Hyeon-Sook,Hong, Jeong-Eui,Lee, Ji-Sam 대한생식의학회 1999 Clinical and Experimental Reproductive Medicine Vol.26 No.3

Objective: This study was designed to evaluate the effects of endogenous LH surge, GnRH agonist (GnRH-a) or human chorionic gonadotropin (hCG) as ovulation trigger on pregnancy rate by intrauterine insemination (IUI). Method: Patients received daily 100 mg of clomiphene citrate (CC) for 5 days starting on the third day of the menstrual cycle followed by human menopausal gonadotropin (hMG) for ovulation induction. Follicles larger than >16 mm in diameter were present in the ovary, frequent LH tests in urine were introduced to detect an endogenous LH surge. Final follicular maturation and ovulation were induced by GnRH-a 0.1 mg (s.c.) or hCG $5,000{\sim}10,000$ IU (i.m.) administration except natural ovulation. Pregnancy was classified as clinical if a gestational sac or fetal cardiac activity was seen on ultrasound. Results: There were no differences in age, duration of infertility and follicle size, but more ampules of hMG were used in GnRH-a group compared to hCG 10,000 IU treated group (p<0.05). Lower level of estradiol ($E_2$) on the day of hCG or GnRH-a injection was observed in hCG 10,000 IU group than other treatment groups (p<0.01). The overall clinical pregnancy rate was 19.8% per cycle (32/162) and 22.2% per patient (32/144). Pregnancy rate was higher in natural-endogenous LH surge group (37.5%, 9/24) than GnRH-a (18.8%) or hCG treated group (20.9% & 13.9%), but this difference was not statistically significant. No patient developed ovarian hyperstimulation. Abortion rate was 22.2% (2/9) in hCG 5,000 IU group. Delivery or ongoing pregnancy rate was 37.5% (9/24), 18.8% (3/16), 16.3% (7/43) and 13.9% (11/79) in endogenous LH surge, GnRH-a, hCG 5,000 IU and hCG 10,000 IU treatment groups, respectively. Conclusion: These results support the concept that use of natural-endogenous LH surge in stimulated cycles may be more effective to obtain pregnancies by IUI than GnRH-a or hCG administration.

낙석방지시설 적용을 위한 팽창메탈의 특성 연구

이종인(Lee Jong-In),정춘교(Jung Chun-Gyo),김성호(Kim Sung-Ho),황영철(Hwang Yeong-Cheol),이승호(Lee Seung-Ho) 한국지반환경공학회 2011 한국지반환경공학회논문집 Vol.12 No.9

산지가 많은 우리나라는 도로 및 철도건설을 위해 사면을 형성하는 구간이 많고, 사계절의 뚜렷한 차이로 인해 해빙기에 암블록의 이완현상 발생과 연평균 강우량의 2/3 정도가 여름철에 집중 발생되는 기후특성이 있으며, 최근 기상이변에 따른 집중호우 등으로 낙석 및 산사태와 같은 도로절개면 붕괴사고가 잦은 편이며, 해마다 장마철이 되면 이와 관련된 사고소식을 매스컴을 통해 쉽게 접할 수 있다. 낙석 발생 시 인명과 재산 피해를 최소화하기 위하여 절개지에 대한 보강공법의 개발 및 현장 적용성에 대한 연구 등이 활발히 이루어지고 있지 않는 실정으로 이에 대한 연구의 필요성이 부각되고 있다. 특히 낙석방지망의 부분적 취약점(일체화가 되지 못함)으로 인해 낙석방지망이 충분한 지지능력을 발휘하지 못하는 문제가 발생됨에 따라 국내에서도 보다 높은 낙석에너지를 지지할 수 있는 낙석방지망에 대한 연구가 필요할 것으로 판단된다. 이에 본 연구에서는 낙석방지망의 대체재료로서 팽창메탈의 적용성을 실험적으로 검증하고, 그 특성에 관해 연구해 보고자 하였다. 시험결과 팽창메탈은 우수한 강도와 일체화된 재료특성으로 기존 PVC망에 비해 최대지지하중이 높게 나타났으며, 현장시험의 흡수가능에너지 또한 높게 나타나 낙석방지망의 대체재료로서 활용이 가능한 것으로 판단된다. There are many mountains in Korean Peninsula, and those used for the construction of roads and railways sectors are forming slopes. Slope collapse occurs with falling rocks and landslide because of the relaxation of the thawing rocks. The heavy rain in summer can also significantly contribute to the process, and abnormal climate change is much more influential than before. Therefore, rockfall-related accidents in rainy season are easily accessible in media every year. There has been a lot of research on application of strengthening compensation of the sections in order to minimize casualties and property damage. Rockfall Protection Net, however, has not been focused on much in the field yet. This study highlights the need of Rockfall Protection Net, since it can segregate the falling rocks inside the net relatively safely. Although there has been a little doubt about the effectiveness of rockfall protection facilities, it is obvious that relevant studies dealing with the solidity of the net are necessary for the rockfall protection net to be capable of supporting rockfall energies. As a result, Expanded metal strength is much more durable compared to the PVC coating net, and it is regarded as an excellent alternative material for the Rockfall Protection Net. In this study, the applicability of Expanded Metal as the alternative of Rockfall Protection Net is verified experimentally.

신생아 외과환아에서 말초혈관을 통한 전비경구적 영양요법에 대한 고찰

이종인,정풍만,Lee, Jong-In,Jung, Poong-Man 대한소아외과학회 1998 소아외과 Vol.4 No.1

Parenteral nutrition has been an essential part of postoperative care of neonates requiring major surgery who are unable to tolerate enteral feeding for long periods during the postoperative period. However, TPN via central venous catheters(central TPN), used in increasing trend, still presents significant morbidity. To find out whether TPN via peripheral veins(peripheral TPN) could be used as a viable alternative for postoperative parenteral nutrition in neonates, a clinical study was carried out by a retrospective analysis of 53 neonates subjected to peripheral TPN for more than 7 days after surgery. Operations consisted of procedures for esophageal atresia with tracheoesophageal fistula, gastroschisis and omphalocele. Surgery was performed at the Division of Pediatric Surgery, Department of Surgery, Hanyang University Hospitall, from 1983 to 1994. The mean total duration of TPN was 13.3 days (range; 7-58 days), the average daily total fluid intake was 117.6 ml/kg during TPN and 158.6 ml/kg during subsequent oral feeding. The average daily total calorie intake was 57.7 kcal/kg during full strength TPN and 101.3 kcal/kg during subsequent oral feeding. The mean urine output was maintained at 3.5 ml/kg/ hour during TPN and at 3.6 ml/kg/hour during subsequent oral feeding. The increment of body weight observed during TPN was 132 g in TEF, 53 g in gastroschisis and 3 g in omphalocele patients, while loss of body weight was not observed. The mortality rate was 5.7 %(3/53) and was related to the underlying congenital anomalies, not the TPN. The most common complication of peripheral TPN observed was laboratory findings suggestive of liver dysfunction in 23 cases(43.4 %) with no significant clinical symptom or signs in any case, transient pulmonary edema in one case, and generalized edema in one case. None of the major complications usually expected associated with central TPN were observed. The result of this study suggest that peripheral TPN can be used for adeguate postoperative nutritional support in neonates requiring 2 to 3 weeks of TPN.

농업 경영,정보분야의 미래유망기술 및 전략기술에 관한 우선순위 재설정 연구

이종인 ( Jong In Lee ),정윤필 ( Yun Pil Jung ),신동철 ( Dong Cheol Shin ),노성훈 ( Sung Hoon Ro ),조근태 ( Keun Tae Cho ) 강원대학교 농업생명과학연구원(구 농업과학연구소) 2009 강원 농업생명환경연구 Vol.21 No.-

The study was focused on setting priority for future core technologies in agricultural Management & Information using AHP. 20 technologies were derived by specialists meetings. Evaluation criteria for the priority setting were decided as `technology`, `market oriented`, and `public concerns`. 10 specialists in agricultural processing answered the questionnaire for AHP. As the results, `market oriented` was decided as the most important evaluation criterion. `Technology realization` in `technology` criterion, `investment profit` in `market oriented` criterion, and `spillover effects on industry` in `public concerns` criterion were decided as sub-criteria in each criterion. The most important technology was construction of effective qualify certification system for friendly-environmental Agricultural Products.

고립성 폐결절에 관한 임상적 고찰

이종인 ( Lee Jong In ),이상수 ( Lee Sang Su ),원구태 ( Won Gu Tae ),안강현 ( An Gang Hyeon ),이성우 ( Lee Seong U ),백순구 ( Baeg Sun Gu ),김승률 ( Kim Seung Lyul ),용석중 ( Yong Seog Jung ),신계철 ( Sin Gye Cheol ),정순희 ( Jeong 대한내과학회 1993 대한내과학회지 Vol.44 No.2

N/A Background : Because there aremany different reporting results about the etologies of solitary pulmonary nodules (SPNs), we cannot know the exact incidence of each causative disease. SPNs have a good prognosis relatively even if it is a malignant lesion. In Korea, where there is a high incidence of pulmonary tuberculosis, the differential diagnosis of SPNs should be performed. Methods : Among 351 patients who visited Wonju Chistian Hospital for SPNs in chest x-ray between 1982 and 1989, we evaluated 74 patients in whom the causes of SPNs could be elucidated by sputum AFB study, cytology, histolgic study, chest of solitary pulmonary nodule (SPN) seen at the Wonju Christian Hospital from 1982 to 1989. The followings were obtained. 1) The malignancies of SPN 74cases were 25 cases (33.7%). The primary lung carcinomas were 24 cases : The epidermoid carcinomas of these were 11 cases (45.8%), metastasis I case, tuberculoma 42 cases, and the other 7 cases. 2) The age distribution of benign lesions was from 19 to 73 years old with the mean age of 46 years old, and the age distribution of malignancies was from 17 to 77 years old with the mean age of 57 years old. The 23 cases (92.0%) of malignant nodules were more than 40 years old. The malignant frequency of SPN in a group of age more than 40 years old was 40.3% and in a group of age less than 40 years old, it was 11.7%. The malignant frequency was directly proportional to the increase of age(p<0.05). 3) The 3 cases of SPN were detected accidentally during physical up, all were benign. The 14 cases were detected during the evaluation of other diseases, 12 cases were benign. The 23 cases (40%) of 57 cases were symptomatic. Chest pain, dyspnea, and weight loss frequency in a group of less than 3cm in size was 11.9% and in a group of less than 3cm in size, it was 62.5% (p<0.05). 6) Calcifications were noted in 15 cases of 74 cases on the plain films, all were 7 central types, 7 diffuse types and 1 popcorn type. One of malignant cases had calcification on the chest CT scar. Among the 59 cases with non-calcified nodules, 25 cases were malignant (42.3%). The mean Hounsfield Unit of benign lesions was 182.5U and that of malignancies was 94U, there was a statistical difference between both groups(p<0.01). 7) The 21 cases (50%) of tuberculomas were located at the apicoposterior segment of upper lobe or the superior segment of lower lobe, but the 7 cases (28%) of malignancies were located at above sites. 8) The diagnostic accuracy of sputum study was 9.4% and that of fiberoptic bronchoscopy (FOB) was 33.3%. The diagnostic accuracy of transbronchial lung biopsy (TBLB) and transthoracic needle aspiration biopsy (TTNAB) was 57.4%. The percentage of primary lung cancer among SPNs which are larger than 3cm in size, occurring in the age of older than 40 years old and with no calcifications on radiologic examintion should be suspected as malignancies and diagnosed with sputum study, fiberoptic bronchoscopy, TBLB, and TTNAB.

경종작물분야의 미래유망기술 및 전략기술에 관한 우선순위 재설정 연구

이종인 ( Jong In Lee ),정윤필 ( Yun Pil Jung ),신동철 ( Dong Cheol Shin ),노성훈 ( Sung Hoon Ro ),조근태 ( Keun Tae Cho ) 강원대학교 농업생명과학연구원(구 농업과학연구소) 2009 강원 농업생명환경연구 Vol.21 No.-

The study was focused on setting priority for future core technologies in crop production technology using AHP. 46 technologies were derived by specialists meetings. Evaluation criteria for the priority setting were decided as `technology`, `market oriented`, and `public concerns`. 9 specialists in crop production technology answered the questionnaire for AHP. As the results, `market oriented` was decided as the most important evaluation criterion. `Technology realization` in `technology` criterion, `investment profit` in `market oriented` criterion, and `spillover effects on industry` in `public concerns` criterion were decided as sub-criteria in each criterion. The most important technology was Development of technology for High-quality brand rice and standardization of rice traceability.

소아 기형종의 임상적 분석

정풍만,이종인,Jung, Poong-Man,Lee, Jong-In 대한소아외과학회 1999 소아외과 Vol.5 No.1

Among 60 children with teratoma, forty-three (71.7 percent) were girls and 17 (28.3 percent) boys, Primary sites were sacrococcygeal in 30 patients (50 percent), retroperitoneal in 12 (20 percent), ovarian in 11 (18.3 percent), testicular in 3 (5 percent), and one in each of nasopharyngeal, gastric, hepatic and pancreatic (1.6 percent, respectively). Fifty-five (91.7 percent) teratomas were benign and 5 (8.3 percent) malignant. Malignant teratomas W8,re detected only in the sacrococcygeal region (16.7 percent). Age greater than 2 mouths at diagnosis, presence of urinary or colonic obstructive symptoms, multiple masses and elevated serum alpha-fetoprotein were indicators of malignancy in the sacrococcygeal region. Tumor size, presence of calcification, and gross apperance (cystic or solid) did not correlate with malignancy. Thirteen (21.7 percent) cases were associated with other anomalies. For the immature teratoma, operative resection without adjuvant chemotherapy was adequate treatment. Three patients with malignant tumors survived, one who received chemotherapy survived 3 years and the others without chemotherapy survived for 5 and 10 years.

연구논문 : 농업용저수지인 오태지의 수생태계구조와 수질과의 관련성

서정관 ( Jung Kwan Seo ),이혜진 ( Hae Jin Lee ),정현기 ( Hyun Gi Jeong ),탁보미 ( Bo Mi Tak ),이재관 ( Jae Kwan Lee ),김인택 ( In Taek Kim ),이종은 ( Jong Eun Lee ),황의욱 ( Ui Wook Hwang ) 한국환경과학회 2010 한국환경과학회지 Vol.19 No.11

This study was carried out to elucidate the relation between water quality and structure of the aquatic ecosystem in the agriculture reservoir Otae-ji from January to December in 2009. The proportion of forest was 46.98%, which means that non-point sources are major contributor of water pollution in this area. The annual mean COD(Chemical Oxygen Demand) in Otae-ji was 3.6 mg L-1, indicating, level II of environmental standards and the trophic state was mesotrophic. Although total phosporus concentration in the reservoir was high in August due to large inflow of nutrients from outside the reservoir during monsoon season, there was no break out of significant algal bloom in the summer. The seasonal succession of phytoplankton showed that the dinophyta dominated in the the spring, chlorophyta in the summer, chrysophyta and chlorophyta in the autumn and chrysophyta in the winter. In case of zooplankton, rotifers dominated in the most seasons, but cladoceran(Bosmina longirostris) dominated in June and copepod(Nauplii) in August. The macrophyte plants showed diverse species composition consisted of 3 varieties, 24 species, 23 genera, 15 families and 14 orders. The macroinvertebrates also showed various FFG(Functional Feeding Groups) such as GC(Gathering-Collector), P(Predator), SH(Shedder), FC(Filter-Collector) and PP(Plant-Piercer). Ecosystem stability analysis using aquatic insects was classified as Group I, which has high resilience and resistance indices. A total of 14 species of fish was collected but exotic species such as Lepomis macrochirus and Micropterus salmoides were not found in Otae-ji. In conclusion, the preservation of healthy food wed in the reservoir ecosystem is closely related to water quality management as well as effective prevention of algal bloom by helping good material circulation in aquatic ecosystems.

독성 및 약물대사 연구를 위한 한국인 부분 간 유래 간세포의 품질 및 활용성 평가

노정권(Jeong-Kwon Noh),장인근(In Keun Jang),김효은(Hyo Eun Kim),이종은(Jong Eun Lee),양말숙(Mal Sook Yang),장은미(Eun Mi Jang),이지현(Ji-Hyun Lee),박혜정(Hey-Jung Park),김영아(Young-A Kim),이석구(Suk-Koo Lee),정호상(Ho-Sang Jeong),안준 한국생물공학회 2014 KSBB Journal Vol.29 No.1

Demand for in vitro pharmacological evaluation and toxicity test using human hepatocytes has been increasing. In USA and Europe, human hepatocytes obtained from donated whole liver unsuitable for transplantation were distributed to researchers and deposited in cell bank facility as cryopreserved vial. In Korea, however, incidence of transplantation-inappropriate whole liver has been quite low and the whole livers almost have so severe liver disease such as fatty or fibrotic liver that cannot meet the demand. In this study we aimed to isolate human hepatocytes from liver resection surgery-originated partial liver, and assure the isolated human hepatocytes and its cryopreserved hepatocytes to be qualified for the in vitro pharmacological evaluation and drug toxicity tests. We compared those with commercially available human hepatocyte, BD GenTest<SUP>TM</SUP> by cell morphology, hepatic gene expression, urea synthesis, albumin secretion, ammonia removal, and cytochrome P450 induction activities. Changes in hepatotoxic gene expression after cryopreservation are evaluated with a typical hepatotoxic drug, acetaminophen. Consequently, the fresh hepatocytes from the partial liver and its cryopreserved hepatocytes expressed their intrinsic hepatic functions well and showed equal hepatotoxicity gene expression trend regardless to cryopreservation. Therefore, liver resection surgery-originated partial liver can be used as a useful source of human hepatocytes for various pharmacological and hepatotoxicity test.

내시경적 점막절제술을 이용한 위의 전암병변 및 조기위암의 치료

정필호(Phil Ho Jung),이동기(Dong Ki Lee),이상철(Sang Cheol Lee),김준명(Jun Myeong Kim),백순구(Soon Koo Baik),김일희(Il Hoi Kim),최윤종(Yeun Jong Choi),조도연(Do Yeun Cho),이종인(Chong In Lee),권상옥(Sang Ok Kwon) 대한내과학회 1998 대한내과학회지 Vol.54 No.4

N/A Objectives: Gastrectomy with lymph node dissection is the stare4rd treatment for early gastric cancer(EGC). However, patients who have high risks demand modifications in surgical treatment for EGC. Recently, endoscopic mucosal resection(EMR) has become accepted in many institutions as a treatment for cancerous mucosal lesions of the stomach. Thus we investigated the efficacy and safety of EMR prospectively in the patients with EGC who have high risks in surgery and those with premalignant lesions. Method: Twenty-five patients were treated with EMR, thirteen were EGC and twelve were premalignant lesions such as tubular adenoma, severe dysplasia. We used standard snare method and endoscopic mucosal resection using a band ligation kits(EMRI.), Resuts : The complete resection rate at the first step of EMR was 100%(13/12) in premalignant lesions, 76.9%(10/13) in EGC. Of three EGC resected incompletely at the first step, one patient was treated by surgery and two patients underwent the third step of EMR. The final complete resection rate was 92%(23/25) and it was 100%(12/12) in the premalignant lesions, 84.6%(11/13) in RX. We final complete resection rate in according to the methods was 100%(5/5) by standard snare method, 75%(6/8) by EMHL, As pathologic results, all cases of F were limited to the mucosa. No serious complications such as perforation, major bleeding were encountered. Conclusion: We consider that EMR is effective and safe in treatment of the patients with EGC who have high risks in surgery and those with prernalignant lesions.