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이장준,송현석,황양하,이호원,서정규,박성파 대한신경과학회 2011 Journal of Clinical Neurology Vol.7 No.3
Background and Purpose Levetiracetam (LEV) is a new antiepileptic drug that has been found to be effective as an adjunctive therapy for uncontrolled partial seizures. However, the results of several studies suggested that LEV has negative psychotropic effects, including irritability, aggressiveness, suicidality, and mood disorders. We investigated the impact of adjunctive LEV on psychiatric symptoms and quality of life (QOL) in patients with drug-refractory epilepsy (DRE) and determined the risk factors provoking psychiatric adverse events. Methods A 24-week, prospective, open-label study was conducted. At enrollment, we interviewed patients and reviewed their medical charts to collect demographic and clinical information. They were asked to complete self-report health questionnaires designed to measure various psychiatric symptoms and QOL at enrollment and 24 weeks later. Results Seventy-one patients were included in the study, 12 patients (16.9%) of whom discontinued LEV therapy due to serious adverse events including suicidality. The risk factor for premature withdrawal was a previous history of psychiatric diseases (odds ratio 4.59; 95% confidence interval, 1.22-17.32). LEV intake resulted in significant improvements in Beck Anxiety Inventory score (p<0.01) and some domains of the Symptom Checklist-90-Revised, such as somatization (p<0.05), obsessive-compulsiveness (p<0.05), depression (p<0.05), and anxiety (p<0.05). These improvements were not related to the occurrence of seizure freedom. The Quality of Life in Epilepsy Inventory-31 overall score and subscale scores, such as seizure worry (p<0.01),overall QOL (p<0.05), emotional well-being (p<0.05), energy-fatigue (p<0.05), and social function (p<0.05), also improved. Conclusions Adjunctive LEV in patients with DRE is likely to improve psychiatric symptoms and QOL. Clinicians should be well aware of the psychiatric histories of patients to prevent them from developing serious adverse events related to LEV.
장준구(張俊九) 한국미술연구소 2017 美術史論壇 Vol.- No.45
Since the late 16<SUP>th</SUP> century the Ming dynasty reached a high plane of achievements in terms of culture while it encountered crisis in terms of politics and military. In those days, The Story of the Water Margin (Shuihuzhuan, 『水滸傳』) was more than a novel. At that time its story was published in books and performed as a play. The general public enjoyed pictures pertaining to this novel and moreover indulged in this story even using gambling devices on which figures from this story were portrayed. This fever for Water Margin was one of the immediate causes of the situations brought about at the end of the Ming dynasty that was on the verge of ruin. The content of Water Margin can be deemed anti-government and anti-state. Characters in the story include outlaws who commit crimes, formed a group, and resist against the government in the first half of the novel. However, those heroic persons subjugated the Liao dynasty founded by the Khitan people and the Jin dynasty founded by the Jurchen people as well as suppressed rebellions domestically. With this content implicatively reflecting the situations of the late Ming dynasty, this novel has been able to work as a symbol of patriotic sentiment. Images associated with The Story of the Water Margin were existent mainly in the form of illustrations. The typical images are from Water Margins Game Cards (Shihu yezi, 《水滸葉子》) by Chen Hongshou(1599~1652). Water Margins Game Cards is a collection of the prints of 40 key figures Chen portrayed among 108 heroes in The Story of the Water Margin. Chen appropriated the image of Guan Yu who had respected as the guardian god of the state for Song Jiang and Lu Junyi and the image of Zhuge Liang who had been regarded as the epitome of wisdom for Zhu Wu and Wu Yong, thereby wishing for salvation from the threat of foreign power. He also represented patriotic sentiment with f lowers set on the heads of good-looking heroes such as Chai Jin and Shi Shou. Chen’s illustrations are not mere portrayals of figures from The Story of the Water Margin but reflect the painter’s patriotic sentiment. The manifestation of such sentiment by the medium of The Story of the Water Margin was closely associated with representations and expressions by ordinary personas as well as intellectuals during the end of the Ming dynasty. They enjoyed the novel The Story of the Water Margin in a variety of forms such as book, theater, painting, gambling, and discourse. The Story of the Water Margin, a novel that emerged at the end of the Ming dynasty was an alternative medium in its chaotic society and a spiritual haven as well as a symbol of patriotic sentiment and a phenomenon penetrating society.
이장준,현범석,유명종 한국항공우주학회 2011 한국항공우주학회 학술발표회 논문집 Vol.2011 No.4
인공위성의 열진공 시험을 수행하기 전에 사전 열해석을 수행하는 것은 여러 측면에서 의미가 있다. 먼저 열진공 시험에 대한 사전 열해석을 수행함으로써 열진공 시험 전체와 각 구간별 소요시간에 대한 예측이 가능하며, 이것은 비용감소 효과를 지닌다. 또한 사전 열해석은 열진공 시험의 각 구간별 외부열원의 용량을 사전에 결정하도록 하여 적절한 시험 준비를 수행할 수 있게 해주고, 열진공 시험 후에 진행될 열해석 모델의 보정작업 기간을 단축시켜 인공위성 개발기간의 단축에 기여한다. 마지막으로 사전열해석은 열진공시험 기간 중 인공위성의 안전에 대한 신뢰도를 향상시킨다. 본 연구에서는 저궤도 인공위성의 열해석 모델을 수립하여 열진공 시험에 대한 사전 열해석을 수행하고 실제 열진공 시험 이전에 각 구간별 외부 열유입량을 사전에 결정하여 열진공 시험의 준비를 수행하였다. Performance of pre-thermal analysis for satellite thermal vacuum test has important meanings in some aspects. First the pre-thermal analysis can predict the duration time for entire thermal vacuum test and each phases, and it leads to cost reduction. In addition, external heating source at each phase could be determined by the thermal analysis, it could provide proper preparation of test and reduce the schedule of satellite development by shortening the thermal math model correlation process. Finally pre-thermal analysis improves the safety of satellite during thermal vacuum test. In this study, thermal math model of low earth orbit satellite was established and pre-thermal analysis has been performed and preparation of thermal vacuum test was performed by determination of external heat source at each phase.