르포씨 1형 골절단술후 코와 상순의 연조직 변화의 삼차원 컴퓨터 단층촬영을 이용한 정량적 측정에 관한 연구

이원덕,유충규,최진영,Lee, Won-Deok,Yoo, Chung-Kyu,Choi, Jin-Young 대한악안면성형재건외과학회 2010 Maxillofacial Plastic Reconstructive Surgery Vol.32 No.1

Objective: To evaluate nasal and upper lip changes after Le Fort I surgery by means of images taken with a three-dimensional computed tomography (3D-CT). Methods: Fifteen patients (9 female and 6 male, mean age 21.9 years) with preoperative and postoperative 3D-CT were studied. The patients underwent maxillary movement with impaction or elongation, and advancement or setback. With the 3D-CT which presents reconstructive soft tissue images, preoperative and postoperative measurement and analysis were performed for nasal tip projection angle, columellar angle, supratip break angle, nasolabial angle, interalar width, internostril width, columella length and nasal tip projection. Results: Postoperative interalar and internostril widening was significant for all categories of maxillary movement. However, there was little significant relation in all parameters between the amount and direction of maxillary movement. Interestingly, movement of the maxilla with upward did show a little decrease in the columellar angle, supra tip break angle and nasolabial angle. Also movement of the maxilla with forward did show a little advancement in the upper lip position. Conclusion: Changes to the nose clearly occur after orthognathic surgery. There was a significant increase in postoperative interalar width and internostril width with maxillary movement. However, no clear correlation could be determined between amount of change and maxillary movement. Interestingly, maxillary impaction did show a little decrease in the columellar angle, supra tip break angle and nasolabial angle. In addition, we used 3D-CT for more precise analysis as a useful tool.

지방 채취 방법에 따른 지방 세포의 생존성에 대한 연구

이원덕,최진영,Lee, Won-Deok,Choi, Jin-Young 대한악안면성형재건외과학회 2008 Maxillofacial Plastic Reconstructive Surgery Vol.30 No.1

Purpose: The purpose of this study is to test the efficacy of various methods of fat harvesting in animal model by viability comparison with assay including cell counting, MTT assay, and histologic evaluation. Materials and methods: New Zealand white rabbits experiments were used. Groin fat pads were subjected to different harvest method varying ingredients of solution(Experiment 1: T1 solution= lidocaine 1000mg/L, epinephrine 1mg/L, sodium bicarbonate 10mgEq/L, Triamcinolone 10mgEq/L; T2 solution=lidocaine 1000mg/L, epinephrine 1mg/L, sodium bicarbonate 0mgEq/L, Triamcinolone 0mgEq/L) and pressure exerted on harvesting with Luer-Lock syringe connected to suction cannula.(Experiment 2: P1 group=3cc intermittent pressure; P2 group=10cc sustained pressure) Fat cell viability was assessed with cell counting with a hemocytometer, MTT assay, and histologic evaluation. Results: Experiment 1 Cell count: T1=2.4/3.4/4.2, T2=9.6/8.4/7.2($\times10^5$ per mL); MTT assay: T1=0.516/0.41/0.453/0.412/0.421, T2=0.925/0.765/0.54/0.634/0.614 in 21 days(absorbance); Histology: T1 showed elongated and, different in size and shape, and ruptured adipocytes with only a few normal adipocytes whereas T2 showed central core of fat with almost intact fat cells Experiment 2 Cell count: P1=1.2/3.2/4.2, P2=1.2/2.4/3.8($\times10^5$ per mL); MTT assay:P1=0.256/0.245/0.258/0.21/0.264, P2=0.12/0.231/0.245/0.313/0.281 in 21 days(absorbance); Histology: P1 showed somewhat evenly distributed normal-looking fat cells and P2 showed relatively irregular shape of fat cells with small blood vessel amongst adiopocytes. Conclusion: Viability was higher in ‘modified tumescent solution’without sodium bicarbonate and triamcinolone and we also found no significantly different viability between using intermittent pressure and using sustained pressure. But in terms of initial viability of fat cell, we can assume that lower intermittent pressure would make better clinical results.

도쿄 대학의 대학원 중점화와 학부교육 개혁

이원덕,Lee, Won-Deok 한국대학교육협의회 1998 大學敎育 Vol.93 No.-

중국 덕주 지역의 구순구개열 의료 봉사 활동 보고 및 치험례 발표

이원덕,이부규,최진영,김종렬,오용석,민병일,김명진,Lee, Won-Deok,Lee, Bu-Kyu,Cho, Jin-Young,Kim, Jong-Ryul,Oh, Yong-Seok,Min, Byoung-Il,Kim, Myung-Jin 대한악안면성형재건외과학회 2009 Maxillofacial Plastic Reconstructive Surgery Vol.31 No.5

Il Woong Cleft lip and palate foundation was founded in 1968 by Professor emeritus Byoung-Il Min. Since then the foundation has operated numerous cleft lip and palate patients not only in Korea but also in under-developed countries such as Vietnam, China, and Cambodia. In December 2005, the foundation was allowed as an incorporated association by Ministry of Foreign affairs and Trade, so that it could have official status. From March 6th 2009 to March 14th 2009, we conductp,d charity cleft lip and palate operations of 23 patients in areas of Deozhou, China. Hereby we present the results of operations.

연구발표 초록 ( 재료 (Ⅰ) ) : 진공여과를 이용한 경사기능재료의 성형체 제작

이원덕(Won Deok Yi),암전정사(M . Iwata),중촌정추(M . Nakamura),외산무수(S . Toyama),이근배(Keun Bae Lee) 한국화학공학회 1991 추계학술발표회 Vol.- No.-

A case of childhood relapsing/remitting multiple sclerosis and interferon β-1b treatment in a Korean patient

김현석,이원덕,이준화,조경래,Kim, Hyun Seok,Lee, Won Deok,Lee, Jun Hwa,Cho, Kyung Lae The Korean Pediatric Society 2007 Clinical and Experimental Pediatrics (CEP) Vol.50 No.6

Multiple sclerosis (MS) is a demyelinating disorder that affects discrete areas of the CNS, including the optic nerves, in a quite variable relapsing-remitting fashion over a prolonged period of time. Although MS is usually considered to be a disease that affects peoples in early to middle adulthood, children do develop multiple sclerosis. The frequency of MS onset before the age of 15 years is 2.7-5% of all cases, while MS onset during infancy and early childhood was observed to be 0.2-0.7% of all cases. We report here on a Korean case of a relapsing-remitting MS female child who was treated with four rounds of intravenous methylpredinsolone pulse therapy and preventive Interferon-$\beta$-1b ($Betaferon^{(R)}$). 다발성 경화증은 중추신경계 백질의 여러 부위를 시간 간격을 두고 침범하는 만성재발성 질환이다. 주로 20세에서 40세 사이에 발병하며 15세 이하 소아에서도 3-5% 정도 발병하는 소아기에는 매우 드문 질환이다. 원인은 아직 정확히 밝혀지지 않았으나 유전적, 환경적 및 감염과 연관된 자가면역반응 등 여러요인이 복합적으로 작용하는 것으로 생각하고 있다. 임상증상은 침범된 백질 부위에 따라 다양한데 사지근력 약화나 저림, 시력장애, 감각장애, 운동실조 등 다양한 증세로 호전과 재발을 반복한다. 본 저자들은 경련, 왼쪽 편마비 등의 증상으로 6세에 첫 발병 후 메틸프레드니솔론(methylprednisolon) 치료 후 증상 완전 회복 있었으나 6개월 후 경련, 두통, 왼쪽 안와주위 통증 등으로 다시 입원하는 등 4년간 추적 관찰 중 4차례 메틸프레드니솔론 치료 실시하였으나 다른 양상의 신경학적 증상으로 재발하여 Interferon-${\beta}$-1b($Betaferon^{(R)}$, SheringAG, Germany) 예방 치료를 실시한 다발성 경화증 환자 1례를 경험 하였기에 문헌 고찰과 함께 보고하는 바이다.

BCGoma 제거 이후 발생한 패혈성 폐 색전증 1례

이해정 ( Hae Jeong Lee ),김현석 ( Hyun Seok Kim ),이원덕 ( Won Deok Lee ),김태홍 ( Tae Hong Kim ),조경래 ( Kyung Rae Cho ),정진아 ( Jin A Jung ),김자형 ( Ja Hyung Kim ),이주석 ( Ju Suk Lee ) 대한소아알레르기호흡기학회 2005 소아알레르기 및 호흡기학회지 Vol.15 No.3

지역콘텐츠 지원정책 개선을 위한 다학제적 접근 - IPA 기법을 중심으로

김세환(Kim, Se Hwan),이원덕(LEE, Won Deok) 한국전시산업융합연구원 2021 한국과학예술융합학회 Vol.39 No.3

본 연구는 콘텐츠산업 지역거점기관의 지원정책을 실증적으로 평가하기 위해서 시작되었다. 본 연구의 목적은 지역콘텐츠 지원정책에 대한 정책 수혜자의 인식을 평가하고, 이를 기반으로 정책학, 지역학, 문화콘텐츠학 등 학제 간 융합을 통해 지역콘텐츠 지원정책의 실효성을 담보하는 개선방안을 제시하는 것이다. 따라서 본 논문은 지원정책별 중요도와 만족도의 차이를 확인하고, IPA 매트릭스로 전환하여 개선방안 도출을 시도하였다. 연구 방법은 다음과 같은 순서로 기술한다. 첫째, 선행연구를 통해 지역콘텐츠 지원정책과 IPA를 활용한 정책연구의 현황과 특징을 살펴보았다. 둘째, 정책 수혜자가 인식하는 지원정책의 중요도와 만족도 차이를 분석하고, 이것을 IPA 매트릭스로 전환하여 정책별 우선순위를 확인하였다. 셋째, 본 연구에서 기술한 내용을 중심으로 지역콘텐츠 지원정책의 개선방안을 제시하고, 이에 대한 시사점을 도출하였다. 연구 결과 및 내용은 다음과 같다. 첫째, 정책 수혜자는 광고 홍보 마케팅 지원을 가장 중요하게 평가했고, 제작 전문기술 교육 지원에 가장 만족하였다. 그리고 광고 홍보 마케팅 지원이 중요도와 만족도 간 차이가 가장 큰 지원정책으로 나타났다. 둘째, IPA 매트릭스로 구분하면 중요도와 만족도가 높아 지속해야 할 정책으로 제작 전문기술 교육, 창작 개발 제작 공간과 설비 제공, 정책자금 및 융자 제공이 나타났다. 중요도는 높지만, 만족도가 낮아 향후 개선이 필요한 지원정책으로 제작 및 유통업체 연계, 광고 홍보 마케팅 지원이 나타났다. 중요도와 만족도가 낮아 대안 마련과 개편이 필요한 정책으로 조세 혜택, 엔젤 및 벤처캐피털 투자연계, 기업 및 기관 간 네트워크 구축지원이 나타났다. 중요도는 낮지만, 만족도가 높아 과잉지원이 이뤄지는 정책으로 경영지원 교육, 경영 컨설팅 및 멘토링, 사무 기자재 제공이 나타났다. 이러한 연구 결과를 바탕으로 지역콘텐츠 지원정책은 기반 구축과 꾸준한 제작이 가능하도록 지속가능성에 초점을 맞춰야 하고, 제작과 유통을 포함하는 융합형 정책이 필요하며, 지역콘텐츠산업의 영세성을 고려하여 직접지원과 간접지원 방식의 균형을 유지하는 방식으로 개선되어야 할 것으로 기대한다. This study was started to empirically analyze the local content promotion agency’s policies. The purpose of this study was to examine beneficiaries’ perception of policies and on this, suggest improvement measures to ensure the effectiveness. Therefore, this study identified the differences in importance and satisfaction for policies, and derived the improvement measures from IPA matrix. The research method is as follows. First, the characteristics of local content promotion agency’s policies and related previous studies using IPA were examined. The differences in the importance and satisfaction of policies perceived by beneficiaries were analyzed, and this was converted into an IPA matrix to identify the priority of each policy. Third, the improvement measures for local content promotion agency’s policies were suggested based on the results. Results were followed. First, the beneficiaries rated supporting advertisement·PR·marketing as the most important, whereas they were most satisfied with the support for production technical training. And supporting advertisement·PR·marketing appeared as the policy with the largest difference between importance and satisfaction. Second, the policies with high importance and satisfaction were found to be production specialized technology education, creation·development·production space and equipment provision, and public funds and loans. The policies with high importance and low satisfaction included linkage with production and distribution companies, supporting advertisement·PR·marketing. Tax benefits, investment connection, and establishing networks between companies and institutions were found as policies with low importance and satisfaction. Management education, consulting and mentoring, and provision of office equipment were found as policies with low importance and high satisfaction. Based on the results, it is needed that the local content promotion agency’s policies focus on sustainability to establish production-infrastructure, convergent methods including production and distribution, and balance between direct and indirect supporting to the beneficiaries.

DMBA 유도 햄스터 협낭 발암모델에서 세포증식 및 사멸과 p63 발현의 관계 분석

박지현(Jee-Hyun Park),이원덕(Won-Deok Lee),민철기(Chul-Gi Min),강진한(Jin-Han Kang),명훈(Hoon Myung),이종호(Jong-Ho Lee),김명진(Myung-Jin Kim) 대한구강악안면외과학회 2005 대한구강악안면외과학회지 Vol.31 No.3

Purpose: Abnormalities in the p53 gene are regarded as the most consistent genetic abnormalities detected in head and neck squamous cell carcinogenesis. Two new members of the p53 gene family, p73 and p63 have recently been identified. They share considerable sequence homology with p53 in the transactivation, DNA binding, and oligomerization domains, indicating possible involvement in carcinogenesis. Disruption of the homeostatic balance between proliferation and apoptosis is widely believed to contribute to human oral carcinogenesis. The aim of this study was to analyze expression of p63 in squamous cell carcinogenesis and to compare with immunochemical markers representing cell proliferation and apoptosis. Materials and Methods: Using the Syrian hamster oral cancer model, the fraction of apoptotic (apoptotic index-AI), proliferating (mitotic index-MI) and p63 expressing keratinocytes were examined at normal, dysplastic and malignant oral epithelium using the TUNEL assay, PCNA and p63 immunostaining. Results: p63 significantly increased between normal and dysplastic epithelium and between dysplastic and malignant epithelium. PCNA significantly increased between normal and dysplastic epithelium and between normal and malignant epithelium. However, increase between dysplastic and malignant epithelium, though still increasing, was not statistically significant. The percentage of TUNEL positive cells increased from normal to dysplastic epithelium and returned to normal keratinocyte level in the malignant epithelium. However, differences between tissue types were not significant. The ratio of MI:AI increased significantly only in the dysplastic-malignant epithelial transition. The increase of p63 expression closely reflected the change in the MI:AI ratio during oral carcinogenesis. Conclusion: The p63 may be associated with the regulation of epithelial proliferation and apoptosis in DMBA-induced hamster buccal pouch squamous cell carcinogenesis. Further study is required to investigate which p63 isoforms are involved in hamster buccal pouch carcinogenesis.

Cytokeratin의 RT-PCR 및 면역조직화학적 분석을 이용한 구강편평세포암종의 임파절 미세전이 진단과 예후인자 효용성 평가

박성진(Sung-Jin Park),이원덕(Won-Deok Lee),임구영(Ku-Young Lim),강진한(Jin-Han Kang),명훈(Hoon Myung),이종호(Jong-Ho Lee),김명진(Myung-Jin Kim) 대한구강악안면외과학회 2005 대한구강악안면외과학회지 Vol.31 No.2

Purpose: The lymph node status assessed by conventional histological examination is the most important prognostic factor in patients undergoing surgery for oral squamous cell carcinoma. The presence of lymph node metastasis has a strong adverse impact on patient survival even after extended radical resection. Despite these findings, tumour recurrence is not rare after surgery, even when histological examination shows no lymph node metastasis. Recently, molecular- genetically and immunohistochemically demonstrated micrometastasis to the lymph nodes has been shown to have a significant adverse influence on survival in patients with squamous cell carcinoma and histologically negative nodes. The present study sought to determine the incidence and clarify the clinical significance of molecular-genetically and immunohistochemically demonstrated nodal micrometastases and to correlate these data with the stage of oral cancer. Methods: Lymph nodes systematically removed from 71 patients who underwent curative resection between 1998 and 2003 with head and neck squamous cell carcinoma were examined molecular-genetically to detect cytokeratin 5 mRNA with RT-PCR and immunohistochemically to detect cells that stained positively for cytokeratins with the monoclonal antibody cocktail AE1/AE3. The postoperative course and survival rates were compared among patients with and without micrometastases, after numerical classification of overt metastatic nodes. Results: micrometastases were detected in 43(60%) of 71 patients by RT-PCR and 26(36%) of 71 patients by immunohistochemistry. By RT-PCR analysis, patients exhibiting a positive band for CK 5 mRNA had a significantly worse prognosis than those were RT-PCR negative. By immunohistochemistry, the presence of micrometastasis did not predict patient outcome. Conclusion: Micrometastases detected by RT-PCR may be of clinical value in identifying patients who may be at high risk for recurrence and who are therefore likely to benefit from systemic adjuvant therapy.