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$H_{2}O_2$와 A$\beta$로 유도된 pc12 cell에서 생산조인(生酸棗仁) 수추출물의 항산화 및 항치매 효과
이상원,김대현,윤종현,김진우,정은영,이성근,이기상,김태헌,류영수,강형원,Lee, Sang-Won,Kim, Dae-Hyun,Yun, Jong-Hyun,Kim, Jin-Woo,Jung, Ejun-Young,Lee, Seoung-Geun,Lee, Key-Sang,Kim, Tae-Heon,Lyu, Yeoung-Su,Kang, Hyung-Won 대한한방신경정신과학회 2008 동의신경정신과학회지 Vol.19 No.3
Objective: The antioxidant and anti-Alzheimer effects of Semen Ziziphi Spinosae (SZS) water extract against the amyloid beta peptide (1-42) or H202-induced oxidative damage and cell death were investigated in rat pheochromocytoma line PC 12. Methods: The cells were incubated with SZS water extract and oxidative damage-inducing materials, amyloid beta peptide (1-42) or H2O2 for 24 h. The cellular viability was assessed by WST-1 assay, cytotoxic damage by LDH activity assay, oxidative damages of cells by fluorescence spectrophotometric method, and apoptosis by TUNEL staining assay. Results and Conclusions: 1. Preincubation of the cells with SZS water extract prior to amyloid beta peptide (1-42) (2 uM) or H2O2 (30 uM) exposure elevated the cell survival close to the control and decreased the level of LDH activity and the fluorescence from the cell homogenates and TUNEL staining of the cells, compared to only amyloid beta peptide (1-42) (2 uM) or H2O2 (30 uM) treated conditions. 2. Our study suggests that Semen Ziziphi Spinosae (SZS) water extract has protective effects against amyloid beta peptide (1-42) or H2O2-induced cell toxicity through the antioxidation mechanism, which might be beneficial for the treatment of Alzheimer's disease.
레버 증폭 구조의 플렉서를 이용한 공초점 현미경의 개발
이상원,김위한,정영대,박민규,김지현,이상인,이호,Lee, Sang-Won,Kim, Wi-Han,Jung, Young-Dae,Park, Min-Kyu,Kim, Jee-Hyun,Lee, Sang-In,Lee, Ho 한국광학회 2011 한국광학회지 Vol.22 No.1
본 연구에서는 레버 증폭 구조를 이용한 플렉서 기반의 나노 스테이지를 설계, 제작하였다. 제작된 나노 스테이지를 샘플 스테이지로 채용한 공초점현미경을 개발하였다. 2차원 이미징의 구현을 위해서, 기존의 공초점현미경은 레이저를 이미징 평면상에 스캐닝하는 방식으로 구현된다. 본 연구에서는 백 나노미터의 구동정밀도를 가지는 나노 스테이지 위에 놓인 샘플을 2차원으로 스캐닝하면서 2차원 이미지를 구현할 수 있는 공초점현미경을 개발하였다. 플렉서 기반의 나노 스테이지는 이중 판스프링, 변위증폭 레버, PZT 엑추에이터 그리고 변위 센서로 구성 되어 있다. 스테이지의 구동 성능 해석을 위해 상용 유한요소 해석 프로그램을 이용하였다. 현미경에 사용되는 광원은 적색광 레이저이며, 레이저는 여러 광학요소를 거쳐 샘플스테이지의 샘플에 입사되고, 반사된 빛은 광센서인 PMT(Photo Multiplying Tube)로 계측되게 된다. 계측된 빛의 크기를 이용하여서 2차원 이미징을 구현하였다. 개발된 공초점 현미경으로 생쥐 귀의 피부조직을 관찰하여 현미경의 이미징 성능을 검증하였다. 설계된 샘플 스테이지는 기존의 공초점 현미경의 기계적인 Beam 스캐너를 대신함으로써 현미경의 광경로 및 전체시스템을 간소화 하였다. A confocal microscope was developed utilizing a scanning sample stage based on a home-built double-compound flexure guide. A scanning sample stage with nano-scale resolution consisted of a double leaf spring based flexure, a displacement amplifying lever, a Piezo-electric Transducer(PZT) actuator and capacitance sensors. The performance of the two-axis stage was analyzed using a commercial finite element method program prior to the implementation. A single line laser was employed as the light source along with the Photo Multiplier Tube(PMT) that served as the detector. The performance of the developed confocal microscope was evaluated with a mouse ear skin imaging test. The designed scanning stage enabled us to build the confocal microscope without the two optical scanning mirror modules that are essential in the conventional laser scanning confocal microscope. The elimination of the scanning mirror modules makes the optical design of the confocal microscope simpler and more compact than the conventional system.
미국도시경찰(美國都市警察)의 법죄예방활동(犯罪預防活動)에 관한 연구(硏究) - NYPD를 중심(中心)으로 -
이상원,Lee, Sang-Won 한국경호경비학회 1999 시큐리티연구 Vol.- No.2
The Police is the provider of the Police Service that is the most evident and active. This paper centers on the crime prevention activity of New york City Police Department that is most large and representable in America on account of the enormity of the scale and the material selection. I examine the duty and organization of the City Police Department the Crime Prevention activity of the city police and I research a conclusion.
A Development of a Software Tool for Automatic SCF Design
이상원,김용섭,김성원,강욱,김수원,김덕진,Lee, Sang-Won,Kim, Yong-Seop,Kim, Seong-Won,Kang, Wook,Kim, Soo-Won,Kim, Duck-Jin The Institute of Electronics and Information Engin 1990 전자공학회논문지 Vol.27 No.4
A software tool implementing cascaded SCF (Switched Capacitor Filter) is developed. A comprehensive procedure is described for the design of cascaded SCF, and some design considerations are discussed. In program several user-selectable filter approximation techniques, and two optimising methods which reduce the total capacitance are included. Analysis of the partial positive feedback and the effect of clock frequency to total capacitance are presented in detail. Two pratical examples are given to prove its validity in reducing the total capacitance. Developed tool can be used for general SCF generator.
서울 경찰(警察)의 방범체제(防犯體制) 개선(改善)에 관한 연구(硏究)
이상원,Lee, Sang-Won 한국경호경비학회 1997 시큐리티연구 Vol.- No.1
I study the actual condition and the problem of the crime prevention system of two seoul police station. that is operated on the unit of police box, and present the new improvement. Stragic and active is the new crime prevention system that introduces a concept of community oriented policing, the tendency of a developed country police. I present a medium - sized police station where 250${\sim}$300 policemen work. It consist of a patrol division, a community division and a administration support division. The chief of police bears the responsibility only for crime prevention service by concentrating on pure Patrol - centered crime prevention activity and community relation activity. Next I present a police inspector system. The most important on this paper is the community policing officer system that a policeman bears responsibility on district apart from a patrol division and support a police service related community. To be operated these systems effectively, these need to be regulated according to a police distinct, a police purpose and it's demand. Also a scale, function, authority of a existing. Police station must be regulated and the police training must be carried out.
전두골에 발생한 콜레스테롤 육아종 1례 - 증례보고 -
이상원,차승헌,박동준,송근성,최창화,이영우,Lee, Sang Weon,Cha, Seung Heon,Park, Dong June,Song, Geun Sung,Choi, Chang Hwa,Lee, Young Woo 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.6
Cholesterol granuloma of frontal bone is a rare disease which usually occurs at the lateral part of the supraorbital ridge. This expanding lesion grows slowly and extends into the orbit and anterior cranial fossa. The most common symptom is proptosis. This granuloma is composed of a granulomatous reaction surrounding cholesterol crystals. Surgical treatment involves aspiration of contents and stripping or curettage of the lining which is highly successful. We experienced a case of cholesterol granuloma of frontal bone with huge intracranial extension, which was cured by surgical removal. The clinical features, radiologic, and pathologic finding were discussed and the pertinent literatures were reviewed.
잡음환경에서 음성-영상 정보의 통합 처리를 사용한 숫자음 인식에 관한 연구
이상원,박인정,Lee, Sang-Won,Park, In-Jung 대한전자공학회 2001 電子工學會論文誌-CI (Computer and Information) Vol.38 No.3
본 논문에서는 한국어 숫자음 인식을 위해 음성과 영상 정보를 사용하고, 음성에 사용하는 선형예측계수 알고리즘을 영상에 적용하는 방법을 제안한다. 입력으로 얻어지는 음성신호는 0.95의 매개변수를 통해 고역 신호가 강조되고, 해밍창과 자기상관 분석, Levinson-Durbin 알고리즘에 의해 13차 선형예측계수를 구한다. 마찬가지로, 그레이 영상신호도, 음성의 자기상관 분석, Levinson-Durbin 알고리즘을 사용하여 13차의 2차원 선형예측계수를 구한다, 이러한 음성/영상 신호에 대한 선형예측계수들은 다층 신경회로망에 적용하여 학습이 이루어졌고, 각 레벨의 잡음이 섞인 음성신호를 적용한 결과, 숫자음 '3', '5', '9' 에서 음성만으로 인식한 결과보다 훨씬 좋은 인식결과를 얻을 수 있었다. 결과적으로, 본 연구에서는 영상 신호의 2차원 선형 예측 계수들이 음성인식에 사용될 경우, 특징 추출에 따른 부가적인 알고리즘이 새로 고안될 필요가 없이, 음성특징 계수를 추출하는 방법을 그대로 사용할 수 있으며, 또한 데이터량과 인식율이 잡음 환경에서 보다 향상되는 효율적인 방법을 제시하고 있음을 알 수 있었다. In this paper, a method that apply LP algorithm to image for speech recognition is suggested, using both speech and image information for recogniton of korean numeral speech. The input speech signal is pre-emphasized with parameter value 0.95, analyzed for B th LP coefficients using Hamming window, autocorrelation and Levinson-Durbin algorithm. Also, a gray image signal is analyzed for 2-dimensional LP coefficients using autocorrelation and Levinson-Durbin algorithm like speech. These parameters are used for input parameters of neural network using back-propagation algorithm. The recognition experiment was carried out at each noise level, three numeral speechs, '3','5', and '9' were enhanced. Thus, in case of recognizing speech with 2-dimensional LP parameters, it results in a high recognition rate, a low parameter size, and a simple algorithm with no additional feature extraction algorithm.