파골세포의 분화와 뼈 흡수에 천남성의 억제 효과

이명수(Myeung Su Lee),이창훈(Chang Hoon Lee),박기인(Kie-In Park),김하영(Ha Young Kim) 한의병리학회 2011 동의생리병리학회지 Vol.25 No.1

파골세포 분화에 목향 물 추출물의 효과

이명수(Myeung Su Lee),김정중(Jeong Joong Kim),오재민(Jae Min Oh),최민규(Min Kyu Choi),송미진(Mi Jin Song),안용환(Yong Hwan Ahn),이정휴(Jeong Hugh Lee),전병훈(Byung Hoon Jeon),박기인(Kie-In Park),장성조(Sung Jo Jang) 한의병리학회 2011 동의생리병리학회지 Vol.25 No.3

저용량 Erythropoietin 을 투여받고 있는 혈액 투석환자에서 빈혈과 영양지표에 대한 안드로겐 병용투여의 효과

이명수(Myeung Su Lee),안선호(Seon Ho Ahn),송주흥(Ju Hung Song) 대한내과학회 2001 대한내과학회지 Vol.61 No.6

N/A Background: Recombinant human erythropoietin (rHuEPO) has become attractive option of anemia therapy in chronic hemodialysis patients, but the use of rHuEPO is primarily limited by its high cost. So, the current cost-containment policy renders valuable any strategies that enhances the erythropoietic response to rHuEPO, thus resulting in lower rHuEPO dosing. Before the widespread availability of rHuEPO, androgen was the mainstay of nontransfusional therapy for the anemia of end-stage renal failure. However, previous studies that used androgen to enhance the response to rHuEPO showed variable results. Methods: We carried out a prospective study to examine the effect of adjuvant androgen on anemia and nutritional parameters in chronic hemodialysis patients using low-dose rHuEPO. Studies were performed in seventeen hemodialysis patients previously treated with low-dose rHuEPO (1,000 U rHuEPO subcutaneously three times a week), mean hemoglobin < 9.0 g/dL for 6 months (group A: before adjuvant androgen therapy). Same patients received the same dose of rHuEPO plus nandrolone decanoate 100 mg intramuscularly weekly for 6 months (group B: after adjuvant androgen therapy). Results: Transferrin saturation, serum ferritin, intact serum parathyroid hormone, plasma aluminium, ALT, ESR, albumin, PCRn and Kt/V were not significantly changed before and after adjuvant androgen therapy. The increase in hemoglobin and hematocrit in the group B was statistically greater than in the group A, respectively (8.99±1.39 g/dL vs 7.75±0.90 g/dL; p=0.001, 26.66±3.91% vs 23.68±2.85%; p= 0.003, respectively). With the exception of mild discomfort at the injected site, there were no significant side effects from nandrolone decanoate. Conclusion: Adjuvant androgen in patients treated with low-dose rHuEPO is effective treatment for the anemia of poor responsive patients to low-dose rHuEPO and lower the economical cost compared with the higher dose rHuEPO treatment alone.(Korean J Med 61:641-649, 2001)

섬유근통증후군 환자의 질병관련 특성과 일상생활장애의 상관관계

이명수(Myeung-Su Lee),황은희(Eun-Hee Hwang) 한국콘텐츠학회 2011 한국콘텐츠학회논문지 Vol.11 No.7

본 연구는 섬유근통증후군 환자의 질병관련 특성과 일상생활 장애의 정도를 파악하고, 그 상관관계를 확인하기 위하여 시도되었다. 대상자는 I시에 소재한 1개 대학병원 류마티스 내과 외래 방문 환자 중 섬유근통증후군 진단을 받은 45명으로, 구조화된 설문지를 이용하여 자료를 수집하였다. 대상자의 압통점은 평균 15.00, 피로는 8.67, 수면의 질은 12.94, 우울은 23.70점이었고, 이들은 평균 대략 6년간의 유병기간을 가지고 있었다. 42.2%의 대상자들이 질병으로 인해 직업이나 학업을 중단하였으며, 지난 3개월동안 평균 41.79일 일상생활 장애를 경험하였다. 일상생활 장애 정도는 압통점, 우울과 양의 상관관계가 있었고, 피로와 우울, 수면의 질과 양의 상관관계가, 수면의 질은 우울과 양의 상관관계가 있었다. 결론적으로 섬유근통 증후군 환자들은 질병과 관련한 다양한 증상을 동반하며, 이로 인한 일상생활 장애를 경험하고 있었다. 따라서 이들이 일상생활을 유지하면서 보다 나은 삶을 유지할 수 있도록 관련 요인을 반영한 중재프로그램을 개발할 필요가 있다. The purpose of this study was to identify the correlations between disease related factors and disturbance of daily living in patients with fibromyalgia. A descriptive survey study design was used. Data were collected from 45 out patients diagnosed of fibromyalgia according to the conditions by American College of Rheumatology in I-city. The mean score of tender points were 15.00, fatigue was 8.67, quality of sleep was 12.94 and depression was 23.70. They have struggled with fibromyalgia for 6 years on an average. Among patients, 42.2% had to discontinue their job/learning due to their disease, and experienced a disturbance of daily living for 41.79 days during last 3 months. There were significant positive correlations between disturbance of daily living and tender points, depression, between fatigue and depression, quality of sleep, between quality of sleep and depression. As a result, fibromyalgia patients suffered from various disease related factors and disturbance of daily living. Therefore, it can be suggested that the consideration of these related factors is important to develope intervention program for the better qualified life of the patients.

βig-h3 절편-RGD 재조합단백의 만성염증성 관절염 치료효과

이명수 ( Myeung Su Lee ) 대한류마티스학회 2012 대한류마티스학회지 Vol.19 No.3

류마티스 관절염 환자의 혈중 아연 및 구리 농도와 질병 활성도와의 관계

이명수 ( Myeung Su Lee ),강효종 ( Hyo Jong Kang ),홍승재 ( Seung Jae Hong ),도주호 ( Ju Ho Do ),윤종현 ( Chong Hyeon Yoon ),김완욱 ( Wan Uk Kim ),민도준 ( Do June Min ),윤지희 ( Jee Hee Youn ),박성환 ( Sung Hwan Park ),조철수 ( Ch 대한류마티스학회 2003 대한류마티스학회지 Vol.10 No.4

Objective: To investigate the relationship between serum trace element levels with disease activity in Korean patients with rheumatoid arthritis (RA). Methods: The serum levels of zinc, copper and ceruloplasmin were measured by inductively coupled plasma atomic emission spectrometers in 80 patients with RA, 26 osteoarthritis (OA), and 30 healthy controls (HC). We also measured the levels of zinc and copper in the synovial fluid (SF) of patients with RA. We investigated the clinical parameters simultaneously obtained at sampling of serum and analyzed correlation between serum levels of trace elements and disease activity in RA. Results: In RA, the levels of serum zinc were significantly lower than that of HC, and the levels of serum copper and ceruloplasmin were significantly higher than those of HC. In active RA, the levels of serum zinc were more decreased, and the levels of serum copper and ceruloplasmin were more increased than those of inactive group of RA. The levels of both copper and ceruloplasmin showed positive correlation with the levels of serum ESR and CRP. On the other hand, the levels of serum zinc showed negative correlation with the levels of serum ESR and CRP. Conclusion: Serum zinc levels are significantly lower and serum copper levels significantly higher in patients with active RA and these trace elements were useful parameter of disease activity in RA.

Klebsiella Pneumonia-Necrotizing Fasciitis followed by Liver Abscess

Seung Hyun Lee(이승현),Jeong Woo Choi(최정우),Myeung Su Lee(이명수) 한국산학기술학회 2018 한국산학기술학회논문지 Vol.19 No.6

본 저자들은 괴사성 근막염 환자에서 간농양이 발생한 사례가 있어 보고하고자 한다. 5일 동안 지속되는 우측 대퇴부의 통증을 동반한 부종, 발열, 오한을 주소로 51세 남자 환자가 본원에 내원하였다. 내원 당시 시행한 MRI 검사 상 우측대퇴부의 후내측과 후외측 부분에 공기 방울로 보이는 다량의 어두운 음영과 액체 군집이 있어 괴사성 근막염으로 추정 진단하였다. 입원 당시 시행한 복부 초음파 검사 상 양측 신장의 실질 에코는 증가하였지만 간 내 농양은 보이지 않았다. 근막절개 10일 후에 시행한 복부 컴퓨터 단층촬영 검사 상 간 내 농양이 보여, 초음파 검사를 통한 경피적 배액술을 시행하였다. 우측 대퇴부와 간농양에서 배약된 농 검체 모두 폐렴 간균이 배양되었다. 환자는 몇 차례 근막 절개술을 시행 받았고 비경구항생제로 치료한 결과 점차 호전이 되기 시작했다. 치료 시작 5주 후 간농양의 크기는 감소하였고, 10주 후 간농양은 사라졌다. 우리가 아는 한 폐렴 간균 괴사성 근막염에서 간농양이 발생한 첫 사례이기에 보고하는 바이다. We report a case of a patient with necrotizing fasciitis followed by liver abscess. A 51-year-old man was admitted to our hospital with a 5-day history of fever and chills with painful swelling of the right thigh. A magnetic resonance imaging (MRI) scan showed fluid collection with numerous dark signal intensities considered as air-bubbles between the posteromedial and posterolateral groups of the right thigh, resulting in presumptive diagnosis of necrotizing fasciitis. At the time of admission, an ultrasonograph of the abdomen showed increased parenchymal echogenicity of both kidneys and no liver abscess. Ten days after fasciotomy, an abdominal computed tomography (CT) scan showed intrahepatic abscess. Sonography-guided percutaneous drainage was performed. Both cultures of pus specimens from the liver abscess and right thigh yielded Klebsiella pneumoniae (K. pneumoniae). The patient was treated with fasciotomy several times and parenteral antibiotics, after which he began to improve. After 5 weeks, liver abscess size was reduced, and after 10 weeks, liver abscess disappeared. To the best of our knowledge, this is the first case of K. pneumoniae-necrotizing fasciitis followed by liver abscess.

이중에너지컴퓨터단층촬영을 이용한 통풍의 진단

이창훈 ( Chang Hoon Lee ),이명수 ( Myeung Su Lee ),안선호 ( Sun Ho Ahn ),이유민 ( Yu Min Lee ),김현정 ( Hyeon Jeong Kim ),송주흥 ( Ju Hung Song ),정선관 ( Seon Kwan Juhng ) 대한류마티스학회 2011 대한류마티스학회지 Vol.18 No.2

Gout is the most common crystal-associated arthropathy. Gout is caused by deposition of monosodium urate crystals within the joints, and it is often associated with hyperuricemia. Acute gout involves the first metatarsophalangeal joint (podagra) in approximately 50% of cases and its peak incidence occurs in middle age. Although the clinical features can help with making the diagnosis of gout, many inflammatory diseases such as cellulitis, pseudogout and septic arthritis can mimic or coexist with it. The definitive diagnosis requires polarized light microscopy of the fluid aspirated from the involved joint and this shows needle-shaped, negative birefringent monosodium urate crystals. However, joint aspiration can be technically difficult, and none of the conventional imaging modalities for gout specifically identifies the chemical composition of uric acid. The advent of Dual-Energy CT (DECT) is a noninvasive method that has the potential to confirm gout and monitor the response to treatment. DECT scan can show monosodium urate deposition by using color coding. The authors performed DECT scans for detecting uric acid deposition and confirming the gout noninvasively.

섬유근통에 대한 국내 임상 연구 동향 및 중재 방향

이정한(Jung-Han Lee),금지혜(Ji-Hye Geum),우현준(Hyeon-Jun Woo),이창훈(Chang-Hoon Lee),정종혁(Chong-Hyuk Chung),이명수(Myeung-Su Lee) 척추신경추나의학회 2020 척추신경추나의학회지 Vol.15 No.2

Objectives The purpose of this review was to analyze the trend of clinical research related to fibromyalgia and to suggest the direction of intervention Methods We reviewed the clinical research by searching seven Korean web databases and classified the studies by the year of publication, academic field, and study design. Results A total of 75 clinical studies were selected. Except for 2002, more than one study was annually published; however, the number was below 10. In the academic field, there were 34 in the medical field, 21 in the Korean medicine field, and 15 in the nursing science field. By study design, there were 62 observational studies, mostly case reports and case-control studies. There were 13 experimental studies, including non-random control studies and one group pre and post-test design studies. Conclusions Fibromyalgia-related clinical research requires a greater number of studies, and a study design with a high level of evidence should be conducted along with various observational and intervention studies. Additionally, multidisciplinary and integrated intervention plans and research are needed.

베체트 증후군 환자에서 Dapsone에 의해 발생한 중증의 DRESS 증후군

이창훈 ( Chang Hoon Lee ),장성조 ( Sung Jo Jang ),오성렬 ( Seong Rheol Oh ),김현정 ( Hyun Jung Kim ),이명수 ( Myeung Su Lee ) 대한류마티스학회 2009 대한류마티스학회지 Vol.16 No.3

Dapsone has been used for several dermatological conditions such as immunobullous disease and ulticarial vasculitis. Dapsone is very useful drug for treating the mucocutaneous manifestations of Behcet`s disease. The widely recognized side effects of dapsone are headache, methemoglobinemia and hemolysis. The severer, but rarer side effect of dapsone is known as dapsone hypersensitivity syndrome, which consists of exfoliative dermatitis, hepatitis, lymphadenopathy and hemolytic anemia. When this is associated with eosinophilia, we can diagnose and treat this drug reaction with eosinophilia and systemic symptoms (DRESS). DRESS is a syndrome of fever, rash, and internal organ involvement that`s secondary to administering the offending medication. We describe here a 47-year-old woman who was hospitalized with fever, skin rash, hemolytic anemia, lymphadenopathy, eosinophilia, pleural effusion and life threatening hepatitis, which could lead to hepatic failure, within three weeks of starting of dapsone therapy for controlling her oral and genital ulcers. We diagnosed the woman as suffering with DRESS syndrome and we started treatment with corticosteroid. Three weeks after starting therapy, her symptoms almost completely resolved and she was discharged.