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정신분열병 환자에서 리스페리돈 투여 전후의 비용-효과에 대한 비교 연구
이명룡,이상일,김창윤,박종익 대한정신약물학회 2005 대한정신약물학회지 Vol.16 No.5
This study was intended to compare cost-effectiveness between before and after risperidone in schizophrenic patients. Twenty-four patients who have been prescribed traditional antipsychotics, and elapsed at least one year after changing into risperidone, were singled out retrospectively and evaluated in terms of treatment effects and quality of life by Brief Psychiatric Rating Scale(BPRS) and Quality of Life Scale(QLS), respectively. And we also reviewed hospitalization days, number of hospitalization, and number of visit to outpatient clinic while they took traditional antipsychotics and risperidone during one year, respectively. As for patients prescribed risperidone, there was a significantly decreasing trend in BPRS by 13.46 on the average, as QLS increased significantly by 18.96, compared to before risperidone medication. In addition, hospitalization days and number of hospitalization decreased by 18.96 days and 0.63 times per capita, respectively after risperidone treatment (p<0.05, p<0.05). The direct costs were estimated about 102,000,000 won for traditional antipsychotics and 100,000,000 won for risperidone during 1 year, showing no significant difference between two groups. The proportion in inpatient units out of total cost occupied 77.2% for traditional antipsychotics in comparison to 33.7% for risperidone. In conclusion, risperidone may have better treatment effects and favorable cost-benefit effect than traditional antipsychotics despite of several limitation.
Q 파 심근경색과 비 - Q 파 심근경색의 임상경과 및 관동맥조영술 소견의 비교
정기영(Ki Young Chung),홍석근(Suk Keun Hong),이명룡(Myung Yong Lee),조주희(Joo Hee Zo),김준수(June Soo Kim),김치정(Chee Jeong Kim),조명찬(Myeong Chan Cho),박영배(Young Bae Park),이명묵(Myoung Mook Lee),최윤식(Yun Shik Choi),서정돈(Ju 대한내과학회 1991 대한내과학회지 Vol.40 No.1
N/A Despite of having smaller infarct size and better left ventricular function, patients with non-Q wave myocardial infarction has been reported to have an high late cardiac event rate, and long term prognosis is ultimately comparable to that of patients with Q wave myocardial infarction. This is because there is more viable tissue in the perfusion zone of infarct-related artery rendering myocardium more prone to reinfarction. To compare the prognosis and clinical characteristics of Q wave myocardial infarction with those of non-Q wave myocardial infarction, 390 patients with acute myocardial infarction were reviewed and analyzed retrospectively. Patients were classified according to electrographic results into Q wave infarction (n=336) and non-Q wave infarction (n=54). Predischarge coronary angiography, gated blood pool scan, end treadmill exercise test were performed. There was no significant difference in sex, age, angina history, previous myocardial infarction, location of infarction, and severity of coronary disease; Q wave myocardial infarction did have higher peak CK (1733.9±1432.6 vs. 511.1±588.8 IU; P<0.01) and CK-MB fraction level (334.2±371.5 vs. 78.7±128.5; P<0.01). Predischarge treadmill exercise test showed no significant difference in the exercise duration, ST segment change, and chest pain. In gated blood pool scan, ejection fraction of left ventricle did not show significant difference, but proportion of normal left ventricular wall motion was significantly higher in non-Q wave infarction. (21/257 vs. 19/42; P<0.01). The extent of coronary artery disease and degree of coronary artery stenosis was not different between two groups, but high degree obstruction (>90%) of infarct related artery was more frequent in Q wave myocardial infarction (134/187 vs. 19/35; P<0.05). During follow-up, in-hospital mortality was significantly higher in Q wave myocardial infarction (13% vs. 2%, p<0.01). But postdischarge mortality and the rate of reinfarction did not different between two groups. Further prospective studies should be performed to clarify the clinical behaviors and long-term prognosis in patients with non-Q wave myocardial infarction.