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피록시캄의 피부투과 및 소염효력에 대한 알코올성 하이드로겔 시스템의 영향
기민효(Min Hyo Ki),신희종(Hee Jong Shin),이강우(Kang Woo Lee),김재욱(Jae Wook Kim),김정우(Jung Woo Kim),홍청일(Chung Il Hong) 한국약제학회 1999 Journal of Pharmaceutical Investigation Vol.29 No.3
These studies were designed to determine the effect of hydroalcoholic gel system (lower alkanol concentration : 40-60%) compared to general hydrogel system (lower alkanol concentration : 10-35%) on transdermal delivery of piroxicam and its anti-inflammatory activity. Piroxicam was incorporated into a hydroalcoholic gel and a hydrogel containing polymers, solvents, and cosolvents. The pH of gel was about 6.3-7.3 and the solvent mixtures were composed of water and various concentrations of ethanol (35, 40, 50, and 60%). For the in vitro study, the skin permeation of piroxicam from the gel formulations was investigated using Franz modified diffusion cells fitted with hairless mouse skin. For the in vivo study, the anti-inflammatory activity of hydroalcoholic gel was compared to other commercial products (piroxicam hydrogel and ketoprofen hydrogel) in rat and human. The anti-inflammatory activity was determined using carrageenan-induced foot edema model in rat. For the clinical study, it was evaluated from determining efficacy and acceptability with 98 patients suffering from musculoskeletal pain. A novel piroxicam hydroalcoholic gel was successfully formulated in the range of 40-50% of ethanol as solvent, more than 10% of propylene glycol, 5% of Transcutol^ⓡ and 1% of benzyl alcohol. The skin permeation of piroxicam using hydroalcoholic gel system was greater than that of general hydrogel system (flux : 139.1-148.2 ㎍/㎠/hr vs. 43.0-84.5 ㎍/㎠/hr) in vitro. In carrageenan-induced edema model, the anti-inflammatory activity of hydroalcoholic gel was better than that of piroxicam hydrogel for edema inhibition (75.1% vs. 62.9%, p<0.01). In clinical study, each visual analogue of pain scale (improvement point: 15.57 point vs. 3.61 point, p<0.05) and global acceptability assessment (satisfied patients: 76.2% vs. 47.7%, p<0.05) of new hydroalcoholic gel was significantly increased compared to ketoprofen hydrogel. The inclusion of piroxicam to the hydroalcoholic gel system was found to improve significantly the skin permeation in vitro and the anti-inflammatory activity in vivo.
이해방 ( Hai Bang Lee ),정제교 ( Je Kyo Jeong ),손세일 ( Se Il Sohn ),변영로 ( Young Ro Byun ),기민효 ( Min Hyo Ki ),서중기 ( Jung Ki Seo ) 한국조직공학과 재생의학회 2009 조직공학과 재생의학 Vol.6 No.4
Drug delivery system(DDS) has been extensively applied the various areas as (1) novel methods for drug administration through several route, (2) development of novel polymeric carrier, and (3) tissue engineering and regenerative medicine. The aim of this review is to report the recent progress of "Development of controlled drug delivery system" supported by Korean Intellectual and Economy(KOIE) for 2004~2009. This project is composed by 5 subproject as (1) development of novel osmotic pump, (2) development of liposome delivery system, (3) development of DDS by bile acid transporter, (4) protein drug delivery system using thermo-sensitive hydrogel, and (5) development of novel transdermal drug delivery system. DDS system might be the core and platform technology for the application of diagnosis, bioinstrument, tissue engineering, regenerative medicine and pharmaceutical industries.
박기민(Ki Min Park),강형길(Hyung Kil Kang),김이수(Lee Su Kim),이봉화(Bong Hwa Lee) 대한두경부종양학회 1997 대한두경부 종양학회지 Vol.13 No.2
Background: Thyroid cancer is a relatively rare neoplasm and its incidence varies geographically and ethnically around the world. Thyroid cancer is the most common endocrine malignancy, but it has a wide spectrum of biologic behavior, histologic appearance, and management. Purpose: The purpose of the study was to analyse and evaluate all aspects of the clinical consideration in thyroid cancer. Method: Between 1986 and 1995, a retrospective analysis of 77 thyrod cancer patients admitted at the Department of Surgery, Hangang Sacred Heart Hospital, Hallym University was made to assess clinical entities. Result: By the pathological classification, the papillary carcinoma was the most common type(83.1%). Male to female ratio was 1 : 5.4 and most prevalent age group was noted from fourth decade to fifth decade(46.8%). The most common duration of illness between the appearance of the symptoms and the treatment was below 6 months(44.2%), and the most common symptom was the palpable mass at the anterior portion of the neck(96.1%). Most cases of the thyroid cancer were appeared as cold nodule in the 99m Tc-thyroid scan(95.7%). In the site of tumor location, the right and left lobe was distributed similarly. In the extent of tumor, incidence of intrathyroidal location was 41.6%, and that of the metastasis to the cervical lymph nodes was 44.2% and that of the direct capsular invasion was 27.3%, and incidence of both involved case was 13%. Surgical procedures were total thyroidectomy alone in 27 cases(35.1%) or with modified neck dissection in 6 cases(7.8%), or with radical neck dissection in 2 cases (2.6%), near total thyroidectomy alone in 22 cases(28.6%), ipsilateral lobectomy with isthmectomy alone in 12 cases(15.6%) or with modified neck dissection in 1 case(1.3%), and biopsy only in 7 cases(9.1%). The most common postoperative complications were transient hypoparathyroidism(5.2%) and transient unilateral recurrent laryngeal nerve paralysis(5.2%). Conclusion: The major problem of management of thyroid cancer include a wide spectrum of clinical behaviour of this tumor entity, the lack of reliable prognostic factors and lack of an objective assessment of the various treatment modalities. But because of showing the favorable prognosis for most thyroid cancer, appropriate and aggressive management should be recommended.
서기민(Ki-Min Seo),임경수(Kyung-Su Lim),이상진(Sang-Jin Lee) 한국정보기술학회 2009 한국정보기술학회논문지 Vol.7 No.2
Rapid increase of the mass storage devices is difficult for forensic examiners to find important evidence. The examiner needs much time to search files that related to the crime in a variety of storage device. Recently, NIST has developed a new database NSRL which contains hashes of trusted operating systems and programs[1]. With disclosing NSRL, they provide support for the examiners analyzing object files less file searching time in the digital evidence and detecting forgery. Thus an accidental or intentional change to the files will almost certainly change the hash value in cryptographic hash function. The similarity is not because of the characteristics of hash value detected. By considering the known fuzzy hashing and statistical analysis, we present a method which detected similar files. In this paper, we develop a similar files detection tool that detected damaged and intentional changed files.
우기민,이영상,김용호,Woo Ki-Min,Lee Young-Sang,Kim Yong-Ho 한국작물학회 2005 한국작물학회지 Vol.50 No.suppl1
미강으로부터 정제된 tocotrienol은 DPPH를 기질로 확인한 결과 매우 뛰어난 항산화력을 가지는 것으로 판명되었다. 또한 정상세포와 암세포를 배양하면서 tocotrienol을 처리하고 세포내의 항산화에 가장 큰 역할을 하는 superoxide dismutase와 glutathione peroxidase 활성을 측정한 결과 두 효소 모두 tocotrienol에 의하여 활성이 증가되는 것을 볼 수 있었으며, 전체적으로 암세포에서 GPX가 SOD보다 더 민감하게 증가함을 알 수 있었다. The pharmaceutical function of tocotrienol in rice bran was evaluated. Distinctive antioxidative effects by 1,1-diphenyl-2-picrylhydrazyl(DPPH) could be observed. Also, Superoxide Dismutase(SOD) and Glutathione Peroxidase(GPX) activities of the cultured cells such as human firbroblast and hepatocyte, were increased up to 2 fold by the treatment of tocotrienol. The effects on GPX activity were more evident than SOD activity, and the stimulation was up to 2 fold. The changes of gene expression patterns were examined by applying the cell extracts of fibroblast treated with the increasing concentrations of tocotrienol on two-dimensional gel electrophoresis(2-D gel electrophoresis). As the concentrations increasing, many proteins began to appear with the increasing amounts, while several proteins diminished or disappeared. From these results, tocotrienol was clearly shown to have abilities on protecting any oxidizing damages and stimulating anti-oxidizing activities of the organisms.
Nitrobenzene을 guest로 포접한 3차원 금속착체 포접화합물의 결정구조
박기민,박상윤,이욱,이와모토 토시타케,Park, Ki-Min,Park, Sang-Yun,Lee, Uk,Iwamoto, Toschitake 대한화학회 1996 대한화학회지 Vol.40 No.7
3차원 금속착체 포접화합물 $Cd(pn)Ni(CN)_4{\cdot}0.5NO_2C_6H_5$(pn: 1,2-diaminopropane=propylenediamine)은 사방정계 공간군 $Pn2_1$a로, a=13.868(5), b=26.591(4), c=7.840(1)${\AA}$, V=2891(1)${\AA}^3$, Z=4이며, 28000개의 독립적인 회절반점에 대한 R값은 0.054이다. 이 포접화합물의 host구조는 가지 달린 지방족 guest 분자를 포접한 포접화합물의 host 구조(T-type)와 같다. Nitrobenzene guest 분자는 T-type의 nodal형 턴넬속에 안정하게 포접되는데, 이는 node 위치체 pn-amino group이 놓이고, antinode 위치에 부피가 큰 방향조 고리가 놓이며, 이들 사이에 극성인 nitro group이 있기 때문이다. 턴넬형의 포접골간을 갖는 금속착체 $Cd(pn)Ni(CN)_4$의 host 구조가 가지 달린 방향족 guest 분자를 포접하고 있다. The three-dimensional metal complex inclusion compound $Cd(pn)Ni(CN)_4{\cdot}0.5NO_2C_6H_5$(pn: 1,2-diaminopropane=propylenediamine) crystallizes in the orthorhombic space group, $Pn2_1$a, (a=13.868(5), b=26.591(4), c=7.840(1)${\AA}$, V=2891(1)${\AA}^3$, Z=4), R=0.054 for 2800 independent reflections. The host structure of the inclusion compound appears the same one(T-type) of inclusion compound with branched aliphatic-guest molecule. The nitrobenzeneguest molecule attains the stable position in the nodal channel of T-type by placing the polar nitro group between the pn-amino groups at the node and the bulky aromatic ring in the antinodal zone of the channel. The substituted aromatic guest molecule is accommodated in the host structure of metal complex $Cd(pn)Ni(CN)_4$ with channel cavity.