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최해석(Haeseok Choi),박현민(Hunmin Park),이현철(Hunchol Lee),장익근(Ikkun Jang),윤영한(Younghan Youn) 대한기계학회 2005 대한기계학회 춘추학술대회 Vol.2005 No.5
This research is about a door trim assessment for the passenger safety when it does a side impact. We are research about the method to verify the door trim before the full car side impact test. We have prescribed by the nation at the laws and regulations assessment method the case of a full car side impact test. But an assessment regulation about the door trim only does not exist. We related with full car side impact simulation and studied a goal performance of the door trim. We studied the goal absorption energy and impactor velocity for evaluate a door trim side impact performance. A door trim goal performance which is desired by the vehicle has the difference. We used the energy to happen after a side impact and found the goal absorption energy. We found a impactor velocity of a door trim assessment device from an energy relation. We prepared theoretical key point for a goal performance assessment about every vehicle through this research.
Enhanced cell growth inhibition by thiacremonone in paclitaxel-treated lung cancer cells
반정옥,황철주,박미희,황인국,정헌상,이희범,현병국,김지영,윤해석,함영완,윤도영,한상배,송민종,홍진태 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.7
Activation of nuclear factor kappa-B (NF-jB) is implicated in drug resistant of lung cancer cells. Our previous data showed that thiacremonone inhibited activation of NF-jB. In the present study, we investigated whether thiacremonone enhanced susceptibility oflungcancercellstoa common anti-cancer drug paclitaxel by further inhibition of NF-jB. Thus, we used the threefold lower doses of IC50 values (50 lg/ml thiacremonone and 2.5 nM paclitaxel). We found that combination treatment with thiacremonone and paclitaxel was more susceptible (combination index; 0.40inNCI-H460cellsand0.46inA549cells)incellgrowth inhibition of two types of lung cancer cell lines compared to a single agent treatment. Consistent with the combination effect on cancer cell growth inhibition, the combination treatment further induced apoptotic cell death and arrested the cancer cells in G2/M phase accompanied with a much lowerexpressionofcdc2andcyclinB1,andinhibitedcolony formation. Much more inactivation of NF-jB and greater expression of NF-jB target apoptosis regulated genes such as caspase-8 and PARPs were found by the combination treatment. Molecular model and pull down assay as well as MALDI-TOF analysis demonstrated that thiacremonone directly binds to p50. These data indicated that thiacremonone leads to increased apoptotic cell death in lung cancer cell lines through greater inhibition of NF-jB by the combination treatment with paclitaxel.
의료기기 일괄허가 및 기술문서 심사를 위한 품목별 길라잡이 개발
김용우,신채민,방지영,이정연,오현주,배우진,최진만,임경미,오헌진,김미영,허찬회,김형범,최민용,곽지영,김수연,황상연,윤해석,홍혜경,안소영,이창형,정진백,구자중,강세구,정재훈,임경택,임창근,김민수,이성희,이재근,박기정 대한의용생체공학회 2010 의공학회지 Vol.31 No.4
Approvals of medical device increase every year as industry of medical device grows. Therefore KFDA keeps trying to improve approval systems. However, the firms of medical device are in trouble due to regulation amendment, a firm of small size, exchange of the person in charge. The staffs of KFDA increase their work load because applicants of approval of medical device aren't used to writing of document. Therefore the firm of medical device in business have a long term. KFDA develops eight guidance document item by item for one-step evaluation and approval for Medical Devices because applicants of approval of medical device write documents easily. KFDA reviewer can carry on quick reviewing in use of this eight guidances. This guidance are improved on satisfaction of applicants of approval of medical device.