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Imipenem 내성 Pseudomonas aeruginosa의 분리 현황과 내성 획득 기전
윤외숙,이보영,배일권,권수봉,정석훈,정태전,정연욱 대한임상미생물학회 2005 Annals of clinical microbiology Vol.8 No.1
Background: Spread of imipenem-resistant Pseudomonas aeruginosa isolates is an important clinical threat. The aim of this study is to survey the prevalence of carbapenem-resistant P. aeruginosaisolates in a university hospital, Busan, Korea, and to determine the mechanisms of the resistance. Methods: P. aeruginosa isolates from the patients in Kosin University Gospel Hospital were collected during the period of June through September, 2004. Antimicrobial susceptibilities were tested by the disk diffusion method, and production of carbapenemase and metallo-β-lactamase was determined by the modified Hodge and EDTA-disk synergy tests, respectively. MICs were determined by the agar dilution method, and pIs of β-lactamases were determined by the isoelectric focusing. Genotypes of carbapenemases were determined by direct sequencing of amplified products. Results: A total of 77 clinical isolates of P. aeruginosa were collected. Twenty-two (55.0%) and 15 (37.5%) isolates showed positive results in the modified Hodge and EDTA-disk synergy tests, respectively. Searches for blaOXA-23 and blaIMP-1 genes showed positive results in 15 and 12 isolates, respectively. MIC ranges of imipenem and meropenem to OXA-23-producing isolates were 8-16 ㎍/mL and 2-32 ㎍/mL, respectively, and those to IMP-1-producing isolates were 2-≥256 ㎍/mL and 2-128 ㎍/mL, respectively. Conclusion: Production of OXA-23 or IMP-1 is the most prevalent mechanism of imipenemresistance in P. aeruginosa isolates in a university hospital, Busan, Korea. Periodical surveys are necessary to monitor the spreading of imipenem-resistant isolates and emerging new mechanisms of imipenem-resistance.
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한일 양국의 식생활관련 가사노동의 수행 실태에 관한 연구
이기영,김외숙,윤미림 한국가족자원경영학회 1998 가족자원경영과 정책 Vol.2 No.2
The purpose of this study was to compare the performance mode of housework related to daily meals. The data for 214 Korean couples living in Seoul and 136 Japanese Couples in Tokyo were collected using structured questionnaires and time diaries. The performance mode of housework were analyzed according to the employment status of wives. The results were as follows; Generally Koreans and Japanese wives had similar patterns in the time use of meals preparation and dish washing. In both nations Husbands seldom participated meals preparation, wives did most part of the work. But Japanese husbands of full-time employed wives spent more time on meals preparation than their Korean counterparts did. Korean wives received more help from other family members and paid labor, on the contrary Japanese wives purchased more ready-made goods for food preparation.
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