苦練丸의 항산화 및 항염증 효과에 관한 실험 연구

윤예슬,조성희,양승정 대한한방부인과학회 2024 大韓韓方婦人科學會誌 Vol.37 No.2

Objectives: The purpose of this study is to evaluate the antioxidant and anti- inflammatory effects of Goryeon-hwan (GRH), which is mentioned in ≪Donguibogam≫ that treats leukorrhea. Methods: In this study, the antioxidant efficacy of GRH was evaluated by measuring the total polyphenol and flavonoid content, DPPH radical scavenging activity, ABTS radical scavenging activity, and ROS production through RAW264.7 cells. The concentration of GRH cytotoxicity was confirmed through the cell viability of RAW264.7 cells, and the production of NO, the production of Cytokine through ELISA assay, and the expression of genes through Real-time PCR were measured to evaluate anti-inflammatory efficacy. Protein phosphorylation and protein expression were measured through Western blot analysis. Results: As a result of the experiment, GRH contained polyphenol and flavonoid, and concentration-dependent increased DPPH radical scavenging activity and ABTS radical scavenging activity and decreased ROS production. The anti-inflammatory efficacy measurement results showed a significant decrease in NO and Cytokine production in the GRH administration group compared to the control group. In terms of gene expression and protein expression, there was a significant decrease in iNOS, COX-2, IL-1β, IL-6, and TNF-α depending on the concentration, and a significant increase in HO-1 and NQO1. Protein phosphorylation measurements showed a concentration-dependent significant decrease in the GRH group at ERK and p38. Conclusions: As a result, the study experimentally confirmed the antioxidant and anti-inflammatory effects of GRH, suggesting that it may be used as a treatment for various gynecological inflammatory diseases including vaginitis.

간호사 되어감에서의 피드백 경험

윤예슬,홍소윤,김수 한국간호과학회 2020 한국간호과학회 학술대회 Vol.2020 No.10

위성기반 가뭄지수의 상호비교를 통한 한반도 농업가뭄 분석

윤예슬,이수진,박성욱,이양원,김나리,손은하,장재동 건국대학교 기후연구소 2018 기후연구 Vol.13 No.4

Drought is one of the natural disasters that slowly begin to accumulate over a long period. Although there are many kinds of drought indices, one single universally accepted definition does not currently exist, which makes it difficult to evaluate drought severity comprehensively and objectively. This paper describes the comparisons of satellite-based drought indices such as SPI (Standardized Precipitation Index), NDDI (Normalized Difference Drought Index), NMDI (Normalized Multi-band Drought Index), VHI (Vegetation Health Index) and SDCI (Scaled Drought Condition Index) to analyze agricultural drought in Korea. Through an experiment using the five drought indices, we found that VHI and the SPI2 calculated from 2-month accumulated precipitation were highly correlated and appropriate to express agricultural drought in South and North Korea. Also, the SPI2 and VHI showed close relationships with hydro-meteorological factors and vegetation production variables. For future work, it is necessary to develop a comprehensive drought index which can cover various aspects of drought including precipitation, evapotranspiration, soil moisture, and vegetation state.

2021년도 광주광역시 한방 난임 치료 지원 사업에 대한 결과 보고

윤예슬,양승정,조성희,정소미 대한한방부인과학회 2022 大韓韓方婦人科學會誌 Vol.35 No.2

Objectives: The purpose of this study is to report the results of Korean medicine treatment infertility support program in Gwang-ju Metropolitan City in 2021. Methods: Participants of Korean medicine treatment infertility support program were provided Herbal medicine, acupuncture, pharmacopuncture and Counseling for 3 months and followed up for 3 months after the treatments. The project was carried out for 100 infertile women under the age of 42 living in Gwang-ju Metropolitan City, of which 91 completed treatment until the end. Collected data of 91 women containing pregnancy rates, characteristics of subjects, treatments, and satisfaction of the program were analyzed. Results: After the treatment, 23 out of 91 subjects were pregnant, two of whom were miscarried, and 21 were maintained. The average age of pregnant women in 23 pregnant subjects was 33.8 years old, of which the average age of those who maintained pregnancy was 32.4 years old, and the age of one miscarried person was 39 years old. More than 85% of subjects answered that they were satisfied with the program in the satisfaction survey. Conclusions: Based on this report, the clinical data were obtained from the infertility treatment program. This study can be used as basic data to help establish infertility support programs and subsequent policies like support for men in the future Korean medicine infertility project and extension of the herbal medicine treatment period.

Influence of Nursing Manager's Ethical Leadership Perceived by Nurses in Patient-Engaged Nursing Services: Mediating Effect of Patient Participation Culture

윤예슬,지윤정,이태화 간호행정학회 2023 간호행정학회지 Vol.29 No.4

Purpose: This study investigated the mediating effect of patient participation culture in the relationship between ethical leadership and performance in patient-engaged nursing services. Methods: This study employed a cross-sectional descriptive online survey design. The sample comprised 104 nurses from small- and middle-sized Korean hospitals. Data were collected between May 10 and September 10, 2019 using the Smart Patient Engagement Assessment Checklist, Korean versions of the Patient Participation Culture Tool for healthcare workers, the Ethical Leadership Scale, and a questionnaire about nurses’ demographic and work characteristics. A mediation analysis was conducted using multiple regression and a simple model applying the PROCESS macro using SPSS Windows software version 26.0. Results: Ethical leadership directly affected (c’=0.28, p<.001) performance in patient-engaged nursing services. Patient participation culture partially mediated the relationship between ethical leadership and performance in patient-engaged nursing services (a․b=0.51 × 0.20=0.10, 95% Boot CI=0.18-0.20). Conclusions: Optimizing the patient participation culture and adherence to ethical leadership among hospital administrators and managers can improve nurses’ performance in patient-engaged nursing services. Nurse managers’ ethical leadership should be strengthened, and patient participation culture should be encouraged at policy levels through systematic nurse education on patient safety and engagement to enhance performance-engaged nursing services.

자궁평활근종의 수술적 치료 후유증에 대한 보허탕가감방 한방 치험 5례

윤예슬,조성희,양승정 대한한방부인과학회 2023 大韓韓方婦人科學會誌 Vol.36 No.2

Objectives: The purpose of this case study is to report clinical effectiveness of the Boheo-tang-gagambang with acupuncture, moxa and physiotherapy treatments on the after-effects of myomectomy or hysterectomy. Methods: The subjects of this study were five women who were diagnosed with uterine myoma and underwent myomectomy or hysterectomy. They mainly complained of lower abdominal pain, back pain, and pelvic pain. They received combination treatment of Korean medicine and physiotherapy. The Korean medicine included Boheo-tang-gagambang, acupuncture and moxa. The effects were evaluated through Numeric Rating Scale (NRS). Results: In this study, patient's clinical symptoms, including lower abdominal pain, low back pain, and pelvic pain, improved after hospitalization treatment. Conclusions: This case report shows that the combination treatment of Korean medicine with Boheo-tang-gagambang, acupuncture and moxa may be effective for treating after-effects of myomectomy or hysterectomy.

Development of Potential Water Stress Index (PWSI) for Drought Monitoring Using Satellite Precipitation and Evapotranspiration Data

윤예슬,이수진,이양원 건국대학교 기후연구소 2022 기후연구 Vol.17 No.3

Drought is a natural disaster in which the land surface suffers a severe water shortage for a long time. Unlike other natural disasters, determining the beginning and the end of the drought is difficult, so drought can have different meanings and categories according to the application purposes. In this paper, we presented the Potential Water Stress Index (PWSI), a new drought index by combining satellite-based precipitation and potential evapotranspiration data in terms of water supply and consumption of the land surface. In the case study for the Korean Peninsula, we analyzed two types of droughts: (i) a typical drought due to the lack of precipitation and (ii) a sudden drought due to extraordinary heatwaves and excessive evapotranspiration. The proposed PWSI could express both types of droughts well, while Standardized Precipitation Index (SPI) was not appropriate for the sudden drought. Moreover, the PWSI agreed with the pattern of vegetation health with some time lags. Under the rapid increase of climate change, the sudden drought, which has not been introduced well, can be more frequent in the future. Therefore the proposed PWSI can help the expression of agricultural droughts in the context of the relationship between water stress and vegetation health. Real-time or high-resolution data can support more effective management of droughts in monitoring systems.

가상현실 시뮬레이션을 활용한 간호사대상 재난대비교육의 효과: 체계적 문헌고찰

윤예슬,김민지 한국간호과학회 2020 한국간호과학회 학술대회 Vol.2020 No.10

한반도 농지에 대한 다양한 위성 기반 가뭄지수의 적합성 검증

윤예슬(Ye-Seul Yun),이양원(Yang-Won Lee) 대한공간정보학회 2019 한국지형공간정보학회 학술대회 Vol.2019 No.5

한국어판 간호실무 준비도 측정도구 개발을 위한 예비타당도 평가

이태화,윤예슬,지윤정,지현주,이수정 한국간호과학회 2020 한국간호과학회 학술대회 Vol.2020 No.10