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윤보현,전승주,조시현,최영식,이병석,서석교 대한폐경학회 2016 대한폐경학회지 Vol.22 No.3
Objectives: Decreased renal function is associated with increased cardiovascular risk. Our study was planned to verify the association of decreased renal function and subclinical coronary atherosclerosis in postmenopausal women.Methods: We performed a retrospective review of 251 Korean postmenopausal women who visited the health promotion center for a routine health checkup. Estimated glomerular filtration rate (eGFR) was used to show renal function, which was estimated by calculated using the Cockcroft-Gault (CG) and the modification of diet in renal disease (MDRD) formulas. Coronary atherosclerosis was assessed by 64-row multidetector computed tomography.Results: Women with reduced eGFR (< 60 mL/minute/1.73 m2) had significantly higher brachial-ankle pulse wave velocity (baPWV) than women with normal eGFR (≥ 60 mL/minute/1.73 m2). The eGFR was negatively correlated with baPWV (r = -0.352, P < 0.001), significantly. The eGFR was lower in women with coronary atherosclerosis than in normal control women, markedly. Reduced eGFR was significantly associated with the presence of coronary atherosclerosis (odds ratio [OR] = 7.528, 95% confidence interval [CI] = 2.728-20.772, P < 0.001).Conclusions: Decreased eGFR was closely associated with increased arterial stiffness and coronary atherosclerosis in postmenopausal women. Evaluating subclinical atherosclerosis by screening the renal function in postmenopausal women may be helpful screening high risk group and considering starting menopausal hormone therapy before atherosclerosis development. (J Menopausal Med 2016;22:167-173)
한국형 양극성 장애 약물치료 알고리듬 2006(V):유지치료
윤보현,박원명,배승오,정상근,김원,신영철,조현상,권준수,서정석,하규섭,민경준,이은,전덕인 대한정신약물학회 2006 대한정신약물학회지 Vol.17 No.6
Objective: Since the previous publication of Korean Medication Algorithm Project for Bipolar Disorder (KMAP-BP) in 2002, there has been a substantial need for the revision of treatment algorithm due to rapid progress in the management for bipolar disorder. We focused on the maintenance treatment of bipolar I and bipolar II disorders of KMAP-BP revised in 2006. Method: The questionnaire to survey the expert opinion of medication for bipolar disorder was completed by the review committee consisting of 70 experienced psychiatrists. It was composed of 37 questions, and each question includes various sub-items. We classified the expert opinion to 3 categories (the first-line treatment, the second-line, the third-line) by X2 test. A part of this revision regarding maintenance treatment had 6 items; 2 on bipolar I and 4 on bipolar II disorder. Results: There was no ‘treatment of choice’ in maintenance treatment. In case of bipolar I mania without history of depression, mood stabilizer (MS) monotherapy was 1st-line treatment. In maintenance management for bipolar II disorder, two treatment options were recommended. Treatment with MS alone or combinations of MS and atypical antipsychotics were preferred in recently recovered patients from hypomania. Atypical antipsychotics were more favored in the maintenance treatment for bipolar I and II disorders than previous KMAP-BP. Conclusions: There is no ‘treatment of choice’ in maintenance strategies for bipolar disorder. Atypical antipsychotics are more preferred than the previous KMAP-BP. Also there is an increasing interest on the maintenance use of lamotrigine in bipolar depression.
국내 주식시장의 새로운 대안 인덱스 도입 연구 – 스마트 베타를 중심으로
윤보현,손경우,유원석 한국재무학회 2016 한국재무학회 학술대회 Vol.2016 No.05
본 연구는 국내주식시장에서 패시브 자산운용전략을 통해 시장위험대비 초과수익률 달성이 가 능한지 분석한다. 이를 위해 주식시장의 이례현상(anomaly)을 일으키는 요인을 기준으로 종 목을 선정하고, 특정 목적치가 최적화되도록 각 종목의 비중을 결정하여 최적 포트폴리오를 구축하였다. 구축된 최적포트폴리오의 성과를 전통적인 시장 인덱스에 대한 대안 인덱스 개념 으로 그 성과를 측정하고 분석한 결과, 기존 위험요인으로 설명되지 않는 알파를 창출할 수 있는 대안 인덱스의 구축 가능성과, 이를 활용하여 전통적인 시장인덱스 효율성의 제고가능성 을 확인할 수 있었다. 이러한 본 연구 결과는 패시브 방식 자산운용이 점차 확대되고 있는 상 황에서 액티브 운용의 장점을 절충함으로써 패시브 운용의 효율성 제고와 관련된 시사점을 제 공한다. 본 연구에서 제시된 대안 인덱스는 패시브 포트폴리오의 새로운 효율적 벤치마크를 개발하는데 유용하게 활용될 수 있다.