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유종한,Jae-Ho Shin,Min Sung An,Tae Kwun Ha,Kwang Hee Kim,배기범,Tae Hyeon Kim,최창수,Kwan Hee Hong,Jeong Kim,정수진,Sun Hee Kim,Kuk Hwan Rho,김종태,양영일 대한대장항문학회 2012 Annals of Coloproctolgy Vol.28 No.3
Purpose: This experimental study verified the effect of adipose-tissue-derived stem cells (ASCs) on the healing of ischemic colonic anastomoses in rats. Methods: ASCs were isolated from the subcutaneous fat tissue of rats and identified as mesenchymal stem cells by identification of different potentials. An animal model of colonic ischemic anastomosis was induced by modifying Nagahata’s method. Sixty male Sprague-Dawley rats (10-week-old, 370 ± 50 g) were divided into two groups (n = 30 each): a control group in which the anastomosis was sutured in a single layer with 6-0 polypropylene without any treatment and an ASCtreated group (ASC group) in which the anastomosis was sutured as in the control group, but then ASCs were locally transplanted into the bowel wall around the anastomosis. The rats were sacrificed on postoperative day 7. Healing of the anastomoses was assessed by measuring loss of body weight, wound infection, anastomotic leakage, mortality, adhesion formation,ileus, anastomotic stricture, anastomotic bursting pressure, histopathological features, and microvascular density. Results: No differences in wound infection, anastomotic leakage, or mortality between the two groups were observed. The ASC group had significantly more favorable anastomotic healing, including less body weight lost, less ileus, and fewer ulcers and strictures, than the control group. ASCs augmented bursting pressure and collagen deposition. The histopathological features were significantly more favorable in the ASC group, and microvascular density was significantly higher than it was in the control group. Conclusion: Locally-transplanted ASCs enhanced healing of ischemic colonic anastomoses by increasing angiogenesis. ASCs could be a novel strategy for accelerating healing of colonic ischemic risk anastomoses.
유종한,이종원,손병호,김성원,박수경,이민혁,김이수,노우철,김은규,윤대성,이지연,정진향,정상설,공경엽,안세현 한국유방암학회 2014 Journal of breast cancer Vol.17 No.2
Purpose: Mutations in BRCA genes are the main cause of hereditarybreast cancer in Korea. The aim of this study was to investigatethe characteristics of breast cancers involving BRCA1(BRCA1 group) and BRCA2 (BRCA2 group) mutations. Methods:We retrospectively reviewed the medical records of patients withBRCA1 (BRCA1 group) or BRCA2 (BRCA2 group) mutation positivebreast cancer from multiple centers and compared the datato that of the Korean Breast Cancer Society registry (registrygroup). Results: The patients of the BRCA1 group were diagnosedat a younger age (median age, 37 years) and had tumorsof higher histological (61.3% with histological grade 3) and nuclear(37.5% with nuclear grade 3) grade than those of the registrygroup. In addition, the frequency of ductal carcinoma in situin the BRCA1 group was lower (3.7%) than in the registry group,and the BRCA1 group were more likely to be triple-negativebreast cancer (61.3%). Patients in the BRCA2 group were alsoyounger at diagnosis (mean age, 41 years) and were more likelyto have involvement of the axillary node than the registry group(45.5% vs. 33.5%, p=0.002). The BRCA1 and BRCA2 groupsdid not show a correlation between tumor size and axillary nodeinvolvement. Conclusion: We report the characteristics of BRCAmutation positive breast cancer patients in the Korean populationthrough multicenter data and nation-wide breast cancerregistry study. However, BRCA-mutated breast cancers appearhighly complex, and further research on their molecular basis isneeded in Korea.
유전알고리즘을 이용한 Optical Disk Drive의 퍼지 PID 제어기 설계
유종화(Jong Hwa Yu),주영훈(Young Hoon Joo),박진배(Jin Bae Park) 한국지능시스템학회 2004 한국지능시스템학회논문지 Vol.14 No.5
광디스크에 저장된 데이터를 읽기 위한 광디스크 드라이브는 광학헤드 구동기의 포커싱 서보계와 트랙킹 서보계로 구성된다. 기존에 사용하는 지상-진상-진상 보상기는 시스템의 배속이 증가하면서 광학헤드의 구동기 제어가 점점 어려워지는 추세이다. 따라서 본 논문에서는 광학헤드 구동기 서보계 구현을 위하여 유전알고리즘 기반 퍼지 PID 제어 광학헤드 구동기 설계 기법을 제안한다. 제안된 광학헤드 구동기는 두개의 퍼지 PI, PD 제어 블록으로 구성되며 두제어기의 퍼지 규칙은 유전알고리즘을 사용하여 최적화된다. 구동기의 포커싱, 트랙킹 서보계의 플랜트 모델은 유사하므로 트랙킹 서보계의 모의실험만을 통하여 제안된 기법의 우수성을 보인다. An optical head actuator of an optical disk drive consists of two servo mechanisms for the focusing and the tracking to acquire data from disk. As the rotational speed of the disk grows, the utilized lag-lead-lead compensator has known to be above its ability for precisely controlling the optical head actuator. To overcome the difficulty, this paper propose a new controller design method for optical head actuator based fuzzy proportional-integral-derivative (PID) control and the genetic algorithm(GA). It employs a two-stage control structure with a fuzzy PI and a fuzzy PD control and is optimized by the GA to yield the suboptimal fuzzy PID control performance. It is shown the feasibility of the proposed method through a numerical tracking actuator simulation.