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四鹽化炭素로 肝障害를 誘導한 家兎에서의 抗結核劑의 排泄에 關한 硏究
元章喜,權昌鎬 慶熙大學校 1984 論文集 Vol.13 No.-
The drug metabolism of several antituberculosis was investigated in liver injuried rabbits. Antituberculosis drugs which used on this experiment were Rifampicin, Isoniazide and Pyrazinamide. The results were as follows. 1. Activities of sGOT and sGPT of rabbits induced liver injury by CCl_4 were increased (in sGOT, from 48.9 ± 1.48 units/ml to 370 ± 19 units/ml and in sGPT, from 42.5 ± 1.22 units/ml to 386 ± 32 units/ml) after the lapse of 24 hours from CCl_4 administration and then they were decreased gradually with the lapse of time (in sGOT, to 310 ± 25 units/ml and in sGPT, to 285 ± 26 units/ml after the lapse of 72 hours from CCl_4 administration). 2. The rifampicin which cxcreted mainly through bile at a small dose administration was excreted in urine at a large dose administration. 3. Each antituberculosis drugs which administrated on this experiment was excreted more quantity in urine of CCl_4 pretreated rabbits as compared with normal rabbits. particularly, Rifampicin was excreted far more quantity in urine of CCl_4 pretreated rabbits all the time. 4. From the above results, it was recognized that many notice about use of Antituberculosis drugs to liver injuried body must be required.