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오동훈,양병환,최준호,Oh, Dong-Hoon,Yang, Byung-Hwan,Choi, Joonho 대한생물정신의학회 2007 생물정신의학 Vol.14 No.4
Recent researches have shown that important cellular-based autoprotective mechanisms are mediated by heat-shock proteins(HSPs), also called 'molecular chaperones'. HSPs as molecular chaperones are the primary cellular defense mechanism against damage to the proteome, initiating refolding of denatured proteins and regulating degradation after severe protein damage. HSPs also modulate multiple events within apoptotic pathways to help sustain cell survival following damaging stimuli. HSPs are induced by almost every type of stresses including physical and psychological stresses. Our nervous system in the brain are more vulnerable to stress and damage than any other tissues due to HSPs insufficiency. The normal function of HSPs is a key factor for endogenous stress adaptation of neural tissues. HSPs play an important role in the process of neurodevelopment, neurodegeneration, and neuroendocrine regulation. The altered function of HSPs would be associated with the development of several neuropsychiatric disorders. Therefore, an understanding of HSPs activities could help to improve autoprotective mechanism of our neural system. This paper will review the literature related to the significance of HSPs in neuropsychiatric field.
오동훈,이중우,금동호,전성환,김강민,Oh, Dong-Hoon,Lee, Joong-Woo,Keum, Dong-Ho,Jun, Sung-Hwan,Kim, Kang-Min 한국항해항만학회 2006 한국항해항만학회지 Vol.30 No.10
부산항(북항) 재개발사업은 노후화된 북항 일반부두를 해양관광의 중심지역 그리고 부산시민을 위한 친수공간으로 개발하기 위해 그동안 많은 연구와 노력이 진행되어 왔으며, 현재 구체적인 방안이 모색되는 실행단계로 진입하였다. 한편, 재개발로 인한 유동장 및 해수교환의 변화는 환경적인 측면에서 중요한 검토사항 중 하나이다. 본 연구에서는 북항 재개발에 따른 일반적인 자료를 수집 분석하고, 이를 바탕으로 하여 재개발에 따른 유동장의 변화와 만 내 해수교환을 수치실험으로 검토하였다. 실험결과, 조류속 변화는 북항 및 내항에서 감소가 나타나고 주수로상에서 증가가 나타나고 있다. 해수교환 변화는 15일이 지난 준 정상상태에서 재개발 전후 공히 약 77% 내외에 달하는 것으로 나타났다. In connection with redevelopment of Busan North Port, there has been lots of studies and efforts for the development of superannuated North general piers into a center of marine tourism and waterfront for the citizens of Busan. Recently it has moved to the stage of execution, after several trials to find concrete solutions. On the other hand, the change of flow field and tidal exchange cuased by redevelopment is one of the important investigation subjects. This study deals with the change of flow field and water exchange after redevelopment using numerical simulation technique, based on the general data which were collected and analyzed. As a result of simulation, the speed of tidal currents are tended to decrease near the North and inner-port and increase at the main waterway. Furthermore, the tidal exchange had a tendency to be small both before and after redevelopment by about 77% in a quasi steady state, which is about 15 days after.
정신분열병의 시각자극 사건유발전위 P300에 대한 연구
오동훈,남정현,안동현,김석현,최준호,Oh, Dong-Hoon,Nam, Jung-Hyun,Ahn, Dong-Hyun,Kim, Seok-Hyun,Choi, Joon-Ho 대한생물정신의학회 2004 생물정신의학 Vol.11 No.1
Objective:Event-related potentials(ERPs) are electrical changes recorded at the surface of the scalp in response to stimulus presentation, and their latency and amplitude change according to cognitive processes. Through past studies of the auditory ERP in schizophrenia, the P300 has been reported to be statistically smaller and delayed in schizophrenia than comparison groups. However, studies of the visual ERP have not been systematically examined. The present study was designed to investigate the visual P300 in patients with schizophrenia and normal controls and to compare the pattern of P300 between them. Methods:The subjects were composed of patients(N=22) with schizophrenia by DSM-IV and normal controls(N=22). The visual ERPs were measured by the visual continuous performance test. P300 amplitude and latency measured on 5 scalp electrodes(Fz, Cz, Pz, $T_7$, $T_8$) were compared between patients and controls. Results:The P300 latencies measured on Fz, Cz, Pz, and $T_7$ electrodes were significantly longer in patients than controls(p<0.05). The P300 amplitudes in patients were smaller than controls. However, the difference between them was not statistically significant. Conclusion:Analysis of the visual ERPs showed that the P300 latency is significantly delayed and the P300 amplitude is slightly smaller in patients than controls. These results are similar to established studies of the auditory P300 in schizophrenia.
오동훈,강영진,정혁,송혜진,조유석,김도진,Oh, Dong-Hoon,Kang, Young-Jin,Jung, Hyuck,Song, Hye-Jin,Cho, You-Suk,Kim, Do-Jin 한국재료학회 2009 한국재료학회지 Vol.19 No.9
Thin films of single-wall carbon nanotubes (SWNT) with various thicknesses were fabricated, and their optical and electrical properties were investigated. The SWNTs of various thicknesses were directly coated in the arc-discharge chamber during the synthesis and then thermally and chemically purified. The crystalline quality of the SWNTs was improved by the purification processes as determined by Raman spectroscopy measurements. The resistance of the film is the lowest for the chemically purified SWNTs. The resistance vs. thickness measurements reveal the percolation thickness of the SWNT film to be $\sim$50 nm. Optical absorption coefficient due to Beer-Lambert is estimated to be $7.1{\times}10^{-2}nm^{-1}$. The film thickness for 80% transparency is about 32 nm, and the sheet resistance is 242$\Omega$/sq. The authors also confirmed the relation between electrical conductance and optical conductance with very good reliability by measuring the resistance and transparency measurements.
안구운동 민감 소실 및 재처리 요법(Eye Movement Desensitization and Reprocessing) 치료 후 국소 뇌 혈류 변화:두 증례의 SPECT 연구
오동훈,최준호,Oh, Dong-Hoon,Choi, Joonho 대한생물정신의학회 2004 생물정신의학 Vol.11 No.2
Over the last decade, EMDR(Eye Movement Desensitization and Reprocessing) has emerged as a promising new treatment for trauma and other anxiety-based disorders. However, neurobiological mechanism of EMDR has not been well understood. Authors report SPECT findings of two patients of PTSD before and after EMDR. Brain 99mTc-ECD-SPECT was performed before and after EMDR treatment. To evaluate the significance of changes in the regional cerebral perfusion, t-test was conducted on the resulting images using SPM99. In addition, clinical scales(CAPS, CGI, STAI) were employed to asses the changes in the clinical symptoms of the patients. After EMDR treatment, each showed significant improvement in clinical symptoms. The cerebral perfusion increased in bilateral dorsolateral prefrontal cortex, and decreased in the temporal association cortex. The differences in the cerebral perfusion between patients after treatment and normal controls decreased. These changes appeared mainly in the limbic area the and the prefrontal cortex. These results suggest that EMDR may show the therapeutic effect through 1) improvement in the emotional control by increased activity in the prefrontal cortex, 2) inhibited hyperstimuli on amygdala by deactivation of the association cortex, 3) inhibition on past trauma related memory, and 4) keeping the functional balance between the limbic area and the prefrontal cortex. This case report needs further replication from studies with larger sample.
오동훈(Oh Dong Hun),이재순(Lee Jae Soon),정만모(Chung Man Mo) 한국도시행정학회 2006 도시 행정 학보 Vol.19 No.2
The purpose of this paper is to present the improvement schemes enhancing the efficiency of Feasibility Study for Constructing Public Cultural Facility through reviewing the problems on the current methodology of the feasibility study. Research targets in the study are limited to Public Library and Center for Culture and Athletics. The authors find out the problems of the selected research reports conducting feasibility study for Constructing Public Culture Facility by 6 kinds of standpoint such as policy, location, economy, technology, fund raising, and management. They also review the method and efficiency of the feasibility study. Improvement schemes presented in this paper are as follow; 1) Approach considering demand-side rather than supply-side is strongly recommended. 2) The standardized instruction including main valuation items for feasibility appraisal is required. 3) Various fund raising tools such as PFI, BTL, BOT should be considered. 4) Competitive bid system could be applied to research project with service cost of less than 30 million won. 5) Plan improving both location and accessibility should be prepared when the subject facility is not located on the best site.
원심분리력에 의한 100㎚이상 거대 나노 입자 제거 기술
오동훈(Dong-Hoon Oh),김남수(Nam-soo Kim) 한국생산제조학회 2008 한국공작기계학회 추계학술대회논문집 Vol.2008 No.-
Nano sized particles have been paid attention in various applications due to their physical and chemical properties such as surface area and reactivity In this study, synthesis of Nano particles using Poly-vinyl pyrrolidone(PVP) as a reducing agent. PVP has many advantages, because PVP is soluble in water, solvent and Surfactant. For separation of each sized particles, centrifuge is desperate needed. The main factors rotatory power in rpm. As changing the factors and checking the particles sizes, find the best condition of each sized particles. Though the mechanical process, it is possible to obtain pure and each sized Nano particles.