성남 시청사 및 의회 건립공사

양종한(梁鍾漢),하정석(河正錫),이인호(李仁鎬),신호석(申昊錫) 한국조명·전기설비학회 2008 조명.전기설비 Vol.22 No.2

Hermansky-Pudlak Syndrome(HPS)생쥐 모델의 폐 항산화계 활성: 방사선의 영향

신호상,양우정,최은미 환경독성보건학회 2007 환경독성보건학회지 Vol.22 No.1

Hermansky-Pudlak Syndrome (HPS) 환자에서 조기에 발생되는 폐섬유화의 원인을 알아보고자, 생쥐HPS 모델인 ep/ep,pe/pe돌연변이종의 폐 항산화계의 활성과 방사선에 대한 반응을 측정하였다. HPS 폐에서는 대조군에 비해 glutathione이 더 산화되어 있었고, catalase, glutathione S-transferase(GST) 등의 항산화효소의 활성이 저하되어 있었으며, 10Gy의 방사선을 조사하였을 때, glutathione 양이 감소하였고, 대조군 폐에서 보여 지는 방사선에 의한 γ-glutamylcysteine ligase(GCL), glutathione peroxidase(GPx) 활성의유의성 있는 증가가 관찰되지 않았다. 이 결과로부터 HPS 환자의 폐는 항산화계 활성이 저하되어 있을뿐 아니라, 산화적 스트레스가 가해 졌을 때 적응 반응이 매우 취약하여 산화적 환경에 노출된 폐의 병증을 유발할 수 있음을 추측할 수 있다.

Antioxidant Activities in the Lung of Murine Hermansky-Pudlak Syndrome (HPS) Model

Ho-Sang Shin(신호상),Woo-Jung Yang(양우정),Eun-Mi Choi(최은미) 환경독성보건학회 2007 환경독성보건학회지 Vol.22 No.1

Hermansky-Pudlak Syndrome (HPS) 환자에서 조기에 발생되는 폐섬유화의 원인을 알아보고자, 생쥐 HPS 모델인 ep/ep,pe/pe 돌연변이종의 폐 항산화계의 활성과 방사선에 대한 반응을 측정하였다. HPS 폐에서는 대조군에 비해 glutathione이 더 산화되어 있었고, catalase, glutathione S-transferase (GST) 등의 항산화효소의 활성이 저하되어 있었으며, 10 Gy의 방사선을 조사하였을 때, glutathione 양이 감소하였고, 대조군 폐에서 보여 지는 방사선에 의한 γ-glutamylcysteine ligase (GCL), glutathione peroxidase (GPx) 활성의 유의성 있는 증가가 관찰되지 않았다. 이 결과로부터 HPS 환자의 폐는 항산화계 활성이 저하되어 있을 뿐 아니라, 산화적 스트레스가 가해 졌을 때 적응 반응이 매우 취약하여 산화적 환경에 노출된 폐의 병증을 유발할 수 있음을 추측할 수 있다.

불안정성 흉·요추부 질환에서 Kaneda기구를 이용한 전방융합술

양의중,안계훈,김충현,장석정,안태형,도성신,신호 대한신경외과학회 1990 Journal of Korean neurosurgical society Vol.19 No.2

Recently anterior spinal device in the treatment of the unstable thoraco-lumbar spine has been used. We have experienced 11 patients of the unstable thoraco-lumbar spine, which were composed of 8 patients with burst fracture and 3 patients with tuberculous spondylitis. The 11 patients with neurological deficit were treated with an one stage anterior operation consisting of anterior decompression through vertebrectomy, realignment with Kaneda device. No patient showed neurologic deterioration after surgery. The anterior spinal instrumentation with Kaneda device affored enough stability to enable early ambulation with good alignment and solid fusion.

소아 측뇌실에 발생한 Choroid Plexus Papilloma 1예

양의중,장석정,신호 대한신경외과학회 1990 Journal of Korean neurosurgical society Vol.19 No.5

The choroid plexus papillomas are uncommon neoplasms of the central nervous system, and constitute 0.5-0.6 percent of intracranial tumors. These tumor are sugically treatable and the encouraging results of surgical removal justify an aggressive surgical approach. We present a case of lateral ventricle choroid plexus papilloma in a child with communicating hydrocephalus.

Chiari기형(Type Ⅰ)을 동반한 경수 및 흉수부에 발생한 척수공동증 치험 1례

안계훈,양의중,김충현,장석정,신호 대한신경외과학회 1990 Journal of Korean neurosurgical society Vol.19 No.6

We have recently managed a case of syringomyelia associated with Chiari ⅠType malformation. The syrinx was found at C₂ level to T_(10) level. And the patient complained left forearm pain and paresthesia in left shoulder, arm with segmental dissociated sensory loss. The cranio-vertebral decomression(suboccipital craniectomy, cervical laminectomy) and the shunting procedures were performed. Postoperative course was not uneven, the clinical and neurological improvement was observed. M.R.I. permitted rapid, exact diagnosis including localization of syrinx and information of associated anormaly.

제3뇌실내 낭미충증 1례

안계훈,양의중,김충현,장석정,안태형,도성신,신호 대한신경외과학회 1990 Journal of Korean neurosurgical society Vol.19 No.3

Cerebral cysticercosis is relatively common disease in Korea. But cysts in the ventricular system are rare form. In the ventricular system, they occur most frequently in the 4th ventricle, more rarely in the lateral and 3rd ventricle. We have recently experienced a case of cerebral cysticercosis which involved the 3rd ventricle. A sixty-year old man was admitted because of generalized seizure attack followed by drowsy mentation. On admission, there were no specific localizing and lateralizing neurological abnormalities except bilateral, mild degree optic papilledema. Brain CT scan after intraventricular metrizamide administration disclose a cystic mass in the third ventricle. And the serum ELISA test was positive(patient' s titer : 0.31, normal : below 0.18). Anterior trancallosal approach was performed and cystic mass was removed from the third ventricle. Pathological diagnosis of the specimen was cysticercosis. Following surgery, the patient's symptom cleared up and papilledema disappeared gradually.

인태아 척수신경절 발육에 관한 전자현미경적 연구

전판석,양의중,장석정,김충현,윤재룡,신호 대한신경외과학회 1994 Journal of Korean neurosurgical society Vol.23 No.7

The development and differentiation of cells in the spinal ganglion were studied by electron microscopy in human fetuses ranging from 12㎜ to 260㎜ crown rump length. At 12㎜ embryo the primitive neuroblasts which had a single process, contained a large numbers of free ribosome and mitochondria but very little rough endoplasmic reticulum. At 30㎜ fetus, the primitive spinal ganglion consisted of bipolar neuroblasts, satellite cells and undifferentiated cells. Spindle-shaped bipolar neuroblasts formed spinal ganglion of loosely grouped cells at 50㎜ fetus. Two neuroblast cell types, a small cell contained large clumps of rough endoplasmic reticulum at periphery, could be distinguished. At 80㎜ fetus, the spinal ganglion constituted of bipolar neuroblast with apparently random distribution of small and large neurous with process, together with satellite cells and blood vessels. The presences of a large numbers of neurotubules in the Golgi-central region were one of the first sign of further maturation of the neuroblast. During next prenatal stage from 120㎜ on fetus, the ganglion cells were large and contained much rough endoplasmic reticulum, neurotubules and extensive Golgi complex. A large number of neuroblasts became transformed into unipolar cells from 180㎜ to 260㎜ feuts. Nissl bodies appeared during this stage. The ganglion-satellite cell boundary became complicated with increasing age, thus enlarging in parallel with the increase in volume of the nerve cell. During next prenatal stage up to 180㎜ fetus, the unipolar ganglion cell increased in number and size, and the cytoplsm contained all intracytoplasmic structures which were also found in mature spinal ganglion except for large pigment granules.

티타늄 추경나사 기구(Diapason^(TM))의 전산화 단층촬영 및 자기공명영상과의 융화성

박종선,조하영,양의중,장석정,김영숙,신호 대한신경외과학회 1994 Journal of Korean neurosurgical society Vol.23 No.11

After spinal fixation using conventional stainless steel screw fixation system, postoperative evaluation of spinal canal and identification of screw positions are very difficult because of severe image halation on computerized tomography(CT) or magnetic resonance imaging(MRI). As a result, diagnosis is interfered in cases of screw malposition, infection, and when demonstration of spinal decompression is needed. For this reason, titanium implants have been developed. Titanium is neither magnetic nor paramagnetic, so it produces minimal artifacts on CT or MRI. Titanium pedicular screw system(Diapason^(TM)) is one of these instruments. In this study, the authors investigated the compatibility of this instrument with CT and MRI postoperatively. The use of titanium pedicular screw system permits high quality image of spinal cord, nerve root and screws on CT and MRI.

고혈압성 천막상부 뇌실질내출혈이 있는 혼수상태 환자에서 뇌정위적 혈종제거술 및 뇌실외배액술의 결과

홍성봉,유대진,송진규,양의중,장석정,신호 대한신경외과학회 1994 Journal of Korean neurosurgical society Vol.23 No.11

The purpose of this study was to analyze and evaluate therapeutic results of stereotactic evacuation of hematoma, urokinase irrigation and external ventricular drainage(EVD) in comatose patients who had hypertensive supratentorial intracerebral hemorhage. The authors carried out stereotactic evacuation of hematoma and external ventricular drainage in the consecutive 45 cases who were admitted to the Department of Neurosurgery, Chosun University Hospital, from Sep. 1990 to Jun. 1993. The therapeutic results were as follows : 1) The peak age incidences were 6th to 7th decades. The incidence was higher in female than male. The age was not related to the prognosis. 2) The hematoma was located at the basal ganglia in 37 cases, and the thalamic area in 8 cases. The prognosis was poorer as the area of hematoma extended more wider and deeper. 3) The volume of hematoma ranged from 8 to 155㎖. The prognosis of the patient was unfavorable in large volume of hematoma. 4) Intraventricular hemorrhage(IVH) occured in forty cases(89.9%) and motality rate was 45%. The mortality rate was increased in cases with IVH than in cases without it. 5) The motality rates based on the Glasgow coma scale(GCS) on admission were 50% in GCS score 4 group, 50% in GCS score 5 group, 40% in GCS score 6 group, 27% in GCS score 7 group. Cases of low Glasgow coma scale on admission showed high mortality rate. 6) The overall motality rate was 42%. These results suggest that stereotactic evacuation of hematoma and EVD decreased the mortality rate when compared with conservative treatment and conventional craniotomy in the literatures.