In Vivo Real-Time Monitoring of Hyaluronic of Acid Derivative As A Novel Drug Carrler Using Quantum Dots

심지석,한세광 한국고분자학회 2007 한국고분자학회 학술대회 연구논문 초록집 Vol.2007 No.4

도재 수복물의 연마 방법에 대한 고찰

심지석,류재준,Shim, Ji Suk,Ryu, Jae Jun 대한심미치과학회 2015 Journal of the Korean Academy of Esthetic Dentistr Vol.24 No.2

심미수복물에서의 연마와 마무리 과정은 수복물의 심미성, 강도, 치주건강, 그리고 대합치의 마모도에 영향을 끼칠 수 있는 중요한 과정이라 할 수 있다. 그러므로 심미수복물에 대한 연마 방법의 영향을 이해하고, 어떠한 방법으로 연마를 할 것인가에 대한 고려를 하는 것은 심미수복물의 바람직한 예후를 위해 필요하다. Although the finishing of ceramic restorations affects overall results of prosthetic procedures, the importance of finishing procedures has been underestimated. Finishing procedures have influence on the esthetics, and strength of ceramic restorations, and attrition of opposite tooth. For achieving the appropriate results of these factors, the overall understanding related to the finishing procedures of ceramic restoration is necessary.

Effect of light-curing, pressure, oxygen inhibition, and heat on shear bond strength between bis-acryl provisional restoration and bis-acryl repair materials

심지석,이정열,최연조,신상완,류재준 대한치과보철학회 2015 The Journal of Advanced Prosthodontics Vol.7 No.1

PURPOSE. This study aimed to discover a way to increase the bond strength between bis-acryl resins, using a comparison of the shear bond strengths attained from bis-acryl resins treated with light curing, pressure, oxygen inhibition, and heat. MATERIALS AND METHODS. Self-cured bis-acryl resin was used as both a base material and as a repair material. Seventy specimens were distributed into seven groups according to treatment methods: pressure - stored in a pressure cooker at 0.2 Mpa; oxygen inhibition- applied an oxygen inhibitor around the repaired material,; heat treatment - performed heat treatment in a dry oven at 60C, 100C, or 140C. The shear bond strength was measured with a universal testing machine, and the shear bond strength (MPa) was calculated from the peak load of failure. A comparison of the bond strength between the repaired specimens was conducted using one-way ANOVA and Tukey multiple comparison tests (α=.05). RESULTS. There were no statistically significant differences in the shear bond strength between the control group and the light curing, pressure, and oxygen inhibition groups. However, the heat treatment groups showed statistically higher bond strengths than the groups treated without heat, and the groups treated at a higher temperature resulted in higher bond strengths. Statistically significant differences were seen between groups after different degrees of heat treatment, except in groups heated at 100C and 140C. CONCLUSION. Strong bonding can be achieved between a bis-acryl base and bis-acryl repair material after heat treatment.

디지털 인상채득을 이용한 소구증을 가진 환자의 전악 임플란트 수복

심지석(Ji Suk Shim),류재준(Jae Jun Ryu) 대한치과의사협회 2018 대한치과의사협회지 Vol.56 No.11

This clinical case highlights the failure of long length implants, and the prosthodontic procedures necessary to rehabilitate the maxillary dentition of a patient with microstomia. The integrated digital technology of intra-oral scanning, computer-aided design, and three-dimensional printing can provide an alternative method to make conventional impressions for patients with microstomia who cannot insert the appropriate tray in their mouths.

과도한 치아 마모 환자에서 교합수직고경 증가를 동반한 완전구강회복 증례

이종석,심지석,류재준 대한치과보철학회 2023 대한치과보철학회지 Vol.61 No.3

Tooth wear refers to the loss of dental hard tissue caused by various physiological and pathological causes, and excessive pathological wear can cause complications such as pathological changes in dimensions, occlusal disharmony, loss of function, and aesthetic problems. The cause of tooth wear can be caused by attrition, abrasion, corrosion and abfraction, and it is known to act in a multifactorial etiology in interocclusal activity. In patients with excessive pathological wear, it is important to determine whether or not the vertical dimension of occlusion is reduced, and complete oral rehabilitation should be achieved with the adaptation of the neuromuscular and temporomandibular joint through accurate diagnosis and analysis. The patient in this case was a 63-year-old male patient, who presented discomfort to cold beverage due to severe tooth wear. After analysis of the patient’s vertical dimension of occlusion, a full mouth rehabilitation was performed with increasing vertical dimension of occlusion. The goal of treatment was to improve the occlusal plane with the equal-intensity contact of all teeth, harmonious anterior guidance and immediate disclusion of all posterior contacts. After rehabilitation, the patient was satisfied with function and esthetic appearance. 치아 마모는 다양한 생리적, 병리적인 원인으로 일어나는 치아 경조직의 상실을 의미하며, 과도한 병적 마모는 치수의 병적 변화, 교합 부조화, 저작 기능 상실 및 심미적 문제 등의 합병증을 유발할 수 있다. 이러한 마모의 원인에 대해서는 교모, 마모, 부식, 굴곡파절에 의해 유발될 수 있으며 구강 내 교합하는 환경에서는 복합적으로 작용함이 알려져 있다. 과도한 병적 마모를 가진 환자의 경우 수복 전 수직 고경의 감소 유무에 대한 판단이 중요하며, 정확한 진단 및 분석과 예지성 있는 치료 계획 수립을 통해 근신경계와 악관절의 안정과 적응을 동반한 완전구강회복이 이루어져야 한다. 본 증례의 환자는 63세 남환으로 치아들이 많이 닳아 있으며 전반적으로 시리다는 주소로 본원에 내원하였으며, 환자의 교합수직고경에 관한 면밀한 분석 이후 교합수직고경의 증가를 동반한 완전구강회복을 시행하였다. 전체 치아의 균등한 접촉, 기능적 악운동과 조화를 이루는 전방 유도 및 측방 운동 시 구치부 이개와 교합 평면의 개선을 치료 목표로 하였으며, 만족스러운 심미 및 기능적 결과를 얻었기에 이를 보고하고자 한다.

CAD-CAM으로 제작된 임플란트 피개의치를 이용한 무치악 환자의 보철 수복 증례

이한나,심지석,이정열,Lee, Han-na,Shim, Ji-Suk,Lee, Jeong-Yol 대한치과보철학회 2022 대한치과보철학회지 Vol.60 No.4

This case report introduces a 74-year-old male patient who visited retention deficiency of the mandibular implant overdenture, which was fabricated 20 years ago. When the existing dentures were used, the vertical dimension was reduced, the maxillary complete denture lacked lip support and retention, and the mandibular overdenture lacked clip retention due to damage to the bar attachment. After removing the damaged bar attachment, it was replaced with a ball attachment, and impressions were taken using the DENTCA^TM Tray and then the vertical dimension was measured. The gothic arch tracing was performed to record the centric relation. Obtained impressions were scanned and the shape of final dentures was designed using software and try-in dentures were fabricated using 3D printer. After evaluating the occlusal plane, occlusal relationship, facial shape, and pronunciation using the try-in dentures, the bite registration was recorded, and the final denture was manufactured based on this. The inner surface of the denture was adjusted and bilateral balanced occlusion was formed, and the housing was connected to the mandibular denture by a direct method. This case reports have shown satisfactory resultin recovering improved retention and esthetic outcome by increasing the vertical dimension and the lip support using CAD-CAM technique and the ball attachment.

고기능성 폴리머(PEKK)를 프레임워크로 하는 임플란트 지지 고정성 보철물의 6년 경과관찰 증례

박연경,심지석,이정열 대한치과보철학회 2024 대한치과보철학회지 Vol.62 No.1

고기능성 폴리머 중 하나인 Polyetherketoneketone (PEKK)는 좋은 생체적합성과 우수한 물성을 가져 치과 영역을 포함한 다양한 분야에서 사용되고 있다. 이러한 PEKK를 프레임워크로 하는 임플란트 지지 고정성 보철물에 관한 성공적인 증례들이 많이 보고되어 왔으나, 보고된 증례에 대한 장기간의 관찰과 합병증에 관한 고찰은 부족한 상태이다. 이에 본 증례보고에서는 PEKK 프레임워크를 composite resin, lithium disilicate crown, high-impact polymethyl methacrylate PMMA로 각각 veneering하여 임플란트 지지 고정성 보철 수복을 한 세 가지 증례와 각각의 6년간의 경과관찰 결과를 소개하고 이를 고찰해 보고하고자 한다. As a high-performance polymer, Polyetherketoneketone (PEKK) has good biocompatibility and excellent physical properties and is used in several areas, including dentistry. Many successful cases of implant-supported fixed prostheses with a PEKK framework have been reported; however, a long-term observation of the reported cases and discussion of complications are not available. In this case report, we present three cases of implant-supported fixed prostheses with a PEKK framework veneered with composite resin, lithium disilicate crown, and high-impact polymethyl methacrylate (PMMA), and discuss their 6-year follow-up results.

Effects of ulinastatin on coagulation in high-risk patients undergoing off-pump coronary artery bypass graft surgery

김나영,심재광,송종욱,방서욱,심지석,곽영란 대한마취통증의학회 2013 Korean Journal of Anesthesiology Vol.64 No.2

Background: Both systemic inflammatory reaction and regional myocardial ischemia/reperfusion injury may elicit hypercoagulability after off-pump coronary artery bypass grafting (OPCAB). We investigated the influence of ulinastatin, which suppresses the activity of polymorphonuclear leukocyte elastase and production of pro-inflammatory cytokines, on coagulation in patients with elevated high-sensitivity C-reactive protein (hsCRP) undergoing OPCAB. Methods: Fifty patients whose preoperative hsCRP > 3.0 mg/L were randomly allocated into the ulinastatin (600,000 U) or control group. Serum concentrations of thrombin-antithrombin complex (TAT) and prothrombin fragment 1+2 (F1+2) were measured preoperatively, immediately after surgery, and at 24 h after surgery, respectively. Secondary endpoints included platelet factor (PF)-4, amount of blood loss, and transfusion requirement. Results: All baseline values of TAT, F1+2, and PF-4 were higher than the normal range in both groups. F1+2 was elevated in both groups at immediate, and at 24 h after surgery as compared to baseline value, without any significant intergroup differences. Remaining coagulation parameters, transfusion requirement and blood loss during operation and postoperative 24 h were not different between the two groups. Conclusions: Intraoperative administration of ulinastatin did not convey beneficial influence in terms of coagulation and blood loss in high-risk patients with elevated hsCRP undergoing multivessel OPCAB, who already exhibited hypercoagulability before surgery.

무치악 환자들을 위한 한국어 버전의 구강건강영향지수 신뢰도와 타당성 평가를 위한 모의연구

신재섭,배소영,박진홍,심지석,이정열 大韓齒科補綴學會 2021 대한치과보철학회지 Vol.59 No.3

목적: 이 연구는 무치악 환자들을 위한 한국어 버전의 구강건강영향지수(OHIP-EDENT K) 의 신뢰성을 평가하고 기존의 OHIP K, OHIP-14 K와의 타당성을 파악하기 위한 향후 연구의 예비적 탐색을 목적으로 시행되었다. 대상 및 방법: 고려대학교 구로병원 치과보철과로 내원한 환자들 가운데 임플란트 오버덴처를 착용중인 환자 12명을 대상으로 연구를 진행하였다. 모든 환자들은 한국어 버전의 구강건강영향지수 설문을 진행하였다. 기존의 구강건강영향지수의 축약버전인 OHIP-14 K와 OHIP-EDENT K를 진행한 설문조사의 내용을 바탕으로 얻어내었다. OHIP-EDENT K의 내적 신뢰도를 평가하기 위해 크론바흐 알파 테스트를 진행하였다. 기존의 OHIP K와의 관련성을 평가하기 위해 스피어만 상관계수 분석방법을 이용해 OHIP-EDENT K와의 타당성을 평가하였다. 결과: OHIP-EDENT K의 크론바흐 알파값은 0.736으로 신뢰도가 수용 가능한 정도의 값을 보였다. OHIP-EDENT K와 기존의 49개 문항의 OHIP은 스피어만 상관계수가 0.966을 보였으며 통계적으로 유의미한 값을 보였다 (P < .001). OHIP-EDENT K는 OHIP-14 K에 비해 바닥효과가 적게 나타나며 OHIP K와 비슷하게 효과적으로 구강건강 만족도를 평가할 수 있음을 알 수 있었다. 결론: 무치악 환자들의 구강건강과 관련된 삶의 질을 평가하기 위해 19개의 설문문항을 갖는 OHIP-EDENT K는 49개의 설문 문항을 갖는 경우와 비슷한 측정 수준을 보임을 알 수 있었다. OHIP-EDENT K는 OHIP K와 OHIP-14 K의 대안으로 사용가능 할 수 있으며, OHIP-EDENT K의 신뢰도, 응답성 그리고 타당성을 입증하기 위해서는 보다 많은 표본 수와 추가적인 연구를 포함한 연구가 필요하다. Purpose. The purpose of this pilot study is to evaluate the reliability and validity of the Korean version of the oral health impact profile (OHIP-EDENT K) for edentulous patients. Materials and methods. The study was conducted on 12 patients who fabricated overdenture in the Department of Prosthodontics, Korea University, Guro Hospital. All subjects completed the Korean version of Oral Health Impact Profile (OHIP K) questionnaire. Shorten version of the OHIP called OHIP-14 K and OHIP-EDENT K were derived from the datasets. Cronbach’s alpha was used to measure internal consistency of the summary scores for OHIP-EDENT K. The Spearman’s correlation coefficient between the summary scores for OHIPEDENT K and OHIP K was calculated to evaluate concurrent validity. Results. The reliability of the summary scores for OHIP-EDENT K was acceptable (α=.736). The Spearman’s correlation coefficient of the summary scores for OHIP-EDENT K and OHIP K was 0.966, which was statistically significant (P<.001). OHIP-EDENT K exhibited less susceptibility to floor effects than OHIP-14 K and appeared to measure change as effectively as OHIP K. In order to prove the reliability, responsiveness and validity of OHIP-EDENT K, further studies with more samples are needed. Conclusion. The OHIP-EDENT K, a questionnaire on oral health-related QOL comprising 19 items, has measurement properties comparable with the full 49-item version. This modified shortened version can be an alternative questionnaire to full version of OHIP K and OHIP-14 K in edentulous patients.