창간 3 주년 기념호 : 계획수필 ; 바다를 향한 여심 - 짭짤한 삶

신선희 한국해사문제연구소 1976 (月刊)海洋韓國 Vol.37 No.-

소아에서 aminoglycoside의 1일 1회 요법

신선희 대한소아청소년과학회 2008 Clinical and Experimental Pediatrics (CEP) Vol.51 No.10

Aminoglycosides are frequently used antibiotics in children. The multiple daily dosing (MDD) in infants and children is twice or three times daily depending on age. Recent studies in adults have shown that once daily dosing (ODD) maximizes the bactericidal activity and might minimize the toxicity of antibiotics. So, I reviewed many studies about efficacy, toxicity and cost effectiveness of ODD of aminoglycosides in children. Most studies suggest that ODD compared with MDD of aminoglycosides is theoretically more efficacious and has no higher toxicity in infants and children. But, the total number of patients included in the studies is not large. Multi-center, controlled prospective studies are required in larger numbers of infants and children to determine the efficacy and safety of the ODD regimen in children before ODD of aminoglycosides can be recommended for routine use.

Gelatinized and Fermented Powders of Lepidium meyenii (Maca) Improve Physical Stamina and Epididymal Sperm Counts in Male Mice

신선희,박동선,전정희,주성수,김윤배,강현구 사단법인 한국동물생명공학회 2008 한국동물생명공학회지 Vol.23 No.4

Lepidium meyenii, known as Maca, is traditionally employed in the Andean region for its supposed properties to improve energy and fertility. In the present study, we investigated the effects of gelatinized and fermented Maca on improvement of physical stamina and epididymal sperm counts, and on blood biochemical parameters related to fatigue and tissue injury: creatine phosphokinase, aspartate transaminase, lactate dehydrogenase, blood urea nitrogen, glucose, total cholesterol and total proteins. Adult male mice was divided at random into two main groups (resting and excercise groups). The excercise group was separated into three subgroups (exercise only, exercise with gelatinized Maca and fermented Maca-treatment groups). Gelatinized or fermented Maca (800 mg/kg) were orally administered for 30 days. All animals in exercise groups were subjected to daily 30-min swimming for 28 days 30 min after Maca treatment. Daily exercise decreased the body weight gain, and fermented Maca further attenuated the body weight increase. Gelatinized and fermented Maca significantly increased the maximum swimming time on 14 and 28 days of treatment (p<0.05), respectively, suggestive of a long-term stamina-enhancing effect of fermented Maca. Both Maca fully or significantly recovered blood parameters of energy as well as muscular and hepatocytic injuries changed by repeated exercise and maximum swimming performance (p<0.01). Moreover, gelatinized and fermented Maca increased epididymal sperm counts 22.0% and 32.0%, respectively. In conclusion, the results indicate potential benefits of Maca for improving both physical stamina by minimizing muscular and hepatic damage and preserving energy during swimming exercise and male reproductive function by increasing epididymal sperm counts.

< 심청전 > 의 현대적 수용과 변용

신선희 한국고소설학회 2000 古小說 硏究 Vol.9 No.1

Modern adaptions of the classical literatures were studied more by the modern literature scholars rather than the classical literature scholars. The study is a meaningful job in finding the internal strength of the continuity of our literature. "Pansori" novels, especially, have been adapted throughout many genres. Not only "shin(new)" novel which rewrote the pansori, but contemporary entertainments also widely borrowed main themes from pansori. Operas, dramas, musicals and movies are some of them. Mode구 Adaptions of the classical literatures can be considered as reading, writing and appreciating the classics in another view points. In this respect, studying the modern deployment and adaptation of <Shimchungjun> is studying the connection of modern and classical literatures, continued pathos and logos in Korean literature, and way of portraying contents. Past studies focused on the similarities and dissimilarities of the new and old <Shimchungjun>, and tried to find out the meaning of the differences. The focus of the study was on the new <Shimchungjun> showing what, why, how it is different from the old <Shimchungjun>. This study, however, tries to find how so many various transformations of <Shimchungjun> is possible by many writers through ages by focusing on the narrative structure. Finding the origin of narrative and dramatic recreation of <Shimchungjun> is similiar to re-read it. The metaphor of the contradiction and discord troubles in the old <Shimchungjun> was changed into the metapor of inclusion/exclusion and consolidation of contradiction and irrationality in the later works. It seems that various narrative discourses of the old <Shimchungjun> make it possible to be adapted and deployed in many genres by the choice of dramatic narratives.

부록 : 제 1 회 ( 1984 학년도 ) 졸업생 졸업 논문 요약 / 김 유정 소설의 해학성

신선희 새얼어문학회 1985 새얼語文論集 Vol.1 No.-

Effects of Erinacol?, Extract of Hericium erinacium Cultivated with Artemisia iwayomogi, on Alcoholic Fatty Liver

신선희,장자영,최병일,전정희,지형진,문설희,정동현,여영길,백성진,황석연,정재현,김윤배 한국실험동물학회 2006 Laboratory Animal Research Vol.22 No.2

The Effects of Model Misspecification on the Analysis of Judge Ratings

신선희 한국교육평가학회 2013 교육평가연구 Vol.26 No.4

본 연구는 과제별로 다양한 변별도를 허용하도록 일반화부분점수모형을 확장하여 채점자 성향을 분석하였다. 모형에는 수험자, 채점자, 문항, 채점영역 등 총 4-국면이 포함되었다. SAS NLMIXED는 수용 가능한 수준으로 모수를 추정했으며, 모든 반복분석에서 참 모형을 거짓 모형보다 올바른 모형으로 구분해 낼 수 있었다. 본 연구의 결과는, 실제로 모형오류가 수행평가 분석에서 모수추정의 결과를 왜곡시킬 수 있음을 보여 주었다. 특히, 일부 단계난이도 추정치들의 바이어스가 훨씬 커졌으며, 채점자 효과에 대한 통계적 유의성 검정 결과에서 I종 오류가 자주 발생하였다. The study extended the generalized partial credit model to embrace varying degrees of discriminability across different tasks in the analysis of rater severity. Examinees, judges, items, and dimensions were the four facets for the study. SAS NLMIXED recovered model parameters at an acceptable level and identified the true model over the false model uniformly over all replications. The findings of the study indicated that model misspecification might distort parameter recovery in the analysis of judge ratings. In particular, the bias in some step difficulty estimates became much larger, and the significance tests for rater effects resulted in more Type I errors.

The Comparison of Clinical Characteristics in Three Types of Viral Acute Diarrhea in Infants and Toddlers and the Effect of Lactobacillus acidophilus on Rotaviral Diarrhea

신선희,신해순 대한미생물학회 2018 Journal of Bacteriology and Virology Vol.48 No.4

The most common causes of acute viral diarrhea in infants and toddlers are rotavirus, astrovirus and norovirus. The purpose of this study was to evaluate epidemiological data of pathogens obtained from stool exams and compare them with the clinical course in pediatric patients with symptoms of viral acute diarrhea and to investigate the clinical efficacy of Lactobacillus acidophilus (L. acidophilus) for acute diarrhea caused by rotavirus. Clinical data for three types of viral acute diarrhea were compared with the viral detection results by enzyme-linked immunosorbent assay. Viruses were detected in 65.8% of subjects, with rotavirus being the most commonly reported in 63.3% of subjects. To examine the characteristics of each virus, a clinical epidemiological study was performed for 482 cases. Noroviral infection symptoms included vomiting and diarrhea in patients of all age groups. Dehydration in noroviral acute diarrheal patients was less common than in rotaviral acute diarrheal patients. The clinical efficacy of orally administered L. acidophilus in the treatment of acute viral diarrhea in infants and toddlers was also evaluated. L. acidophilus was a probiotic adjuvant in viral acute diarrhea in infants and toddlers.

중국의 인구 고령화가 경제성장에 미치는 영향에 관한 실증연구 ― 동ㆍ중ㆍ서부 3대 경제지역 비교를 중심으로

신선희,김부용 고려대학교 중국학연구소 2023 中國學論叢 Vol.- No.81

This study empirically examines the impact of population aging on economic growth in China and the eastern, central and western regions. Moreover, this study aims to estimate the magnitude of the impact. To this end, this study uses the fixed effect estimation method to estimate the Solow growth model, and empirically analyzes the impact of population aging on economic growth by constructing provincial-level panel data from 2002 to 2020. In particular, this study distinguishes the eastern, central, and western regions, and divides the analysis period into two periods, 2002-2010 and 2011-2020, for empirical analysis. The empirical results show that during the period from 2002 to 2010, the proportion of China's elderly population had no statistically significant impact on economic growth. Moreover, China’s population aging had a statistically significant negative effect on economic growth during the period 2011~2020. According to the estimate, for every 1%p increase in the proportion of the elderly population, the average annual economic growth rate will decrease by 0.61%p. Moreover, the degree of negative impact showed regional differences. The negative impact of population aging on the less developed central and western provinces is greater than that in the developed eastern provinces. To sum up, due to the population aging, China’s demographic bonus that supported economic growth in the past has turned into a demographic onus in the 2010s.

Effect of Hericium Gold® on Hepatic Dysfunction and Alcoholic Hangover

신선희,류재면,김태명,서임권,이경미,전정희,황석연,여영길,정동현,정재현,김윤배,박동선 한국실험동물학회 2007 Laboratory Animal Research Vol.23 No.3

The improving efficacies of Hericium Gold® containing fermented extract of Hericium erinaceum on acute hepatic dysfunction and alcoholic hangover were investigated via the effects on carbon tetrachloride (CCl4)-induced hepatitis and ethanol overdosage, respectively. Oral administration with Hericium Gold®, especially at 100 mg/kg, attenuated the delayed excretion and blood clearance of bromosulphalein induced by CCl4 (1 ml/kg). Hericium Gold® also reduced the increase in blood alanine transaminase (ALT) and aspartate transaminase (AST) activities following CCl4 exposure. Although Hericium Gold® did not reduce the peak blood concentration of ethanol which was observed 1 hr after oral administration of alcohol (3 ml/kg), it enhanced the blood clearance at 100 mg/kg. Taken together, the results suggest that Hericium Gold® possesses hepatoprotective activity against exposure to CCl4 or alcohol, and that could be a candidate for the improvement of chemical-induced or alcoholic liver disorders.