http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
손석호,유승아,남기수,오선화,이경민,이재연,신인철 한국통합생물학회 2022 Animal cells and systems Vol.26 No.5
Brain type of creatine kinase (CKB) regulates energy homeostasis by reversibly transferring phosphate groups between phosphocreatine and ATP at sites of high energy demand. Several types of cancer cells exhibit upregulated CKB expression, but the function of CKB in cancer cells remains unclear. In this study, we investigated the function of CKB in breast cancer by overexpressing CKB in MDA-MB-231 cells. The overexpression of CKB did not affect cell growth rate, cell cycle distribution, ATP level or key mediators of aerobic glycolysis and lactate dehydrogenase isoform levels. Meanwhile, CKB overexpression did increase resistance to doxorubicin. TGF-β-induced Smad phosphorylation and Smad-dependent transcriptional activity were significantly up-regulated by CKB expression without changes in inhibitory Smad protein levels. Moreover, treatment with TGF-β considerably enhanced cell viability during doxorubicin treatment and decreased doxorubicin-induced apoptosis in CKB-expressing MDA-MB-231 cells compared to control cells. These results suggest that CKB attenuates doxorubicin-induced apoptosis and potentiates resistance to doxorubicin by enhancing TGF-β signaling in MDA-MB- 231 cells.
Wing Design Optimization for a Long-Endurance UAV using FSI Analysis and the Kriging Method
손석호,최병률,진원진,이융교,김철완,최동훈 한국항공우주학회 2016 International Journal of Aeronautical and Space Sc Vol.17 No.3
In this study, wing design optimization for long-endurance unmanned aerial vehicles (UAVs) is investigated. The fluidstructure integration (FSI) analysis is carried out to simulate the aeroelastic characteristics of a high-aspect ratio wing for a long-endurance UAV. High-fidelity computational codes, FLUENT and DIAMOND/IPSAP, are employed for the loose coupling FSI optimization. In addition, this optimization procedure is improved by adopting the design of experiment (DOE) and Kriging model. A design optimization tool, PIAnO, integrates with an in-house codes, CAE simulation and an optimization process for generating the wing geometry/computational mesh, transferring information, and finding the optimum solution. The goal of this optimization is to find the best high-aspect ratio wing shape that generates minimum drag at a cruise condition of CL = 1.0. The result shows that the optimal wing shape produced 5.95 % less drag compared to the initial wing shape.
손석호 대한영상의학회 1993 대한영상의학회지 Vol.29 No.2
During a 12-month period high-resolution, real-time ultrasonography (US) with graded compression was performed on 268 consecutive patients with clinically suspected acute appendicitis and its complications. US visualization of a fluid-filled, non-compressed appendix or a decompressed, thick-walled appendix was the primary criterion for a diagnosis of acute appendicitis. The sonographic ficdings were correlated with surgical-pathologic outcome in 92 cases and with the findings of clinical follow-ups in the remainder, US was found to be accurate in the diagnosis of acute appendicitis and its complication with a sensitivity of 93.3%, a specificity of 98.9% and an accuracy of 9.7%. The predictive value of a positive test was 97.7%, that of a negative test was 96.7% There were two false-paositive examinations in patients with a thick-walled appendix or periapperdiceal abscess, which were six false-negative examinations in patients with a sonographically no-visible appendix, which were confirmed surgically as acute appendicitis (n=5) and perforated appendicitis (n=1). Our results show that high-resolution, real-time US is an accureate imaging modality in the diagnosis of acute appendicitis and the evaluation of its complications.
새로운 소결 방법으로 제조된 n형 $\textrm{Bi}_{2}\textrm{Te}_{2.4}\textrm{Se}_{0.6}$열전재료의 특성
손석호,장경욱,이동희,Son, Seok-Ho,Jang, Gyeo-Uk,Lee, Dong-Hui 한국재료학회 1997 한국재료학회지 Vol.7 No.5
열전재료 분말을 AI관에 진공봉입하고 형틀가입한 후 소결하는 새로운 방법으로 n형 B $i_{2}$T $e_{2.4}$S $e_{0.6}$를 제조하여 소결조건에 따른 소결성과 열전특성을 조사.분석하였다. AI은 소결시 열전재료와 반응하지 않아 보호 용기로 적합하였으며, 평균입도 195$\mu\textrm{m}$의 분말을 사용하여 성형압 280 MPa, 온도 400에서 50$0^{\circ}C$에서 소결할 경우 성능지수는 1.9x $10^{-3}$K였다.다.
Surgical Results of Third or More Cardiac Valve Operation
손석호,안혁,황호영,김경환,김기봉 대한흉부외과학회 2015 Journal of Chest Surgery (J Chest Surg) Vol.48 No.1
Background: We evaluated operative outcomes after third or more cardiac operations for valvular heart disease,and analyzed whether pericardial coverage with artificial membrane is helpful for subsequent reoperation. Methods:From 2000 to 2012, 149 patients (male:female=70:79; mean age at operation, 57.0±11.3 years) underwent theirthird to fifth operations for valvular heart disease. Early results were compared between patients who underwenttheir third operation (n=114) and those who underwent fourth or fifth operation (n=35). Outcomes were also comparedbetween 71 patients who had their pericardium open during the previous operation and 27 patients who hadartificial membrane coverage. Results: Intraoperative adverse events occurred in 22 patients (14.8%). Right atrium(n=6) and innominate vein (n=5) were most frequently injured. In-hospital mortality rate was 9.4%. Total cardiopulmonarybypass time (225±77 minutes vs. 287±134 minutes, p=0.012) and the time required to prepare aorticcross clamp (209±57 minutes vs. 259±68 minutes, p<0.001) increased as reoperations were repeated. However,intraoperative event rate (13.2% vs. 20.0%), in-hospital mortality (9.6% vs. 8.6%) and postoperative complicationswere not statistically different according to the number of previous operations. Pericardial closure using artificialmembrane at previous operation was not beneficial in reducing intraoperative events (25.9% vs. 18.3%) and shorteningoperation time preparing aortic cross clamp (248±64 minutes vs. 225±59 minutes) as compared tono-closure. Conclusion: Clinical outcomes of the third or more operations for valvular heart disease were acceptablein terms of intraoperative adverse events and in-hospital mortality rates. There were no differences in the incidenceof intraoperative adverse events, early mortality and postoperative complications between third cardiac operationand fourth or more.