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중학생이 지각한 부모의 심리적 통제가 사회불안에 미치는 영향: 완벽주의적 자기제시와 부정적 평가에 대한 두려움의 매개효과
배효숙,홍혜영 한국청소년학회 2017 청소년학연구 Vol.24 No.8
This study aims to prove the mediation effect of perfectionistic self-presentation and fear of negative evaluation in the relationship between parental psychological control and social anxiety perceived by middle school students. To this end, a survey was conducted among 384 middle school students about parental psychological control, social anxiety, perfectionistic self-presentation and fear of negative evaluation to collect data. The conclusions are as follows: First, correlation analysis was shown the significant positive relationship between all variables of parental psychological control, perfectionistic self-presentation, social anxiety, and fear of negative evaluation. Second, it was shown the significant mediation effect of perfectionistic self-presentation between parental psychological control and social anxiety, however it wasn't shown the significant mediation effect for the fear of negative evaluation. Third, the dual mediation effect was significant in perfectionistic self-presentation and fear of negative evaluation in the relationship between parental psychological control and social anxiety. Finally, this study suggests the implications, limitations, and suggestions for future studies. 본 연구는 중학생이 지각한 부모의 심리적 통제와 사회불안과의 관계에서 완벽주의적 자기제시와 부정적 평가에 대한 두려움의 매개효과를 검증하기 위해 진행되었다. 이를 위해 중학생 384명을 대상으로 부모의 심리적 통제, 사회불안, 완벽주의적 자기제시, 부정적 평가에 대한 두려움에 관한 설문을 실시하여 자료를 수집하였다. 본 연구의 결과는 다음과 같다. 첫째, 부모의 심리적 통제, 완벽주의적 자기제시, 부정적 평가에 대한 두려움, 사회불안 간에 유의한 정적 상관을 나타내었다. 둘째, 부모의 심리적 통제와 사회불안과의 관계에서 완벽주의적 자기제시는 유의한 매개효과를 나타내었으나, 부정적 평가에 대한 두려움은 유의하지 않았다. 셋째, 부모의 심리적 통제와 사회불안과의 관계에서 완벽주의적 자기제시와 부정적 평가에 대한 두려움의 이중매개효과가 유의한 것으로 나타났다. 이러한 연구 결과를 바탕으로 연구의 시사점과 제한점 및 후속 연구를 위한 제언을 논의하였다.
The Effect of Body Mass Index on Survival in Advanced Epithelial Ovarian Cancer
배효숙,홍진화,기경도,송재윤,신진우,이낙우,이찬,이규완,김용민,이종민,이재관 대한의학회 2014 Journal of Korean medical science Vol.29 No.6
Controversy remains regarding the effect of obesity on the survival of patients with ovariancancer in Asia. This study examined the impact of obesity on the survival outcomes inadvanced epithelial ovarian cancer (EOC) using Asian body mass index (BMI) criteria. Themedical records of patients undergoing surgery for advanced (stage III and IV) EOC werereviewed. Statistical analyses included ANOVA, chi-square test, Kaplan-Meier survival andCox regression analysis. Among all 236 patients, there were no differences in overallsurvival according to BMI except in underweight patients. In a multivariate Cox analysis,surgical optimality and underweight status were independent and significant prognosticfactors for survival (HR, 2.302; 95% CI, 1.326-3.995; P = 0.003 and HR, 8.622; 95% CI,1.871-39.737; P = 0.006, respectively). In the subgroup of serous histology and optimalsurgery, overweight and obese I patients showed better survival than normal weightpatients (P = 0.012). We found that underweight BMI and surgical optimality areindependent risk factors for the survival of patients with advanced ovarian cancer. HighBMI groups (overweight, obese I and II) are not associated with the survival of advancedEOC patient. However, in the subgroup of EOC patients with serous histology and afteroptimal operation, overweight and obese I group patients show better survival than thenormal weight group patients.
정예원,배효숙,한송이,송재윤,김인선,강재성 대한부인종양학회 2010 Journal of Gynecologic Oncology Vol.21 No.4
Toremifene is an anti-estrogen which has been shown to be effective in the treatment of breast cancer, and is thought to be a less uterotrophic agent than tamoxifen. The risk assessment concerning endometrial cancer has been inconclusive because of its rare use up to the mid-1990s. We report a case of an adenosarcoma, which is a very rare type of uterine malignancy, after toremifene treatment for 5 years in a breast cancer patient. After 1 year of toremifene use, the patient had a benign Mullerian adenofibroma. After an additional 4 years of toremifene treatment, the endometrial polypoid lesion was transformed into a Mullerian adenosarcoma. Although toremifene is a promising anti-estrogenic agent in the treatment of breast cancer patients, clinicians should not neglect the possibility of a uterine malignancy.
Ovarian Hyper-Response to Administration of an GnRH-Agonist Without Gonadotropins
박현태,배효숙,김탁,김선행 대한의학회 2011 Journal of Korean medical science Vol.26 No.10
Several case reports have indicated that a small subgroup of patients may develop ovarian hyperstimulation following the administration of gonadotropin-releasing hormone agonists (GnRHa) without gonadotropins. However, since only few such cases have been published,it is unclear what course to follow in subsequent cycles after ovarian hyperstimulation in the first cycle using only GnRHa. A 33-yr-old woman was referred to in vitro fertilization for oocyte donation. A depot preparation (3.75 mg) of tryptorelin without gonadotropins induced ovarian multifollicular enlargement with high estradiol level, and was followed by human chorionic gonadotropin administration and oocyte retrieval. In a subsequent cycle of the same patient, a low dose of tryptorelin (0.05 mg) did not induce ovarian hyperstimulation, and resulted in clinical pregnancy. This report shows potential management of ovarian hyperstimulation following the administration of GnRHa without gonadotropins.
Candidates for Tumor Markers of Cervical Cancer Discovered by Proteomic Analysis
송재윤,배효숙,Do Hyoung Koo,이재관,정학현,Kyu Wan Lee,이낙우 대한의학회 2012 Journal of Korean medical science Vol.27 No.12
Cervical cancer is the second most common gynecological cancer among Korean women. While nationwide screening program has developed, the pathogenesis of cervical cancer is unknown. The aim of this study was to compare the protein expression profiles between cervical squamous carcinomas and normal cervical tissues in order to identify proteins that are related to the cancer. Three cervical cancer tissue samples and three normal cervical tissue samples were obtained and protein expression was compared and was identified in the samples with the use of matrix assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF-MS). A total of 20 proteins that showed up-regulated expression in the cervical cancer tissue samples were selected and identified. Seven proteins were matched to allograft inflammatory factor 1 (AIF-1), actine-like protein 2 (ALP2), brain type fatty acid-binding protein (B-FABP), NCK adaptor protein 1 (NCK-1), islet cell autoantigen 1 (ICA69), cationic trypsinogen (PRSS1), and cyclin-dependent kinase 4 (CDK4), but the remaining 13 proteins were unidentifiable. After confirmation by RT-PCR, Western blotting and immunohistochemistry, we found that B-FABP, NCK-1, and CDK4 were related to the pathogenesis of cervical cancer. These proteins are suggested as candidates of new pathological tumor markers for cervical cancer.