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MUC1 from the Mucin Family as Potential Tools in Breast Cancer Immunotherapy
박흥규,U Hyoung Seo 한국유방암학회 2009 Journal of breast cancer Vol.12 No.3
Many breast cancer patients develop minimal residual disease that becomes resistance to treatments, and finally are faced with relapse and progression of disease. Currently, immunotherapy has become a potential therapy in treating minimal residual disease and preventing cancer occurrence. Cancer vaccines provide a unique therapeutic modality in that they initiate a dynamic process of activating the host’s own immune system. A lot of tumor specific antigens as a target of immune system were identified and some have been applied for cancer vaccine. Mucin 1 (MUC1) oncoprotein, which is overexpressed in breast cancer in contrast with normal mammary tissue, is one of the first tumor antigens shown to be a target for human tumor-specific T cells and thus a valid target for immunotherapy. MUC1 is a high-molecular-weight glycoprotein rich in serine and threonine residues that are O-glycosylated. MUC1 is expressed on glandular epithelia and on epithelial tumors. But, tumor MUC1 differs from normal MUC1 by modified glycan side chains. Over-expression and aberrant glycosylation of MUC1 antigen by epithelial tumors results in endogenous antibody responses in cancer patients to MUC1 antigen. This finding has led to the identification of MUC1 derived peptide epitopes that induce T-cell responses. MUC1 based clinical trials have used peptides, protein, DNA, pulsed dendritic cells, or glycopeptide. This review will summarize the potential utility of breast cancer immunotherapy of MUC1, as well as the structure and function.
朴興奎 관동대학교 1997 關大論文集 Vol.25 No.2
In order to utilize soft clay, as subbase course in terms of improving its technological properties with the addition of some ESC. the study attempts to examine Durability of ESC stabilized soft clay when repeated Freezing & Thawing and Wetting & Drying. The results are : Unconfined compression Strength shows rectilineal increase in propotion to the ESC addition ratio. At the same percentage of added additions, Compressive strength of ESC is larger than cement. According as the number of freezing and thawing cycle increased, the lower compressive strength at 7 day was, the larger decrease of compressive strength was. Specimen which had high strength at 7 day and much added ESC was shown low rate of decrease of strength according to freezing and thawing cycle.
朴興奎 관동대학교 1989 關大論文集 Vol.17 No.1
本 硏究는 다짐을 한 흙의 供試體에 最大 10萬回까지 反復載荷을 加하였을 때 殘留變形 및 彈性變形 그리고 反復後, 一軸壓縮試驗을 行하여 應力一變形率 關係等을 求하였으며, 여기에 영향을 미치는 含水比, 密度, 反復回數, 反復荷重 等에 대해서 검토하였다. This study attempts to examine (1) the residual deformation and elastic deformation derived from the repeated loads (up to the maximum of 100,000 times) on fully compacted the soil specimen, (2) the relation between stress and strain in terms of unconfined compressive test, and (3) water content, dry density, number of cycle, repeated load, etc affecting the stress-strain relation.
花崗岩質風化土의 흙시멘트에 關한 硏究 : 다짐試驗에 의한 壓縮强度 An Unconfined Compression Strength by Compaction Test
朴興奎 관동대학교 1985 關大論文集 Vol.13 No.3
This study was attempted in order to search for the properties of the cement mixture with weathered Granite soils. Physical and mechanical tests were conducted to find out the standard properties of the used soil. Various cement contents used in this test were 6%, 8%, 10% and 12% and the compressive strength was tested after 7 days, 14 days and 28 days of standand suring in the above each cement content respectively. The results obtained are summarized as follows. 1. Optimum moisture content and maximum dry density increased with increase of the cement content but was changed ununiformly with cement content. 2. The compressive strength was increased with the cement content and compaction number. 3. As the cement contents were creased, the compressive strength of the cement Mixture with weathered Granite soil were almost proportianlly increased.