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박재형,Kenya Kusunose,Deborah H. Kwon,Margaret M. Park,Serpil C. Erzurum,James D. Thomas,Richard A. Grimm,Brian P. Griffin,Thomas H. Marwick,Zoran B. Popović 대한심장학회 2015 Korean Circulation Journal Vol.45 No.5
Background and Objectives: Right ventricular longitudinal strain (RVLS) is a new parameter of RV function. We evaluated the relationship of RVLS by speckle-tracking echocardiography with functional and invasive parameters in pulmonary arterial hypertension (PAH) patients. Subjects and Methods: Thirty four patients with World Health Organization group 1 PAH (29 females, mean age 45±13 years old). RVLS were analyzed with velocity vector imaging. Results: Patients with advanced symptoms {New York Heart Association (NYHA) functional class III/IV} had impaired RVLS in global RV (RVLSglobal, -17±5 vs. -12±3%, p<0.01) and RV free wall (RVLSFW, -19±5 vs. -14±4%, p<0.01 to NYHA class I/II). Baseline RVLSglobal and RVLSFW showed significant correlation with 6-minute walking distance (r=-0.54 and r=-0.57, p<0.01 respectively) and logarithmic transformation of brain natriuretic peptide concentration (r=0.65 and r=0.65, p<0.01, respectively). These revealed significant correlations with cardiac index (r=-0.50 and r=-0.47, p<0.01, respectively) and pulmonary vascular resistance (PVR, r=0.45 and r=0.45, p=0.01, respectively). During a median follow-up of 33 months, 25 patients (74%) had follow-up examinations. Mean pulmonary arterial pressure (mPAP, 54±13 to 46±16 mmHg, p=0.03) and PVR (11±5 to 6±2 wood units, p<0.01) were significantly decreased with pulmonary vasodilator treatment. RVLSglobal (-12±5 to -16±5%, p<0.01) and RVLSFW (-14±5 to -18±5%, p<0.01) were significantly improved. The decrease of mPAP was significantly correlated with improvement of RVLSglobal (r=0.45, p<0.01) and RVLSFW (r=0.43, p<0.01). The PVR change demonstrated significant correlation with improvement of RVLSglobal (r=0.40, p<0.01). Conclusion: RVLS correlates with functional and invasive hemodynamic parameters in PAH patients. Decrease of mPAP and PVR as a result of treatment was associated with improvement of RVLS
박재형,Margaret M. Park,Samar Farha,Jacqueline Sharp,Erika Lundgrin,Suzy Comhair,Wai Hong Tang,Serpil C. Erzurum,James D. Thomas 한국심초음파학회 2015 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.23 No.2
Background: New 2-dimensional strain echocardiography enables quantification of right ventricular (RV) mechanics byassessing global longitudinal strain of RV (GLSRV) in patients with pulmonary arterial hypertension (PAH). However, theprognostic significance of impaired GLSRV is unclear in these patients. Methods: Comprehensive echocardiography was performed in 51 consecutive PAH patients without atrial fibrillation (40females, 48 ± 14 years old) with long-term follow-up. GLSRV was measured with off-line with velocity vector imaging (VVI,Siemens Medical System, Mountain View, CA, USA). Results: GLSRV showed significant correlation with RV fractional area change (r = -0.606, p < 0.001), tricuspid annular planesystolic excursion (r = -0.579, p < 0.001), and RV Tei index (r = 0.590, p < 0.001). It showed significant correlations with pulmonaryvascular resistance (r = 0.469, p = 0.001) and B-natriuretic peptide concentration (r = 0.351, p = 0.012). During a clinical followuptime (45 ± 15 months), 20 patients experienced one or more adverse events (12 death, 2 lung transplantation, and 15 heartfailure hospitalization). After multivariate analysis, age [hazard ratio (HR) = 2.343, p = 0.040] and GLSRV (HR = 2.122, p =0.040) were associated with adverse clinical events. Age (HR = 3.200, p = 0.016) and GLSRV (HR = 2.090, p = 0.042) were alsosignificant predictors of death. Impaired GLSRV (≥ -15.5%) was associated with lower event-free survival (HR = 4.906, p = 0.001)and increased mortality (HR = 8.842, p = 0.005). Conclusion: GLSRV by VVI showed significant correlations with conventional echocardiographic parameters indicating RVsystolic function. Lower GLSRV (≥ -15.5%) was significantly associated with presence of adverse clinical events and deaths inPAH patients.
건물의 높이 변화에 따른 풍상면 및 풍하면 평균풍압의 연직분포 특성
박재형,이은지,황성권,하영철 대한건축학회지회연합회 2008 대한건축학회지회연합회 학술발표대회논문집 Vol.2008 No.1
This study summarizes basic results on the characteristics of the vertical mean wind pressure distribution, which is needed to estimate reasonable vertical wind load of buildings, through simultaneous multi-point wind pressure test. Side ratio of rectangular wind pressure models have been fixed to one and aspect ratios are changed into 4 types. Wind pressure tests are conducted on the Boundary Layer Wind Tunnel at Kumoh National Institute of Technology. The characteristics of vertical mean wind pressure distribution with respect to various heights of buildings are analyzed into windward direction and leeward. The result shows that wind pressure is decreased as the aspect ratio is decreased.