Therapeutic hypothermia reduces inflammation and oxidative stress in the liver after asphyxial cardiac arrest in rats

박윤수,안지현,이태경,김보라,태현진,박준하,신명철,조준휘,원무호 대한중환자의학회 2020 Acute and Critical Care Vol.35 No.4

Background: Few studies have evaluated the effects of hypothermia on cardiac arrest (CA)- induced liver damage. This study aimed to investigate the effects of hypothermic therapy on the liver in a rat model of asphyxial cardiac arrest (ACA). Methods: Rats were subjected to 5-minute ACA followed by return of spontaneous circulation (RoSC). Body temperature was controlled at 33°C±0.5°C or 37°C±0.5°C for 4 hours after RoSC in the hypothermia group and normothermia group, respectively. Liver tissues in each group were collected at 6 hours, 12 hours, 1 day, and 2 days after RoSC. To examine hepatic inflammation, mast cells were stained with toluidine blue. Superoxide anion radical production was evaluated using dihydroethidium fluorescence straining and expression of endogenous antioxidants (superoxide dismutase 1 [SOD1] and SOD2) was examined using immunohistochemistry. Results: There were significantly more mast cells in the livers of the normothermia group with ACA than in the hypothermia group with ACA. Gradual increase in superoxide anion radical production was found with time in the normothermia group with ACA, but production was significantly suppressed in the hypothermia group with ACA relative to the normothermia group with ACA. SOD1 and SOD2 levels were higher in the hypothermia group with ACA than in the normothermia group with ACA. Conclusions: Experimental hypothermic treatment after ACA significantly inhibited inflammation and superoxide anion radical production in the rat liver, indicating that this treatment enhanced or maintained expression of antioxidants. Our findings suggest that hypothermic therapy after CA can reduce mast cell-mediated inflammation through regulation of oxidative stress and the expression of antioxidants in the liver.

Fabrication and Characterization of a GaN Light-emitting Diode (LED) with a Centered Island Cathode

박윤수,이환기,Chung-Mo Yang,Dong-Seok Kim,배진혁,조성재,이정희,강인만 한국광학회 2012 Current Optics and Photonics Vol.16 No.4

Uniform spreading of injection current in light-emitting diodes (LEDs) is one of the crucial requirements for better device performances. It is reported that non-uniform current spreading leads to low output power,high current crowding, heating, and reliability degradation of the LED device. This paper reports on the effects of different surface and electrode geometries in the LEDs. To increase the output power of LEDs and reduce the series resistance, a rectangular-type LED (RT-LED) with a centered island cathode has been fabricated and investigated by comparison with a conventional LED (CV-LED). The performances of RT-LEDs were prominently enhanced via uniform current spreading and low current crowding. Performances in terms of increased output power and lower forward voltage of simulated RT-LEDs are much superior to those of CV-LEDs. Based on these results, we investigated the correlation between device geometries and optical characteristics through the fabricated CV and RT-LEDs. The measured output power and forward voltage of the RT-LEDs at 100 mA are 64.7% higher and 8% smaller compared with those of the CV-LEDs.

중국의 강제인증제도(CCC Mark)

박윤수,Park, Yun-Su 기술표준원 2003 기술표준 Vol.14 No.-

MICP 미생물을 이용한 하수슬러지의 고형화/안정화에 관한 연구

박윤수,이재영 한국폐기물자원순환학회 2017 한국폐기물자원순환학회 학술대회 Vol.2017 No.05

하수처리장의 증가와 함께 하수슬러지의 발생량 또한 매년 상승하고 있으며, 2025년은 2006년 대비 2배가 더 발생하게 된다. 이러한 하수슬러지는 주로 해양투기와 재활용에 의하여 처리되어 왔으나, 가장 단순하고 저렴한 방식이었던 해양투기가 2012년 01월부터 전면금지가 되었다. 현재 하수슬러지의 처리방법 중 재활용은 약 56% 정도를 차지하고 있다. 이 중 재활용은 매립지의 복토재, 건설자재, 토목자재, 시멘트 원료화 등으로 활용되고 있다. 지금까지 재활용 처리방법 중 매립지의 복토재로 재활용하는 것이 많은 연구가 진행되어 왔으나 친환경적인 처리방법 및 MICP 미생물에 관한 고형화/안정화 연구는 아직 미흡하다고 판단된다. 따라서, 본 연구에서는 MICP를 형성하는 미생물을 이용하여 하수슬러지를 고형화/안정화 한 후 매립지의 복토재로서 가능성을 보고자 한다. 이에 본 연구는 MICP를 형성하는 미생물의 생물학적 및 광물학적 분석을 하였으며 하수슬러지 및 고화제의 물리화학적 분석을 수행하였다. 본 연구를 위하여 하수슬러지의 고형화적 품질기준인 pH, 수분함량, 투수계수, 일축압축 강도, 유해물질 함량 분석을 실시하였다. 또한, MICP를 형성하는 미생물에 의하여 하수슬러지가 고화처리 된 것인지 확인하기 위하여 탄산칼슘의 광물학적 분석을 병행하여 고형화/안정화에 대한 신뢰성을 갖고자 한다.

Can Religion Save Our Health?: Quasi-Experimental Evidence from the U.S.

박윤수 한국개발연구원 2018 KDI Journal of Economic Policy (KDI JEP) Vol.40 No.1

There is a large amount of empirical literature reporting that people who regularly attend religious services tend to have better health outcomes. However, it remains an unanswered question as to whether the observed correlation reflects any causality. Exploiting exogenous changes in church attendance driven by law changes in 21 states of the U.S., I find tentative but suggestive evidence that the observed strong correlation between religious participation and health is likely to be driven by endogenous selection.

Nocardia Brain Abscess in an Immunocompetent Patient

박윤수,김수영,이강록,이동민,정지훈,문송미,양동기,서일혜,유찬종,조용균 대한감염학회 2014 Infection and Chemotherapy Vol.46 No.1

Nocardia cerebral abscess is rare, constituting approximately 1-2% of all cerebral abscesses. Mortality for a cerebral abscess ofNocardia is three times higher than that of other bacterial cerebral abscesses, therefore, early diagnosis and therapy is important. Nocardia cerebral abscess is generally occur among immunocompromised patients, and critical infection in immunocompetentpatients is extremely rare. We report on a case of a brain abscess by Nocardia farcinica in an immunocompetent patientwho received treatment with surgery and antibiotics. This is the second case of a brain abscess caused by N. farcinica in an immunocompetentpatient in Korea.

[버닝썬 게이트 취재 후기] 우리 사회 부정<SUB>不正</SUB>의 절정, 끝나지 않는 버닝썬 게이트

박윤수 (사)방송기자연합회 2019 방송기자 Vol.48 No.-

선진각국의 공산품규격 실태 및 현황

박윤수,Park, Yun-Su 대한건축사협회 1983 建築士 Vol.1983 No.3

Clinical Outcomes of Tuberculosis in Renal Transplant Recipients

박윤수,최준용,조정호,장경희,송영구,김유선,김준명 연세대학교의과대학 2004 Yonsei medical journal Vol.45 No.5

Tuberculosis (TB) is an important cause of morbidity and mortality in renal transplant recipients. Rifampin has a potent sterilizing activity, but it reduces the serum concentrations of the immunosuppressive agents. Moreover, the possible contribution made by mycobacterial infection to the incidence of graft rejection or renal dysfunction remains unclear. In this study, we investigated the recurrence of TB and graft survival duration according to rifampin usage, and we evaluated the factors that could influence the duration time until the recurrence of TB. Seventy-eight TB patients diagnosed after kidney transplantation were studied. Pulmonary TB was diagnosed in 26 of the 78 patients (33.3%), pleural TB in 23 (29.5%), combined pulmonary and pleural TB in 5 (6.4%), miliary TB in 19 (24.4%), and intestinal TB in 2 patients. In the pulmonary (pulmonary TB and pleural TB) TB group, no differences in graft survival and the TB free duration period were observed between the rifampin usage subgroup and the non- rifampin usage subgroup. In the extrapulmonary TB group, no difference was found in mean graft survival time between the rifampin usage subgroup and the non-rifampin usage subgroup, but the rifampin usage subgroup showed that the TB had a tendency to recur later than for the non-rifampin usage subgroup (87±8 vs. 44±7 months, respectively, p=0.30). The factor affecting the duration period until the recurrence of TB was the treatment duration (RR=0.761, p=0.030). This study suggests that rifampin does not affect graft survival in renal transplant recipients in whom immunosuppression is carefully monitored. Also, the study results indicate that rifampin may prevent a recurrence of extrapulmonary tuberculosis. Prolonged treatment appears to be appropriate for renal transplant recipients with TB.

인플레이션과 주가간의 관계에 대한 연구

박윤수 한국증권학회 1990 Asia-Pacific Journal of Financial Studies Vol.12 No.1