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권성원,조용명,김규태,강전홍,박영태 ( Sung Won Kwon,Y . M . Cho,K . T . Kim,J . H . Kang Y . T . Park ) 한국센서학회 1998 센서학회지 Vol.7 No.6
A dual-channel automatic ac-do voltage transfer error measurement system in which the output voltages of two thermal voltage converters which are ac voltage standard are directly measured at the same time to reduce the output voltage drift is described. Forward-reverse measurement method by using a two-channel scanner is used to cancel the offset voltage of the voltmeters. The agreements of the 4-V TVC comparison results between other national standards institute and Korea Research Institute of Standards and Science were less than about ±2 ppm in the frequency range of 40 Hz∼100 kHz, and were less than about ±4 ppm at 200 kHz∼1 MHz. Measurement uncertainty is reduced significantly from ?5 ppm of manual system to ±3 ppm of new system(up to 100 kHz) typically and great increase in comparison efficiency has been achieved by this system.
크론병 환자에서 인플릭시맵과 메살라진 치료 후 발생한 지연발생 급성 세뇨관간질 신염 증례
유양재 ( Yang Jae Yoo ),정상윤 ( Sang Yoon Chung ),구대회 ( Dae Hoe Gu ),고강지 ( Gang Jee Ko ),표희정 ( Heui Jung Pyo ),권영주 ( Young Joo Kwon ),박영태 ( Young Tae Bak ),원남희 ( Nam Hee Won ) 대한소화기학회 2014 대한소화기학회지 Vol.63 No.5
Infliximab is a chimeric anti-tumor necrosis factor-alpha monoclonal antibody. Infusion related reactions and infection are well known side effects of infliximab; however, renal complications have not been well recognized. We report on a patient with late onset-acute tubulointerstitial nephritis (ATIN) after treatment with infliximab and mesalazine for Crohn’s disease. A 25-year-old woman was admitted with a purpuric rash on both lower extremities and arthralgia. She had been diagnosed with Crohn’s disease 5.6 years previously and had been treated with mesalazine and infliximab. Serum creatinine level, last measured one year ago, was elevated from 0.6 mg/dL to 1.9 mg/dL. Results of urinalysis, ultrasound, and serologic examinations were normal. With a tentative diagnosis of Henoch-Schonlein purpura, oral prednisolone was given, and serum creatinine decreased to 1.46 mg/dL, but was elevated to 2.6 mg/dL again at two months after discontinuation of prednisolone. Renal biopsy indicated that ATIN was probably ind ced by drug, considering significant infiltration of eosinophils. Concomitant use of infliximab with mesalazine was supposed to trigger ATIN. Oral prednisolone was administered, and serum creatinine level showed partial recovery. Thus, ATIN should be suspected as a cause of renal impairment in Crohn’s disease even after a long period of maintenance treatment with infliximab and mesalazine.
한국인 A 형 간염 환자에서 A 형 간염 바이러스의 유전자형에 관한 연구
권오상,송기준,박상훈,송진원,김재선,김종헌,변관수,이창홍,연종은,백락주,박영태 대한간학회 2000 Clinical and Molecular Hepatology(대한간학회지) Vol.6 No.3
$quot;목적: 한국에서 과거 A형 간염은 낙후된 개인위생 및 자연환경으로 유소아기에 불현성 감염으로 앓고 지나가게 되어 청소년 및 성인에서 HAV에 대한 항체 보유율이 매우 높고 성인에서의 급성 A형 간염은 매우 드물게 보고되었다. 그러나 고도의 경제성장과 더불어 식생활, 위생상태의 개선, 상하수도의 보급 등으로 유소아기의 A형 간염 이환율이 현격히 감소하면서 청소년 및 성인에서 HAV 항체가 없는 인구집단 즉 HAV에 감염되면 현증 간염이 발생할 수 있는 인구 집단이 증가되어 최근 수 년 사이에 현증 A형 간염이 폭발적으로 증가하게 되었다. 이에 저자는 HAV의 유전자형을 알아보고 이미 보고된 각국의 HAV와 연관성을 알아보고자 본 연구를 시행하였다. 대상과 방법: 1994년부터 1998년까지 한국에서 산발적으로 발생한 18예의 A형 간염 환자의 혈청에서 HAV RNA를 추출, 역전사-중화효소 연쇄반응법(RT-PCR)으로 증폭하여 직접 염기서열의 분석을 통해 국내 HAV 사이에 염기서열, 아미노산의 차이 등을 알아보고 세계 각국에서 보고되었던 HAV 분리주들과 비교하였다. 결과: HAV 게놈의 특정부위인 VP1/2A 연결부위 168 bp 길이에서 시행한 염기서열 분석 결과 한국에서 분리된 18예의 HA이러스는 최근 해외에서 유입된 바이러스일 가능성은 적으며 따라서 장기간 국내에서 토착화된 바이러스일 것으로 생각된다. $quot;Background/Aims: Studies of genotypes and changes in nucleotide and amino acid sequences of hepatitis A virus (HAV) may provide valuable information on the epidemiological aspects of a particular region. In Korea the prevalence of anti-HAV in the 1 - 20 year age group declined from 60% in 1980 to 9% in 1995. As a result this age group has a high risk of HAV infection. Actually over 1,500 cases of clinically overt hepatitis A occurred in 1998 while few cases of clinical hepatitis A had been reported until the early 1990s. The aims of this study are to determine the genotypes of HAV which have been circulating in Korea and to define the phylogenetic relationships of geographically defined isolates. Method: From 1994 - 1998 a total of 18 serum specimens was obtained from patients in Korea with sporadic form acute hepatitis A. The HAV nucleic acid from serum specimens was subjected to genomic sequence analysis following viral RNA extraction, reverse transcription and amplification of the cDNA by PCR. DNA sequencing was performed in both directions of each PCR product. Results: All isolates clustered within the subgenotype IA irrespective of the geographic locations and timing of the clinical hepatitis. Among 18 Korean isolates, 9 isolates had 2 amino acid sequence changes and 2 isolates had 1 amino acid sequence change. These changes in the amino acid sequences are unique and have never been reported in HAV subgenotype IA. Conclusions: All isolated HAV had genotype (IA). Eleven of 18 isolates had unique changes in amino acid sequences. These data indicate that the endemic HAV has been circulating in Korea over a long period of time.
담낭 담석으로 인한 복강경 담낭절제술시 총수담관결석 동반 유무의 예측인자
최상용,김진호,권오상,김재선,최창원,변관수,박영태,김종극,임형준,정길만 대한소화기학회 1998 대한소화기학회지 Vol.30 No.3
Background/Aims: Accurate preoperative prediction of cho]edocholithiasis is essential in order to minitnize patients risk and to avoid unnecessary procedures. We preforme 1 this study identify independent risk factors for choledocholithiasis in patients who had undergone cholecystectomy for symptomatic cholelithiasis. Methods: The medical records of patients who had undergone cholecystectomy between Septernber, 1993 and December, ]996 were reviewed. Patients who were already found to have either extrahepatic or intrahepatic hiliary stones on sonogram were excluded. 79 of these patients in whom the presence or absence of choledocholithiasis had been confirmed(preoperative ERCP in 69, operative choangiography in 10) were eligible for analysis. Candidate predictor variables included age, sex, presence of fever, and maximum preoperative values for each of the followings: common bile duct(CBD) diarneter, white blood cell counts, AST, ALT, alkaline phosphatase, total bilirubin, and amylase. The analysis was conducted using SPSS(V 5.0.2). Results: Choledocholithiasis was confirmed in 16(20.3%) of the 79 eligible patients. Univariate analysis identified age, alkaline phosphatase, and CBD diameter as predictors. Multivariate analysis subsequently identified alkaline phosphatase and CBD diameter as independent predictors of choledocholithiasis. The probability of choledocholithiasis was 86% when two independent predictors were present, but was 3% when all two predictors were absent. Conclusions: ERCP or operative cholangiography is not thought to be necessary for patients with symptomatic cholelithiasis who have both normal biliary tree on sonogram and normal serum alkaline phosphatase. However patients with syrnptomatic cholelithiasis who have both dilated CBD on sonogram and elevated serum alkaline phosphatase, or are found to have CBD stone on abdominal sonogram, do necessarily require do not necessarily reqine what? RCP? To confirm the presence of CBD stone.
만성 바이러스성 간염 환자에서 인터페론 치료로 인한 갑상선 기능 이상과 갑상선 자가 항체의 발현에 관한 연구
김진호,권오상,최창원,연종은,변관수,이창홍,박영태,박상훈,임형준,정길만 대한소화기학회 1999 대한소화기학회지 Vol.33 No.3
Background/Aims: Interferons have been employed in the treatment of patients with hepatitis B and C. However, immunomodulatory properties of interferon are known to induce thyroid dysfunction. In the present study, we examined the prevalence of thyroid dysfunction and the development of thyroid autoantibodies following administration of interferon alpha (IFN-α), and investigated predictive fac tors that induced thyroid dysfunction. Methods: Sixty-eight patients with chronic hepatitis B and 42 patients with chronic hepatitis C were investigated retrospectively. All of them were treated with IFN α. Before and after the treatment, FT3, FT4, TSH, antithyroglobulin antibody (Tg-Ab) and antimicro somal antibody (Ms-Ab) were measured. Results: During treatment, thyroid dysfunction developed in 8 (7.3%) of the 110 patients. At the start of IFN-αtherapy, 3 cases had detectable thyroid autoanti bodies. During IFN-αtherapy, 6 additional cases became to have thyroid autoantibodies. Logistic regression analysis was prmed for the variables such as age, gender, IFN dose and duration, HBV vs HCV, thyroid autoantibodies. It revealed that positivity of thyroid autoantibodies during and before therapy were statistically significant and independent risk factors for the development of thyroid diseases. Conclusions: IFN-αtherapy in chronic viral hepatitis can induce thyroid dysfunction. All patients undergoing IFN-αtherapy should be screened for thyroid autoantibodies and TFT before therapy and monitored during therapy. The occurrence of thyroid dysfunction requires a decision whether to maintain or interrupt IFN-αtherapy, taking into account the response to therapy and theseverity of the thyroid disease.