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Senescent tumor cells: an overlooked adversary in the battle against cancer
박순상,최용원,김장희,김홍석,Park Tae Jun 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-
Senescent cells in cancer tissue, including senescent fibroblasts and macrophages, have been reported to increase the malignant potency of cancer cells by secreting senescence-associated secretory phenotype (SASP). Otherwise, Senescence of tumor cells has been believed to inhibit tumor growth by halting the massive proliferation and increasing the chances of immune clearance. In particular, senescent tumor cells (STCs) have been thought that they rarely exist in carcinomas because oncogene-induced senescence needs to be overcome for protumorigenic cells to become malignant. However, recent studies have revealed that a considerable number of STCs are present in cancer tissue, even in metastatic sites. In fact, STCs are widely involved in cancer progression by leading to collective invasion and building a cytokine barrier to protect nonsenescent tumor cells from immune attack. Furthermore, therapy-induced STCs can induce tumor progression and recurrence by increasing stemness. However, obscure causative factors and their heterogeneity in various cancers make it difficult to establish the physiological role of STCs. Here, we summarize and review the current knowledge of the pathophysiology and role of STCs. We also outline the current status of therapeutic strategies for directly removing STCs or modulating the SASPs to maximize the positive functions of STCs while suppressing the negative functions.
고온 고압 환경에서 가변추력기용 핀틀의 열전달 계수에 대한 수치적 연구 및 2D 실험
박순상,문영기,곽재수,Park, Soon Sang,Moon, Young gi,Kawk, Jae Su 항공우주시스템공학회 2012 항공우주시스템공학회지 Vol.6 No.4
In this paper, 2-D experiment and steady-state computational fluid analysis were conducted for measuring the hear transfer coefficient of pintle type controllable thruster in high pressure and temperature. In case of 2-D experiment, transient liquid crystal technique was used for measuring heat transfer coefficient for the 2-D pintle model. The experimental result was used to validate the CFD result. The CFD results well predicted the heat transfer coefficient on the pintle surface except the nozzle downstream region, where the results by CFD was higher than experimental results. The CFD results were also compared with the result by Bartz equation and the it was shown that the Bartz equation overestimated the heat transfer coefficient on the nozzle throat as much as 80%.