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이예현,남의화,박설희,송치윤,이용욱,이종명,박정훈,황철용,Lee, Ye-Hyun,Nam, Eui-Hwa,Park, Seol-Hee,Song, Chi-Youn,Lee, Yong-Uk,Lee, Jong-Myung,Park, Jung-Hoon,Hwang, Cheol-Yong 대한수의학회 2013 大韓獸醫學會誌 Vol.53 No.3
Two dogs were presented with melena, vomiting and depression after accidental swallowing of candy form of Strepsils (flurbiprofen), which is one of non-steroidal anti-inflammatory drugs used in human medicine for controlling a sore throat. These dogs had common signs of anemia induced by gastrointestinal ulceration and hemorrhage with azotemia and leukocytosis. The dogs were treated with blood transfusion, fluid therapy, proton-pump inhibitor, antiemetics, mucus protectant and antibiotic. Although most of clinical signs of two dogs were resolved, azotemic problem with evidence of renal injury have remained.
이은의(Eun Eui Lee),박설희(Seol Hee Park),박기호(Ki Ho Park),이규완(Kyu Wan Lee) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.2
N/A Objective: Although ovarian cancer is the leading cause of death among all cancers of the female reproductive tract, the genetic alterations involved in ovarian cancer remains largely unknown. Recently, mutations of the p53 gene have been documented in many types of human cancer including ovarian cancer. Methods: In tbe present study, p53 gene mutation was examined in DNA samples extracted from paraffin embedded surgical specimens of ovarian cancer. Furthermore, clinicopathological parameters were examined in relation to p53 gene mutation in order to understand the role of p53 mutation in the development of ovarian cancer. Using the polymerase chain reaction(PCR) and single strand conformational polymarphism(PCR-SSCP), p53 gene mutation was examined and the mutations were confirmed by DNA scquencing in 17 cases of ovarian cancer. Results: Abnormal bands indicating mutation were detected in 2/17(11.8%). DNA sequencing confirmed in 2 mutations and revealed C to T and A to T nucleotide chmges. In clinicopathological parameters, FIGO stage, grade, and recunence were not correlated with the p53 gene mutation. However, the recurrence rate was higher in patients with mutant p53 compared with those with wild type p53(50.0% vs 13.3%), altbough this is not statisticaUy significant. Conclusion: In conclusion, p53 gene mutation shows no correlation with stage, grade and recurrence, and p53 gene mutation does not appear to be a marker that predicts the biological behavior or the outmme of the disease. This study suggested useful data to elucidate the mechanism of chemotherapy-resistant ovarian cancer and further p53 expression assay would be mandatory for p53 nonfunctioning ovarian cancas.
자궁경부의 염증 및 종양병변에서 Epstein-Barr 바이러스의 검출
정혜진,이응석,림정화,박설희,강재성,김인선,Jeong, Hye-Jin,Lee, Eung-Seok,Lin, Zhen-Hua,Park, Seol-Hee,Kang, Jae-Sung,Kim, In-Sun 대한세포병리학회 2001 대한세포병리학회지 Vol.12 No.2
The prevalence of Epstein-Barr virus(EBV) in the uterine cervix was investigated to define the possible etiologic role in cervical carcinogenesis. The viral genotyping and LMP-1 30bp deletion were also stooled. The materials included 169 uterine cervical swabs(152 within normal limits, 12 atypical squamous cells of uncertain significance, 3 low grade intraepithelial lesions, and 2 high grade squamous intraepithelial lesion) and 104 uterine cervical tissues obtained from hysterectomy specimens(32 carcinoma in situ, 9 microinvasive squamous cell carcinomas, 37 invasive squamous cell carcinomas, 7 adenocarcinomas, 7 adenosquamous carcinomas, and 12 cervicitis). EBV detected by PCR for EBNA-1 was positive in 52(56.5%) of 92 invasive and noninvasive cervical carcinomas, and 80(48.8%) of 164 inflammatory or normal cervices. The viruses detected in carcinomas were all type A, and LMP-1 30bp deletion form was more frequent in premalignant and malignant cervical lesions than in nonneoplastic cervices. From the above results, it may be concluded that EBV is one of common viruses detected in uterine cervix of Korean women, and type A virus and LMP-1 30bp deletion form may have a role in cervical carcinogenesis.
한국 토양균중 Leucine aminopeptidase 저해제의 검색 및 분리에 관한 연구(제1보)
전정순(Jeong Soon Jeon),박설희(Seol Hee Park),최응칠(Eung Chil Choi),김병각(Byong Kak Kim) 한국생약학회 1987 생약학회지 Vol.18 No.1
To find microorganisms producing leucine aminopeptidase inhibitors, microbes were isolated from soil samples that were collected at different locations in Korea and screened for inhibitory activity. Strain DMC-454 which was found to show the inhibitory activity was very similar to Streptomyces griseofuscus. It was grown in a liquid medium containing oatmeal, yeast extract and mineral salts. The highest inhibitory activity was obtained by the three-day old culture. The inhibitor of this strain was purified by means of adsorption on Amberite XAD-4 and column chromatography on Amberlite CG-120 and gave a single spot at Rf 0.36 with n-butanol-acetic acid-distilled water (4:1:1). The mode of the enzyme inhibition was competitive type.
김봉석(Bong-Suk Kim),원용희(Yong-Hee Won),박설희(Seol-Hee Park),배상준(Sang-Joon Bae),장광동(Kwang-Dong Jang) 한국생산제조학회 2016 한국생산제조학회지 Vol.25 No.1
With the increasing running speed of trains, new railway lines in metropolitan areas, and the rising demand for green transportations, the number of underground and tunnel sections are constantly becoming larger, and installations of overhead rigid conductor systems are becoming wider. However, domestic commercial products for overhead rigid conductors are limited to 120 km/h train speeds. In this study, to develop a high-speed (250 km/h) overhead rigid conductor, R-Bar (Rigid Bar), the electrical and mechanical stability was enhanced through the improvement of the cross sectional shape of the R-Bar; the transition structure was also designed for flexibility and natural frequency isolation. In addition, the evaluation of contact forces between a pantograph and the overhead rigid conductor system for 250 km/h train speeds was performed using dynamic analysis.
이예현(Ye Hyun Lee),남의화(Eui Hwa Nam),박설희(Seol Hee Park),송치윤(Chi Youn Song),이용욱(Yong Uk Lee),이종명(Jong Myung Lee),박정훈(Jung Hoon Park),황철용(Cheol Yong Hwang) 대한수의학회 2013 大韓獸醫學會誌 Vol.53 No.3
Two dogs were presented with melena, vomiting and depression after accidental swallowing of candy form of Strepsils (flurbiprofen), which is one of non-steroidal anti-inflammatory drugs used in human medicine for controlling a sore throat. These dogs had common signs of anemia induced by gastrointestinal ulceration and hemorrhage with azotemia and leukocytosis. The dogs were treated with blood transfusion, fluid therapy, proton-pump inhibitor,antiemetics, mucus protectant and antibiotic. Although most of clinical signs of two dogs were resolved, azotemic problem with evidence of renal injury have remained.