차량속도 결정요인에 관한 운전자의 행태분석 및 심리학적 특성에 관한 연구

박미소,윤효진 경기대학교 산업기술종합연구소 2008 산업기술종합연구소 논문집 Vol.33 No.-

구기지황탕 투여 후 호전된 경도인지장애 환자 1례에 대한 증례보고

박미소,강석만,유대원,채인철,김경순,성현주,정광렬,유호룡,Park, Mi-so,Kang, Seock-man,Yoo, Dai-won,Chae, In-cheol,Kim, Gyeong-soon,Seong, Hyun-joo,Chung, Kwang-yeol,Yoo, Ho-ryong 대한한방내과학회 2021 大韓韓方內科學會誌 Vol.42 No.5

Objective: Alzheimer's disease is characterized by progressive, irreversible brain damage and cognitive decline. Although the diagnosis and treatment of the prodromal symptoms of dementia are important, no treatment for mild cognitive impairment has been currently established. Herein, we report the case of an 80-year-old female patient with memory complaints treated with Gugijihwang-tang, a traditional Korean medicine herbal formula, as an add-on medication. Case Presentation: The patient was diagnosed with mild cognitive impairment based on clinical examinations using the Mini-Mental State Examination (MMSE), the Consortium to Establish a Registry for Alzheimer's Disease (CERAD), Activities of Daily Living (ADL) Scale, Global Deterioration (GDR) Scale, and Clinical Dementia Rating (CDR) Scale. She was treated with Gugijihwang-tang bis in die for 12 months while continuing her original medications, including 5-mg donepezil and 590-mg acetyl-l-carnitine. The MMSE score in the Korean Version of the CERAD Assessment Packet increased from 21 to 27 during the 12-month treatment period, and the CERAD 2 score increased from 33 to 62. The instrumental ADL scale score improved from 11 to 5. Other clinical examination results also showed improvement. The patient was satisfied and experienced no significant adverse events related to the Gugijihwang-tang treatment. Conclusion: This case suggests that Gugijihwang-tang could be considered as a treatment method for patients with mild cognitive impairment.

Phosphatidylserine receptor-targeting therapies for the treatment of cancer

박미소,Keon Wook Kang 대한약학회 2019 Archives of Pharmacal Research Vol.42 No.7

Asymmetric distribution of phospholipids acrossthe plasma membrane is a unique characteristic ofeukaryotic cells. Phosphatidylcholine and sphingomyelinare exposed in the outer leaflet, and phosphatidylserine(PS) is predominantly located in the inner leaflet. Redistributionof PS to the cell surface can be observed in severalphysiological conditions, such as apoptosis and plateletactivation, or in pathological conditions, such as the releaseof microvesicles/exosomes from tumor tissues. PS bindingto the phosphatidylserine receptor (PSR) on immune cellsinitiates immunosuppressive pathways that can lead toimmune evasion by cancer cells. Conversely, PSR activationof cancer cells plays an important role in their survival,proliferation and metastasis. Herein, we briefly summarizeboth recent advances in our understanding of the pathologicalroles of PS and its receptor in cancer biology, aswell as relevant pharmacological approaches.

특발성 부종의 중의치료에 대한 임상연구 동향 - CNKI검색을 중심으로

박미소,김수덕,공건식,최요섭,배지은,백혜경,김영준,신동국 대한한방내과학회 2022 大韓韓方內科學會誌 Vol.43 No.4

Objectives: This study investigated the latest clinical studies on Korean medicine treatment of idiopathic edema in the Chinese National Knowledge Infrastructure Database (CNKI). Methods: We searched the last 9 years of clinical studies discussing Oriental medicine-based treatments for idiopathic edema in the CNKI database. The search focused on the authors, publication year, type of study, purposes of study, method and duration of treatment, evaluation criteria, and results of the selected articles. Results: The search identified 7 randomized controlled trials (RCTs) and 9 others. All studies used oral herbal medicine for treatment. The most commonly used herbs were Poria Sclerotium (茯苓), Atractylodis Rhizoma Alba (白朮), and Alismatis Rhizoma (澤瀉), which are the constituent herbs of Oryeong-san (五苓散). All 16 studies confirmed the efficacy of Oriental medicine treatments. Conclusion: More varied and scientifically designed clinical studies are required to develop treatments for idiopathic edema. The results of this study could be used as basic data for further studies on idiopathic edema.

파킨슨병 환자의 개인별 Wearing-off 증상 및 해결책 현황 조사를 위한 설문 연구

박미소,박상수,류호룡,편우석,허왕정,박신영,Miso S. Park,Sang Soo Park,Horyong Yoo,Jaeson Pyeon,Wang Jung Hur,Shin Young Park 턱관절균형의학회 2023 턱관절균형의학회지 Vol.13 No.sup

Objectives: Parkinson's disease (PD) is currently the most rapidly increasing degenerative brain disease due to population aging and westernization of lifestyle. Levodopa is the most commonly used drug to manage PD symptoms. However, levodopa has a problem in that the wearing-off phenomenon occurs as the duration and dose of administration increase. In order to investigate the wearing-off phenomenon in PD patients and devise countermeasures, we conducted a questionnaire survey in Korea. Methods: For the study, a questionnaire with a total of seven items was prepared. Part IV of the MDS-UPDRS (Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale) and the WOQ-9 (9-symptom Wearing-off Questionnaire) were used as references. Results: Of the 48 patients who completed the questionnaire, all 47 patients who completed the questionnaire experienced the wearing-off phenomenon. Only one of the patients diagnosed with PD a year ago did not experience the wearing-off phenomenon. Patients frequently mentioned a lack of sleep and stress as aggravating factors for wearing-off. They also stated that in order to resolve the off-state, they walked, massaged, warmed up the body, stretched and exercised. Conclusions: Because wearing-off is such a common occurrence, it is thought necessary to develop wearing-off prevention and resolution measures that PD patients can use in their daily lives.

뇌진탕 후 증후군의 중의치료에 대한 임상연구 동향 - CNKI검색을 중심으로

박미소,주아라,최요섭,백혜경,황보경,신동국,장승원,Park, Mi-so,Ju, Ah-ra,Choi, Yo-sup,Baek, Hye-kyung,Hwang, Bo-kyung,Shin, Dong-guk,Jang, Seung-won 대한한방내과학회 2021 大韓韓方內科學會誌 Vol.42 No.6

Objectives: The aim of this study was to investigate the latest clinical studies on Korean medicine treatment of post-concussion syndrome (PCS) in the Chinese National Knowledge Infrastructure Database (CNKI). Methods: We searched the last 10 years of clinical studies discussing Oriental medicine-based treatments for PCS in the CNKI database. The search focused on the authors, publication year, type of study, purpose of the study, method and duration of treatment, evaluation criteria, and results of each article. Results: Of the 22 selected studies, 1 was a non-randomized controlled trial (nRCT), 2 were case series, and 19 were randomized controlled trials (RCTs). Treatments included oral herbal medicine in 16 studies, oriental medicine through external use in 2 studies, acupuncture in 3 studies, and traditional Chinese medicine injection in 2 studies. The most frequently used herb was Cnidii Rhizoma (川芎). All 22 studies confirmed the efficacy of Oriental medicine treatments. Conclusion: More varied and scientifically designed clinical studies are required to develop treatments for PCS. The results of this study could be used as basic data for further PCS studies.

소아 익사의 예후 예측

박미소,서원희,제보경,송대진,권정현 대한소아응급의학회 2021 대한소아응급의학회지 Vol.8 No.2

Purpose: Despite the well-known mortality of pediatric drowning, there is a paucity of evidence on the implications of an initial evaluation on the relevant outcome of drowning. This study aimed to investigate the association of initial clinical findings with outcome of children undergoing drowning. Methods: This retrospective study was conducted using the medical records of 56 children undergoing drowning who visited 3 Korean academic hospitals from January 2000 through May 2020. We analyzed information regarding the prehospital resuscitation, drowning time, a 4-tiered chest radiographic grade, and the baseline characteristics. The grade was defined based on the findings of initial chest radiographs. The poor outcomes were defined as the need for intensive care unit care or death aftercare. We analyzed the association of the prehospital resuscitation, submersion time, and the radiographic grade with the poor outcomes using binary logistic regression. Results: Among the 56 children, 31 (55.4%) were aged 1-4 years. Prehospital resuscitation and 1-5 minutes of submersion time were noted in the 25 (44.6%) and 30 children (53.6%), respectively. The chest radiographic grades 1 through 4 accounted for 17 (30.4%), 20 (35.7%), 12 (21.4%), and 3 children (5.4%), respectively. Poor outcomes occurred in 17 children (30.4%), including 3 deaths (5.4%). The association with the poor outcomes was noted in the submersion time of longer than 5 minutes (adjusted odds ratio, 21.49; 95% confidence interval, 1.11-415.73; compared with < 1 minute) while not in the submersion time and chest radiographic grade. Conclusion: This study confirms that submersion time is an outcome predictor of drowning

침 및 운동 치료로 호전된 파킨슨병 환자 1례에 대한 증례보고

박미소,박상수,이승현,허왕정,유호룡 대한한방내과학회 2022 大韓韓方內科學會誌 Vol.43 No.5

Objectives: Parkinson’s disease is characterized by progressive, irreversible damage to dopamine neurons in the substantia nigra pars compacta, as well as motor and non-motor symptoms. This disease currently has no dependable disease-modifying treatment. In this paper, we describe the treatment of a 67-year-old female with Parkinson’s disease using acupuncture and exercise therapy. Case Presentation: Clinical symptoms and the United Kingdom Parkinson’s Disease Society Brain Bank Diagnostic Criteria were used to diagnose the patient with Parkinson’s disease. Over a 12-week period, the patient visited a Korean medicine hospital 18 times and was treated with acupuncture and exercise therapy in addition to anti-Parkinson’s drugs. Before and after treatment, clinical examinations were performed using tools such as the Unified Parkinson’s Disease Rating Scale, Fall Efficacy Scale, Parkinson’s Disease Questionnaire, Berg Balance Scale, and Non-Motor Symptoms Scale. Furthermore, functional near-infrared spectroscopy was used to assess cortical hemodynamics. All clinical examination results improved after 12 weeks of intervention. In particular, improvements on the Total Unified Parkinson’s Disease Rating Scale and Part III of this scale demonstrated large, clinically important differences. Conclusion: This case suggests that combining acupuncture and exercise therapy could produce an effective treatment for Parkinson’s disease patients.

음식물 섭취로 인한 혀 색상 변화가 설진에 미치는 영향

박미소,이주호,황윤신,김민서,박상수,유호룡,김기왕 한의병리학회 2020 동의생리병리학회지 Vol.34 No.4

The purpose of this pilot study was to examine the effect of tongue color change due to food ingestion on tongue diagnosis by both Korean Medicine doctors and digital tongue diagnosis system. In order to obtain objective and quantitative data, we used digital camera to collect the data. Prior to our investigation, we conducted a brief survey of 26 Korean Medicine doctors and found out that tongue diagnosis is frequently used and food-stained tongue could be commonly observed in clinics. Depending on their color, viscosity, and amount of intake, various foods caused stains with different colors and thicknesses. Also, duration and amount of food stain on tongue were different from person to person. Since coffee-stained tongue was the most frequently observed one in clinics according to the survey, we used coffee to evaluate the effect of food-stained tongue on tongue diagnosis. Korean Medicine doctors tended to interpret coffee-stained tongue as having yellow tongue coat but their judgement on tongue body color did not differ in spite of the coffee stains. Meanwhile, tongue diagnosis system algorithm tended to judge coffee-stained tongue as having normal but yellowish tongue coat and reddish tongue body. Altogether, food color on tongue can influence tongue diagnosis outcomes. Further research is needed in order to develop more efficient tongue diagnosis algorithm and digital medical service system.

UAV와 딥러닝을 활용한 야적퇴비 탐지 및 관리등급 산정

박미소,김흥민,김영민,박수호,김탁영,장선웅 대한원격탐사학회 2024 大韓遠隔探査學會誌 Vol.40 No.1

This research assessed the applicability of the You Only Look Once (YOLO)v8 and DeepLabv3+models for the effective detection of compost heaps, identified as a significant source of non-pointsource pollution. Utilizing high-resolution imagery acquired through Unmanned Aerial Vehicles (UAVs),the study conducted a comprehensive comparison and analysis of the quantitative and qualitativeperformances. In the quantitative evaluation, the YOLOv8 model demonstrated superior performanceacross various metrics, particularly in its ability to accurately distinguish the presence or absence of coverson compost heaps. These outcomes imply that the YOLOv8 model is highly effective in the precisedetection and classification of compost heaps, thereby providing a novel approach for assessing themanagement grades of compost heaps and contributing to non-point source pollution management. Thisstudy suggests that utilizing UAVs and deep learning technologies for detecting and managing compostheaps can address the constraints linked to traditional field survey methods, thereby facilitating theestablishment of accurate and effective non-point source pollution management strategies, and contributingto the safeguarding of aquatic environments.