A Case of Large Laryngomucocele

문수진,이지은,홍승노,최효근,김광현,정영호,Mun, Sue Jean,Lee, Ji-Eun,Hong, Seung No,Choi, Hyo Geun,Kim, Kwang Hyun,Jung, Young Ho The Korean Society for Head and Neck Oncology 2012 대한두경부 종양학회지 Vol.28 No.2

후두낭종은 후두소낭의 비정상적인 팽창으로 발생하는 드문 질환이다. 후두낭종의 크기와 증상에 따라 치료 방법은 단순 경과관찰에서부터 흡인, 경화제 주입, 수술적 치료까지 다양하다. 수술적 치료는 외적 접근법, 내시경적 접근법 또는 두 접근법을 혼용한 접근법을 통해 이루어진다. 최근 저자들은 경부 외적 접근법 및 연골막하 절제를 통한 혼합 후두점액낭종 1예의 치료를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

Hemorrhagic pericarditis with cardiac tamponade after percutaneous coronary intervention associated with the use of abciximab

문수진,윤희정,허성호,이종민,안호정,이연정,진승원 대한내과학회 2008 The Korean Journal of Internal Medicine Vol.23 No.3

Glycoprotein (GP) IIb/IIIa inhibitors, such as abciximab, are used as adjunctive therapy for percutaneous coronary intervention (PCI) in high-risk non-ST-elevation myocardial infarction (NSTEMI) and in ST-elevation myocardial infarction (STEMI), although their effects when used for STEMI are less clear. As the use of GP IIb/IIIa inhibitors becomes more widespread, determining the risks associated with them becomes more important. The major risks associated with the use of GP IIb/IIIa inhibitors are the potential for major bleeding and thrombocytopenia. This is the first reported case in Korea of hemorrhagic pericarditis resulting in cardiac tamponade associated with the use of abciximab, a commonly used GP Ilb/IIa inhibitor, following PCI.

위-아래 접근법으로 치료한 전두동 점액낭종 3예

문수진,김순구,정재환,노환중 대한이비인후과학회 부산,울산,경남 지부회 2014 임상이비인후과 Vol.25 No.2

A mucocele is a pseudo-cystic, epithelium-lined mucus containing lesion of the paranasal sinuses. It is caused by chronic inflammation or followed by physical or iatrogenic trauma to the lining mucosa. The frontal sinus and/or ethmoid sinus mucocles are the most frequent sinus of which endonasal endoscopic marsupialization is considered as the first choice of treatment. However, in case of frontal mucocele with lateral extension or when frontal sinus outflow tract is completely obstructed by hypertrophied mucosa or new bone formation, it is hard to open all the lesions using endonasal endoscopic approach only. We report 3 cases of frontal sinus mucocele caused by physical or iatrogenic trauma which was treated with above (trephination) and below (endonasal) approach with a literature review.

Periarticular Osteoporosis Is a Prominent Feature in Early Rheumatoid Arthritis: Estimation Using Shaft to Periarticular Bone Mineral Density Ratio

문수진,Inhye E. Ahn,곽승기,박경수,민준기,박성환,김호윤,주지현 대한의학회 2013 Journal of Korean medical science Vol.28 No.2

We aimed to quantify periarticular osteoporosis and investigate its significance in 45patients with rheumatoid arthritis (RA) and 106 controls. Dual-energy X-ray absorptiometry (DXA) was used to determine the ratio of shaft to periarticular bone mineral density (BMD) as an index of periarticular demineralization. Periarticular osteoporosis was measured by conventional radiography. The BMDs of shaft and periarticular regions in eight designated areas on proximal phalanges were quantified. Clinical variables were examined to identify risk factors for periarticular osteoporosis. The assessment of periarticular osteoporosis on X-ray images reached a moderate degree of interobserver agreement among four physicians (κ = 0.47). For BMD quantification, we designed three types of mathematical formulae: the ratio of shaft to periarticular BMD,the mean of the ratios, and the ratio of the sums. These ratios were significantly higher in the patients with early RA (disease duration ≤ 3 yr) than in controls (P < 0.01). The findings were not as distinctive in patients with established RA. Body mass index,cumulative dose of corticosteroid, and C-terminal telopeptide were correlated with BMD ratios. Conclusively, DXA-assisted localized quantification and BMD ratio calculations are feasible for assessing periarticular demineralization. Periarticular osteoporosis is a relatively distinctive feature of early RA.

디지털 날염 잉크 개발동향

문수진 한국염색가공학회 2006 염색가공 Vol.1 No.-

Ursodeoxycholic Acid Ameliorates Pain Severity and Cartilage Degeneration in Monosodium Iodoacetate-Induced Osteoarthritis in Rats

문수진,정정희,전주연,양은지,민준기,최종영,조미라 대한면역학회 2014 Immune Network Vol.14 No.1

Osteoarthritis (OA) is a degenerative joint disease characterized by a progressive loss of cartilage. And, increased oxidative stress plays a relevant role in the pathogenesis of OA. Ursodeoxycholic acid (UDCA) is a used drug for liver diseases known for its free radical-scavenging property. The objectives of this study were to investigate the in vivo effects of UDCA on pain severity and cartilage degeneration using an experimental OA model and to explore its mode of actions. OA was induced in rats by intra-articular injection of monosodium iodoacetate (MIA) to the knee. Oral administration UDCA was initiated on the day of MIA injection. Limb nociception was assessed by measuring the paw withdrawal latency and threshold. Samples were analyzed macroscopically and histologically. Immunohistochemistry was used to investigate the expression of interleukin-1β (IL-1β), IL-6, nitrotyrosine and inducible nitric oxide synthase (iNOS) in knee joints. UDCA showed an antinociceptive property and attenuated cartilage degeneration. OA rats given oral UDCA significantly exhibited a decreased number of osteoclasts in subchondral bone legion compared with the vehicle-treated OA group. UDCA reduced the expression of IL-1β, IL-6, nitrotyrosine and iNOS in articular cartilage. UDCA treatment significantly attenuated the mRNA expression of matrix metalloproteinase-3 (MMP-3), -13, and ADAMTS5 in IL-1β-stimulated human OA chondrocytes. These results show the inhibitory effects of UDCA on pain production and cartilage degeneration in experimentally induced OA. The chondroprotective properties of UDCA were achieved by suppressing oxidative damage and inhibiting catabolic factors that are implicated in the pathogenesis of cartilage damage in OA.

In vivo action of IL-27: reciprocal regulation of Th17 and Treg cells in collagen-induced arthritis

문수진,박진실,허유정,강창민,김은경,임미애,류준걸,성영철,박경수,박성환,김호연,민준기,박성정,조미라 생화학분자생물학회 2013 Experimental and molecular medicine Vol.45 No.10

Interleukin (IL)-27 is a novel cytokine of the IL-6/IL-12 family that has been reported to be involved in the pathogenesis of autoimmune diseases and has a pivotal role as both a pro- and anti-inflammatory cytokine. We investigated the in vivo effects of IL-27 on arthritis severity in a murine collagen-induced arthritis (CIA) model and its mechanism of action regarding control of regulatory T (Tregs) and IL-17-producing T helper 17 (Th17) cells. IL-27-Fc-treated CIA mice showed a lower severity of arthritis. IL-17 expression in the spleens was significantly decreased in IL-27-Fc-treated CIA mice compared with that in the CIA model. The Th17 population was decreased in the spleens of IL-27-Fc-treated CIA mice, whereas the CD4þCD25þFoxp3þTreg population increased. In vitro studies revealed that IL-27 inhibited IL-17 production in murine CD4þ T cells, and the effect was associated with retinoic acid-related orphan receptor cT and signal transducer and activator of transcription 3inhibition. In contrast, fluorescein isothiocyanate-labeled forkhead box P3 (Foxp3) and IL-10 were profoundly augmented by IL-27 treatment. Regarding the suppressive capacity of Treg cells, the proportions of CTLA-4þ (cytotoxic T-lymphocyte antigen 4), PD-1þ (programmed cell death protein 1) and GITRþ (glucocorticoid-induced tumor necrosis factor receptor) Tregs increased in the spleens of IL-27-Fc-treated CIA mice. Furthermore, in vitro differentiated Treg cells with IL-27 exerted a more suppressive capacity on T-cell proliferation. We found that IL-27 acts as a reciprocal regulator of the Th17 and Treg populations in CD4þ cells isolated from healthy human peripheral blood mononuclear cells (PBMCs), as well as from humans with rheumatoid arthritis (RA) PBMCs. Our study suggests that IL-27 has the potential to ameliorate overwhelming inflammation in patients with RA through a reciprocal regulation of Th17 and Treg cells.

유전성 출혈성 모세혈관확장증의 임상 양상 및 동반 질환

문수진,유영태,조성우,이지은,한두희,민양기,진홍률 대한이비인후과학회 2012 대한이비인후과학회지 두경부외과학 Vol.55 No.4

Background and Objectives Hereditary hemorrhagic telangiectasia (HHT), often manifested as epistaxis, is also manifested in combination with serious comorbid diseases. The authors reviewed 12 cases of HHT and investigated the manifestations and comorbid diseases of HHT in the Korean population. Subjects and Method Medical records of the HHT patients in our department from July 2004 to December 2011 were reviewed retrospectively. Twelve patients who had been classified as definite or possible HHT according to the Curacao criteria were enrolled in this study. Clinical manifestations, treatment methods, results, and comorbid diseases were investigated. Results Recurrent epistaxis occurred in 100% of the patients. Epistaxis was managed by bipolar or laser cauterization (n=9), embolization of the feeding vessel (n=1), intranasal application of bevacizumab (Avastin®)(n=2) or septodermoplasty (n=1). The symptoms of seven patients showed much improvement while the other two did not. Comorbid diseases included pulmonary arteriovenous malformation (AVM) in 5 patients (41.7%) and cerebral AVM in 2 patients (16.7%). Three patients with pulmonary AVM received embolization and one patient with cerebral AVM received gamma knife surgery with good prognosis. Conclusion Epistaxis by HHT can be improved by active treatment using various methods. Pulmonary and cerebral AVMs are common comorbid diseases and should be considered in the management of HHT.

베이지안 모델 평균기법을 적용한 GCM전망의 시공간적 불확실성 평가

문수진,강부식 한국기상학회 2015 한국기상학회 학술대회 논문집 Vol.2015 No.10

o-Nitrobenzyl Ester기를 이용한 감광성 폴리이미드의 합성과 그 특성

문수진,주소영,전병철,홍성일 한국섬유공학회 1992 한국섬유공학회지 Vol.29 No.11

The photosensitive polyamide precursors were synthesized from pyromellitic acid dich-loride di(o-nitrobenzyl) ester with o-nitrobenzyl group and two amines such as m-phenylene diamine and m-diaminobenzophenone by interfacial polycondensation reaction. The polymers obtained were able to be converted into usual polyimide by curing The photoreaction mechanism of photosensitive polyimide precursors was investigated by UV and NMR spectroscopy. It was considered from the absorbance of UV at 23O~28Onm that characteristic rearrangement in the o-nitrobenzyl ester occurred m this system. Their thermal properties were studied using thermogravimetry, both polylmide precursors exhibited the weight loss in two stages. The second weight loss depends on the thermal degradation of polyimide. Noticeable weight loss was observed at about 500˚C. After preparing photoresist from these polyimide precursors synthesized, normalized thickness remaining were measured with varying exposure energy to determine whether the polymers can be used as a commercial photoresist.