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기니픽 대뇌 피질에서 [^3H]norepinephrine 유리에 대한 오피오이드 수용체의 상호작용
백승호,노시운,정회상,장광철,장미경,조규박 의과학연구소 1995 全北醫大論文集 Vol.19 No.1
포유류의 뇌에 존재하는 opioid수용체의 종류에는 μ, δ 그리고 k의 3가지 주된 형이 있으며 그 기능을 발현함에 있어서 상호작용을 하고 있음을 시사하는 많은 증거가 제시되고 있다. 본 연구에서는 [³H]NE 유리 조절에 있어서 서로 다른 opioid 수용체가 관여하는 기니픽과 백서의 대뇌피질 절편에서 prototype μ-agonist인 morphine 고선택적 μ-agonist DAMGO 그리고 k₁-agonist인 U69,593의 [³H]NE 유리억제효과에 대한 δ ₁ 수용체, agonist인 DPDPE 그리고 δ₂수용체 agonist인 deltorphin Ⅱ의 영향을 검토하여 opioid 수용체 상호작용을 시험관내 실험으로써 증명하고, 이를 매개하는 δ 수용체의 subtype을 규명코자 하였다. 본 실험에서 morphine, DAMGO 및 U69,593은 기니픽 대뇌피질절편에서 고칼륨에 의한 [³H]NE 의 유리를 용량의존적으로 억제하였으며, 자체로써 효과를 보이지 않는 농도의 DPDPE또는 DLTP에 의하여 유의하게 강화되었다. 그 강화효과의 정도는 U69,593, morphine 그리고 DAMGO의 순이었다. Morphine 또는 U69,593의 [³H]NE 유리억제효과에 대한 강화작용은 DPDPE보다 DLTP이 더욱 강력하였다. 그러나 백서에서는 기니픽의 경우와 달리 DPDPE 또는DLTP의 첨가는 morphine는 DAMGO의 효과에 전혀 영향을 주지 못하였다. 본 연구의 결과는 opioid δ 수용체와 μ 또는k 수용체간에 기능적인 상호관계를 시험관내 실험을 통하여 증명하는 것이며, 이 상호작용에 의한 효과는 두 수용체의 자극효과가 동일한 경우에 출현하는 것을 시사한다.
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백서 대뇌 피질에서 허혈에 의한 [^3H]5-Hydroxytryptamine의 유리
장영문,송은석,노시운,김성수,김재천,김기원 의과학연구소 1995 全北醫大論文集 Vol.19 No.1
In an attempt to elucidate the mechanisms for ischemia-induced release of neurotransmitters in vitro. I examined the ischemia-induced release of [^3H]5-hydroxytryptamine(5-HT) from cerebral cortex of the rat. Ischemia, deprivation of oxygen and glucose, induced significant release of [^3H]5-HT(about 6% of total tissue content) from the cerebral cortex in vitro. This ischemia-induced release of [^3H]5-HT from the cerebral cortex was significantly attenuated by TTX(1μM), Mg^2+(1.2mM), MK-801(10μM), ketamine(10μM), NMDA receptor antagonists, DNQX(30μM), a kainate/AMPA receptor antagonist, or carbetapentane(30μM), an inhibitor of glutamate release. Dantrolene(30μM) and ryanodine(100μM), inhibitors of intracellular Ca^2+ release, flunarizine(5μM) and ω-conotxin(100μM), inihbitors of N-type Ca^2+ channels, signficantly attenuated the ischemia-induced release of [^3H]5-HT, but verapamil(5μM), and inhibitor of L-type Ca^2+ chnnels, did not. Fluoxetine(1μM), a relatively selective 5-HT transporter blocker, significantly inhibited the ischemia-induced release of [^3H]5-HT. These results suggest that ischemia-evoked release of norepinephrine was caused by release of glutamate via activation of NMDA and non-NMDA receptors, and that CA^2+-dependent and -independent release processes are underlying in this phenomenon.
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기관내 삽관에 의한 혈역학적 변동에 대한 Labetalol 과 Fentanyl 의 효과
김성수,김동찬,송희선,노시운,김동순 대한마취과학회 1992 Korean Journal of Anesthesiology Vol.25 No.5
Induction of general anesthesia with tracheal intubation may eause hypertension and tachycardia with concomitant increase in plasam catecholamine concentration. These transient stress responses are undesirable, especially in patients with cardiovascular or intracrainal diseases. Many drugs(topical or i.v. lidocaine, inhalation anestheties, opioids, adrenergic blockers, etc) are used in an attempt to blunt these potentially adverse hemodynamic responses. This study was made to examine blunting effect of labetalol and fentanyl for hemodynamic changes after tracheal intubation. Eighty patients, ASA physical status I or II, scheduled for elective surgery were selected randomly. They were divided into four groups. Group l: Control(saline)(n=20) Group 2: Labetalol 0.125 mg/kg(n=20) Group 3: Labetalol 0.25 mg/kg(n=20) Group 4: Fentanyl 3 μg/kg(n=20) Study drugs were injected 3 minutes before induction with thiopental sodium. Patients were induced with thiopental sodium 5 mg/kg and succinylcholine chloride l mg/kg iv.in all groups. 5 minutes after injection of study drug, laryngoscopy was initiated and performed tracheal in-tubation. After the completion of intubation, 50% nitrous oxide in oxygen and 1.5vol.% halothane was administed. The blood pressure and heart rate were measured using automated noninvasive blood pressure device and E.C.G. monitoring for 10 minutes per 1 minute. Data were analyzed with Stu- dent's t-test within the group and unpaired t-test between the groups. P$lt;0.05 was considered significant. Labetalol or fentanyl pretreatment significantly blunted the increase in heart rate and rate pressure product caused by laryngoscopy and endotracheal intubation. But the increase of arterial blood pressure was blunted significantly in fentanyl 3 μg/kg group. Labetalol and fentanyl may offer an important role in patients in whom an increase in blood pressure, heart rate and/or rate pressure product should be avoided during the endotracheal intubation.
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최인철,김성덕,고홍,김광우,김석곤,민성원,노시운,김계용,정영균 대한마취과학회 1988 Korean Journal of Anesthesiology Vol.21 No.6
We experienced one case of anesthesia for liver transplantation in a 14-year-old girl with Wilson's disease. The liver was donated from a patient with a brain tumor who was diagnosed as brain death. We monitored blood pressure, heart rate, cardiac output, pulmonary capillary wedge pressure, systemic vascular resistance, arterial pH, arterial PCO_2, serum potassium, ionized calcium, glucose, and blood coagulation states including platelet count, prothrombin time, activated partial thromboplastin time and coagulation factor assay, We used isoflurane and nitrous oxide as the main inhalation anesthetics. The operation was performed without serious problem. The patient became conscious three hours after the operation.
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