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노동현,임수호,차순철,Dong Hyoun Noh,MD,Su-Ho Lim,MD,Soon Cheol Cha,MD,PhD 대한안과학회 2012 대한안과학회지 Vol.53 No.11
Purpose: To compare the corneal endothelial cell changes in both eyes of Korean patients with clinically unilateral exfoliation syndrome using specular microscopy. Methods: A total of 144 eyes of 72 patients diagnosed with clinically unilateral exfoliation syndrome at Yeungnam University Hospital between March 2000 and February 2011 were retrospectively reviewed. Comparisons of corneal morphometric analysis were made including endothelial cell density, coefficient of variation, hexagonality, and central corneal thickness between the exfoliative and fellow non-exfoliative eyes in 72 patients with naive unilateral exfoliation syndrome. If patients received intraocular surgery during the follow-up periods, the number of intraocular surgeries and changes of the above-mentioned morphometric analysis were evaluated. Results: The paired exfoliative and fellow non-exfoliative eyes did not differ in endothelial cell density (2587.0 ± 391.0 vs. 2626.8 ± 354.6 cells/mm2, p = 0.321), in the coefficient of variation of cell size (35.9 ± 5.1 vs. 37.1 ± 4.7%), hexagonality (59.5 ± 7.3 vs. 57.8 ± 6.3%), and central corneal thickness (530.5 ± 37.6 vs. 532.0 ± 35.2 μm). However, the exfoliative eyes had significantly higher values for the number of intraocular surgeries (0.97 ± 0.78 vs. 0.28 ± 0.48, p < 0.001) and decrement of corneal endothelial cells (410.9 ± 538.7 vs. 19.0 ± 284.5 cells/mm2, p = 0.007). Conclusions: There were no significant morphologic differences in corneal endothelium between exfoliative eyes and fellow eyes in the present study. However, the authors suggest that specular microscopic examination be performed before intraocular surgery in eyes with exfoliation syndrome when considering the higher frequency of intraocular surgeries and the resultant corneal endothelial damages observed in the present study.
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노동현,이재열 한국CDE학회 2022 한국CDE학회 논문집 Vol.27 No.3
As the number of personal mobility users increases, it is essential to protect both personal mobility users and car drivers. Although existing supervised learning-based object detection methods can recognize personal mobilities, processing for data collection, labeling, and training is time-consuming and expensive whenever new forms of personal mobilities come to the market. Anomaly detection-based methods are proposed to learn normal patterns and detect abnormal patterns without prior training. This study proposes a new approach to personal mobility user recognition using deep learning-based anomaly detection in dynamically changing driving environments. The proposed approach consists of Human detection, Cropping and Anomaly detection modules. The Human detection module detects human regions. The Cropping module removes unnecessary areas and performs a preprocessing. The memory-based Anomaly detection module distinguishes between pedestrians and personal mobility users. Based on the proposed anomaly detection method, augmented reality (AR) visualization in the head-up display (HUD) is proposed for effective driving assistance. Since it is possible to distinguish pedestrians and mobility users effectively, the AR HUD-based visualization can assist the driver to pay more attention to the mobility user.
노동현,최웅선,김준범,Hyun-Yong Yu,최낙원,조일주 한국바이오칩학회 2018 BioChip Journal Vol.12 No.4
Hydrogel scaffolds composed of multiple components are promising platform in tissue engineering as a transplantation materials or artificial organs. Here, we present a new fabrication method for implementing multi-layered macroscopic hydrogel scaffold composed of multiple components by controlling height of hydrogel layer through precise control of ultraviolet (UV) energy density. Through the repetition of the photolithography process with energy control, we can form several layers of hydrogel with different height. We characterized UV energy-dependent profiles with single-layered PEGDA posts photocrosslinked by the modular methodology and examined the optical effect on the fabrication of multi-layered, macroscopic hydrogel structure. Finally, we successfully demonstrated the potential applicability of our approach by fabricating various macroscopic hydrogel constructs composed of multiple hydrogel layers.
노동현,김도형,김나래,박종선,이창헌,김미경,최영식 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.2
전격성 제1형 당뇨병은 특발성 당뇨병환자에서 임상 경과가 짧고 진단 당시 심각한 대사 합병증을 동반하면서 췌장 효소 수치가 높고 췌도 특이 자가항체가 음성인 새로운 아형으로 알려져 있으며, 일본과 일본 외에서의 유병률에는 차이가 있는 것으로 보인다. 아직 전격성 제1형 당뇨병의 발생 기전은 명확하지 않으며 유전적 감수성이 있는 개체에서 바이러스 감염 등의 환경적인 인자와의 연관성이 가능한 병태생리로 제시되고 있으며 이에 대한 추가적인 연구가 요구된다. 저자들은 케톤산증으로 내원하여 전격성 제1형 당뇨병을 진단받은 증례를 경험하였기에 문헌고찰과 함께 보고 하는 바이다. Some patients with idiopathic type 1 diabetes have a fulminant disorder characterized by the absence of insulitis and of diabetes-related antibodies, a remarkably abrupt onset and high serum pancreatic enzyme concentrations. This is referred to as fulminant type 1 diabetes. A 29-year-old man suffering from abdominal pain, nausea and vomiting consulted to our hospital. Laboratory findings revealed high blood glucose level and the evidence of diabetic ketoacidosis, but the serum HbA1c was normal nevertheless. The low level of plasma C-peptide indicated the loss of endogenous insulin secretion. The patient satisfied the criteria for the diagnosis of fulminant type 1 diabetes. After the patient has been treated with insulin, his symptoms were improved and abnormal laboratory data were normalized. We report this case with a review of the literature