중금속 제거용 셀룰로오즈 잔테이트의 제조 및 응용

김형태,이태호,김상대,이경렬,윤진수,이기세 ( Hyung Tae Kim,Tae Ho Lee,Sang Dae Kim,Kyung Youl Lee,Jin Soo Yun,Ki Say Lee ) 한국화학공학회 1996 화학공학의이론과응용 Vol.2 No.2

경항문 내시경 수술 도구에서의 최적 활동 반경 개선을 위한 컴퓨터 시뮬레이션 연구

김형태,김광기,남경원,김현호,손대경,Kim, Hyung-Tae,Kim, Kwang-Gi,Sohn, Dae-Kyung,Kim, Hyun-Ho,Nam, Kyoung-Won 대한의용생체공학회 2009 의공학회지 Vol.30 No.6

Conventional devices for transanal endoscopic microsurgery that are currently used clinically for intestine or rectal cancer patients have 40 mm external diameter of rectoscope tube - induces anal damage and long-term postoperative pain for small-sized patients. In this paper, we designed rectum and rectoscope models and calculated the changing trends of operation area of the surgical tools in accordance with the step-by-step variation of design parameters of the rectoscope tube - external diameter, axial length, and distal angle. Using the results of computer simulation, we suggested an optimal set of design parameters that minimizes external diameter of the rectoscope tube and at the same time, maintains similar operation area of the surgical tools compared with commercialized devices (${\geq}\;4274.7mm^2$). The results of the simulation showed that the optimal design parameters were 35 mm external diameter, 100 mm axial length, and $45^{\circ}$ distal angle of the rectoscope tube. This result can be applied to the development of endoscopic microsurgery device that can minimize side effects to the intestine or rectal cancer patients.

심한 소장침범을 보인 Henoch-Schonlein Purpura의 치료 2례

김형태,문진수,장현오,조희승,이종국,김기홍,서정욱,김민경,Kim, Hyung Tae,Moon, Jin Soo,Jang, Hyun Oh,Jo, Heui Seung,Lee, Jong Guk,Kim, Ki Hong,Seo, Jung Wook,Kim, Min Kyung 대한소아소화기영양학회 2004 Pediatric gastroenterology, hepatology & nutrition Vol.7 No.1

보존적인 스테로이드 치료로 호전이 없는 심한 복부증상을 동반한 HSP 환자의 치료에는 아직까지 정설이 없으나, 저자들은 면역글로불린 정맥투여로 증상이 호전된 증례와 소장의 경장괴사를 동반하고 수술적 치료로 호전된 증례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Henoch-$Sch{\ddot{o}}nlein$ purpura (HSP) is a vasculitis of the small vessels in skin, joints, gastrointestinal (GI) tract and kidney. GI symptoms occur in up to 85% of patients and may lead to severe problems such as intussusception, obstruction, and perforation. GI symptoms may not be easily controlled, showing refractoriness to the conventional corticosteroid therapy. Although GI involvements of HSP are acute, and self-limited in most instances, they may cause fatal results in some unusual cases. In such conditions all the possible therapeutic modalities should be considered. We report two cases of severe small bowel involvement of HSP. One case presented with severe abdominal pain showing refractoriness to corticosteroid, but improved with IV immunoglobulin therapy. In the second case, HSP with transmural infarction in the small bowel could be cured with surgical intervention.

트리메토프림과 ${\beta}$-시클로덱스트린 고분자 간의 포접복합체 형성에 의한 용출 및 안정성 향상

김형태,박경옥,서성훈,Kim, Hyung-Tae,Park, Kyung-Ock,Seo, Seong-Hoon 한국약제학회 1992 Journal of Pharmaceutical Investigation Vol.22 No.2

To improve the solubility and dissolution rate of trimethoprim (TMP), which is slightly soluble drug, its inclusion complexes were prepared and studied in this experiment. Inclusion complexes of TMP with ${\beta}-cyclodextrin$ and ${\beta}-cyclodextrin$ polymer (CDPS) were prepared according to Fenyvesi method. These were compared with TMP and its physical mixture with CDPS. Water, diluted hydrochloric acid and phosphate buffer solution were used as dissolution media. And accelerated stability test was studied at $50,\;70\;and \;80^{\circ}C$. It was found that solubility and dissolution rate of inclusion complexes were increased in water. Especially, the solubility and dissolution rate of TMP was found to be markedly increased by inclusion complexation with CDPS. In stability test, ${\beta}-cyclodextrin$ inclusion complexes were more or less stable than TMP alone. This tendency was not led in CDPS. Consequently, CDPS was useful in increasing dissolution rate and stability of TMP.

외래에서 시행되는 585 nm 펄스다이레이져 후두수술

김형태,Kim, Hyung-Tae 대한후두음성언어의학회 2009 대한후두음성언어의학회지 Vol.20 No.1

Introduction: 585 nm Pulsed dye laser (PDL) laryngeal surgery is based on the photodynamic characteristics of selective photothermolysis and photoangiolysis and recently considered to be the treatment for a variety of benign laryngeal disease. Objective: To review the indications and outcome of office-based 585nm PDL surgery and summarize new developments. Method: Retrospective study involving 402 patients was performed, The PDL surgery could be applied to various laryngeal diseases such as laryngeal papilloma, vocal fold dysplasia, laryngeal granuloma, vocal polyp, capillarectasia, scarred vocal fold and sulcus vocalis. Results : The physiologic properties of the vascular specificity of PDL provide many advantages and appear to be effective for laryngeal treatment. The PDL resulted in precise, selective coagulation of the microvasculature without damage to the surrounding tissue. Therefore PDL surgery is safe and effective for office-based treatment of benign laryngeal disease and for all patients regardless of their overall medical condition. Conclusion: PDL surgery provides potential benefits and advantage for treating common benign laryngeal disease.

만성 육아종 질환에 동반된 급성 연쇄상 구균 감염 후 사구체 신염 1례

김형태,서정욱,김한성,이종국,Kim Hyung-Tae,Seo Jung-Wook,Kim Han-Seong,Lee Chong-Guk 대한소아신장학회 2003 Childhood kidney diseases Vol.7 No.2

Chronic granulomatous disease(CGD) is a rare inherited disorder of phagocytic cells which results in a susceptibility to infections by catalase-positive bacteria and fungi, as well as granuloma formation. And acute poststreptococcal glomerulonephritis(APSGN) is one of the most common glomerular lesions of gross hematuria in children. We experienced a case of APSGN accompanied with CGD presenting with a liver granuloma. 저자들은 만성 육아종 질환에 동반된 APSGN을 경험하였기에 문헌 고찰과 함께 보고한다.

하악골의 발육중인 생쥐에서 기능력의 변화가 특이-유전자 발현에 미치는 영향

김형태,박주철,이창섭,박헌동,Kim, Hyung-Tae,Park, Joo-Cheol,Lee, Chang-Seop,Park, Heon-Dong 대한소아치과학회 2003 大韓小兒齒科學會誌 Vol.30 No.2

기능력은 뼈의 형성, 유지 및 개조 이외에도 치아이동, 교정치료, 기능성 악교정장치의 사용 등과 관련한 치주인대세포의 특성 변화 등에 중요한 영향을 미친다. 또한, 하악과두에서도 기능력의 변화에 따라서 다양한 특성의 변화가 나타난다. 본 연구에서는 ICR 생쥐를 8주 동안 soft-diet와 hard-diet의 식이 조절을 통해 기능력의 변화를 유도하여, 기능력의 변화와 관련한 특이 유전자를 검출하기 위하여 subtractive hybridization, northern 분석 및 mRNA in-situ hybidization 등의 실험을 시행하여 다음과 같은 결과를 얻었다. 1. Soft-diet군과 hard-diet군의 subtractive hybridization을 통하여 총 39개의 clone을 얻었고 이중에서 11개의 서로 다른 hard-diet군 특이 후보 유전자들을 분리하였다. 2. 11개의 후보 유전자들 중에서 homology 검색과 northern 분석을 통하여 기능력과 관련이 있을 것으로 생각되거나 hard-diet군에서 mRNA가 선택적으로 발현되는 FS-s2, FS-s5, FS-s18 및 Fs-s22 유전자를 선택하였다. 3. Soft-diet군과 hard-diet군의 형태학적 분석에서 soft-diet군은 hard-diet군에 비하여 골모세포의 활성과 골개조의 특성은 저하된 것으로 관찰되었으나, 하악과두의 연골성골화 과정은 오랜 시간동안 지속되는 것으로 나타났다. 4. FS-s2, FS-s5, FS-s18 및 Fs-s22 유전자의 cRNA 탐침자를 이용한 in-situ hybridization에서 4개의 유전자의 mRNA들은 hard-diet군의 세포들에서는 강하게 발현되었으나 soft-diet군의 세포들에서는 그 발현이 미약하거나 나타나지 않았다. 이상의 결과를 종합하여 FS-s2, FS-s5, FS-s18 및 Fs-s22 유전자들은 대부분이 기능이 거의 알려져 있지 않는 것들로 기능력의 변화 과정에서 중요한 역할을 할 것으로 생각되나 앞으로 보완 연구를 통하여 각 각의 유전자들의 보다 정확한 기능을 이해하는 것이 필요 할 것으로 사료된다. Mechanical forces are known to have an effect on bone formation, maintenance and remodeling, and there is evidence that the development of the mandibular condyle in the rat or mouse is influenced by altered functional force. However, studies are lacking in molecular-biologic mechanism such as the identification of differentiation factor induced from functional force. Here a mouse model was used to investigate the functional stress-responsive gene or factors which is related to the altered force by comparing the expression genes of functional state and hypo-functional state of the mouse mandible. ICR mice were provisioned with either a soft, mushy diet (soft-diet group) or hard rat pellets (hard-diet group) beginning at weaning for the alteration of functional force and subsequently sacrificed at 89 days of age. Incisor of mice in group 1 were trimmed twice a week to reduce occlusal forces. After killing the animals, mandibular bone including condyle were collected for RNA extraction, subtractive hybridization, northern blot analysis and mRNA in-situ hybridization. The results as follows; 1. A total of 39 clones were sequenced, and 11 individual sequence types were subsequently identified by subtractive hybridization, as 28 clones were represented twice in the analyzed sets. 2. Consequently four candidate clones, FS-s (functional stress-specific)2, -5, -18, and -22 were identified and characterized by homolgy search and northern analysis. Four of these clones, FS-s2, -5, -18, and -22, were shown to be expressed differentially in the hard-diet group. 3. Histologic sections showed that osteoblastic activity along the bone trabeculae and active bone remodeling were significantly lower in soft than in hard diet animals. A soft diet seems to enable a longer period of endochondral ossification in the mandibular condyle. 4. Although the mRNAs of FS-s2, -5, -18, and -22 were expressed rarely by cells of the soft-diet group, highest expression was detected in the cells of the hard-diet group. Together with the above results, it is suggested that FS-s2, -5, -18, and -22 could act as an important factors controlling the tissue changes in response to functional stress. The exact functional significance of these findings remains to be established.

가임신 흰쥐에 있어서 자궁척출 및 Prostaglandin F2α 투여가 혈청 Progesterone 의 농도 및 황체에 미치는 영향

김형태,정영채,김창근 ( Hyung Tae Kim,Yung Chai Chung,Chang Keun Kim ) 한국축산학회 1981 한국축산학회지 Vol.23 No.4

The purpose of this experiment was to investigate the effects of hysterectomy and administration of PGF₂α on serum progesterone level and corpus luteum in pesudopregnant rats. PGF₂α administration or hysterectomy was performed at day S of pseudopregnancy. Five rats from each group were randomly sacrificed at day 5,6,7,8,9 and 12 of pseudopregnancy for assay of serum progesterone level and microscopic observation of ovary. The results obtained were as follows; 1. In both normal and hysterectomized groups, PGF₂α administration caused significant reduction in serum progesterone level to 24.2% and 30.8% at day 6 and to 11.3% and 34.3% at day 9 of pseudopregnancy as compared with pretreatment level. The serum progesterone level of hysterectomized group untreated with PGF₂α remained elevated until day 12 of pseudopregnancy as compared to those of other three groups. 2. The ovarian weights of control group treated with PGF₂α were significantly reduced as compared to those of other three groups at day 9 of pseudopregnancy (p$lt;0.05). 3. The number of corpus luteum in groups treated with PGF₂α was slightly reduced, but there were no significant difference between PGF₂α and non-PGF₂α treated groups at day 6,7,8,9 of pseudopregnancy. 4. The number of lutein cell in corpus luteum of PGF₂α treated groups on day 9 of pseudopregnancy was significantly lower than those of PGF₂α untreated groups (p$lt;0.05).

의원필담(醫員筆談) 『화한의화(和韓醫話)』를 통한 조일(朝日) 의료 풍속의 고찰

김형태(Kim, Hyung-Tae) 부산대학교 한국민족문화연구소 2014 한국민족문화 Vol.52 No.-

1764년 통신사(通信使) 의원필담 중 일본 의원 야마구치 타다오키(山口忠居)와 조선 양의 이좌국(李佐國)의 대화를 담고 있는 『화한의화』는 당시 조선과 일본에 유행하던 질병과 치법을 비롯한 18세기 양국의 의료 풍속을 자세하게 보여주는 자료이다. 이 점은 다른 의원필담에 비해 처방과 관련한 조선 의원의 답변이 매우 명쾌하다는 특색에 기인한다. 단지 조선의 양의(良醫)와 일본의 의원 사이에 나눈 이야기만 수록되었고, 그 대화의 기회도 짧았기 때문에 평소 양국 의원들이 품었던 의료 관심사를 압축해서 명료하게 보여주고 있는 것이다. 또한 기존 의원필담의 일본 측 의원들이 의서(醫書)에 기반한 의론(醫論) 등 학술적 측면에 관심이 지대했던 데 비해 『화한의화』는 18세기 의학 흐름이 경험방(經驗方)에 입각한 처방 위주의 실제 의료 행위 쪽으로 흘러가고 있었음을 잘 보여준다. 의료 풍속 관련 내용은 일반적으로 질병과 치법(治法), 약재와 물명(物名) 관련 정체성 규명, 서로 주고받은 치료약과 의서(醫書) 등으로 의원필담들에 구현된다. 『화한의화』는 이와 같은 내용을 종합적으로 수록하고 있는 자료이므로 많지 않은 분량으로도 당시 두 나라의 의료 풍속을 살펴볼 수 있는 매우 적절한 텍스트이다. 이 외에도 기존 의원필담들의 대부분에서 확인되는 관심사인 인삼(人蔘) 관련 기록이 매우 흥미롭고 독특하며, 서문(序文)과 발문(跋文)을 통해 의술의 의미와 의원(醫員)에게 요구되는 자질 등에 대한 당시의 가치관 등도 살펴볼 수 있다. 본 연구는 이처럼 종합적 성격의 텍스트인 『화한의화』 분석을 통해 18세기 조선과 일본의 의료 풍속 일면을 살펴보는 데 그 목적이 있다. 본문에서는 우선 『화한의화』의 서지사항을 살펴보았고, 질병 및 병인(病因)과 치법, 약재와 물명 관련 정체성 규명, 당시에 주목한 의서(醫書)와 비방(秘方) 등을 중심으로 논의를 전개하였다. 이러한 연구 과정은 향후 의료적 관점 중심의 동북아시아 풍속사를 재구성할 수 있는 토대라는 점에서 중요한 가치를 지닌다. This book is a conversation recorded Lee, Jwa-Guk(李佐國) and Yamaguchi Tadaoki(山口忠居) of written answer of the medical members(醫員筆談) in 1764. At the time the disease was prevalent in Chosun(朝鮮) and Japan, including the 18th century and cure medical customs of the two countries, showing a detailed source of information. Because the answer is very clear to members of the Chosun(朝鮮) medical members(醫員) had also compressed medical interests would clearly showing. Previously books include medical theory based on medical books and scholarly interests are on the side. But this book is the 18th century, the two countries tend to experience medical prescription of based on actual medical practice shows that is important to us. In general, written answer of the medical members(醫員筆談) customsrelated information contained in the disease, treatment, medicine, the name and identity of objects, each of them received medicines and medical books. The contents of this book is an important source of information containing comprehensive. In addition, customs at the time to look at two of the country"s medical is a very appropriate text. And ginseng(人蔘) records a very interesting and unique. Medicine means and medical members(醫員) at the time of asking for the qualities and values can also look at. Purpose of this paper is the comprehensive nature of the text, 『Hwahanuihwa(和韓醫話)』 18th century, Chosun(朝鮮) and Japan through the analysis to look at the medical customs. This research process in terms of the future medical center in Northeast Asia to reconstruct the history of customs can be important in the foundation.” Main subject of this paper, we first examined the bibliography. The cause and cure of disease and illness in the second chapter examined. Medicine and things related questions and answers are examined in the third chapter. Discreet medical attention at the time prescribed in the book and looked at the last chapter.

1748년 제10차 무진통신사(戊辰通信使) 의원필담(醫員筆談)의 성격 변천 연구 -『대려필어(對麗筆語)』와 『조선필담(朝鮮筆談)』을 중심으로-

김형태 ( Hyung Tae Kim ) 한국한문학회 2010 韓國漢文學硏究 Vol.0 No.46

1748년의 통신사 의원필담집은 내용에 따라 순수 의학적 내용의 필담집과 다양한 관심사를 담고 있는 필담집으로 나눌 수 있다. 後者에는 조선에 대한 정보 수집과 조사라는 일본 측의 의도가 다분히 개입되어 있다. 이를 잘 보여주는 적절한 자료가 칸 도우하쿠[菅道伯]의 『대려필어』와 노로 지쓰오[野呂實夫]의 『조선필담』이다. 이들의 특성 중 `담화 주체의 다양화`는 정보 수집과 조사 목적의 강화를 위한 시도라는 측면에서 파악할 수 있다. 즉, 일본 측 의원들의 목적이 치험례(治驗例) 확인 등 통신사행 초기의 순수한 의학적 관심을 넘어, 일본 측의 의도에 의해 정보 조사의 측면이 강화되었기 때문인 것이다. `서양 문물과 의술의 도입에 대한 언급`에서는 서양의학의 영향 하에 점점 자신감을 확보하는 일본 의원들의 태도를 확인할 수 있다. 반면, 조선에 대해서도 약재 조사 등 기존의 경로를 통한 정밀한 조사를 병행하고 있었다. 이에 대한 조선 의원의 태도는 정보의 유출에 대해 유연한 태도를 지니고 있었다고 할 수 있다. `필담 대화 방식의 변화`는 일본 의원의 축적된 자신감의 표출로 파악할 수 있다. 특히 대화가 문답에서 토론으로 변화한 것이 이를 傍證하며, 이에 따라 필담에 참여했던 수행원들에 대한 병증 진단과 처방도 가능했던 것이라고 할 수 있다. `Pil-dam-chang-hwa-jib`(筆談唱和集, collection of conversation by writing about poetry or sentences) which was remained in Japan through the dispatching of Tong-sin(通信) mission belong to the Chosun(朝鮮) dynasty is a valuable historical records directly to verify sincere relationships with Korea and Japan in the past. Medical conversation of Tong-sin-sa(通信使) in 1748 is to be classified into two ways. It is a purity medical contents and a diversity concerns. The latter is contents that many intention of Japan. It is in collecting information and investigation to Chosun(朝鮮). `Dae-ryeo-pil-ur(對麗筆語)` and `Cho-sun-pil-dam (朝鮮筆談)` are pertinent information of the such circumstances. Diversification of main agent to talk is give the method a go incollecting information and investigation. because of Japan`s original plan is tighten up investigating information. but the previous Japanese oriental doctor have to gain medical experience in Chosun(朝鮮). Japanese oriental doctor go into details to Western civilization and the introduction of medical technology. We saw check the attitude of Japanese oriental doctor that have confidence to undergo various influences in Western medicine. on the other hand, They are side by side with detailed study to Chosun(朝鮮). It is go through existing Way to medicinai stuff etc. Meanwhile oriental doctor of Chosun(朝鮮) has flexible attitude about leak confidential information. the change of character in medical conversation by writing of 1748 meaning of expression that accumulate self-confidence by Japanese oriental doctor. specially clear evidence is question and answer change toward discussion. Consequently, between the two countries oriental doctor is possible prescription for following. After considering with the all factors above, the first half of 18th century`s medical conversation materials are certificated remarkably valuable materials to the cultural history around the physician at that time.