http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
한국인의 위암 발생에서 가장 중요한 인자는 무엇인가: Helicobacter pylori, 숙주 인자 또는 환경 인자?
김학양 ( Hak Yang Kim ) 대한소화기학회 2007 대한소화기학회지 Vol.49 No.2
Epidemiological data including our studies demonstrated the association between Helicobacter pylori (H. pylori) infection and gastric cancer. However, this significant clinical outcome happens only in a small portion of infected person. This suggests that other contributors including host genetic and environmental factors might be involved in the disease process. Studies on the association between virulent strains of H. pylori and clinical outcomes failed to show significant results in Korea. Cytokine gene polymorphism such as interleukin-1 (IL-1) has been thought to play a role in gastric carcinogenesis. Our studies showed the controversial role of IL-1, TNF-A, IL-10 and IL-2 gene polymorphisms in the development of gastric cancer in Korea. Chronic infection and inflammation leading to tumorigenesis are mediated in part through the recognition of various stimuli by toll-like receptors (TLRs). Our studies on the polymorphisms of TLR4 and TLR2 showed no mutant form in Koreans. These discrepancies might reflect the genetic differences between Caucasians and Koreans or might be due to prevalent genetic polymorphisms with masked effect in gastric carcinogenesis in Koreans. As other candidate risk factors, there are constant or inconsistent results on the effect of dietary intake in gastric cancer. There are numerous similar risk for gastric carcinogenesis with different risk ratio including environmental factors in Caucasians and Koreans. Under the background of prevalent H. pylori infection and genetic polymorphisms, environmental factors including diet may potentiate their role in gastric carcinogenesis in Koreans. (Korean J Gastroenterol 2007;49:60-71)
포스터 전시 : 간 ; 전이성간암으로 오인된 간의 림프관종
김억 ( Auk Kim ),이자영 ( Ja Young Lee ),이진헌 ( Jin Heon Lee ),김호철 ( Ho Chul Kim ),김덕환 ( Duck Hwan Kim ),김용범 ( Yong Bum Kim ),김학양 ( Hak Yang Kim ),유재영 ( Jae Young Yoo ) 대한소화기학회 2002 대한소화기학회 춘계학술대회 Vol.2002 No.-
<증례> 60세 여자가 개인 의원에서 우연히 검사한 복부 초음파 검사상 다수의 간내 종괴가 발견되어 본원으로 전원되었다. 과거력상 5년 전 당뇨병과 고혈압을 진단 받고 약물 치료 중이었으며, 가족력상 특이 사항 없었다. 내원 당시 우상복부 동통이나 소화장애, 체중감소 등의 지각증상은 없었으며, 혈압 140/90 mmHg, 맥박수 72회/분, 체온 36.7℃, 호흡수 20회/분, 체온 36.7℃였다. 진찰 소견에서 전신상태는 양호하였고, 두경부, 흉부 및
무증상 한국인에서 Helicobacter Pylori 감염의 위험인자
김나영(Na Young Kim),김재규(Jae Gyu Kim),김진호(Jin Ho Kim),김학양(Hak Yang Kim),김상우(Sang Woo Kim),김재준(Jae Jun Kim),노임환(Im Hwan Roe),심재건(Jae Geon Sim),안형식(Hyeong Sik Ahn),윤병철(Byung Chul Yoon),이상우(Sang Woo Lee),이용 대한내과학회 2000 대한내과학회지 Vol.59 No.4
Background : The prevalence of Helicobacter pylori (H. pylori) infection varies between countries and between social classes. The aim of this study was to identify risk factors for with Helicobacter pylori infection in asymptomatic Korean population. Methods : Sera were collected from 2,687 females and 3,049 males (mean age, 29.1 y; range, 1 m-79 y) in Korea from Mar 1998 through Oct 1998. All asymptomatic subjects completed assessment questionnaires. An enzyme-linked immunosorbent assay was performed to detect IgG antibody to H. pylori.Results : The overall seroprevalence observed was 46.6% and showed no statistical diffrerence between female (45.9%) and male (47.2%). The seroprevalences in children (neonate-15 y) and adult (16-79 y) were 17.2% and 66.9%, respectively. According to multivariate analysis, variables such as sex, age, geographic area, crowding (number of person per room) in childhood, economic status in childhood, and types of housing in childhood were significantly and independently associated with H. pylori seroprevalence of adults. In children, age, geographic area, income, mother's education, and drinking water source were significant risk factors of H. pylori infection. Conclusion : Socioeconomic condition and close person to person contact in childhood are the significant determinants for H. pylori infection in adult. Drinking water source is an another important risk factor for H. pylori infection in children, suggesting the fecal to oral transmission in Korea.(Korean J Med 59:376-387, 2000)
에 대한 혈청 IgG 역가로 위 - 십이지장질환을 감별진단할 수 있는가 ?
최지용(Ji Yong Choi),김학양(Hak Yang Kim),윤덕형(Duck Hyoung Yoon),노승혁(Seung Hyuk Rho),김수진(Soo Jin Kim),이자영(Ja Young Lee),백광호(Gwang Ho Baik),김억(Auk Kim),이진헌(Jin Heon Lee),김용범(Yong Bum Kim),김우중(Woo Joong Kim),유 대한소화기학회 2002 대한소화기학회지 Vol.39 No.3
Background/Aims: Among the diagnostic methods to detect Helicobacter pylori (H. pylori) infection, serological test is a noninvasive, safe, and inexpensive method in clinical practice. This study was performed to determine whether the titer of anti-H. pylori IgG antibody was correlated with endoscopic findings of gastroduodenal diseases, gastric ulcer stage, and age. Methods: Two hundred and eighteen patients who were H. pylori positive by serological method and received gastroduodenal endoscopy were enrolled. All patients had the titers of anti-H. pylori IgG antibody >300 U/mL. We compared the antibody titer according to gastroduodenal diseases, peptic ulcer stage, and age group. Results: There was no statistically significant difference between serum anti-H. pylori IgG antibody titer according to gastroduodenal diseases (chronic gastritis, 999.8±120 U/mL; gastric ulcer, 1043±155.6 U/mL; duodenal ulcer, 1018.5±121.9 U/mL; gastric cancer, 1351±266 U/mL; p=0.504). No significant difference in the anti-H. pylori IgG antibody titer was observed according to peptic ulcer stage (p=0.065) and age (p=0.791). Conclusions: The serum anti-H. pylori IgG antibody titer is not valuable in differentiating the gastroduodenal diseases. (Korean J Gastroenterol 2002;39:167-172)
상부우장관 증사이 없는 한국인에서 Helicobacter pylori 감염의 혈청학적 유병률에 관한 전국적 역학조사
김나영(Na Young Kim),김재규(Jae Gyu Kim),김진호(Jin Ho Kim),김학양(Hak Yang Kim),김상우(Sang Woo Kim),김재준(Jae Jun Kim),노임환(Im Hwan Roe),심재건(Jae Geon Sim),안형식(Hyeong Sik Ahn),윤병철(Byung Chul Yoon),이상우(Sang Woo Lee),이용 대한내과학회 2000 대한내과학회지 Vol.59 No.4
Background : Helicobacter pylori infection occurs throughout the world and causes various gastroduodenal diseases in all age groups. The prevalence of H. pylori infection varies among countries and races. The aim of this study was to evaluate the seroprevalence of H. pylori infection in healthy people in Korea. Methods : From March 1998 to October 1998, 5,732 asymptomatic subjects responded to the self-assessment questionnaires from 54 hospitals were enrolled. Serum level of anti-H. pylori IgG was measured by ELISA test. Results : The overall prevalence of H. pylori infection was 46.6% and showed no significant difference between male (47.2%) and female (45.9%). According to the geographic areas, the highly prevalent provinces were Kangwon (53.4%), Cheju (52.9%) and Jeonra provinces (50.6%), while Seoul (41.9%) was the lowest prevalent area. The seroprevalence increased with age and was the highest at 40's (78.5%). The characteristic feature of this study was that the infection rate increased steeply in three age groups (10-12, 16-19 years old and 30's). In Seoul, there was no different prevalence rate among the districts studied.Conclusion : The nation-wide seroprevalence of H. pylori infection in Korea is higher than that of the developed countries. We hope that this study provides the landmark for the study of H. pylori infection in Korea.(Korean J Med 59:388-397, 2000)
대장암 및 대장용종 환자에서 상부위장관 병변의 동반 빈도
신운건(Woon Geon Shin),김학양(Hak Yang Kim),허필석(Pil Seog Heo),이자영(Ja Young Lee),김억(Aukk Kim),김진봉(Jin Bong Kim),서중산(Joong San Suh),이진헌(Jin Hyon Lee),김종혁(Jong Hyeok Kim),장웅기(Woong Ki Chang),김동준(Dong Joon Kim) 대한소화기학회 2001 대한소화기학회지 Vol.38 No.5
Background/Aims: It is unclear whether further evaluation for upper gastrointestinal tract is needed in the patients with colorectal lesions. We conducted this study to investigate the prevalence of simultaneous upper gastrointestinal lesion in the patients with colon cancer or polyp. Methods: Data of 904 consecutive patients who received both colonoscopic and gastroduodenoscopic examination from July 1997 to August 2000 were analyzed retrospectively. Gastroduodenal mucosal lesions such as gastric ulcer, duodenal ulcer, gastric polyp or gastric cancer were classified as clinically significant lesions. We compared the prevalence of upper gastrointestinal mucosal lesions between the patients with and without colonic lesions. Results: Fifty-five (25.9%) of 212 patients with colonic lesions and 87 (12.6%) of 692 patients without colonic lesions had simultaneous gastroduodenal lesions. The patients with colonic polyp or cancer had more gastroduodenal lesions than those without colonic lesions (p<0.05). According to histologic finding of colonic lesion, the prevalence of gastroduodenal lesions was higher in the patients with hyperplastic polyp (p<0.05) and tubular adenoma (p<0.05) than in the patients without colonic lesions. Conclusions: It is suggested that many of the patients who have colonic hyperplastic polyp and tubular adenoma may have simultaneous colonic and gastroduodenal lesions. Therefore, upper gastrointestinal endoscopy should be performed in the patients with colon neoplasia. (Korean J Gastroenterol 2001;38:336-341)
김성은 ( Sung Eun Kim ),김수진 ( Soo Jin Kim ),김형수 ( Hyoung Su Kim ),김희선 ( Hee Sun Kim ),남은숙 ( Eun Sook Nam ),이상규 ( Sang Kyu Lee ),신수린 ( Su Rin Shin ),김학양 ( Hak Yang Kim ) 대한소화기학회 2006 대한소화기학회지 Vol.48 No.6
Hepatitis A is generally regarded as a mild, self-limiting disease of the liver. Acute renal failure has rarely been reported in association with non-fulminant acute hepatitis A. Acute tubular necrosis is the most common form of renal injury in such patients. We recently experienced two cases of hepatitis A in which acute renal failure occurred early in the course of the illness and had a clinical course suggestive of acute tubular necrosis. In both patients, the clinical course of renal dysfunction was almost parallel to that of hepatic dysfunction. Hemodialysis was performed in patient 1 because of severe uremia despite maintaining urine output more than 2,000 mL per day. On the other hand, hemodialysis was not performed in patient 2 who showed a rapid recovery of renal dysfunction. The renal biopsy of patient 1 demonstrated typical findings of acute tubular necrosis on microscopy. (Korean J Gastroenterol 2006;48:421-426)
한국인에서 Helicobacter pylori 감염의 진단에 있어 Genedia™ H . pylori ELISA 검사의 진단 정확도
정인식(In Sik Chung),김상우(Sang Woo Kim),고재성(Jae Sung Go),김나영(Na Young Kim),김재규(Jae Gyu Kim),김진호(Jin Ho Kim),김학양(Hak Yang Kim),김재준(Jae Jun Kim),노임환(Im Hwan Roe),심재건(Jae Geon Sim),안형식(Hyeong Sik Ahn),윤병철(By 대한내과학회 2001 대한내과학회지 Vol.61 No.1
N/A Background: Genedia™ H. pylori ELISA is a newly developed diagnostic method which detects serum anti-H. pylori IgG antibody. The aim of this study was to assess the accuracy of Genedia™ H. pylori ELISA for the diagnosis of H. pylori infection in Korean population. Methods Genedia : H. pylori ELISA and GAP-IgG were performed in 353 adult sera and Pyloriset-IgG EIA in 184 subjects. In children, 43 serum samples were tested with Genedia™ H. pylori ELISA. H, pylori infection was determined by rapid urease test, histology, culture or (13)C-urea breath test in adults. In children, the subject was considered to he H. pylori positive if (13)C-urea breath test was positive. Results: In adults, the sensitivity and specificity of Genedia™ H. pylori ELISA were 93.2% and 83.5% with positive and negative predictive values of 85.1% and 92.5%. Those for GAP-IgG and Pyloriset-IgG EIA were 67.2%, 82.4%, 79.3%, 71.4% and 89.1%, 88.4%, 71.9%, 96.1%, respectively. In children, sensitivity, specificity, positive and negative predictive values of Genedia™ H. pylori ELISA were 80%, 84.8%, 61.5%, and 93.3%. Sensitivity and negative predictive value of Genedia™ H. pylori ELISA were significantly higher than those of GAP-IgG (93.2% vs. 67.2%, p<0.005 and 92.5% vs 71.4%, p<0.005, respectively). Conclusion : Genedia™ H pylori ELISA is a relatively accurate method for the serodiagnosis of H pylori infection in Korean subjects compared to GAP-IgG. These results may suggest the clinical use of Genedia™ H. pylori ELISA for epidemiological studies of H. pylori infection in Korea. (Korean J Med 61:17-23, 2001)