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소화성 궤양환자의 흡연여부에 따른 혈청 Pepsinogen 1 치의 변화
오재선(Jae Sun Oh),김평남(Pyung Nam Kim),나한식(Han Sik Na),김중남(Jung Nam Kim),문철웅(Chul Oong Moon),김만우(Man Woo Kim),양성훈(Sung Hun Yang) 대한내과학회 1990 대한내과학회지 Vol.39 No.4
N/A Serum group I Pepsinogen (sPG I) levels were measured by radioimmunoassay in 159 patients undergoing endoscopy, then all patients were classified by endoscopic diagnosis, gastric mucosal histology, and smoking habits. The results were as follows: 1) Both nonulcer dyspepsia and duodenal ulcer smokers had significantly higher sPG I levels than their nonsmoking controls (p<0.005). 2) The frequency distvibution of superficial gastritis in the nonulcer dyspcpsia group with smoking habits revealed significantly higher levels than that of the nonsmoking controls (p<0.0025). 3) Serum PG Iin nonulcer dyspepsia patients revealed significantly higher levels in patients with superficial gastritis but there were not related to cigarette smoking. 4) The relationship between the mean level of serum PG I and fundic mucosal histology in duodenal ulcer patients was found to be statistically insignificant, but the mean level of sPG I in the smoking group showed a higher value than that of the nonsmoking controis (p< 0. 05). 5) The frequency distribution of high serum PG I level (> 80 ng/ml) in duodenal ulcer smokers was higher than that of the nonsmoking control group (chi square test: p<0.). From the above findings, it is concluded that the smoking induced increase in sPG I in duodenal ulcer is proposed to release an augmented pepsin secretory capacity, which can have aetiologic significance in association between smoking and duodenal ulcer.
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윤채중,정승문,김영학,김동규,허광식,김태원,배학연,정종훈,이승일,김평남 朝鮮大學校 附設 醫學硏究所 1997 The Medical Journal of Chosun University Vol.22 No.2
통풍은 Purine 대사의 이상으로 발생하는 질환으로, 고뇨산혈증인 사람의 전부가 통풍으로 발현되지 않고 증상의 출현 양상이 다양하여 진단과 치료에 주의가 필요하며, 조기에 적절한 조치를 한다면 충분히 조절이 가능한 질환이다. 본대학 내과학교실에서는 통풍으로 치료한 32명의 환자에서 임상양상, 병력과 검사소견을 분석하여 다음과 같음 결과를 얻었다. 1. 32명 모두 남자이며, 최초 발병 시기는 24세에서 72세로 평균 43.8±11.9세이었으며, 30대에서 40대까지가 19명(59.4%)으로 대부분을 차지하였다. 내원 당시 나이는 27세에서 75세까지로 평균 52.3±10.4세였으며, 내원시 까지 평균 유병기간은 8.5±6.8년으로 나타났다. 2. 동반 질환으로는 고지혈증 12례, 신장질환 10례, 고혈압 12례, 비만 8례, 당뇨 2례 등이었다. 3. 이환된 관절은 단관절 침범이 19례(59.4%), 다관절 침범이 13례 이었으며, 최초 이한된 관절은 족무지 중족골지골 관절로 19례(59.4%)로 가장 많았고, 통풍 결절은 20례(62.5%)에서 관찰되었으며, 유병기간이 10년 이상된 12례중 11례 (91.7%)에서 결절이 관찰되었다. 4. 평균 혈중 요산치는 9.17±1.75 ㎎/dl이었으며, 8.0 ㎎/dl에서 9.9 ㎎/dl 사이가 19명으로 전체의 59.4%를 차지하였다. Objective: The gout is a heterogeneous group of diseases resulting from tissue deposition of monosodium urate or uric acid crystals from extracellular fluids supersaturated with respect to this end product of human purine metabolism. The clinical manifestations are such as hyperuricemia, gouty arthritis, gouty nephropathy, uric acid nephrolithiasis. We analyze of clinical manifestations and associated factors in gout. Method: We have reviewed the medical records, radiologic findings and clinical results of thirty-two patients admitted at our department from April 1996 to July 1997. Result: 1) All patients were male. The mean age at initial attack was 43.8 years old, ranging from 24 to 72 years old. 2) The mean level of serum uric acid was 9.17mg/dl on admission. 3) The first metatarsopharyngeal joint was involved in 19 cases (59.4%). Tophus was observed in 20 cases (62.5%). 4) Hyperuricemia was associated with hypertension, obesity, nephrolithiasis and hyperlipidemia.
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