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대극과식물 등대풀로부터 분리한 가수분해형 탄닌의 tyrosinase활성억제효과
김진준(Jin Joon Kim),이주상(Joo Sang Lee),김소영(So Young Kim),김정아(Jeong Ah Kim),정시련(See Ryun Jung),장태수(Tae Soo Jang),이승호(Seung Ho Lee) 대한약학회 2001 약학회지 Vol.45 No.2
Nineteen hydrolyable tannins isolated from Euphorbia helioscopia(Euphorbiaceae) were tested for the inhibitory effect on mushroom tyrosinase activity in vitro. Inhibitory effect of gallotannin group exhibited more potent than that of phenocarboxylic acid and ellagitannin groups against the enzyme activity. The inhibitory activity by pentagalloyl glucose on mushroom tyrosinase was more potent(IC50, 4.9uM) than that of kojic acid(IC50, 8.7uM)
박태기나무의 잎으로부터 피부멜라닌 색소생성 억제성분의 분리
김소영,김진준,장태수,정시련,이승호,Kim, So-Young,Kim, Jin-Joon,Jang, Tae-Soo,Chung, See-Ryun,Lee, Seung-Ho 한국생약학회 1999 생약학회지 Vol.30 No.4
Tyrosinase plays an important role in the process of melanin polymer biosynthesis. Therefore, the enzyme inhibitors have been of great concern as cosmetics to have skin-whitening effects on the local hyperpigmentation. During the search for new inhibitory compounds on melanin polymer biosynthesis from natural sources, MeOH extracts of 589 higher plants were tested for the inhibitory effect on tyrosinase activity by the muschroom tyrosinase assay in vitro. Among plants tested, the leaves of Cercis chinensis exhibited potent inhibitory effect on mushroom tyrosinase activity. Subsequently seven active compounds were isolated from the ethyl acetate soluble part of acetone extract of the leaves of C. chinensis by the activity guided fractionation monitoring the inhibitory effect on tyrosinase activity. Their chemical structures were identified as $kaempferol-3-0-{\alpha}-L-rhamnoside$, quercitrin, $myricetin-3-0-{\alpha}-L-rhamnoside$, myricetin-3-0-(2'-O-galloyl)- ${\alpha}$ -L-rhamopyranoside (desmanthin), (-)-epicatechin-3-0-gallate, (-)-epigallocatechin-3-0-gallate, and methyl gallate on the basis of the speculation of spectral data and chemical reaction. Among the flavonol rhamnosides, myricetin-3-0-(2'-O-galloyl)- -L-rhamnoside(desmanthin) showed most potent inhibitory effect on tyrosinase activity and the structure of B-ring in flavonol moiety was related to the activity. (-)-Epigallocatechin-3-O-gallate having pyrogallol group in flavan-3-ol moiety exhibited more potent inhibitory effect than (-)-epicatechin-3-0-gallate having catechol group in flavan-3-ol moiety on mushroom tyrosinase activity.
이승호(Seung Ho Lee),박지수(Ji Soo Park),김소영(So Young Kim),김진준(Jin Joon Kim),정시련(See Ryun Chung) 대한약학회 1998 약학회지 Vol.42 No.4
The MeOH extract of the bark of Paeonia moutan showed potent inhibitory effect on the mushroom tyrosinase activity in vitro. The activity-guided fractionation of the MeOH extract resulted in the isolation of three active compounds. The chemical structures of these compounds were elucidated by chemical and spectroscopic evidence as catechin, 1,2,3,6-tetra-O-galloyl-beta-D-glucose and 1,2,3,4,6-penta-0-galloyl-beta-D-glucose, respectively. Among them, the inhibitory activity by 1,2,3,6-tetra-galloyl-beta-D-glucose on mushroom tyrosinase was more potent (IC50=3.5mcM) than that of kojic acid (IC50=8.7mcM),but catechin enhanced the mushroom tyrosinase activity 50% in the concentration of 34.5M.
고등식물로부터 피부멜라닌 생성에 관여하는 티로시나제 활성 억제물질의 탐색
이승호(Seung Ho Lee),박지수(Ji Soo Park),김소영(So Young Kim),김진준(Jin Joon Kim),정시련(See Ryun Chung) 대한약학회 1997 약학회지 Vol.41 No.4
Tyrosinase is known to accelerate the melanin polymer biosynthesis in melanocyte, so tyrosinase inhibitors hinder the melanin polymer biosynthesis and are useful not only for the material used in cosmetics as skin-whitening agents but also as the remedy for disturbances in pigmentation. During our search for new melanin biosynthesis inhibitors from natural sources, 130 higher plants were tested for the inhibitory effect against tyrosinase activity by the mushroom tyrosinase assay. Among them, Carex humilis (IC50, 10vg/ml), Sophora flavescence (IC50, 20~50mcg/ml) and Styrax japonica (IC50, 10mcg/ml) inhibited the tyrosinase activity strongly.