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경기도 부천시 국민학교 1학년 아동들의 아토피 피부염의 유병율과 동반된 보조 피부증상의 빈도
이상진(Sang Chin Lee),변대규(Dae Gyoo Byun),김진우(Won Chul Lee),이원철(Jin Wou Kim) 대한피부과학회 1995 대한피부과학회지 Vol.33 No.1
Bsckground : The incidence of atopic dermatitis(AD) varie widely by different ages and it has been well-founded that the epidemiology of AD has been studied on admission of the first grade schoolchildren. AD is a common skin.disease of childhood and tends to increase significantly during recent decacles, but informations regarding the eact prevalence of AD, based on the large-scale general population study, are unavailable in Korea. Objective : The purpose of this study is to elucidate the prevalence of AD and to evaluate the diagnostic significance of some well-known clinical features associated with AD in the first grade school children in one of Korean citie Puchon, Kyunggi-do. Methods : Four thousands and eighteen first grde school children(boys; 2072, girls; 1946) participated in this study. Two dermatologists determined presence of skin lesions by through skin examination. Diagnosis of AD was made only who typical flexural and/or extensor and/or infraauricular fissure/eczema exist. The frequny as well as their diagnostic significance of ten minor features of AD(xerosis, ichthyosifor skin lesion, hyperlinear palm, keratosis pilaris, non-specific hand/foot dermatitis, cheilitis, ple eczema, perifollicular accentuation, pityriasis alba, Dennie-Morgan infraorbital fold) thught suitable items for field survey by authors, were also evaluated. Results : The total prevalence of AD in the first grade school children of Puchon city was 3.78%. The prevalence in boys was 3.37% and that in girls was 4.1%. Associated minor features in individuals diagnosed as having AD were, in order of frqiency, pityriasis alba(59.8%), perifollicular accentuation(57.8%), keratosis pilaris(56.5%), hyprlinear palms(55.2%), xerosis (43.3%), Dennie-Morgan infraorbital fold(26.3%), etc. All bu the ichthyosiform skin lesions and nipple eczema were significantly more frequent in indivulu, 1s diagnosed as having AD(P<0.01). Conclusion : A relatively low prevalence shown in this stud right be due to arather strict diagnostic criteria. Some belpful and diagnoktically significan tumor clinical features of AD, suitable for field survey suggested. Further studies are need for accurate estimation of the prevalence of AD in Korea including different regional and population. (Kor J Dermatol 1995; 33(1): 1-7)
초고집적소자의 층간절연막용 polysilazane계 spin on glass (SOG)에 관한 연구
나시균(Sa-Kyun Rha),정석철(Seog Chul Chung),이재관(Jae Kwan Lee),김진우(Jin Woo Kim),홍정의(Jeong Eui Hong),이원준(Won-Jun Lee) 한국진공학회(ASCT) 2000 Applied Science and Convergence Technology Vol.9 No.1
초고접적소자의 층간절연막으로서의 polysilazane계 spin on glass (SOG)의 적용 가능성을 평가하였다. 상용화된 무기 SOG 계열의 polysilazane과 polysilazane에 산화제를 첨가하여 SiO₂로의 변환 능력을 향상 시킨 물질을 spin coating 하고 curing하여 SOG 막을 제조한 다음, 400℃에서 900℃까지의 온도범위에서 열처리하면서 SOG 막의 특성을 조사하여 산화제 및 열처리 온도의 효과를 조사하였고, line and space pattem에 SOG 막을 형성하여 gapfill 특성을 비교하였으며, SOG 막에 contact hole을 형성한 다음 습식 세정에 대한 저항성을 평가하였다. 산화제를 첨가함으로써 polysilazane polymer 구조에서 SiO₂로의 변환이 더욱 효과적으로 이루어져, 기존 SOG 막에 비해 밀도 및 습식세정 chemical에 대한 저항성이 우수하고 gapfill 특성은 동등한 수준인 SOG 막을 제조할 수 있었다. 특히, 기존의 SOG 막의 경우 좁은 gap space 내에서 curing이 충분하게 일어나지 않아 습식 세정시 hole profile이 나빠지는 문제를 산화제 첨가를 통해 해결할 수 있었다. We have investigated the feasibility of spin on glass (SOG) film from polysilazane-type resin as a pre-metal dielectric (PMD) layer of the next-generation ultra-large scale integrated (ULSI) devices. A commercial polysilazane resin and a polysilazane-type resin with oxidizing agent were spin-coated and cured to form SOG films. In order to study the effect of oxidizing agent and annealing, the SOG films were characterized as cured and after annealing at 400℃ to 900℃. The density and the resistance against wet chemical of the SOG films were improved by the addition of oxidizing agent, because oxidizing agent enhanced the conversion from polysilazane polymer to SiO₂. The hole profile issue associated with insufficient curing of polysilazane in narrow gaps was also resolved by oxidizing agent, while the gapfill capability of SOG was not deteriorated by oxidizing agent.
Quality of Life and Disease Severity Are Correlated in Patients with Atopic Dermatitis
김동하,이갑석,서성준,Sun Jin Jo,임현우,김철민,김규한,Do Won Kim,Moon-Bum Kim,김진우,노영석,Young Lip Park,박천욱,Seung-Chul Lee,조상현 대한의학회 2012 Journal of Korean medical science Vol.27 No.11
Quantification of quality of life (QOL) related to disease severity is important in patients with atopic dermatitis (AD), because the assessment provides additional information to the traditional objective clinical scoring systems. To document the impact of AD on QOL for both children and adults as well as to quantify the relationship with disease severity, QOL assessments were performed over a 6-month period on 415 patients with AD. A questionnaire derived from the Infants’ Dermatitis Quality of Life Index (IDQOL), the Children’s Dermatology Life Quality Index (CDLQI) and the Dermatology Life Quality Index (DLQI) was used to determine the QOL for 71 infants, 197 children and 147 adults,respectively. To measure AD severity, both the Rajka & Langeland scoring system and the Scoring of Atopic Dermatitis (SCORAD) index were used. The mean scores were as follows:7.7 ± 5.5 for IDQOL, 6.6 ± 6.3 for CDLQI, and 10.7 ± 7.9 for DLQI. In conclusion, these QOL scores are correlated with AD severity scores as estimated by the Rajka & Langeland severity score and the SCORAD. The outcome of the QOL instruments in this study demonstrates that atopic dermatitis of both children and adults affects their QOL.
초고집적소자의 층간절연막용 polysilazane계 spin on glass (SOG)에 관한 연구
나사균,정석철,이재관,김진우,홍정의,이원준 대전산업대학교 반도체기술연구소 2000 半導體技術硏究所報 Vol.2 No.-
초고집적소자의 층간절연막으로서의 polysilazane계 spin on glass (SOG)의 적용 가능성을 평가하였다. 상용화된 무기 SOG 계열의 polysilazane과 polysilazane에 산화제를 첨가하여 SiO_2로의 변환 능력을 향상시킨 물질을 spin coating하고 curing하여 SOG 막을 제조한 다음, 400℃에서 900℃까지의 온도범위에서 열에 SOG막을 형성하여 gapfill 특성을 비교하였으며, SOG막에 contact hole을 형성한 다음 습식 세정에 대한 저항성을 평가하였다. 산화제를 첨가함으로써 polysilazane polymer 구조에서 SiO_2로의 변환이 더욱 효과적으로 이루어져, 기존 SOG 막에 비해 밀도 및 습식세정 chemical에 대한 저항성이 우수하고거 gapfill 특성은 동등한 수준인 SOG 막을 제조할 수 있었다. 특히, 기존의 SOG 막의 경우 좁은 gap space 내에서 curing이 충분하게 이어나지 않아 습식 세정시 hole profile이 나빠지는 문제를 산화제 첨가를 통해 해결할 수 있었다. We have investigated the feasibility of spin on glass (SOG) film from polysilazane-type resin as a premetal dielectric (PMD) layer of the next-generation ultra-large scale integrated (ULSI) devices. A commercial polysilazane resin and a polysilazane-type resin with oxidzing agent were spin-coated and cured to form SOG films. In order to study the effect of oxidizing agent and annealing, the SOG films were characterized as cured and after annealing at 400℃ to 900℃. The density and the resistance against wet chemical of the SOG films were improved by the addition of oxidizing agent, because oxidizing agent enhanced the conversion from polysilazane polymer to siO_2. The hole profile issue associated with insufficient curing of polysilazane innarrow gaps was alao resolved by oxidizing agent, while the gapfill capability of SOG was not deteriorated by oxidizing agent.
조백기,박종갑,김형옥,김성욱,백승철,김진우,김시용,안규중,전재복,오지원,김낙인,이규석,오칠환,김수남,김상태,손숙자,신용우,김동석,이원우,권경술,서대헌,황규왕,이종석,고재경,강원형,정기양,최응호,김기홍,박석돈,강승주,함정희,명기범,김방순,구상완,김병수,원영호,김한욱,송은섭,정병수,노병인,홍창권,박장규,한지윤,김광중,구대원,김종민,김재홍,유희준,양경미 대한의진균학회 1998 대한의진균학회지 Vol.3 No.2
Background: Onychomycosis, especially toenail onychomycosis has become one of the common fungal infection and has historically been regarded as a cosmetic rather than medical problem by many patients, even by physicians. Recently, however, there are several reports that is a refractory disease which may cause a deleterious effect on patiets quality of life (QOL). Objective: The purpose of this study was to investigate the impact of toenail onychomycosis on QOL in Korea and to assess the chandes of QOL after treatment. Methods: Total 1004 patients with toenail onychomycosis which was confirmed by clinical findings and KOH preparation were were enrolled at 47 dermatologic centers in Korea, and interviewed with standardized QOL questionnaire before and after sytemic antifungal treatment. Responses to the questionnaire were scored by 5-point scale (1∼4) and averaged, and were analyzed for 5 dimensions of emotional impact, social impact, symptorn and functional impact, patients views concerning treatment, and relationship with doctor. Results: 1. Before and after treatment, the most serious impact was emotional dimension showing 1.90 and 1.30 in average score (AS), and social (AS: 1.14 and 0.83) and symptom and functional impact (AS: 1.05 and 0.92) was also affected. 2. In female rather than male, statistically more significant impact on patients QOL was observed in all dimensions. 3. After treatment, 3 of 5 dimensions were improved significantly - emotional dimension (AS : from 1.90 to 1.30), social dimension (AS: from 1.14 to 0.83), patients view concerning treatment (AS: from 1.34 to 1.02). 4. The drgree of patients satisfaction at the therapeutic effect was very high- 62.4% (immediately after treatment) and 65.8% (9 months affer initiation of treatment) of patients answered excellent or good. Conclusion: This study confirms that toenail onychomycosis has significant impact on the overall QOL of patients. Also the effect of antifungal therapy on patients QOL were watisfactory. Therefore, both doctor and patient should pay more attention to the treatment of onychomycosis. [Kor J Med Mycol 3(1): 115∼124]
Cho, Baik Kee,Jeong, So Hee,Lee, Dong Won,Park, Chul Jong,Lee, Sang Chin,Paik, Seung Churl,Cho, Sang Hyun,Yi, Jong Yuk,Kim, Tae Yoon,Kim, Jin Wou,Kim, Si Yong,Cheong, Ji Yun,Yang, Kyung Mee 대한의진균학회 2000 대한의진균학회지 Vol.5 No.1
이 트라코나졸은 약물역동학적으로 피부 각질에 친화성이 높고 투약 종료 후에도 4주간 지속되며 고용량 단기간 투여가 효과적이라는 것이 알려지면서 각화형의 수장부/족부 백선 치료에도 고용량단기간 투여법이 시도되고 있다. 본 연구는 각화형의 수장부/족부 백선 환자 97명을 대상으로 이트라코나졸 1일 400 mg을 7일간 투여하여 효과 및 안전성을 평가하였다. 투약 전, 투약 후, 투약 종료 4주후에 임상적, 진균학적으로 효과를 평가하여 임상적으로 73.8%에서 중등도 이상의 개선, 진균학적으로는 84.5%의 완치율을 얻었다. 97.6%의 환자에서 양호한 내약성을 나타내었고, 2.4%에서 위장관 증상, 피부 발진 등이 발생하였으나 특별한 치료 없이 호전되었다. 이상과 같은 결과로 각화형의 수장부/족부 백선 치료에 이트라코나졸 400mg 7일 투여는 효과적이면서 동시에 안전한 치료법임을 확인하였다. [의진균지 5(1): 7-12]