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- 저자 : 김지원 ( Kim Ji Won ) (검색결과 748 건)
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한국인에서 조현병과 Cannabinoid Receptor 1 유전자의 삼핵산 반복서열의 연합에 대한 연구
김지원,노양호,김민재,김채리,박병래,배준설,신형두,최인근,한상우,황재욱,우성일,Kim, Ji-Won,Roh, Yang-Ho,Kim, Min-Jea,Kim, Chea-Ri,Park, Byung-Lae,Bae, Joon Seol,Shin, Hyoung Doo,Choi, Ihn-Geun,Han, Sang-Woo,Hwang, Jaeuk,Woo, Sung-Il 대한생물정신의학회 2014 생물정신의학 Vol.21 No.3
Objectives Previous studies suggest that the cannabinoid receptor 1 (CNR1) gene could be an important candidate gene for schizophrenia. According to linkage studies, this gene is located on chromosome 6q14-q15, which is known to harbor the schizophrenia susceptibility locus (locus 5, SCZ5, OMIM 803175). The pharmacological agent delta-9-tetrahydrocannabinol (${\Delta}$-9-THC) seems to elicit the symptoms of schizophrenia. The association between CNR1 polymorphisms and schizophrenia is actively being investigated, and some studies have linked the AAT-trinucleotide repeats in CNR1 to the onset of schizophrenia. In this study, we have investigated the association between the AAT-trinucleotide repeats in CNR1 and schizophrenia by studying schizophrenia patients and healthy individuals from Korea. Methods DNA was extracted from the blood samples of 394 control subjects and 337 patients diagnosed with schizophrenia (as per the Diagnostic and Statistical Manual of Mental Disorders, fourth edition criteria). After polymerase chain reaction amplification, a logistic regression analysis, with age and gender as the covariates, was performed to study the variations in the AAT-repeat polymorphisms between the two groups. Results In total, 8 types of trinucleotide repeats were identified, each containing 7, 8, 10, 11, 12, 13, 14, and 15 repeats, respectively. $(AAT)_{13}$ allele was most frequently observed, with a frequency of 33.6% and 31.6% in the patient and control groups, respectively. The frequency of the other repeat alleles in the patient group (in the decreasing order) was as follows : $(AAT)_{13}$ 33.6%, $(AAT)_{14}$ 21.6%, $(AAT)_{12}$ 18.5%, and $(AAT)_{7}$ 11.1%. The frequency of the repeat alleles in the control group (in the decreasing order) was as follows : $(AAT)_{13}$ 31.6%, $(AAT)_{14}$ 24.5%, $(AAT)_{12}$ 17.2%, and $(AAT)_{7}$ 11.6%. However, there were no significant differences in the AAT-repeat polymorphisms of the CNR1 gene between the patient group and the control group. Conclusions Although our study revealed no significant association of the AAT-repeat polymorphism of the CNR1 gene with schizophrenia, it will serve as a good reference for future studies designed to examine the cannabinoid hypothesis of schizophrenia.
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김지원,정희경,이주영,김광휘,김태연,이태걸,김동은,Kim, Ji-Won,Jeong, Hu-Gyeong,Lee, Joo-Young,Kim, Kwang-Hwi,Kim, Tae-Yeon,Lee, Tae-Geol,Kim, Dong-Eun 대한한방안이비인후피부과학회 2017 한방안이비인후피부과학회지 Vol.30 No.4
Objectives : The purpose of this study is to investigate recent clinical studies on the effect of acupuncture on hearing loss. Methods : Based on the PubMed search with the key search terms of 'hearing loss, acupuncture', dated from 2004 to 2017, 1 controlled trials, 3 case reports and 3 case series was found, and were analyzed for this study. Results : 1. The most commonly used acupoints were Shuaigu(GB8) and Fengchi(GB20). 2. The most commonly used meridians were the du channel, the gall bladder meridian of foot-shaoyang, and the triple bunner meridian of hand shaoyang. 3. Acupuncture treatment was effective for conductive and sensorineural hearing loss, especially sudden sensory neural hearing loss. 4. More clinical studies are needed to prove the effectiveness of the acupuncture on hearing loss. To be more objective on the study results, we can measure auditory brainstem response for hearing loss after acupuncture treatment.
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김지원,정홍영,김효희,권유리,엄광문,이정환,김경섭,전재훈,박병규,Kim, Ji-Won,Jeong, Hong-Young,Kim, Hyo-Hee,Kwon, Yu-Ri,Eom, Gwang-Moon,Lee, Jeong-Whan,Kim, Kyung-Seoup,Jun, Jae-Hoon,Park, Byung Kyu 대한의용생체공학회 2012 의공학회지 Vol.33 No.4
Elderly women are reported to have greater risk of falls. The purpose of this paper was to investigate the possible gender differences in the reaction performance of ankle joint muscles, which have dominant role in the control of sagittal plane balance. Twenty-six elderly men and women with comparable mean age participated in this study. Reaction times to the audible beeps were measured in the tibialis anterior muscle and gastrocnemius muscle. Reaction time variables included premotor time, electromechanical delay and total reaction time. Gender difference in each reaction time was investigated by independent t-test. In both muscles, premotor time was longer in men but the electromechanical delay was longer in women (p < 0.05). Resulting total reaction time was longer in men in tibialis anterior muscle (p < 0.01) and it tended to be longer in men also in gastrocnemius muscle (p = 0.25). The results demonstrates that the overall reaction performances of elderly women is better than or comparable to those of elderly men in ankle joint muscles. This suggests that the reaction performance of ankle muscles is hardly the cause of the greater risk of falls in elderly women.
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부산.경남지역의 일부 고등학교 교사들의 물리치료에 대한 인식도 조사
김지원,박상현,주성희,김용권,안덕현,Kim, JI-Won,Park, Sang-Hyeon,Joo, Sung-Hui,Kim, Yong-Kwon,Ahn, Duck-Hyun 대한물리치료과학회 2003 대한물리치료과학회지 Vol.10 No.2
This study randomly chose 10 humanity high schools, which are located in Busan and KyoungNam province. We then examined the recognition rate of physical therapy among 378 teachers who were and still are working in the schools. 1. The recognition grade of physical therapeutics between men and women was significantly different with results of 80.7% of men and 69.7% of women(p<0.05). In the case of experiencing physical therapy, 83.6% of people said they knew the physical therapeutics and in the case of the opposite side, the result was also significantly different with a result of 67.8%(p<0.05). 2. We ranked the people on how much they knew about the physical therapeutics among men and women. With men, the actual experience of physical therapeutic came before what they heard from other people. In the case of women, what they heard from other people came first and the actual experience of physical therapeutic came after. According to the public information from Inje University, the recognition grade is recorded in the 3rd grade department as 21.5% while in the case of experiencing treatment from a physical therapist, the result was 39.1%. In the other department (the 1st grade department), what men and women heard from mass media was recorded at 17.5% and what they heard from other people, it was recorded at 33.8%(p<0.05). 3. The research about the recognition of academic ability of being a physical therapist was that 55.6% of teachers thought that 3-year-college was the best, which made the results different from the recognition grade of the experience of education(p<0.05). 4. In the recognition grade of physical therapeutics, there were significantly differences from 50.2% of men and 45.2% of women were expecting about 1mil ion won to 1.99million won. In case of 25.2% of people who have experience less than 15years at work, they expected about 2million to 2.99million won. The figures were higher than 10.1% of people who have experiences over 15years. About the recognition grade of physical therapists social level in the future is 48.8% of people who had experienced of physical therapy and 63.8% of people who never had experienced of it said it would be better in the future. From these results, the recognition about physical therapeutics and the view of its social status are optimistic and they know well about the level of academic ability of physical therapists. On the other hand, most teachers don't know exactly about physical therapists work. So we have to inform them aggressively for enhancing the recognition of physical therapy because high school students are well affected by their teachers when they face their future or major in university.
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김지원,Kim, Ji-Won 대한출판문화협회 1998 출판저널 Vol.238 No.-
서울출판인포럼은 지난 10일 서울 조선호텔에서 가진 조찬모임에 이해찬 교육부 장관을 초청, '교육과 출판' 을 둘러싼 광범위한 의견을 나눴다. 이장관은 교육부가 초.중.고 권장도서목록을 올해 안에 선정할 수 있도록 30명으로 이뤄진 '새로운공동체추진위원회'(가칭)를 이달 25일까지 발족시키고, 이를 강력히 실천할 수 있도록 지역단위의 '새교육공동체 시민모임'의 정착에 간접지원하겠으며, 독서가 학교 교과과정의 한 형태로 자리잡을 수 있도록 제도화하겠다고 밝혔다. 교육의 입장에서 바라본 이장관의 독서와 출판에 대한 시각과 함께 출판인과 나눈 대화 내용을 정리해 싣는다.
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김지원,Kim, Ji-Won 대한출판문화협회 1998 출판저널 Vol.235 No.-
군계일학의 뛰어난 아름다움을 지닌 독창적인 신라금관을 제대로 해설할 수 없다면 곧 우리 문화유산을 올바로 이해하고 감상할 수 없다는 것입니다.
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김지원,Kim, Ji-Won 대한출판문화협회 1995 출판저널 Vol.175 No.-
광복 50년의 역사에는 출판계의 크고 작은 사건들이 자리한다. 출판 50년의 세월은 고스란히 굴곡 많은 우리나라 현대사의 격랑과 함께 걸오온 셈이다. 광복 직후 극심했던 용지난과 일어판 문제 등 업계 공동으로 해결해야 할 과제들이 늘어나자 '조선출판문협회'를 결성했다. 60, 70년대에는 출판계가 꾸준히 요구해온 출판영업 면세안이 국회에서 통과됐는가 하면 80년대는 출판자유화 조치와 함께 이념도서가 해금돼 출판의 금서영역을 무너뜨렸다. 90년대에는 첫 국제도서전시회를 치렀는가 하면 출판계 숙원이 '출판문화단지'의 꿈이 더욱 가시화하기 시작했다. 그런가 하면 '검인정 교과서 파동'이나 '출판사등록 무너기 취소' 학생들의 '서점불매운동' 등 깊은 상처로 남은 사건들도 있다. 긍정적이든 부정적이든 지나온 사건들은 오늘의 출판문화를 일군 밑거름이 된 셈이다. 광복 직후부터 오늘에 이르기까지 출판계에 전기를 마련한 핵심적인 사안들을 살펴봄으로써 우리 출판문화의 미래상을 생각해본다.
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