[구약] 선지식 해체와 의미의 재구성 - 창세기 3장을 중심으로

김지명 한국성서학연구소 2017 성서마당 : 한국교회를 위한 성경연구지 Vol.- No.124

누설 및 순환전류에 따른 ESS의 안전성 평가방안에 관한 연구

김지명,최성문,이나경,김윤호,노대석 대한전기학회 2023 대한전기학회 학술대회 논문집 Vol.2023 No.10-1

빈혈 환자에서 철결핍의 예측인자로서 혈중 Pro-hepcidin

김지명,손용학,임춘화 대한진단검사의학회 2011 Laboratory Medicine Online Vol.1 No.2

Background: Hepcidin has recently been known as a negative regulatory hormone of iron. Hepcidin precursor, pro-hepcidin has been used as a surrogate and reported to be related to iron deficiency. We investigated serum pro-hepcidin levels in patients with iron deficiency anemia (IDA),anemia of chronic disorder (ACD) and ACD concomitant iron deficiency (ACD/ID) to assess its usefulness as a marker of iron deficiency and examined whether its level is associated with anemia, iron status or inflammation profiles involved in the synthesis of hepcidin. Methods: We enrolled 50 patients with IDA, 46 with ACD, 12 with ACD/ID and 60 healthy controls. Complete blood cell count, iron parameters (iron, TIBC, trasferrin saturation, ferritin), C-reactive protein (CRP) and serum pro-hepcidin were measured. Results: Patients with iron deficiency, the IDA group and ACD/ID group had lower serum pro-hepcidin levels than healthy controls and the ACD group. The cutoff value of pro-hepcidin for detecting iron deficiency was 230 ng/mL (sensitivity 88.1%, specificity 51.2%). Patients with increased CRP showed higher mean pro-hepcidin level than those with normal CRP and the difference was significant in the IDA group (P =0.02). And serum pro-hepcidin level was positively correlated with CRP level (r=0.30, P =0.04) in the IDA group but not with hemoglobin. Conclusions: In patients with anemia, pro-hepcidin measurement may be useful for differentiating anemia patients with iron deficiency, IDA and ACD/ID from those with ACD. Serum pro-hepcidin levels may be more affected by inflammation than by the degree of anemia.

한국인 비호지킨림프종의 백혈병성 골수침습에 대한 임상혈액학적 소견

김지명,박찬정,장성수,지현숙,허주령,강윤구,서종진 대한진단검사의학회 2011 Laboratory Medicine Online Vol.1 No.2

Background: The purpose of the present study was to investigate the clinico-hematological findings of bone marrow (BM) involvement and leukemic phase in Korean patients with non-Hodgkin lymphoma (NHL). Methods: We included 791 patients with NHL that were classified with the WHO (2008) criteria. Laboratory data, bone marrow histomorphologic features and medical records were reviewed. Leukemic phase was defined as when the proportion of neoplastic lymphoid cells comprised more than 10% of leukocytes in the peripheral blood or more than 25% of nucleated cells in the BM. Results: We found that 21.7% (172/791) of the patients had BM involvement, and 6.2% (49/791) developed leukemic phase of the disease. NHL subtypes showing high frequencies of leukemic phase development were mantle cell lymphoma (40%), angioimmunoblastic T cell lymphoma (40%),lymphoblastic lymphoma (36.4%), and Burkitt lymphoma (26.1%). Compared to B-cell type, T-cell type of NHL showed significantly higher frequencies of BM involvement (18.6% vs 30.9%; P =0.0004) and leukemic phase development (4.8% vs 10.3%, P =0.008). Complete remission rate was significantly lower in leukemic (55.6%) than in non-leukemic (85.9%) group of patients (P =0.0002), whereas relapse rate was not different between the two groups. Death rate was higher in leukemic (46.9%) than in non-leukemic (30.1%) group of patients, and the 5-yr overall survival probability was significantly lower in leukemic group (P =0.02). Conclusions: The incidence of leukemic phase development in NHL was lower in Korean patients than that reported for Western populations and higher in T-cell lymphoma. We confirmed that the presence of leukemic phase in NHL patients is associated with a poor prognosis.

백미와 발아현미의 혼합비율이 압출성형 멥쌀가루의 이화학적 특성에 미치는 효과

김지명,우맹영,신말식,Kim, Ji Myoung,Yu, Mengying,Shin, Malshick 한국식품조리과학회 2012 한국식품조리과학회지 Vol.28 No.6

To develop the high quality gluten-free rice products with health functionality and desirable texture with moistness, the physicochemical properties of extruded rice flours prepared from the mixture of germinated brown and white rices were investigated. The domestic organic Samgwangbyeo was used to make white and germinated brown rices. White rice (WR) was dried after soaked for 6 h at $15{\pm}3^{\circ}C$ and mixed with germinated brown rice (GBR) with different mixing ratios (100:0, 75:25, 50:50, 25:75, 0:100). The operating conditions of twin screw extruder were 250 rpm of screw speed, $120^{\circ}C$ of barrel temperature, and 25% moisture content of rice flour. The ash, crude protein and crude lipid contents were significantly different (p<0.05) and those of extruded GBR were the highest values, but those of extruded WR were the lowest. The color difference of extruded WR based on white plate showed the lowest among them. The water binding capacity (334.16%), swelling power (8.83 g/g), solubility (33.13%), and total starch (79.50%) were the lowest in extruded GBR. The viscosities of all extruded rice flours by RVA were maintained during heating. The peak and total setback viscosities of extruded rice flours ranged 127-352 and 58.0-85.5 cP, respectively. The novel food biomaterial from germinated brown rice as well as white rice was developed by twin screw extruder. The extruded rice flours control the moistness to improve the texture and also have functional materials, dietary fiber, GABA, and ferulic acid, etc to increase quality of gluten free rice products.

스마트 건설을 위한 건설산업의 디지털화와 디지털 전환 방안 연구: 데이터 허브와 응용프로그래밍 인터페이스(API) 활용

김지명,손승현,윤경철 한국건축시공학회 2022 한국건축시공학회지 Vol.22 No.4

While the construction industry is striving to make changes suitable for the 4th industrial revolutionera through the introduction of 4th industrial revolution technologies, such change is progressingmore slowly than in other industries. Nevertheless, the recent digitization and digital transformationof the construction industry can provide a new paradigm to address and innovate the chronic problemsfaced by the construction industry. Therefore, in this study, a case study using a data hub and API foruse of the data hub, which is essential for digitalization and digital transformation, was conducted, andthe efficiency and feasibility of using the data hub and API were considered. When the API system wasintroduced, it was found that the average budget savings per person was about 23%, and the costbenefitratio was about 4.4 times higher, indicating that the feasibility of the project was very high. Theresults and framework of this study can serve as fundamental research data for related research, andprovide a worthy case study to promote the introduction of related technologies. This will ultimatelycontribute to digitalization and digital transformation for smartization of the construction industry. 다양한 산업분야에서 4차 산업혁명 기술은 그 활용도가 날로 커지고 있다. 건설업계에서도 드론, IoT, 센서기술, 디지털트원 등의 도입을 통해 4차 산업혁명에 걸맞은 변화를 꾀하고 있으나, 그 변화는 타 산업에 비해 더디게 진행되고 있다. 그럼에도 불구하고 최근 불고 있는 건설업계의 디지털화와 디지털 전환은 건설산업이 처해 있는 고질적인 문제들을 개선하고 혁신하는 새로운 패러다임이 될 수 있다. 따라서 본 연구에서는 디지털화와 디지털 전환에 반드시 필요한 데이터 허브와 데이터 허브의 이용을 위한 API를 활용한 케이스 스터디를 진행해 보고, 이를 통해 데이터 허브와 API 활용에 대한 효율성과 타당성에 대해 고찰해 보았다. API 시스템 도입 시 일인 평균 약 23%의 예산 절감 효과가 있는 것으로 나타났으며, 약 4.4배의비용대비 편익이 발생하는 것으로 나타나 사업 추진 타당성은 매우 높은 것으로 나타났다. 따라서, 본 연구의 결과 및 프레임워크는 관련 연구의 기초 연구자료가 될 것이며, 관련 기술 도입을 촉진하기 위한 좋은 사례 연구가 될 것이다. 이는 궁극적으로는 건설업의 스마트화를 위한 디지털화와 디지털 전환에 기여 할 것이다.

[구약] 하나 됨의 선하고 아름다움 - 시편 133:1-3

김지명 한국성서학연구소 2021 성서마당 : 한국교회를 위한 성경연구지 Vol.- No.140

초기 신생아 세균 감염의 진단에 있어서의 Procalcitonin의 유용성

김지명,장미영,구선회,권계철 대한진단검사의학회 2014 Laboratory Medicine Online Vol.4 No.2

Background: The use of several biochemical markers has improved the diagnosis of neonatal bacterial infection, which remains an important cause of morbidity and mortality. Recently, serum procalcitonin (PCT) has been investigated as a new marker for the detection of bacterial infection. The aim of this study was to assess the usefulness of PCT in early neonatal bacterial infection and compare the diagnostic utility of PCT with that of C-reactive protein (CRP). Methods: We retrospectively studied 216 neonates (109 full term, 107 preterm) whose PCT was measured 24 hr after birth. Thirty-five were clinically classified into an infected group, of which 17.4% had positive cultures. Clinical data, PCT, CRP, leukocyte, and neutrophil counts were evaluated. The diagnostic performance of PCT and CRP was studied using receiver operating characteristic analysis. Results: Compared to the non-infected group, the infected group displayed significantly higher median PCT (0.82 vs. 12.29 ng/mL, P<0.0001) and CRP (1.0 vs. 5.0 mg/L, P<0.0001) values, but similar leukocyte and neutrophil counts. The thresholds for PCT and CRP were 2.75 ng/mL (sensitivity, 97.1%; specificity, 76.7%) and 3.1 mg/L (sensitivity, 68.6%; specificity, 83.3%), respectively. The area under the curve for PCT was 0.937 (95% confidence interval [CI], 0.896-0.965) and 0.781 for CRP (95% CI, 0.720-0.834). Conclusions: During the first 24 hr after birth, PCT is a more sensitive marker than CRP for bacterial infection and has predictive value for early neonatal bacterial infection. 배경: 여러 생화학 표지자의 사용은 신생아에서 세균감염의 진단율을 향상시켰으나 여전히 세균감염은 신생아의 유병률 및 사망률의 주요 원인이다. 최근 혈청 procalcitonin (PCT)이 세균감염의 검출을 위한 새로운 표지자로 연구되어 왔다. 이에 저자들은 초기 신생아 세균감염에서 PCT의 유용성을 평가하고자 하였으며 PCT의 진단적 효용성을 C-반응단백(CRP)과 비교하였다. 방법: 생후 24시간에 PCT가 의뢰된 216명의 신생아(109명의 만기출산아, 107명의 조산아)를 대상적으로 후향적으로 진행하였다. 35명이 감염군으로 분류되었으며 감염군에서 배양 양성률은 17.4%이었다. 임상자료, PCT, CRP, 백혈구 수 및 호중구 수가 조사되었다. PCT와 CRP의 진단적 효용성은 receiver operating characteristic analysis로 분석하였다. 결과: 감염군의 PCT (0.82 vs. 12.29 ng/mL, P<0.0001)와 CRP (1.0 vs. 5.0 mg/L, P<0.0001)의 중앙값은 비감염군보다 유의하게 높았으나 백혈구 수나 호중구 수는 차이를 보이지 않았다. PCT는 경계치 2.75 ng/mL에서 민감도 97.1%, 특이도 76.7%를 나타냈으며 CRP는 경계치 3.1 mg/L에서 민감도 68.6%, 특이도 83.3%이었다. 또한 PCT와 CRP의 곡선하면적은 각각 0.937 (95% CI, 0.896-0.965) 및 0.781 (95% CI, 0.720-0.834)이었다. 결론: 생후 24시간의 PCT는 CRP보다 세균감염의 보다 민감한 표지자이며 초기 신생아 세균감염의 예측에 유용하다.

혈소판 수혈불응과 관련된 주요 인자 분석

김지명,이우창,이선화,권석운 大韓輸血學會 1998 大韓輸血學會誌 Vol.9 No.1

국내와 해외 선진국의 안전교육 비교

김지명 한국건축시공학회 2019 건축시공 Vol.19 No.3